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Results overview: Found 11 records in 0.03 seconds.
Articles, 8 records found
Research literature, 3 records found
Articles 8 records found  
1.
6 p, 665.3 KB Can bioinformatics help in the identification of moonlighting proteins? / Hernández, Sergio (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Calvo, Alejandra (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología) ; Ferragut, Gabriela (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología) ; Franco Serrano, Luís (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Hermoso, Antoni (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Amela Abellan, Isaac (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gómez, Antonio (Institut d'Investigació Biomèdica de Bellvitge) ; Querol Murillo, Enric (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Cedano Rodríguez, Juan Antonio (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología)
Protein multitasking or moonlighting is the capability of certain proteins to execute two or more unique biological functions. This ability to perform moonlighting functions helps us to understand one of the ways used by cells to perform many complex functions with a limited number of genes. [...]
2014 - 10.1042/BST20140241
Biochemical Society Transactions, Vol. 42, issue 6 (Dec. 2014) , p. 1692-1697  
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2.
4 p, 966.2 KB A hypothesis explaining why so many pathogen virulence proteins are moonlighting proteins / Franco-Serrano, Luís (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cedano Rodríguez, Juan Antonio (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología) ; Pérez-Pons, Josep A. (Josep Antoni) (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Mozo Villarias, Ángel (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Piñol Ribas, Jaume (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Amela Abellan, Isaac (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Querol Murillo, Enric (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Moonlighting or multitasking proteins refer to those proteins with two or more functions performed by a single polypeptide chain. Proteins that belong to key ancestral functions and metabolic pathways such as primary metabolism typically exhibit moonlighting phenomenon. [...]
2018 - 10.1093/femspd/fty046
Pathogens and disease, Vol. 76, issue 5 (July 2018)  
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3.
4 p, 947.1 KB MultitaskProtDB-II : an update of a database of multitasking/moonlighting proteins / Franco-Serrano, Luís (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Hernández, Sergio (Universitat Autònoma de Barcelona. Departamento de Bioquímia i Biologia Molecular) ; Calvo, Alejandra (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología) ; Severi, María A. (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología) ; Ferragut, Gabriela (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología) ; Pérez-Pons, Josep A. (Josep Antoni) (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Piñol Ribas, Jaume (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pich, Òscar M. (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Mozo Villarias, Ángel (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Amela Abellan, Isaac (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Querol Murillo, Enrique (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cedano Rodríguez, Juan Antonio (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología)
Multitasking, or moonlighting, is the capability of some proteins to execute two or more biological functions. MultitaskProtDB-II is a database of multifunctional proteins that has been updated. In the previous version, the information contained was: NCBI and UniProt accession numbers, canonical and additional biological functions, organism, monomeric/oligomeric states, PDB codes and bibliographic references. [...]
2017 - 10.1093/nar/gkx1066
Nucleic acids research, Vol. 46, Database issue D645-D648 (2018) , p. D645-D648  
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4.
16 p, 3.2 MB Bioinformatics and moonlighting proteins / Hernández, Sergio (Universitat Autònoma de Barcelona. Departamento de Bioquímia i Biologia Molecular) ; Franco-Serrano, Luís (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Calvo, Alejandra (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología) ; Ferragut, Gabriela (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología) ; Hermoso, Antoni (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Amela Abellan, Isaac (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gómez, Antonio (Institut d'Investigació Biomèdica de Bellvitge) ; Querol Murillo, Enrique (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cedano Rodríguez, Juan Antonio (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología)
Multitasking or moonlighting is the capability of some proteins to execute two or more biochemical functions. Usually, moonlighting proteins are experimentally revealed by serendipity. For this reason, it would be helpful that Bioinformatics could predict this multifunctionality, especially because of the large amounts of sequences from genome projects. [...]
2015 - 10.3389/fbioe.2015.00090
Frontiers in Bioengineering and Biotechnology, Vol. 3 (June 2015) , art. 90  
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5.
4 p, 2.6 MB MultitaskProtDB : a database of multitasking proteins / Hernández, Sergio (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ferragut, Gabriela (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología) ; Amela Abellan, Isaac (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Pérez-Pons, Josep A. (Josep Antoni) (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Piñol Ribas, Jaume (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Mozo Villarias, Angel (Universitat de Lleida. Departament de Medicina Experimental) ; Cedano Rodríguez, Juan Antonio (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología) ; Querol Murillo, Enrique (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
We have compiled MultitaskProtDB, available online at , to provide a repository where the many multitasking proteins found in the literature can be stored. Multitasking or moonlighting is the capability of some proteins to execute two or more biological functions. [...]
2013 - 10.1093/nar/gkt1153
Nucleic acids research, Vol. 42, Database issue D517-D520 (2014)  
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6.
11 p, 1.3 MB Gene ontology function prediction in Mollicutes using protein-protein association networks / Gómez, Antonio (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cedano Rodríguez, Juan Antonio (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Amela Abellan, Isaac (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Planas, Antoni (Institut Químic de Sarrià) ; Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Querol Murillo, Enrique (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Many complex systems can be represented and analysed as networks. The recent availability of large-scale datasets, has made it possible to elucidate some of the organisational principles and rules that govern their function, robustness and evolution. [...]
2011 - 10.1186/1752-0509-5-49
BMC systems biology, Vol. 5 (April 2011) , art. 49  
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7.
8 p, 354.0 KB Pathogen Proteins Eliciting Antibodies Do Not Share Epitopes with Host Proteins : A Bioinformatics Approach / Amela Abellan, Isaac (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cedano Rodríguez, Juan Antonio (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Querol Murillo, Enrique (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
The best way to prevent diseases caused by pathogens is by the use of vaccines. The advent of genomics enables genome-wide searches of new vaccine candidates, called reverse vaccinology. The most common strategy to apply reverse vaccinology is by designing subunit recombinant vaccines, which usually generate an humoral immune response due to B-cell epitopes in proteins. [...]
2007 - 10.1371/journal.pone.0000512
PloS one, Vol. 2 (June 2007) , p. e512  
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8.
11 p, 1.8 MB DockAnalyse : an application for the analysis of protein-protein interactions / Amela Abellan, Isaac (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Delicado, Pedro (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ; Gómez, Antonio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Bonàs, Sílvia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Cedano Rodríguez, Juan Antonio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Background: Is it possible to identify what the best solution of a docking program is? The usual answer to this question is the highest score solution, but interactions between proteins are dynamic processes, and many times the interaction regions are wide enough to permit protein-protein interactions with different orientations and/or interaction energies. [...]
2010 - 10.1186/1472-6807-10-37
BMC Structural biology, Vol. 10, N. 37 (October 2010) , p.
2 documents
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Research literature 3 records found  
1.
174 p, 3.4 MB Proteínas "moonlighting": identificación y relación con la infección por microorganismos patógenos y clínica humana / Franco Serrano, Luis, autor. ; Querol Murillo, Enrique, supervisor acadèmic. ; Amela Abellan, Isaac, supervisor acadèmic. ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Moonlighting (multitasking, multifunctional) es la capacidad de algunas proteínas de ejecutar dos o más funciones bioquímicas. Normalmente, las proteínas moonlighting son descubiertas por "serendipia". [...]
Moonlighting (multitasking, multifunctional) is the ability of some proteins to perform two or more biochemical functions. Normally, moonlighting proteins are discovered by "serendipity". The multifunctionality of proteins acquires greater importance from recent discoveries about the human proteome (and animal models such as mice). [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
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2.
1 p, 1.2 MB Moonlighting proteins and human diseases / Jiménez Rosés, Mireia ; Querol Murillo, Enrique, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Amela Abellan, Isaac, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2014
Grau en Biologia [812]  
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3.
174 p, 2.7 MB Bioinformatics approaches to protein interaction and complexes : application to pathogen-host epitope mimicry and to Fe-S cluster biogenesis model / Amela Abellan, Isaac ; Querol Murillo, Enrique, dir. (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cedano Rodríguez, Juan Antonio, dir. (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Les interaccions antigen/anticòs són un dels tipus més interessants d'interaccions proteiques. La millor manera de prevenir les malalties causades per patògens és mitjançant l'ús de vacunes. L'aparició de la genòmica permet fer cerques a tot el genoma de nous candidats vacunals, tècnica anomenada vaccinologia inversa. [...]
Antigen/antibody interactions are one of the most interesting kinds of protein interactions. The best way to prevent diseases caused by pathogens is by the use of vaccines. The advent of genomics enables genome-wide searches of new vaccine candidates, called reverse vaccinology. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2013  
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