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Articles 161 registres trobats  anterior11 - 20següentfinal  anar al registre: La cerca s'ha fet en 0.01 segons. 
11.
25 p, 4.8 MB Functional Characterization of Mouse and Human Arachidonic Acid Lipoxygenase 15B (ALOX15B) Orthologs and of Their Mutants Exhibiting Humanized and Murinized Reaction Specificities / Kakularam, Kumar R. (Charité-Universitätsmedizin Berlin. Department of Biochemistry) ; Canyelles-Niño, Miquel (Universitat Autònoma de Barcelona. Departament de Química) ; Chen, Xin (Charité-Universitätsmedizin Berlin. Department of Biochemistry) ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Kuhn, Hartmut (Charité-Universitätsmedizin Berlin. Department of Biochemistry)
The arachidonic acid lipoxygenase 15B (ALOX15B) orthologs of men and mice form different reaction products when arachidonic acid is used as the substrate. Tyr603Asp+His604Val double mutation in mouse arachidonic acid lipoxygenase 15b humanized the product pattern and an inverse mutagenesis strategy murinized the specificity of the human enzyme. [...]
2023 - 10.3390/ijms241210046
International journal of molecular sciences, Vol. 24, Issue 12 (June 2023) , art. 10046  
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12.
13 p, 6.6 MB Integrated gene expression profiles reveal a transcriptomic network underlying the thermogenic response in adipose tissue / Rodó, Jordi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Garcia, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Casaña Lorente, Estefania (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Muñoz, Sergio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Jambrina Pallarés, Claudia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sacristan, Victor (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Franckhauser, Sylvie (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Grass Costa, Ignasi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Jimenez, Veronica (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Obesity and type 2 diabetes are two closely related diseases representing a serious threat worldwide. An increase in metabolic rate through enhancement of non-shivering thermogenesis in adipose tissue may represent a potential therapeutic strategy. [...]
2023 - 10.1038/s41598-023-33367-w
Scientific reports, Vol. 13 (May 2023) , art. 7226  
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13.
8 p, 3.0 MB Association of Serum Ferritin Levels Before Start of Conditioning With Mortality After alloSCT - A Prospective, Non-interventional Study of the EBMT Transplant Complications Working Party / Penack, Olaf (Charité - Universitätsmedizin Berlin) ; Peczynski, Christophe (EBMT Statistical Unit) ; van der Werf, Steffie (EBMT Data Office) ; Finke, Jürgen (University of Freiburg) ; Ganser, Arnold (Hannover Medical School) ; Schoemans, Helene (University Hospitals Leuven (Bèlgica)) ; Pavlu, Jiri (Imperial College London) ; Niittyvuopio, Riitta (HUCH Comprehensive Cancer Center) ; Schroyens, W.ilfried (University Hospital Antwerp (Bèlgica)) ; Kaynar, Leylagül (Erciyes University) ; Blau, Igor W. (Department of Hematology. Oncology. and Tumor Immunology) ; van der Velden, Walter J.F.M. (Radboud University) ; Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau) ; Cortelezzi, Agostini (University of Milan) ; Wulf, Gerald (Universitätsklinikum Göttingen) ; Turlure, Pascal (CHRU Limoges) ; Rovira Argelagués, Montserrat (Hospital Clínic i Provincial de Barcelona) ; Ozkurt, Zubeydenur (Gazi University) ; Pascual-Cascon, Maria J. (Hospital Regional Universitario de Málaga) ; Moreira, Maria C. (Instituto National do Cancer) ; Clausen, Johannes (Ordensklinikum Linz Elisabethinen) ; Greinix, Hildegard (Medical University of Graz) ; Duarte, Rafael F. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ; Basak, Grzegorz (Medical University of Warsaw) ; Universitat Autònoma de Barcelona
Elevated serum ferritin levels occur due to iron overload or during inflammation and macrophage activation. A correlation of high serum ferritin levels with increased mortality after alloSCT has been suggested by several retrospective analyses as well as by two smaller prospective studies. [...]
2020 - 10.3389/fimmu.2020.00586
Frontiers in immunology, Vol. 11 (15 2020) , p. 586  
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14.
10 p, 508.1 KB Extracellular vesicles : where the amyloid precursor protein carboxyl-terminal fragments accumulate and amyloid-β oligomerizes / Pérez-González, Rocío (Institut d'Investigació Biomèdica Sant Pau) ; Kim, Y. (New York University School of Medicine) ; Miller, C. (Nathan S. Kline Institute) ; Pacheco-Quinto, J. (Biomedical Research Institute of New Jersey) ; Eckman, E.A. (Biomedical Research Institute of New Jersey) ; Levy, E. (New York University School of Medicine) ; Universitat Autònoma de Barcelona
Pleiotropic roles are proposed for brain extracellular vesicles (EVs) in the development of Alzheimer's disease (AD). Our previous studies have suggested a beneficial role for EVs in AD, where the endosomal system in vulnerable neurons is compromised, contributing to the removal of accumulated material from neurons. [...]
2020 - 10.1096/fj.202000823R
FASEB Journal, Vol. 34 Núm. 9 (january 2020) , p. 12922-12931  
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15.
11 p, 2.6 MB Metabolic Correlates of Dopaminergic Loss in Dementia with Lewy Bodies / Huber, Maria (LMU Munich) ; Beyer, Leonie (LMU Munich) ; Prix, Catharina (LMU Munich) ; Schönecker, Sonja (LMU Munich) ; Palleis, Carla (LMU Munich) ; Rauchmann, Boris-Stephan (LMU Munich) ; Morbelli, Silvia (University of Genoa) ; Chincarini, Andrea (Genoa section) ; Bruffaerts, Rose (University Hospitals Leuven (Bèlgica)) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; Van Laere, Koen (University Hospitals Leuven (Bèlgica)) ; Kramberger, Milica G. (University Medical Centre) ; Trost, Maja (University Medical Centre) ; Grmek, Marko (University Medical Centre) ; Garibotto, Valentina (Geneva University) ; Nicastro, Nicolas (University of Cambridge) ; Frisoni, Giovanni B. (Geneva University Hospitals) ; Lemstra, Afina W. (VU Medical Center Alzheimer Center) ; van der Zande, Jessica (VU Medical Center Alzheimer Center) ; Pilotto, Andrea (Isidoro Hospital) ; Padovani, Alessandro (University of Brescia) ; Garcia-Ptacek, Sara (Internal Medicine) ; Savitcheva, Irina (Karolinska University Hospital and Karolinska Institutet (Suecia)) ; Ochoa-Figueroa, Miguel A. (Linköping University) ; Davidsson, Anette (Linköping University Hospital) ; Camacho, Valle (Institut d'Investigació Biomèdica Sant Pau) ; Peira, Enrico (University of Genoa) ; Arnaldi, Dario (University of Genoa) ; Bauckneht, Matteo (University of Genoa) ; Pardini, Matteo (Clinical Neurology. Department of Neuroscience (DINOGMI). University of Genoa) ; Sambuceti, Gianmario (University of Genoa) ; Vöglein, Jonathan (DZNE-German Center for Neurodegenerative Diseases) ; Schnabel, Jonas (LMU Munich) ; Unterrainer, Marcus (LMU Munich) ; Perneczky, Robert (University of Munich) ; Pogarell, Oliver (LMU Munich) ; Buerger, Katharina (University of Munich) ; Catak, Cihan (University of Munich) ; Bartenstein, Peter (Munich Cluster for Systems Neurology (SyNergy)) ; Cumming, Paul (Queensland University of Technology) ; Ewers, Michael (DZNE-German Center for Neurodegenerative Diseases) ; Danek, Adrian (Ludwig-Maximilians-Universität) ; Levin, Johannes (Munich Cluster for Systems Neurology (SyNergy)) ; Aarsland, Dag (King's College London) ; Nobili, Flavio (University of Genoa) ; Rominger, Axel (University of Bern) ; Brendel, Matthias (Munich Cluster for Systems Neurology (SyNergy)) ; Universitat Autònoma de Barcelona
Striatal dopamine deficiency and metabolic changes are well-known phenomena in dementia with Lewy bodies and can be quantified in vivo by I-Ioflupane brain single-photon emission computed tomography of dopamine transporter and F-fluorodesoxyglucose PET. [...]
2020 - 10.1002/mds.27945
Movement Disorders, Vol. 35 Núm. 4 (january 2020) , p. 595-605  
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16.
17 p, 1.6 MB A TetR-Like Transcriptional Regulator Involved in Fatty Acid Metabolism Is Controlled by Quorum Sensing Signals / Coves, Xavier (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Bravo, Marc (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Esteve-Codina, Anna (Centre de Regulació Genòmica) ; Dabad, Marc (Centre de Regulació Genòmica) ; Gut, Marta (Centre de Regulació Genòmica) ; Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Stenotrophomonas maltophilia is an environmental bacterium as well as an emerging opportunistic multidrug-resistant pathogen. They use the endogenous diffusible signal factor (DSF) quorum sensing (QS) system to coordinate population behavior and regulate virulence processes but can also respond to exogenous N-acyl-homoserine lactone (AHL) signals produced by neighboring bacteria. [...]
2023 - 10.1128/aem.00635-23
Applied and Environmental Microbiology, Vol. 89, Issue 6 (June 2023)  
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17.
20 p, 1.1 MB Exploring the Relationship between Neutrophil Activation and Different States of Canine L. infantum Infection : Nitroblue Tetrazolium Test and IFN-γ / Blasi Brugué, Carles (Universitat Autònoma de Barcelona. Hospital Clínic Veterinari) ; Martínez-Flórez, Icíar (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Baxarias, Marta (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; del Rio-Velasco, Joan (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Solano Gallego, Laia (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
This study aimed to understand the role of neutrophils in canine leishmaniosis (CanL) by assessing neutrophil activation and its relationship with different states of Leishmania infantum infection and antibody and IFN-γ production. [...]
2023 - 10.3390/vetsci10090572
Veterinary Sciences, Vol. 10 (september 2023)  
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18.
9 p, 2.3 MB Solute carrier nutrient transporters in rheumatoid arthritis fibroblast-like synoviocytes / Torres, Alyssa (University of California) ; Pedersen, Brian (San Diego Healthcare System) ; Guma, Monica 1971- (Universitat Autònoma de Barcelona. Departament de Medicina)
Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic disruption. Metabolic changes in fibroblast-like synoviocytes (FLS) likely contribute to FLS abnormal response and strongly contribute to joint destruction. [...]
2022 - 10.3389/fimmu.2022.984408
Frontiers in immunology, Vol. 13 (october 2022)  
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19.
17 p, 2.8 MB Metabolomics Insights into the Differential Response of Breast Cancer Cells to the Phenolic Compounds Hydroxytyrosol and Luteolin / Garcia-Guasch, Maite (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Escrich, Eduard (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Moral Cabrera, Raquel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Duarte, Iola F. (University of Aveiro. Department of Chemistry)
The aim of this study was to investigate the effects of two phenolic compounds found in extra virgin olive oil, hydroxytyrosol (HT) and luteolin (LUT), on the metabolism of breast cancer (BC) cells of different molecular subtypes. [...]
2023 - 10.3390/molecules28093886
Molecules, Vol. 28, Issue 9 (May 2023) , art. 3886  
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20.
19 p, 12.6 MB Disruption of cortical cell type composition and function underlies diabetes-associated cognitive decline / Little, Karis (Queen's University Belfast) ; Singh, Aditi (Queen's University Belfast) ; Del Marco, Angel (Instituto de Investigacion e Innovacion en Ciencias Biomedicas de la Provincia de Cadiz) ; Llorián-Salvador, María (Hospital Universitari Vall d'Hebron) ; Vargas-Soria, Maria (Instituto de Investigacion e Innovacion en Ciencias Biomedicas de la Provincia de Cadiz) ; Turch-Anguera, Mireia (Hospital Universitari Vall d'Hebron) ; Solé Piñol, Montserrat (Hospital Universitari Vall d'Hebron) ; Bakker, Noëlle (Amsterdam UMC location University) ; Scullion, Sarah (Queen's University Belfast) ; Comella i Carnicé, Joan Xavier 1963- (Hospital Universitari Vall d'Hebron) ; Klaassen, Ingeborg (Amsterdam UMC location University of Amsterdam) ; Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron) ; Garcia-Alloza, Monica (Instituto de Investigacion e Innovacion en Ciencias Biomedicas de la Provincia de Cadiz) ; Tiwari, Vijay K. (Odense University Hospital (Dinamarca)) ; Stitt, Alan W. (Queen's University Belfast) ; Universitat Autònoma de Barcelona
Type 2 diabetes is associated with increased risk of cognitive decline although the pathogenic basis for this remains obscure. Deciphering diabetes-linked molecular mechanisms in cells of the cerebral cortex could uncover novel therapeutic targets. [...]
2023 - 10.1007/s00125-023-05935-2
Diabetologia, Vol. 66 (june 2023) , p. 1557-1575  
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