Results overview: Found 2 records in 0.02 seconds.
Articles, 1 records found
Research literature, 1 records found
Articles 1 records found  
1.
10 p, 1.3 MB Altering the Ad5 packaging domain affects the maturation of the ad particles / Alba Fernández, Raúl (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i Teràpia Gènica (CBATEG)) ; Cots, Dan (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i Teràpia Gènica (CBATEG)) ; Ostapchuk, Philomena (Stony Brook University. Department of Molecular Genetics and Microbiology (Nova York, Estats Units d'Amèrica)) ; Bosch i Merino, Assumpció (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Hearing, Patrick (Stony Brook University. Department of Molecular Genetics and Microbiology (Nova York, Estats Units d'Amèrica)) ; Chillón Rodríguez, Miguel (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i Teràpia Gènica (CBATEG))
We have previously described a new family of mutant adenoviruses carrying different combinations of attB/attP sequences from bacteriophage PhiC31 flanking the Ad5 packaging domain. These novel helper viruses have a significantly delayed viral life cycle and a severe packaging impairment, regardless of the presence of PhiC31 recombinase. [...]
2011 - 10.1371/journal.pone.0019564
PloS one, Vol. 6, Issue 5 (May 2011) , p. e19564  

Research literature 1 records found  
1.
206 p, 3.6 MB Caracterización del sistema attB/attP-[Phi]C31 para la producción de adenovirus gutless / Alba Fernández, Raúl ; Chillón Rodríguez, Miguel, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
El Ad es el vector más utilizado en ensayos clínicos con humanos. Para evitar la respuesta inmune celular inducida por los Ad de 1ª y 2ª generación, se han generado los vectores de 3ª generación, también llamados gutless o helper dependientes. [...]
Adenovirus is the most used vector in human clinical trials. In order to overcome cellular inmune response evoked by first and second generation adenovirus, third generation, also called gutless or helper-dependent adenovirus have been generated. [...]

Bellaterra : Universitat Autònoma de Barcelona, 2007  

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