Published articles

Published articles 2 records found  Search took 0.00 seconds. 
2 p, 188.6 KB Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds / Pérez-Areales, Francisco Javier (University of Barcelona) ; Garrido, María (Instituto de Química Avanzada de) ; Catalunya (IQAC-CSIC) ; Aso, Ester (University of Barcelona) ; Bartolini, Manuela (Department of Pharmacy and Biotechnology. Alma Mater Studiorum University of Bologna) ; De Simone, Angela (University of Bologna. Department for Life Quality Studies) ; Espargaró Colomé, Alba (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ginex, Tiziana (University of Barcelona) ; Sabate, Raimon (University of Barcelona) ; Pérez, Belén (Autonomous University of Barcelona. Therapeutics and Toxicology) ; Andrisano, Vincenza (University of Bologna. Department for Life Quality Studies) ; Luque, Francisco Javier (University of Barcelona) ; Ferrer, Isidro (Universitat de Barcelona. Unitat de Neuropatologia Experimental) ; Ciruela, Francisco (University of Barcelona) ; Messeguer, Àngel (Instituto de Química Avanzada de) ; Catalunya (IQAC-CSIC) ; Muñoz Torrero, Diego (Universitat de Barcelona. Laboratori de Química Farmacèutica)
Simultaneous modulation of several targets or athological events with a key pathogenic role is a promising strategy to tackle thus far difficult-to-cure or incurable multifactorial diseases, such as Alzheimer's disease (AD). [...]
2019 - 10.3390/proceedings2019022071
Proceedings, Vol. 22 (2019) , p. 1-2  
1 p, 134.6 KB Dibenzylxanthines as PPEPCK-M inhibitors for cancer therapy / Aragó, Marc (University of Barcelona. Department of Physiological Sciences, Faculty of Medicine) ; Rodríguez-Arévalo , Sergio (University of Barcelona. Institute of Biomedicine) ; Moreno, Juan (University of Barcelona. Faculty of Medicine) ; Abás, Sònia (University of Barcelona. Faculty of Pharmacy, and Institute of Biomedicine (IBUB)) ; Figueras, Agnès (Institut d'Investigació Biomèdica de Bellvitge) ; Pérez, Belén (Universitat Autònoma de Barcelona. Farmacologia Terapèutica i Toxicologia) ; Viñals, Francesc (Institut D'Investigació Biomèdica de Bellvitge (IDIBELL)) ; Carmen Escolano, María (University of Barcelona. Institute of Biomedicine(IBUB)) ; Carlos Perales, José (University of Barcelona. Faculty of Medicine)
Phosphoenolpyruvate carboxykinase (PEPCK) is the key enzyme in gluconeogenesis/glyceroneogenesis, which catalyzes the decarboxylation of oxaloacetate to phosphoenolpyruvate. In eukaryotes, there are two isozymes present either in the cytosol (PEPCKC, PCK1) or the mitochondria (PEPCK-M, PCK2). [...]
2019 - 10.3390/proceedings2019022079
Proceedings, Vol. 22 (2019) , p. 1  

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