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14 p, 836.1 KB |
Predictive performance of interferon-gamma release assays and the tuberculin skin test for incident tuberculosis : an individual participant data meta-analysis
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Hamada, Yohhei (University College London) ;
Gupta, Rishi K. (University College London) ;
Quartagno, Matteo (MRC Clinical Trials Unit) ;
Izzard, Abbie (University College London) ;
Acuna-Villaorduna, Carlos (Boston University Medical Center) ;
Altet, Neus (Unitat de TDO de la Tuberculosis 'Servicios Clínicos' (Espanya)) ;
Diel, Roland (Universitätsklinikum Schleswig-Holstein (Alemanya)) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Floyd, Sian (London School of Hygiene & Tropical Medicine) ;
Gupta, Amita (Johns Hopkins University School of Medicine) ;
Huerga, Helena (Epicentre (França)) ;
Jones-López, Edward C. (University of Southern California) ;
Kinikar, Aarti (Sassoon General Hospital (India)) ;
Lange, Christoph (Tuberculosis Network European Trials Group (Alemanya)) ;
van Leth, Frank (Amsterdam Public Health Research Institute) ;
Liu, Qiao (Center for Disease Control and Prevention of Jiangsu Province) ;
Lu, Wei (Center for Disease Control and Prevention of Jiangsu Province) ;
Lu, Peng (Center for Disease Control and Prevention of Jiangsu Province) ;
Rueda, Irene Latorre (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martinez, Leonardo (Boston University) ;
Mbandi, Stanley Kimbung (South African Tuberculosis Vaccine Initiative) ;
Muñoz, Laura (Universitat de Barcelona) ;
Padilla, Elisabeth Sánchez (Epicentre (França)) ;
Paradkar, Mandar (Johns Hopkins India (India)) ;
Scriba, Thomas (South African Tuberculosis Vaccine Initiative) ;
Sester, Martina (Saarland University) ;
Shanaube, Kwame (Zambart, Zambia) ;
Sharma, Surendra K. (Datta Meghe Institute of Medical Sciences (India)) ;
Sloot, Rosa (Stellenbosch University (Sud Àfrica)) ;
Sotgiu, Giovanni (University of Sassari) ;
Thiruvengadam, Kannan (Indian Council of Medical Research) ;
Vashishtha, Richa (All India Institute of Medical Sciences (Nova Delhi, Índia)) ;
Abubakar, Ibrahim (University College London) ;
Rangaka, Molebogeng X. (University of Cape Town) ;
Universitat Autònoma de Barcelona
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Evidence on the comparative performance of purified protein derivative tuberculin skin tests (TST) and interferon-gamma release assays (IGRA) for predicting incident active tuberculosis (TB) remains conflicting. [...]
2023 -  10.1016/j.eclinm.2022.101815
EClinicalMedicine, Vol. 56 (january 2023)
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12 p, 995.8 KB |
Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children
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Altet, Neus (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron) ;
Soriano-Arandes, Antoni (Hospital Universitari Vall d'Hebron) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Milà, Celia (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Fernández, Pablo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Godoy, Pere (Institut de Recerca Biomèdica de Lleida) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Jiménez-Ruiz, Carlos A. (Comunidad Autónoma de Madrid. Unidad de Tabaquismo) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays' (IGRAs) performance and cytokine immune responses. [...]
2022 - 10.3390/jcm11072000
Journal of clinical medicine, Vol. 11 (april 2022)
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13 p, 1.6 MB |
Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis
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Serra-Vidal, Mᵃdel Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franken, Kees L. C. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Díaz, Jéssica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maldonado, José (Serveis Clínics (Barcelona)) ;
Milà, Celia (Hospital Universitari Vall d'Hebron) ;
Solsona, Jordi (Hospital Universitari Vall d'Hebron) ;
Jimenez-Fuentes, M. Ángeles (Hospital Universitari Vall d'Hebron) ;
Altet, Neus (Hospital Universitari Vall d'Hebron) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ottenhoff, Tom H. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The aim of our work here was to evaluate the immunogenicity of 60 mycobacterial antigens, some of which have not been previously assessed, notably a novel series of in vivo -expressed Mycobacterium tuberculosis (IVE-TB) antigens. [...]
2014 - 10.3389/fmicb.2014.00517
Frontiers in microbiology, Vol. 5 (october 2014)
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18 p, 1.6 MB |
Tuberculosis recurrences and predictive factors in a vulnerable population in Catalonia
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Brugueras Torrella, Silvia (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Molina-Pinargote, Israel (Serveis Clínics (Barcelona)) ;
Casas, Xavier (Serveis Clínics (Barcelona)) ;
González, Yoel-Domingo (Serveis Clínics (Barcelona)) ;
Forcada, Nuria (Serveis Clínics (Barcelona)) ;
Romero, Dora (Serveis Clínics (Barcelona)) ;
Rodés, Anna (Agència de Salut Pública de Barcelona) ;
Altet Gómez, María Neus (Serveis Clínics (Barcelona)) ;
Maldonado, José (Serveis Clínics (Barcelona)) ;
Martin-Sánchez, Mario (Parc de Salut MAR de Barcelona) ;
Caylà, Joan A. (Fundació de la Unitat d'Investigació en Tuberculosi de Barcelona) ;
Orcau, Àngels (Fundació de la Unitat d'Investigació en Tuberculosi de Barcelona) ;
Rius i Gibert, Maria Cristina (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Millet, Joan-Pau (Fundació de la Unitat d'Investigació en Tuberculosi de Barcelona)
Patients with a history of tuberculosis (TB) have a high probability of recurrence because long-term cure is not always maintained in successfully treated patients. The aim of this study was to identify the probability of TB recurrence and its predictive factors in a cohort of socially vulnerable patients who completed treatment in the TB referral center in Catalonia, which acts as the center for patients with social and health problems. [...]
2020 - 10.1371/journal.pone.0227291
PloS one, Vol. 15 (january 2020)
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11 p, 1.7 MB |
Use of IP-10 detection in dried plasma spots for latent tuberculosis infection diagnosis in contacts via mail
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Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Jiménez, María A. (Hospital Universitari Vall d'Hebron) ;
Ruiz Manzano, J (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pilarte, Jose (Hospital Universitari Vall d'Hebron) ;
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cantos, Adela (Hospital Universitari Vall d'Hebron) ;
Altet, Neus (Hospital Universitari Vall d'Hebron) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
González-Díaz, Yoel D. (Unidad Clínica de Tratamiento Directamente Observado "Serveis Clinics") ;
Molina-Pinargote, Israel (Unidad Clínica de Tratamiento Directamente Observado "Serveis Clinics") ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruhwald, Morten (Statens Serum Institut (Copenhagen, Dinamarca). Department of Infectious Disease Immunology) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The aim of this study was to test the use of IP-10 detection in dried plasma from contact studies individuals (contacts of smear positive patients), by comparing it with IP-10 and IFN-γ detection in direct plasma, to establish IP-10 detection in DPS as a useful assay for LTBI diagnosis. [...]
2019 - 10.1038/s41598-019-40778-1
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 3943
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17 p, 1.5 MB |
Assessment of the influence of direct tobacco smoke on infection and active TB management
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Altet, Neus (Hospital Universitari Vall d'Hebron) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron) ;
Maldonado, José (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Molina Romero, Israel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
González-Díaz, Yoel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Milà, Celia (Hospital Universitari Vall d'Hebron) ;
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Laabei, Maisem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Godoy, Pere (Generalitat de Catalunya. Departament de Salut) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Solano Reina, Segismundo (Hospital General Universitario Gregorio Marañón) ;
Jiménez-Ruiz, Carlos A. (Comunidad Autónoma de Madrid. Unidad de Tabaquismo) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
PII Smoking SEPAR Working Group
Background. Smoking is a risk factor for tuberculosis (TB) infection and disease progression. Tobacco smoking increases susceptibility to TB in a variety of ways, one of which is due to a reduction of the IFN-γ response. [...]
2017 - 10.1371/journal.pone.0182998
PloS one, Vol. 12 Núm. 8 (august 2017) , p. 1
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9 p, 502.6 KB |
Factors associated with smoking among tuberculosis patients in Spain
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Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron) ;
Rodrigo, Teresa (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Altet Gómez, María Neus (Serveis Clínics (Barcelona)) ;
Jiménez-Ruiz, Carlos A. (Unidad Especializada de Tabaquismo de la Comunidad de Madrid, Madrid, Spain) ;
Casals, Martí (agencia de salut publica) ;
Penas, Antón (Hospital Universitario Lucus Augusti (Lugo)) ;
Mir, Isabel (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ;
Solano Reina, Segismundo (Hospital General Universitario Gregorio Marañón) ;
Riesco-Miranda, Juan Antonio (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Caylà, Joan A.. (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
To determine the prevalence of smoking and analyze associated factors in a cohort of patients diagnosed with tuberculosis (TB) in Spain between 2006 and 2013. Multicenter, cross-sectional, descriptive, observational study using a national database of TB patients, using logistic regression to calculate odds ratios (OR) and confidence intervals (CI). [...]
2016 - 10.1186/s12879-016-1819-1
BMC Infectious diseases, Vol. 16 (september 2016)
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