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25 p, 24.0 MB AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer / Muñoz-Lorente, Miguel A. (Centro Nacional de Investigaciones Oncológicas) ; Martínez, Paula (Centro Nacional de Investigaciones Oncológicas) ; Tejera, Águeda (Centro Nacional de Investigaciones Oncológicas) ; Whittemore, Kurt (Centro Nacional de Investigaciones Oncológicas) ; Moisés-Silva, Ana Carolina (Centro Nacional de Investigaciones Oncológicas) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Blasco, María A. (Centro Nacional de Investigaciones Oncológicas)
Short and dysfunctional telomeres are sufficient to induce a persistent DNA damage response at chromosome ends, which leads to the induction of senescence and/or apoptosis and to various age-related conditions, including a group of diseases known as "telomere syndromes", which are provoked by extremely short telomeres owing to germline mutations in telomere genes. [...]
2018 - 10.1371/journal.pgen.1007562
PLoS Genetics, Vol. 14 (august 2018)  
Detailed record - Creative Commons

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