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11 p, 838.8 KB |
Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia : a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)
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Welte, Tobias (Carl-Neuberg-Str. 1, 30625 Hannover, Germany) ;
Dellinger, R. Phillip (Cooper Medical School of Rowan University. Department of Medicine) ;
Ebelt, Henning (Universitätsklinikum Halle (Saale). Klinik und Poliklinik für Innere Medizin III) ;
Ferrer, Miguel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Opal, Steven M. (Rhode Island Hospital. Infectious Disease Division) ;
Singer, Mervyn (University College London. Bloomsbury Institute of Intensive Care Medicine) ;
Vincent, Jean-Louis (Erasme University Hospital. Department of Intensive Care) ;
Werdan, Karl (St. James's Hospital. Trinity Centre for Health Sciences) ;
Martin-Loeches, Ignacio (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Almirall, Jordi (Hospital de Mataró. Unitat de Cures Intensives) ;
Artigas, Antonio (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ignacio Ayestarán, Jose (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Nuding, Sebastian (Hospital Universitario Mútua de Terrassa) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sirgo Rodríguez, Gonzalo (Hospital Universitari Joan XXIII de Tarragona) ;
Shankar-Hari, Manu (Guy's and St. Thomas' NHS Foundation Trust. Intensive Care Medicine) ;
Álvarez-Lerma, Francisco (Hospital del Mar (Barcelona, Catalunya)) ;
Riessen, Reimer (Universitätsklinikum Tübingen. Internistische Intensivstation) ;
Sirvent, Josep-Maria (Hospital Universitari de Girona Doctor Josep Trueta) ;
Kluge, Stefan (Universitätsklinikum Hamburg-Eppendorf. Klinik für Intensivmedizin) ;
Zacharowski, Kai (Universitätsklinikum Frankfurt. Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie) ;
Bonastre Mora, Juan (Hospital Universitari i Politècnic La Fe de València) ;
Lapp, Harald (Medizinische Klinik, Kardiologie und Intensivmedizin, Helios Klinikum Erfurt, Erfurt, Germany) ;
Wöbker, Gabriele (Klinik für Intensivmedizin, Helios Universitätsklinikum Wuppertal, Wuppertal, Germany) ;
Achtzehn, Ute (Klinikum Chemnitz gGmbH. Innere Medizin IV - Pneumologie) ;
Brealey, David (Critical Care Unit, NIHR University College London Hospitals Biomedical Research Centre, University College London Hospitals, NHS Foundation Trust, London, UK) ;
Kempa, Axel (Katharinenhospital, Stuttgart. Klinik für Allgemeine Innere Medizin) ;
Sánchez García, Miguel (Hospital Clínico San Carlos (Madrid)) ;
Brederlau, Jörg (Helios Klinikum Berlin-Buch, Klinik für Intensivmedizin) ;
Kochanek, Matthias (University Hospital of Cologne. Department I of Internal Medicine) ;
Reschreiter, Henrik Peer (Poole Hospital NHS Foundation Trust) ;
Wise, Matthew P. (Heath Park, Cardiff) ;
Belohradsky, Bernd H. (University Children's Hospital Munich) ;
Bobenhausen, Iris (Biotest AG) ;
Dälken, Benjamin (Biotest AG) ;
Dubovy, Patrick (Biotest AG) ;
Langohr, Patrick (Biotest AG) ;
Mayer, Monika (Biotest AG) ;
Schüttrumpf, Jörg (Biotest AG) ;
Wartenberg-Demand, Andrea (Biotest AG) ;
Wippermann, Ulrike (Biotest AG) ;
Wolf, Daniele (Biotest AG) ;
Torres, Antoni (Hospital Clínic i Provincial de Barcelona)
The CIGMA study investigated a novel human polyclonal antibody preparation (trimodulin) containing ~ 23% immunoglobulin (Ig) M, ~ 21% IgA, and ~ 56% IgG as add-on therapy for patients with severe community-acquired pneumonia (sCAP). [...]
2018 -  10.1007/s00134-018-5143-7
Intensive Care Medicine, Vol. 44 (april 2018) , p. 438-448
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8 p, 202.9 KB |
Prevention of Ventilator-Associated Pneumonia : The Multimodal Approach of the Spanish ICU "Pneumonia Zero" Program*
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Álvarez-Lerma, Francisco (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Palomar-Martínez, Mercedes ;
Sánchez-García, Miguel (Hospital Clínico San Carlos (Madrid)) ;
Martínez-Alonso, Montserrat ;
Álvarez-Rodríguez, Joaquín (Service of Intensive Care Medicine, SEMICYUC Working Group on Safety, Quality and Management, Hospital de Fuenlabrada, Fuenlabrada, Madrid, Spain) ;
Lorente, Leonardo (Service of Intensive Care Medicine, SEMICYUC Working Group on Infectious Diseases, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain) ;
Arias-Rivera, Susana (Hospital Universitario de Getafe (Madrid)) ;
Garcia, Rosa (Hospital de Basurto (Bilbao, Biscaia)) ;
Gordo, Federico (Service of Intensive Care Medicine, SEMICYUC Working Group on Acute Respiratory Insufficiency, Hospital Universitario del Henares, Colsada, Madrid, Spain) ;
Añón, José M. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Jam-Gatell, Rosa (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Vázquez-Calatayud, Mónica (Clínica Universidad de Navarra) ;
Agra Varela, Yolanda (Patient Safety Unit, Spanish Ministry of Health, Social Policy and Equality, Madrid, Spain) ;
Universitat Autònoma de Barcelona
Supplemental Digital Content is available in the text. The "Pneumonia Zero" project is a nationwide multimodal intervention based on the simultaneous implementation of a comprehensive evidence-based bundle measures to prevent ventilator-associated pneumonia in critically ill patients admitted to the ICU. [...]
2018 - 10.1097/CCM.0000000000002736
Critical Care Medicine, Vol. 46 (january 2018) , p. 181-188
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9 p, 446.3 KB |
Impact of colistin plasma levels on the clinical outcome of patients with infections caused by extremely drug-resistant Pseudomonas aeruginosa
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Sorlí, Luisa (Universitat Autònoma de Barcelona) ;
Luque, Sonia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Segura, Concepción (Laboratori de Referència de Catalunya (El Prat de Llobregat, Catalunya)) ;
Campillo, Nuria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Montero, Milagro (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Esteve, Erika (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Herrera, Sabina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Benito, Natividad (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Alvarez-Lerma, Francisco (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Grau, Santiago (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Horcajada, Juan Pablo (Universitat Autònoma de Barcelona)
Colistin has a narrow therapeutic window with nephrotoxicity being the major dose-limiting adverse effect. Currently, the optimal doses and therapeutic plasma levels are unknown. Prospective observational cohort study, including patients infected by colistin-susceptible P. [...]
2017 - 10.1186/s12879-016-2117-7
BMC Infectious diseases, Vol. 17 (january 2017)
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11 p, 762.2 KB |
Multiple time scales in modeling the incidence of infections acquired in intensive care units
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Wolkewitz, Martin (Freiburg Center of Data Analysis and Modelling, Albert-Ludwigs University Freiburg, Freiburg, Germany) ;
Cooper, Ben S. (University of Oxford. Centre for Tropical Medicine and Global Health) ;
Palomar-Martinez, Mercedes (Hospital Universitari Arnau de Vilanova) ;
Alvarez-Lerma, Francisco (Parc de Salut MAR de Barcelona) ;
Olaechea-Astigarraga, Pedro (Hospital de Galdakao (Usansolo, Biscaia)) ;
Barnett, Adrian G. (Institute of Health and Biomedical Innovation and School of Public Health and Social Work, Queensland University of Technology, Brisbane QLD, 4059 Australia) ;
Schumacher, Martin (Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany) ;
Universitat Autònoma de Barcelona
When patients are admitted to an intensive care unit (ICU) their risk of getting an infection will be highly depend on the length of stay at-risk in the ICU. In addition, risk of infection is likely to vary over calendar time as a result of fluctuations in the prevalence of the pathogen on the ward. [...]
2016 - 10.1186/s12874-016-0199-y
BMC Medical Research Methodology, Vol. 16 (september 2016)
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6 p, 291.8 KB |
Moisturizing body milk as a reservoir of Burkholderia cepacia : outbreak of nosocomial infection in a multidisciplinary intensive care unit
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Álvarez Lerma, F. (Hospital del Mar (Barcelona, Catalunya)) ;
Coll Figa, Pedro (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Maull, Elena (Hospital del Mar (Barcelona, Catalunya)) ;
Terradas, Roser (Hospital del Mar (Barcelona, Catalunya)) ;
Segura, Concepción (Laboratori de Referència de Catalunya (El Prat de Llobregat, Catalunya)) ;
Planells, Irene (Hospital Universitari Vall d'Hebron) ;
Knobel, Hernando (Hospital del Mar (Barcelona, Catalunya)) ;
Vázquez, Antonia (Hospital del Mar (Barcelona, Catalunya))
Background: An outbreak of severe nosocomial Burkholderia cepacia infections in patients admitted to intensive care unit (ICU), including investigation of the reservoir, is described. Methods: Over a period of 18 days, isolates of Burkholderia cepacia were recovered from different biological samples from five patients who were admitted to a multidisciplinary 18-bed intensive care unit. [...]
2008 - 10.1186/cc6778
Critical care, 12:R10 : 2008
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