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13 p, 4.6 MB Generation of cattle knockout for galactose-α1,3-galactose and N-glycolylneuraminic acid antigens / Perota, Andrea (Laboratory of Reproductive Technologies) ; Lagutina, Irina (Laboratory of Reproductive Technologies) ; Duchi, Roberto (Laboratory of Reproductive Technologies) ; Zanfrini, Elisa (Laboratory of Reproductive Technologies) ; Lazzari, Giovanna (Fondazione Avantea) ; Judor, Jean Paul (CHU Nantes) ; Conchon, Sophie (CHU Nantes) ; Bach, Jean-Marie (University of Nantes) ; Bottio, Tomaso (Padova University School of Medicine) ; Gerosa, Gino (Padova University School of Medicine) ; Costa Farré, Cristina (Hospitalet de Llobregat) ; Galiñanes, Manuel (Hospital Universitari Vall d'Hebron) ; Roussel, Jean Christian (Nantes University Hospital (França)) ; Padler-Karavani, Vered (Tel Aviv University) ; Cozzi, Emanuele (University Hospital of Padova (Pàdua, Itàlia)) ; Soulillou, Jean Paul (CHU Nantes) ; Galli, Cesare (Fondazione Avantea) ; Universitat Autònoma de Barcelona
Two well-characterized carbohydrate epitopes are absent in humans but present in other mammals. These are galactose-α1,3-galactose (αGal) and N -glycolylneuraminic acid (Neu5Gc) which are introduced by the activities of two enzymes including α(1,3) galactosyltransferase (encoded by the GGTA1 gene) and CMP-Neu5Gc hydroxylase (encoded by the CMAH gene) that are inactive in humans but present in cattle. [...]
2019 - 10.1111/xen.12524
Xenotransplantation, Vol. 26 (may 2019)  

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