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9 p, 1.2 MB

Intrathecal Administration of IGF-I by AAVrh10 Improves Sensory and Motor Deficits in a Mouse Model of Diabetic Neuropathy / Homs i Avila, Judit (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pagès i Pi, Gemma (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ariza, Lorena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Chillón Rodríguez, Miguel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Bosch i Merino, Assumpció (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Different adeno-associated virus (AAV) serotypes efficiently transduce neurons from central and peripheral nervous systems through various administration routes. Direct administration of the vectors to the cerebrospinal fluid (CSF) could be an efficient and safe strategy. [...]
2014 - DOI (Digital Object Identifier)

10.1038/mtm.2013.7
Molecular Therapy. Methods & Clinical Development, Vol. 1, Article 7 (2014) , p. 1-9

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