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35 p, 1.9 MB |
Neutron-irradiated antibody-functionalised carbon nanocapsules for targeted cancer radiotherapy
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Wang, Julie T. W. (King's College London. Institute of Pharmaceutical Science) ;
Spinato, Cinzia (Centre National de la Recherche Scientifique (França)) ;
Klippstein, Rebecca (King's College London. Institute of Pharmaceutical Science) ;
Costa, Pedro M. (King's College London. Institute of Pharmaceutical Science) ;
Martincic, Markus (Institut de Ciència de Materials de Barcelona) ;
Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia) ;
Pérez Ruiz De Garibay, Aritz (Centre National de la Recherche Scientifique (França)) ;
Ménard-Moyon, Cécilia (Centre National de la Recherche Scientifique (França)) ;
Feldman, Robert (Cis Bio International Ion Beam Applications SA) ;
Michel, Yves (Cis Bio International Ion Beam Applications SA) ;
Šefl, Martin (University of Ioannina Medical School) ;
Kyriakou, Ioanna (University of Ioannina Medical School) ;
Emfietzoglou, Dimitris (University of Ioannina Medical School) ;
Saccavini, Jean-Claude (Cis Bio International Ion Beam Applications SA) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Tobias, Gerard (Institut de Ciència de Materials de Barcelona) ;
Bianco, Alberto (Centre National de la Recherche Scientifique (França)) ;
Al-Jamal, Khuloud T. (King's College London. Institute of Pharmaceutical Science)
Radiotherapy is a cancer treatment utilising high doses of ionizing radiation to destroy cancer cells. Our team has pioneered neutron activation of Sm, filled and sealed into single-walled (SWCNTs) and multi-walled carbon nanotubes (MWCNTs), to create stable and high-dose radioactive carbon nanocapsules for cancer radiotherapy. [...]
2020 -  10.1016/j.carbon.2020.02.060
Carbon, Vol. 162 (June 2020) , p. 410-422
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2.
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59 p, 2.2 MB |
Neutron Activated 153Sm Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy
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Wang, Julie T. W. (King's College London. Institute of Pharmaceutical Science) ;
Klippstein, Rebecca (King's College London. Institute of Pharmaceutical Science) ;
Martincic, Markus (Institut de Ciència de Materials de Barcelona) ;
Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia) ;
Feldman, Robert (Cis Bio International Ion Beam Applications SA) ;
Šefl, Martin (Czech Technical University in Prague) ;
Michel, Yves (Cis Bio International Ion Beam Applications SA) ;
Asker, Daniel (King's College London. Institute of Pharmaceutical Science) ;
Sosabowski, Jane K. (Queen Mary University of London) ;
Kalbáč, Martin (J. Heyrovsky Institute of the Physical Chemistry) ;
Da Ros, Tatiana (University of Trieste. Department of Chemical and Pharmaceutical Sciences) ;
Ménard-Moyon, Cécilia (Centre National de la Recherche Scientifique (França)) ;
Bianco, Alberto (Centre National de la Recherche Scientifique (França)) ;
Kyriakou, Ioanna (University of Ioannina Medical School) ;
Emfietzoglou, Dimitris (University of Ioannina Medical School) ;
Saccavini, Jean-Claude (Cis Bio International Ion Beam Applications SA) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Al-Jamal, Khuloud T. (King's College London. Institute of Pharmaceutical Science) ;
Tobias, Gerard (Institut de Ciència de Materials de Barcelona)
Radiation therapy along with chemotherapy and surgery remain the main cancer treatments. Radiotherapy can be applied to patients externally (external beam radiotherapy) or internally (brachytherapy and radioisotope therapy). [...]
2020 - 10.1021/acsnano.9b04898
ACS nano, Vol. 14, Issue 1 (January 2020) , p. 129-141
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3.
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16 p, 5.4 MB |
Microwave-assisted synthesis of SPION-reduced graphene oxide hybrids for magnetic resonance imaging (MRI)
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Llenas, Marina (Institut de Ciència de Materials de Barcelona) ;
Sandoval, Stefania (Institut de Ciència de Materials de Barcelona) ;
Costa, Pedro M. (King's College London. Institute of Pharmaceutical Science) ;
Oró Solé, Judith (Institut de Ciència de Materials de Barcelona) ;
Lope-Piedrafita, Silvia (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Al-Jamal, Khuloud T. (King's College London. Institute of Pharmaceutical Science) ;
Tobias, Gerard (Institut de Ciència de Materials de Barcelona)
Magnetic resonance imaging (MRI) is a useful tool for disease diagnosis and treatment monitoring. Superparamagnetic iron oxide nanoparticles (SPION) show good performance as transverse relaxation (T) contrast agents, thus facilitating the interpretation of the acquired images. [...]
2019 - 10.3390/nano9101364
Nanomaterials, Vol. 9, Issue 10 (October 2019) , art. 1364
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4.
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12 p, 1.4 MB |
Evaluation of the immunological profile of antibody-functionalized metal-filled single-walled carbon nanocapsules for targeted radiotherapy
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Pérez Ruiz De Garibay, Aritz (Centre National de la Recherche Scientifique (França)) ;
Spinato, Cinzia (Centre National de la Recherche Scientifique (França)) ;
Klippstein, Rebecca (King's College London. Institute of Pharmaceutical Science) ;
Bourgognon, Maxime (King's College London. Institute of Pharmaceutical Science) ;
Martincic, Markus (Institut de Ciència de Materials de Barcelona) ;
Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Ménard-Moyon, Cécilia (Centre National de la Recherche Scientifique (França)) ;
Al-Jamal, Khuloud T. (King's College London. Institute of Pharmaceutical Science) ;
Tobias, Gerard (Institut de Ciència de Materials de Barcelona) ;
Bianco, Alberto (Centre National de la Recherche Scientifique (França))
This study investigates the immune responses induced by metal-filled single-walled carbon nanotubes (SWCNT) under in vitro, ex vivo and in vivo settings. Either empty amino-functionalized CNTs [SWCNT-NH 2 (1)] or samarium chloride-filled amino-functionalized CNTs with [SmCl 3 @SWCNT-mAb (3)] or without [SmCl 3 @SWCNT-NH 2 (2)] Cetuximab functionalization were tested. [...]
2017 - 10.1038/srep42605
Scientific reports, Vol. 7 (February 2017) , art. 42605
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19 p, 868.7 KB |
Design of antibody-functionalized carbon nanotubes filled with radioactivable metals towards a targeted anticancer therapy
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Spinato, Cinzia (Centre national de la recherche scientifique (França). Institut de Biologie Moléculaire et Cellulaire) ;
Pérez Ruiz De Garibay, Aritz (Centre national de la recherche scientifique (França). Institut de Biologie Moléculaire et Cellulaire) ;
Kierkowicz, Magdalena (Institut de Ciència de Materials de Barcelona) ;
Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia) ;
Martincic, Markus (Institut de Ciència de Materials de Barcelona) ;
Klippstein, Rebecca (King's College London. Institute of Pharmaceutical Science) ;
Bourgognon, Maxime (King's College London. Institute of Pharmaceutical Science) ;
Wang, Julie Tzu-Wen (King's College London. Institute of Pharmaceutical Science) ;
Ménard-Moyon, Cécilia (Centre national de la recherche scientifique (França). Institut de Biologie Moléculaire et Cellulaire) ;
Al-Jamal, Khuloud T. (King's College London. Institute of Pharmaceutical Science) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Tobias, Gerard (Institut de Ciència de Materials de Barcelona) ;
Bianco, Alberto (Centre national de la recherche scientifique (França). Institut de Biologie Moléculaire et Cellulaire)
In the present work we have devised the synthesis of a novel promising carbon nanotube carrier for the targeted delivery of radioactivity, through a combination of endohedral and exohedral functionalization. [...]
2016 - 10.1039/c5nr07923c
Nanoscale, Vol. 8, issue 25 (2016) , p. 12626-12638
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8 p, 2.5 MB |
Protein-Corona-by-Design in 2D : A Reliable Platform to Decode Bio-Nano Interactions for the Next-Generation Quality-by-Design Nanomedicines
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Mei, Kuo-Ching (King's College London) ;
Ghazaryan, Artur (Max Planck Institute for Polymer Research) ;
Teoh, Er Zhen (King's College London) ;
Summers, Huw D. (Swansea University) ;
Li, Yueting (Guizhou Medical University) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Piasecka, Justyna (Swansea University) ;
Walters, Adam (King's College London) ;
Hider, Robert C. (King's College London) ;
Mailänder, Volker (Johannes Gutenberg-University. Department of Dermatology) ;
Al-Jamal, Khuloud T. (King's College London)
Hard corona (HC) protein, i. e. , the environmental proteins of the biological medium that are bound to a nanosurface, is known to affect the biological fate of a nanomedicine. Due to the size, curvature, and specific surface area (SSA) 3-factor interactions inherited in the traditional 3D nanoparticle, HC-dependent bio-nano interactions are often poorly probed and interpreted. [...]
2018 - 10.1002/adma.201802732
Advanced materials, Vol. 30, Issue 40 (October 2018) , art. 1802732
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7.
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16 p, 2.1 MB |
Cationic liposome- multi-walled carbon nanotubes hybrids for dual siPLK1 and doxorubicin delivery in vitro
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Pereira, Sara (University of East Anglia. School of Pharmacy) ;
Lee, Jin (King's College London. Institute of Pharmaceutical Science) ;
Rubio, Noelia (King's College London. Institute of Pharmaceutical Science) ;
Hassan, Hatem A. F. M. (King's College London. Institute of Pharmaceutical Science) ;
Suffian, Izzat Bin Mohamed (King's College London. Institute of Pharmaceutical Science) ;
Wang, Julie T. W. (King's College London. Institute of Pharmaceutical Science) ;
Klippstein, Rebecca (King's College London. Institute of Pharmaceutical Science) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Al-Jamal, Wafa' T. (University of East Anglia. School of Pharmacy) ;
Al-Jamal, Khuloud T. (King's College London. Institute of Pharmaceutical Science)
To formulate f -MWNTs-cationic liposome hybrids for the simultaneous delivery of siPLK1 and doxorubicin to cancer cells. f -MWNTs-cationic liposome hybrids were prepared by the thin film hydration method where the lipid film was hydrated with 100 μg/ml or 1 mg/ml of ox-MWNTs-NH₃+ or MWNTs-NH₃+ in 5% dextrose. [...]
2015 - 10.1007/s11095-015-1707-1
Pharmaceutical research, Vol. 32, Issue 10 (Oct. 2015) , p. 3293-3308
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8.
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16 p, 4.7 MB |
The interaction of carbon nanotubes with an in vitro blood-brain barrier model and mouse brain in vivo
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Kafa, Houmam (King's College London. Institute of Pharmaceutical Science) ;
Wang, Julie Tzu-Wen (King's College London. Institute of Pharmaceutical Science) ;
Rubio, Noelia (King's College London. Institute of Pharmaceutical Science) ;
Venner, Kerrie (University College London. Institute of Neurology) ;
Anderson, Glenn (Great Ormond Street Hospital for Children (Londres)) ;
Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Preston, Jane E. (King's College London. Institute of Pharmaceutical Science) ;
Abbott, N. Joan (King's College London. Institute of Pharmaceutical Science) ;
Al-Jamal, Khuloud T. (King's College London. Institute of Pharmaceutical Science)
Carbon nanotubes (CNTs) are a novel nanocarriers with interesting physical and chemical properties. Here we investigate the ability of amino-functionalized multi-walled carbon nanotubes (MWNTs-NH₃+) to cross the Blood-Brain Barrier (BBB) in vitro using a co-culture BBB model comprising primary porcine brain endothelial cells (PBEC) and primary rat astrocytes, and in vivo following a systemic administration of radiolabelled f -MWNTs. [...]
2015 - 10.1016/j.biomaterials.2015.02.083
Biomaterials, Vol. 53 (June 2015) , p. 437-452
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