Resultats globals: 10 registres trobats en 0.03 segons.
Articles, 10 registres trobats
Articles 10 registres trobats  
1.
11 p, 4.3 MB Antigen-specific immunotherapy combined with a regenerative drug in the treatment of experimental type 1 diabetes / Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ; Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ; Perna-Barrull, David (Institut Germans Trias i Pujol) ; Ampudia, Rosa Maria (Institut Germans Trias i Pujol) ; Gomez-Muñoz, Laia (Institut Germans Trias i Pujol) ; Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ; Aguilera, Eva (Institut Germans Trias i Pujol) ; Risueño, Ruth M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Vázquez, Federico (Institut Germans Trias i Pujol) ; Vives-Pi, Marta (Institut Germans Trias i Pujol)
Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. To revert type 1 diabetes, the suppression of the autoimmune attack should be combined with a β-cell replacement strategy. [...]
2020 - 10.1038/s41598-020-76041-1
Scientific reports (Nature Publishing Group), Vol. 10 (2020) , art. 18927  
2.
8 p, 1.3 MB Preclinical evaluation of antigen-specific nanotherapy based on phosphatidylserine-liposomes for type 1 diabetes / Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ; Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ; Ampudia, Rosa Maria (Institut Germans Trias i Pujol) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Perna-Barrull, David (Institut Germans Trias i Pujol) ; Bertran-Cobo, Cesc (Institut Germans Trias i Pujol) ; Ehrenberg, Clara (Institut Germans Trias i Pujol) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Vives Pi, Marta (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-producing cells. Due to the ability of apoptotic cells clearance to induce tolerance, we previously generated liposomes rich in phophatidylserine (PS) -a feature of apoptotic cells- loaded with insulin peptides to mimic apoptotic beta-cells. [...]
2020 - 10.1080/21691401.2019.1699812
Artificial Cells, Nanomedicine and Biotechnology, Vol. 48, issue 1 (2020) , p. 77-83  
3.
14 p, 2.6 MB Repurposed analog of GLP-1 ameliorates hyperglycemia in type 1 diabetic mice through pancreatic cell reprogramming / Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ; Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol) ; Perna-Barrull, David (Institut Germans Trias i Pujol) ; Ampudia, Rosa Maria (Institut Germans Trias i Pujol) ; Gomez-Muñoz, Laia (Institut Germans Trias i Pujol) ; Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ; Aguilera, Eva (Institut Germans Trias i Pujol) ; Coma, Mireia (Anaxomics Biotech SL) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Vázquez, Federico (Institut Germans Trias i Pujol) ; Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ; Vives Pi, Marta (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. An ideal immunotherapy should combine the blockade of the autoimmune response with the recovery of functional target cell mass. [...]
2020 - 10.3389/fendo.2020.00258
Frontiers in Endocrinology, Vol. 11 (May 2020) , art. 258  
4.
15 p, 4.1 MB Prenatal Betamethasone interferes with immune system development and alters target cells in autoimmune diabetes / Perna-Barrull, David (Institut Germans Trias i Pujol) ; Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ; Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ; Gieras, A. (Department of Immunology. University Medical Center Hamburg-Eppendorf) ; Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ; Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ; Glau, L. (Department of Immunology. University Medical Center Hamburg-Eppendorf) ; Tolosa, E. (Department of Immunology. University Medical Center Hamburg-Eppendorf) ; Vives Pi, Marta (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Non-genetic factors are crucial in the pathogenesis of type 1 diabetes (T1D), a disease caused by autoimmunity against insulin-producing β-cells. Exposure to medications in the prenatal period may influence the immune system maturation, thus altering self-tolerance. [...]
2019 - 10.1038/s41598-018-37878-9
Scientific reports (Nature Publishing Group), Vol. 9 Núm. 1 (january 2019) , p. 1235  
5.
18 p, 2.6 MB Partial remission and early stages of pediatric type 1 diabetes display immunoregulatory changes. A pilot study / Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ; Fonolleda, Mireia (Institut Germans Trias i Pujol) ; Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ; Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ; Perna-Barrull, David (Institut Germans Trias i Pujol) ; Raina, María Belén (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Quirant, Bibiana (Institut Germans Trias i Pujol) ; Planas, Raquel (Institut Germans Trias i Pujol) ; Teniente Serra, Aina (Institut Germans Trias i Pujol) ; Bel, J. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Vives Pi, Marta (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Type 1 diabetes (T1D) is a chronic metabolic disease of unknown etiology that results from β-cell destruction. The onset of the disease, which arises after a long asymptomatic period of autoimmune attack, may be followed by a relapsing and remitting progression, a phenomenon that is most evident during the partial remission phase (PR). [...]
2019 - 10.1016/j.trsl.2019.03.002
Translational Research, Vol. 210 (august 2019) , p. 8-25  
6.
12 p, 2.5 MB Liposome-based immunotherapy against autoimmune diseases : Therapeutic effect on multiple sclerosis / Pujol Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Mansilla López, Maria José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Navarro-Barriuso, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ampudia, Rosa Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rius, Aleix (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; García Jimeno, Sonia (Institut Català de Nanociència i Nanotecnologia) ; Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Based on the ability of apoptosis to induce immunological tolerance, liposomes were generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our aim was to validate the immunotherapy in other autoimmune disease: multiple sclerosis. [...]
2017 - 10.2217/nnm-2016-0410
Nanomedicine, Vol. 12, Issue 11 (June 2017) , p. 1231-1242  
7.
5 p, 584.6 KB Immunotherapy with Tolerogenic Dendritic Cells Alone or in Combination with Rapamycin Does Not Reverse Diabetes in NOD Mice / Pujol Autonell, Irma (Institut Germans Trias i Pujol. Banc de Sang i Teixits) ; Ampudia, Rosa Maria (Institut Germans Trias i Pujol. Banc de Sang i Teixits) ; Monge, Pau (Institut Germans Trias i Pujol. Banc de Sang i Teixits) ; Lucas, Anna M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Carrascal, Jorge (Institut de Recerca Biomèdica de Lleida) ; Verdaguer, Joan (Institut de Recerca Biomèdica de Lleida) ; Vives Pi, Marta (Institut Germans Trias i Pujol. Banc de Sang i Teixits)
Type 1 diabetes is a metabolic disease caused by autoimmunity towards β -cells. Different strategies have been developed to restore β -cell function and to reestablish immune tolerance to prevent and cure the disease. [...]
2013
ISRN Endocrinology, Vol. 2013 (march 2013)  
8.
22 p, 3.3 MB The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells / Badia, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Pujantell, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Riveira Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Puig, Teresa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Torres Torronteras, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martí Seves, Ramon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ampudia, Rosa Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Este, José (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ballana Guix, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Macrophages are a heterogeneous cell population strongly influenced by differentiation stimuli that become susceptible to HIV-1 infection after inactivation of the restriction factor SAMHD1 by cyclin-dependent kinases (CDK). [...]
2016 - 10.1371/journal.ppat.1005829
PLoS pathogens, Vol. 12 Núm. 8 (August 2016)  
9.
19 p, 1.2 MB Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetes / Pujol Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Serracant Prat, Arnau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Ampudia, Rosa Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sànchez, Àlex (Sànchez Pla) (Universitat de Barcelona. Departament d'Estadística) ; Izquierdo Castro, Cristina (Universitat de Barcelona. Departament de Fisiologia i Immunologia) ; Stratmann, Thomas (Universitat de Barcelona. Departament de Fisiologia i Immunologia) ; Puig Domingo, Manuel Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ; Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona
INTRODUCTION: The development of new therapies to induce self-tolerance has been an important medical health challenge in type 1 diabetes. An ideal immunotherapy should inhibit the autoimmune attack, avoid systemic side effects and allow β-cell regeneration. [...]
2015 - 10.1371/journal.pone.0127057
PloS one, Vol. 19, Issue 6 (June 2015) , p. e0127057  
10.
10 p, 893.6 KB Efferocytosis Promotes Suppressive Effects on Dendritic Cells through Prostaglandin E2 Production in the Context of Autoimmunity / Pujol Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ampudia, Rosa Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Planas, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Marin-Gallen, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Carrascal, Jorge (Universitat de Lleida. Departament de Ciències Bàsiques) ; Sanchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Marin, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Puig Domingo, Manuel (Institut Germans Trias i Pujol) ; Pujol-Borrell, Ricardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Verdaguer, Joan (Universitat de Lleida. Departament de Ciències Bàsiques) ; Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Introduction: Efferocytosis is a crucial process by which apoptotic cells are cleared by phagocytes, maintaining immune tolerance to self in the absence of inflammation. Peripheral tolerance, lost in autoimmune processes, may be restored by the administration of autologous dendritic cells loaded with islet apoptotic cells in experimental type 1 diabetes. [...]
2013 - 10.1371/journal.pone.0063296
PloS one, Vol. 8 Issue 5 (May 2013) , p. e63296  

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