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21 p, 2.4 MB |
Selective brain entry of lipid nanoparticles in haemorrhagic stroke is linked to biphasic blood-brain barrier disruption
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Al-Ahmady, Zahraa S. (The University of Manchester. Nanomedicine Lab, Division of Pharmacy and Optometry) ;
Dickie, Ben R. (University of Manchester. Geoffrey Jefferson Brain Research Centre) ;
Aldred, Isabelle (The University of Manchester. Nanomedicine Lab, Division of Pharmacy and Optometry) ;
Jasim, Dhifaf A. (The University of Manchester. Nanomedicine Lab, Division of Pharmacy and Optometry) ;
Barrington, Jack (University of Manchester. Division of Neuroscience and Experimental Psychology) ;
Haley, Michael J (University of Manchester. Division of Neuroscience and Experimental Psychology) ;
Lemarchand, Eloise (University of Manchester. Division of Neuroscience and Experimental Psychology) ;
Coutts, Graham (University of Manchester. Division of Neuroscience and Experimental Psychology) ;
Kaur, Satinderdeep (Nottingham Trent University. Pharmacology Department) ;
Bates, Jessica (Nottingham Trent University. Pharmacology Department) ;
Curran, Sarah (Nottingham Trent University. Pharmacology Department) ;
Goddard, Ruth (Nottingham Trent University. Pharmacology Department) ;
Walker, Megan (Nottingham Trent University. Pharmacology Department) ;
Parry-jones, Adrian (University of Manchester. Geoffrey Jefferson Brain Research Centre) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Allan, Stuart M. (University of Manchester. Geoffrey Jefferson Brain Research Centre)
Haemorrhagic stroke represents a significant public health burden, yet our knowledge and ability to treat this type of stroke are lacking. Previously we showed that we can target ischaemic-stroke lesions by selective translocation of lipid nanoparticles through the site of blood-brain barrier (BBB) disruption. [...]
2022 - 10.7150/thno.72167
Theranostics, Vol. 12, Issue 10 (May 2022) , p. 4477-4497
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30 p, 397.4 KB |
The IMPROVE Guidelines (Ischaemia Models : Procedural Refinements Of in Vivo Experiments)
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Percie du Sert, Nathalie (National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), London, UK) ;
Alfieri, Alessio (The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian, UK) ;
Allan, Stuart M. (Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK) ;
Carswell, Hilary V. O. (Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, Glasgow, UK) ;
Deuchar, Graeme A. (Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow/Arum Biosciences, Glasgow, UK) ;
Farr, Tracy D. (School of Life Sciences, University of Nottingham Medical School, Nottingham, UK) ;
Flecknell, Paul (Comparative Biology Centre, Newcastle University, UK) ;
Gallagher, Lindsay (Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow/Arum Biosciences, Glasgow, UK) ;
Gibson, Claire L. (Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK) ;
Haley, Michael J. (Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK) ;
Macleod, Malcolm R. (Centre for Clinical Brain Sciences. University of Edinburgh) ;
McColl, Barry W. (The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian, UK) ;
McCabe, Christopher (Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow/Arum Biosciences, Glasgow, UK) ;
Morancho, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Moon, Lawrence D. F. (King's College London. Wolfson Centre for Age-Related Diseases) ;
O'Neill, Michael J. (Eli Lilly and Co., Windlesham, Surrey, UK) ;
Pérez de Puig, Isabel (Institut d'Investigacions Biomèdiques de Barcelona) ;
Planas, Anna Maria (Institut d'Investigacions Biomèdiques de Barcelona) ;
Ragan, C. Ian (NC3Rs Board, London, UK) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Roy, Lisa A. (Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow/Arum Biosciences, Glasgow, UK) ;
Ryder, Kathryn O. (Home Office, London, UK) ;
Simats Oriol, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sena, Emily S. (Centre for Clinical Brain Sciences. University of Edinburgh) ;
Sutherland, Brad A. (School of Medicine, Faculty of Health, University of Tasmania, Hobart, Australia) ;
Tricklebank, Mark D. (King's College London) ;
Trueman, Rebecca C. (School of Life Sciences, University of Nottingham Medical School, Nottingham, UK) ;
Whitfield, Lucy (University of London. Royal Veterinary College (Hatfield, Regne Unit)) ;
Wong, Raymond (Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK) ;
Macrae, I Mhairi (Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow/Arum Biosciences, Glasgow, UK) ;
Universitat Autònoma de Barcelona
Most in vivo models of ischaemic stroke target the middle cerebral artery and a spectrum of stroke severities, from mild to substantial, can be achieved. This review describes opportunities to improve the in vivo modelling of ischaemic stroke and animal welfare. [...]
2017 - 10.1177/0271678X17709185
Journal of Cerebral Blood Flow & Metabolism, Vol. 37 (august 2017) , p. 3488-3517
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