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Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients
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Sadovnick, A. Dessa (Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ;
Traboulsee, Anthony L. (Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ;
Bernales, Cecily Q. (Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ;
Ross, Jay P. (Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ;
Forwell, Amanda L. (Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ;
Yee, Irene M. (Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ;
Guillot-Noel, Lena (Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, France) ;
Fontaine, Bertrand (Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, France) ;
Cournu-Rebeix, Isabelle (Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, France) ;
Alcina, Antonio (Department of Cell Biology and Immunology, Instituto de Parasitología y Biomedicina López Neyra (IPBLN), CSIC, 18100 Granada, Spain) ;
Fedetz, Maria (Unidad de Esclerosis Múltiple, Hospital Universitario Virgen Macarena, 41071 Sevilla, Spain) ;
Izquierdo, Guillermo (Unidad de Esclerosis Múltiple, Hospital Universitario Virgen Macarena, 41071 Sevilla, Spain) ;
Matesanz, Fuencisla (Department of Cell Biology and Immunology, Instituto de Parasitología y Biomedicina López Neyra (IPBLN), CSIC, 18100 Granada, Spain) ;
Hilven, Kelly (Laboratory for Neuroimmunology, Neurosciences, University of Leuven, 1022, Belgium) ;
Dubois, Bénédicte (Department of Neurology, University Hospitals Leuven, University of Leuven, Belgium) ;
Goris, An (Laboratory for Neuroimmunology, Neurosciences, University of Leuven, 1022, Belgium) ;
Astobiza, Ianire (Achucarro Basque Center for Neuroscience, 48170 Spain) ;
Alloza, Iraide (IKERBASQUE, Basque Foundation for Science, 48011 Spain) ;
Antigüedad, Alfredo (Servicio de Neurología, Hospital Universitario Basurto-Osakidetza, 48940 Bilbao, Spain) ;
Vandenbroeck, Koen (IKERBASQUE, Basque Foundation for Science, 48011 Spain) ;
Akkad, Denis A. (Department of Human Genetics, Ruhr University, 44801 Bochum, Germany) ;
Aktas, Orhan (Department of Neurology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany) ;
Blaschke, Paul (Department of Neurology, University of Rostock, 18059 Germany) ;
Buttmann, Mathias (Department of Neurology, University of Würzburg, 97080 Würzburg, Germany) ;
Chan, Andrew (Department of Neurology, University Hospital Bern and University of Bern, 3010 Bern, Switzerland) ;
Epplen, Joerg T. (Department of Human Genetics, Ruhr University, 44801 Bochum, Germany) ;
Gerdes, Lisa-Ann (Institute for Clinical Neuroimmunology, Ludwig Maximilian University, 80539 Munich, Germany) ;
Kroner, Antje (Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226) ;
Kubisch, Christian (Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany) ;
Kümpfel, Tania (Institute for Clinical Neuroimmunology, Ludwig Maximilian University, 80539 Munich, Germany) ;
Lohse, Peter (Institute of Laboratory Medicine and Human Genetics, 78224 Singen, Germany) ;
Rieckmann, Peter (Department of Neurology, Sozialstiftung Bamberg Hospital, 96049 Germany) ;
Zettl, Uwe K. (Department of Neurology, University of Rostock, 18059 Germany) ;
Zipp, Frauke (Department of Neurology, Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg-University Mainz, 55122 Germany) ;
Bertram, Lars (School of Public Health, Medicine, Imperial College London, SW7 2AZ, UK) ;
Lill, Christina M (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernandez, Oscar (Department of Neurology, UGC Neurociencias Clínicas. IBIMA-Hospital Regional Universitario de Málaga, 29010 Spain) ;
Urbaneja, Patricia (Department of Neurology, UGC Neurociencias Clínicas. IBIMA-Hospital Regional Universitario de Málaga, 29010 Spain) ;
Leyva, Laura (Research Laboratory, UGC Neurociencias Clínicas. IBIMA-Hospital Regional Universitario de Málaga, 29010 Spain) ;
Alvarez-Cermeño, Jose Carlos (Immunology and Neurology Service, Multiple Sclerosis Unit, Ramón y Cajal University Hospital-IRYCIS, 28034 Madrid, Spain) ;
Arroyo, Rafael (Department of Neurology, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC, 28040 Madrid, Spain) ;
Garagorri, Aroa M. (Department of Immunology, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC, Madrid, Spain) ;
García-Martínez, Angel (Department of Immunology, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC, Madrid, Spain) ;
Villar, Luisa M. (Immunology and Neurology Service, Multiple Sclerosis Unit, Ramón y Cajal University Hospital-IRYCIS, 28034 Madrid, Spain) ;
Urcelay, Elena (Department of Immunology, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC, Madrid, Spain) ;
Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Berger, Thomas (Department of Clinical Neurology, Medical University of Innsbruck, 6020 Austria) ;
Fazekas, Franz (Department of Neurology, Medical University of Graz, 8010 Austria) ;
Reindl, Markus (Department of Clinical Neurology, Medical University of Innsbruck, 6020 Austria) ;
Schmied, Mascha C. (Department of Neurology, Medical University of Vienna, 1090 Austria) ;
Zimprich, Alexander (Department of Neurology, Medical University of Vienna, 1090 Austria) ;
Vilariño-Güell, Carles (Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ;
Universitat Autònoma de Barcelona
Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p. G420D) in plasminogen (PLG) as a putative genetic risk factor for MS. [...]
2016 -  10.1534/g3.116.030841
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