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Articles, 11 records found
Articles 11 records found  1 - 10next  jump to record:
1.
11 p, 4.3 MB Antigen-specific immunotherapy combined with a regenerative drug in the treatment of experimental type 1 diabetes / Villalba Felipe, Adrián (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ; Perna-Barrull, David (Institut Germans Trias i Pujol) ; Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ; Gomez-Muñoz, Laia (Institut Germans Trias i Pujol) ; Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ; Aguilera, Eva (Institut Germans Trias i Pujol) ; Risueño, Ruth M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Vázquez, Federico (Institut Germans Trias i Pujol) ; Vives-Pi, Marta (Institut Germans Trias i Pujol)
Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. To revert type 1 diabetes, the suppression of the autoimmune attack should be combined with a β-cell replacement strategy. [...]
2020 - 10.1038/s41598-020-76041-1
Scientific reports (Nature Publishing Group), Vol. 10 (2020) , art. 18927  
2.
5 p, 584.6 KB Immunotherapy with Tolerogenic Dendritic Cells Alone or in Combination with Rapamycin Does Not Reverse Diabetes in NOD Mice / Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ; Monge, Pau (Institut Germans Trias i Pujol) ; Lucas, Anna M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Carrascal, Jorge (Universitat de Lleida) ; Verdaguer, Joan (Universitat de Lleida) ; Vives Pi, Marta (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Type 1 diabetes is a metabolic disease caused by autoimmunity towards β -cells. Different strategies have been developed to restore β -cell function and to reestablish immune tolerance to prevent and cure the disease. [...]
2013 - 10.1155/2013/346987
ISRN Endocrinology, Vol. 2013 (march 2013)  
3.
8 p, 1.3 MB Preclinical evaluation of antigen-specific nanotherapy based on phosphatidylserine-liposomes for type 1 diabetes / Villalba Felipe, Adrián (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ; Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Perna-Barrull, David (Institut Germans Trias i Pujol) ; Bertran-Cobo, Cesc (Institut Germans Trias i Pujol) ; Ehrenberg, Clara (Institut Germans Trias i Pujol) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Vives Pi, Marta (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-producing cells. Due to the ability of apoptotic cells clearance to induce tolerance, we previously generated liposomes rich in phophatidylserine (PS) -a feature of apoptotic cells- loaded with insulin peptides to mimic apoptotic beta-cells. [...]
2020 - 10.1080/21691401.2019.1699812
Artificial Cells, Nanomedicine and Biotechnology, Vol. 48, issue 1 (2020) , p. 77-83  
4.
14 p, 2.6 MB Repurposed analog of GLP-1 ameliorates hyperglycemia in type 1 diabetic mice through pancreatic cell reprogramming / Villalba Felipe, Adrián (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol) ; Perna-Barrull, David (Institut Germans Trias i Pujol) ; Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ; Gomez-Muñoz, Laia (Institut Germans Trias i Pujol) ; Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ; Aguilera, Eva (Institut Germans Trias i Pujol) ; Coma, Mireia (Anaxomics Biotech SL) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Vázquez, Federico (Institut Germans Trias i Pujol) ; Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ; Vives Pi, Marta (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. An ideal immunotherapy should combine the blockade of the autoimmune response with the recovery of functional target cell mass. [...]
2020 - 10.3389/fendo.2020.00258
Frontiers in Endocrinology, Vol. 11 (May 2020) , art. 258  
5.
15 p, 4.1 MB Prenatal Betamethasone interferes with immune system development and alters target cells in autoimmune diabetes / Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ; Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ; Gieras, A. (Department of Immunology. University Medical Center Hamburg-Eppendorf) ; Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ; Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ; Glau, L. (Department of Immunology. University Medical Center Hamburg-Eppendorf) ; Tolosa, E. (Department of Immunology. University Medical Center Hamburg-Eppendorf) ; Vives Pi, Marta (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Non-genetic factors are crucial in the pathogenesis of type 1 diabetes (T1D), a disease caused by autoimmunity against insulin-producing β-cells. Exposure to medications in the prenatal period may influence the immune system maturation, thus altering self-tolerance. [...]
2019 - 10.1038/s41598-018-37878-9
Scientific reports (Nature Publishing Group), Vol. 9 Núm. 1 (january 2019) , p. 1235  
6.
18 p, 2.6 MB Partial remission and early stages of pediatric type 1 diabetes display immunoregulatory changes. A pilot study / Villalba Felipe, Adrián (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Fonolleda, Mireia (Institut Germans Trias i Pujol) ; Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ; Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ; Perna-Barrull, David (Institut Germans Trias i Pujol) ; Raina, María Belén (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Quirant, Bibiana (Institut Germans Trias i Pujol) ; Planas, Raquel (Institut Germans Trias i Pujol) ; Teniente Serra, Aina (Institut Germans Trias i Pujol) ; Bel, J. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Vives Pi, Marta (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Type 1 diabetes (T1D) is a chronic metabolic disease of unknown etiology that results from β-cell destruction. The onset of the disease, which arises after a long asymptomatic period of autoimmune attack, may be followed by a relapsing and remitting progression, a phenomenon that is most evident during the partial remission phase (PR). [...]
2019 - 10.1016/j.trsl.2019.03.002
Translational Research, Vol. 210 (august 2019) , p. 8-25  
7.
12 p, 2.5 MB Liposome-based immunotherapy against autoimmune diseases : Therapeutic effect on multiple sclerosis / Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Mansilla López, Maria José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Navarro-Barriuso, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rius, Aleix (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; García Jimeno, Sonia (Institut Català de Nanociència i Nanotecnologia) ; Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Based on the ability of apoptosis to induce immunological tolerance, liposomes were generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our aim was to validate the immunotherapy in other autoimmune disease: multiple sclerosis. [...]
2017 - 10.2217/nnm-2016-0410
Nanomedicine, Vol. 12, Issue 11 (June 2017) , p. 1231-1242  
8.
5 p, 584.6 KB Immunotherapy with Tolerogenic Dendritic Cells Alone or in Combination with Rapamycin Does Not Reverse Diabetes in NOD Mice / Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Banc de Sang i Teixits) ; Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol. Banc de Sang i Teixits) ; Monge, Pau (Institut Germans Trias i Pujol. Banc de Sang i Teixits) ; Lucas, Anna M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Carrascal, Jorge (Institut de Recerca Biomèdica de Lleida) ; Verdaguer, Joan (Institut de Recerca Biomèdica de Lleida) ; Vives Pi, Marta (Institut Germans Trias i Pujol. Banc de Sang i Teixits)
Type 1 diabetes is a metabolic disease caused by autoimmunity towards β -cells. Different strategies have been developed to restore β -cell function and to reestablish immune tolerance to prevent and cure the disease. [...]
2013
ISRN Endocrinology, Vol. 2013 (march 2013)  
9.
22 p, 3.3 MB The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells / Badia, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Pujantell, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Riveira Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Puig, Teresa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Torres Torronteras, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martí, Ramon A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Este, José (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Macrophages are a heterogeneous cell population strongly influenced by differentiation stimuli that become susceptible to HIV-1 infection after inactivation of the restriction factor SAMHD1 by cyclin-dependent kinases (CDK). [...]
2016 - 10.1371/journal.ppat.1005829
PLoS pathogens, Vol. 12 Núm. 8 (August 2016)  
10.
19 p, 1.2 MB Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetes / Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Serracant Prat, Arnau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sànchez, Àlex (Sànchez Pla) (Universitat de Barcelona. Departament d'Estadística) ; Izquierdo Castro, Cristina (Universitat de Barcelona. Departament de Fisiologia i Immunologia) ; Stratmann, Thomas (Universitat de Barcelona. Departament de Fisiologia i Immunologia) ; Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ; Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona
INTRODUCTION: The development of new therapies to induce self-tolerance has been an important medical health challenge in type 1 diabetes. An ideal immunotherapy should inhibit the autoimmune attack, avoid systemic side effects and allow β-cell regeneration. [...]
2015 - 10.1371/journal.pone.0127057
PloS one, Vol. 19, Issue 6 (June 2015) , p. e0127057  

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