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21 p, 24.0 MB The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy / Vázquez-Fernández, Ester (University of Alberta. Centre for Prions and Protein Folding Diseases) ; Vos, Matthijn R. (FEI Company) ; Afanasyev, Pavel (Maastricht University. The Maastricht Multimodal Molecular Imaging Institute) ; Cebey, Lino (University of Alberta. Centre for Prions and Protein Folding Diseases) ; Sevillano, Alejandro M. (Universidade de Santiago de Compostela) ; Vidal Barba, Enric (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ; Rosa, Isaac (Universidade de Santiago de Compostela) ; Renault, Ludovic (University of Alberta. Department of Biochemistry) ; Ramos, Adriana (Universidade de Santiago de Compostela) ; Peters, Peter J. (Maastricht University. The Maastricht Multimodal Molecular Imaging Institute) ; Fernández, José Jesús (Centro Nacional de Biotecnologia - CSIC) ; van Heel, Marin (Imperial College London. Faculty of Natural Science) ; Young, Howard S. (University of Alberta. Department of Biochemistry) ; Requena, Jesús R. (Universidade de Santiago de Compostela) ; Wille, Holger (University of Alberta. Centre for Prions and Protein Folding Diseases)
The structure of the infectious prion protein (PrP Sc), which is responsible for Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, has escaped all attempts at elucidation due to its insolubility and propensity to aggregate. [...]
2016 - 10.1371/journal.ppat.1005835
PLOS pathogens, Vol. 12 (september 2016)  

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