Resultats globals: 7 registres trobats en 0.02 segons.
Articles, 6 registres trobats
Documents de recerca, 1 registres trobats
Articles 6 registres trobats  
1.
23 p, 1.5 MB The Role of Purported Mucoprotectants in Dealing with Irritable Bowel Syndrome, Functional Diarrhea, and Other Chronic Diarrheal Disorders in Adults / Alonso Cotoner, Carmen (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Abril-Gil, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Albert-Bayo, Mercé (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Mall, John-P. Ganda (Linköping University. Department of Biomedical and Clinical Sciences) ; Expósito, Elba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; González-Castro, Ana María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lobo, Beatriz (Universitat Autònoma de Barcelona. Facultat de Medicina) ; Santos, Javier (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Chronic diarrhea is a frequent presenting symptom, both in primary care medicine and in specialized gastroenterology units. It is estimated that more than 5% of the global population suffers from chronic diarrhea. [...]
2021 - 10.1007/s12325-021-01676-z
Advances in Therapy, march 2021, p. 1-23  
2.
24 p, 1.4 MB Intestinal mucosal mast cells : key modulators of barrier function and homeostasis / Albert-Bayo, Mercé (Hospital Universitari Vall d'Hebron) ; Paracuellos, Irene (Hospital Universitari Vall d'Hebron) ; González-Castro, Ana María (Hospital Universitari Vall d'Hebron) ; Rodríguez-Urrutia, Amanda (Universitat Autònoma de Barcelona) ; University of Barcelona ; Alonso Cotoner, Carmen (Hospital Universitari Vall d'Hebron) ; Santos, Javier (Hospital Universitari Vall d'Hebron) ; Vicario Perez, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca)
The gastrointestinal tract harbours the largest opulation of mast cells in the body; this highly specialised leukocyte cell type is able to adapt its phenotype and function to the microenvironment in which it resides. [...]
2019 - 10.3390/cells8020135
Cells, Vol. 8 (2019) , p. 1-24  
3.
11 p, 2.3 MB Decreased TESK1-mediated cofilin 1 phosphorylation in the jejunum of IBS-D patients may explain increased female predisposition to epithelial dysfunction / Rodiño-Janeiro, Bruno K. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fortea, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lobo Álvarez, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pigrau Pastor, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nieto, Adoración (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; González-Castro, Ana María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Salvo Romero, Eloísa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Guagnozzi, Danila (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pardo-Camacho, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Iribarren, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Azpiroz Vidaur, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Alonso Cotoner, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Santos, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vicario Perez, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Disturbed intestinal epithelial barrier and mucosal micro-inflammation characterize irritable bowel syndrome (IBS). Despite intensive research demonstrating ovarian hormones modulation of IBS severity, there is still limited knowledge on the mechanisms underlying female predominance in this disorder. [...]
2018 - 10.1038/s41598-018-20540-9
Scientific reports (Nature Publishing Group), Vol. 8 (2018) , art. 2255  
4.
22 p, 609.1 KB A Review of Microbiota and Irritable Bowel Syndrome : Future in Therapies / Rodiño-Janeiro, Bruno K. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vicario, María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Alonso-Cotoner, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pascua-García, Roberto (Servicio de Atención Primaria de Celanova, Orense, Spain) ; Santos, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Irritable bowel syndrome (IBS), one of the most frequent digestive disorders, is characterized by chronic and recurrent abdominal pain and altered bowel habit. The origin seems to be multifactorial and is still not well defined for the different subtypes. [...]
2018 - 10.1007/s12325-018-0673-5
Advances in Therapy, Vol. 35 (march 2018) , p. 289-310  
5.
14 p, 2.6 MB miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea / Martínez, Cristina (Hospital Universitari Vall d'Hebron) ; Rodiño-Janeiro, Bruno K (Hospital Universitari Vall d'Hebron) ; Lobo, Beatriz (Hospital Universitari Vall d'Hebron) ; Stanifer, Megan L (University of Heidelberg) ; Klaus, Bernd (European Molecular Biology Laboratory (EMBL)) ; Granzow, Martin (Institute of Human Genetics, University of Heidelberg) ; González-Castro, Ana María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Salvo-Romero, Eloisa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Alonso-Cotoner, Carmen (COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network) ; Pigrau Pastor, Marc (Hospital Universitari Vall d'Hebron) ; Roeth, Ralph (nCounter Core Facility, Institute of Human Genetics, University of Heidelberg) ; Rappold, Gudrun (Institute of Human Genetics, University of Heidelberg) ; Huber, Wolfgang (European Molecular Biology Laboratory (EMBL)) ; González-Silos, Rosa (Institute of Medical Biometry and Informatics, University of Heidelberg) ; Lorenzo, Justo (Institute of Medical Biometry and Informatics, University of Heidelberg) ; Torres, Inés de (Hospital Universitari Vall d'Hebron) ; Azpiroz Vidaur, Fernando (COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network) ; Boulant, Steeve (Research Group 'Cellular Polarity and Viral Infection' (F140), German Cancer Research Center (DKFZ)) ; Vicario, María (COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network) ; Niesler, Beate (nCounter Core Facility, Institute of Human Genetics, University of Heidelberg) ; Santos, Javier (COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network)
Micro-RNAs (miRNAs) play a crucial role in controlling intestinal epithelial barrier function partly by modulating the expression of tight junction (TJ) proteins. We have previously shown differential messenger RNA (mRNA) expression correlated with ultrastructural abnormalities of the epithelial barrier in patients with diarrhoea-predominant IBS (IBS-D). [...]
2017 - 10.1136/gutjnl-2016-311477
Gut, Vol. 66 (january 2017) , p. 1537-1538  
6.
18 p, 945.8 KB Role of Corticotropin-releasing Factor in Gastrointestinal Permeability / Rodiño-Janeiro, Bruno K (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Alonso-Cotoner, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pigrau Pastor, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lobo, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vicario, María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Santos, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
The interface between the intestinal lumen and the mucosa is the location where the majority of ingested immunogenic particles face the scrutiny of the vast gastrointestinal immune system. Upon regular physiological conditions, the intestinal micro-flora and the epithelial barrier are well prepared to process daily a huge amount of food-derived antigens and non-immunogenic particles. [...]
2015 - 10.5056/jnm14084
Journal of Neurogastroenterology and Motility, Vol. 21 (january 2015) , p. 33-50  

Documents de recerca 1 registres trobats  
1.
266 p, 6.0 MB Molecular mechanisms and effect of acute and psychosocial stress on the intestinal barrier function : implications on the irritable bowel syndrome / Pigrau Pastor, Marc ; Santos Vicente, Francisco Javier, dir. ; Vicario Perez, Maria, dir. ; Alonso Cotoner, Carmen, dir. ; Azpiroz Vidaur, Fernando, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
El estrés psicosocial es uno de los grandes problemas de salud en las sociedades modernas. En condiciones fisiológicas el estrés representa una amenaza para la homeostasis. En respuesta al estrés se genera una respuesta coordinada que implica a los sistemas autonómico, endocrino e inmunitario para mantener la estabilidad del medio. [...]
Psychosocial stress is becoming a huge health problem in modern societies in the last years. In physiological conditions, stress represents a threat to the internal homeostasis, and in response to stress a coordinated response involving autonomic, endocrine, and immune systems is generated to maintain stability. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2019.  

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