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13 p, 668.0 KB |
Glucocorticoid-based pharmacotherapies preventing PTSD
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Florido, Antonio (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Velasco, Eric Raúl (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Monari, Sílvia (Geneva University Hospitals. Department of Psychiatry) ;
Cano, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Cardoner, N. (Narcís) (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Sandi, Carmen (École Polytechnique Fédérale de Lausanne (Suïssa). Brain Mind Institute) ;
Andero Galí, Raül (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Perez-Caballero, Laura (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Posttraumatic stress disorder (PTSD) is a highly disabling psychiatric condition that may arise after exposure to acute and severe trauma. It is a highly prevalent mental disorder worldwide, and the current treatment options for these patients remain limited due to low effectiveness. [...]
2023 -  10.1016/j.neuropharm.2022.109344
Neuropharmacology, Vol. 224 (2023) , 109344
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17 p, 3.3 MB |
PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus
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Velasco García, Eric Raúl (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Florido Torres, Antonio Luis (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Flores, África (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Senabre, Eric (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Gomez-Gomez, A. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Torres, A. (Hospital Clínic i Provincial de Barcelona) ;
Roca, A. (Hospital Clínic i Provincial de Barcelona) ;
Norrholm, S. (Wayne State University. Department of Psychiatry and Behavioral Neuroscience) ;
Newman, Emily L. (McLean Hospital. Department of Psychiatry. Harvard Medical School) ;
Das, P. (Department of Neuroscience. Albert Einstein College of Medicine) ;
Ross, R.A. (Department of Neuroscience. Albert Einstein College of Medicine) ;
Lori, A. (Emory University) ;
Pozo, Oscar J (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ressler, Kerry J. (McLean Hospital. Department of Psychiatry. Harvard Medical School) ;
Garcia-Esteve, L.L. (Hospital Clínic i Provincial de Barcelona) ;
Jovanovic, T. (Wayne State University. Department of Psychiatry and Behavioral Neuroscience) ;
Andero Galí, Raül (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Exposure to traumatic stress can lead to fear dysregulation, which has been associated with posttraumatic stress disorder (PTSD). Previous work showed that a polymorphism in the PACAP-PAC1R (pituitary adenylate cyclase-activating polypeptide) system is associated with PTSD risk in women, and PACAP (ADCYAP1)-PAC1R (ADCYAP1R1) are highly expressed in the hypothalamus. [...]
2022 - 10.1038/s41467-022-31442-w
Nature communications, Vol. 13 Núm. 1 (december 2022) , p. 4374
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19 p, 3.5 MB |
Sex differences in fear memory consolidation via Tac2 signaling in mice
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Florido Torres, Antonio Luis (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Velasco García, Eric Raúl (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Soto-Faguás, C. M. (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Gomez-Gomez, A. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Perez-Caballero, Laura (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Molina, P. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Nadal, Roser (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Pozo, Oscar J. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Saura Antolín, Carlos A.. (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Andero Galí, Raül (Universitat Autònoma de Barcelona. Institut de Neurociències)
Memory formation is key for brain functioning. Uncovering the memory mechanisms is helping us to better understand neural processes in health and disease. Moreover, more specific treatments for fear-related disorders such as posttraumatic stress disorder and phobias may help to decrease their negative impact on mental health. [...]
2021 - 10.1038/s41467-021-22911-9
Nature communications, Vol. 12 (may 2021)
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16 p, 1.8 MB |
A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction
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Domingo-Rodriguez, Laura (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Ruiz de Azua, Inigo (3 Leibniz Institute for Resilience Research) ;
Dominguez, Eduardo (Centre de Regulació Genòmica) ;
Senabre, Eric (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Serra, Irene (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Kummer, Sami (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Navandar, Mohit (Johannes Gutenberg University. Faculty of Biology and Center of Computational Sciences) ;
Baddenhausen, Sarah (University Medical Center of the Johannes Gutenberg University Mainz. Institute of Physiological Chemistry) ;
Hofmann, Clementine (Johannes Gutenberg University Mainz. Focus Program Translational Neuroscience) ;
Andero Galí, Raül (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Gerber, Susanne (Johannes Gutenberg University. Faculty of Biology and Center of Computational Sciences) ;
Navarrete, Marta (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Dierssen, Mara (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lutz, Beat (Leibniz Institute for Resilience Research, Mainz, Germany) ;
Martín-García, Elena (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Maldonado, Rafael 1961- (Institut Hospital del Mar d'Investigacions Mèdiques)
Food addiction is linked to obesity and eating disorders and is characterized by a loss of behavioral control and compulsive food intake. Here, using a food addiction mouse model, we report that the lack of cannabinoid type-1 receptor in dorsal telencephalic glutamatergic neurons prevents the development of food addiction-like behavior, which is associated with enhanced synaptic excitatory transmission in the medial prefrontal cortex (mPFC) and in the nucleus accumbens (NAc). [...]
2020 - 10.1038/s41467-020-14458-y
Nature communications, Vol. 11 (february 2020)
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35 p, 995.9 KB |
Sex differences in the behavioural and hypothalamic-pituitary-adrenal response to contextual fear conditioning in rats
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Daviu Abant, Núria (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Andero Galí, Raül (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Armario, Antonio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Nadal, Roser (Universitat Autònoma de Barcelona. Institut de Neurociències)
In recent years, special attention is being paid to sex differences in susceptibility to disease. In this regard, there is evidence that male rats present higher levels of both cued and contextual fear conditioning than females. [...]
2014 - 10.1016/j.yhbeh.2014.09.015
Hormones and behavior, Vol. 66 Núm. 5 (Nov. 2014) , p. 713-723
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15 p, 1.8 MB |
Deoxygedunin, a natural product with potent neurotrophic activity in mice
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Jang, Sung-Wuk (Emory University. School of Medicine. Department of Pathology and Laboratory Medicine) ;
Liu, Xia (Emory University. School of Medicine. Department of Pathology and Laboratory Medicine) ;
Chan, Chi Bun (Emory University. School of Medicine. Department of Pathology and Laboratory Medicine) ;
France, Stefan A. (Georgia Institute of Technology. School of Chemistry and Biochemistry) ;
Sayeed, Iqbal (Emory University. School of Medicine. Department of Emergency Medicine) ;
Tang, Wenxue (Emory University. School of Medicine. Department of Otolaryngology and Cell Biology) ;
Lin, Xi (Emory University. School of Medicine. Department of Otolaryngology and Cell Biology) ;
Xiao, Ge (Centers for Disease Control and Prevention (U.S.)) ;
Andero Galí, Raül (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Chang, Qiang (University of Wisconsin-Madison. Department of Genetics and Neurology) ;
Ressler, Kerry J. (Emory University. School of Medicine. Department of Psychiatry and Behavioral Science) ;
Ye, Keqiang (Emory University. Department of Pathology and Laboratory Medicine)
Gedunin, a family of natural products from the Indian neem tree, possess a variety of biological activities. Here we report the discovery of deoxygedunin, which activates the mouse TrkB receptor and its downstream signaling cascades. [...]
2010 - 10.1371/journal.pone.0011528
PloS one, Vol. 5 Issue 7 (July 2010) , p. e11528
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2 p, 161.6 KB |
Un fàrmac redueix en ratolins la por causada per traumes previs
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Andero Galí, Raül (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Haver viscut una experiència traumàtica afavoreix la persistència de la por associada a un estímul aversiu, una por condicionada que es pot alleujar en ratolins amb una sola dosi de 7,8-dihidroxiflavona, un derivat flavonoide que potencia nous aprenentatges emocionals. [...]
Vivir una experiencia traumática favorece la persistencia del miedo asociado a un estímulo adverso, un miedo condicionado que se puede mitigar en ratones con una sola dosis de 7,8-dihidroxiflavona, un derivado flavonoide que potencia nuevos aprendizajes emocionales. [...]
Living a traumatic experience favours the persistence of fear associated with an aversive stimulus, known as fear conditioning and which, in mice, can be eased with a single dosis of 7,8-Dihydroxyflavone, a type of flavonoid which boosts the ability to acquire new emotional habits. [...]
2011
UAB divulga, Gener 2011, p. 1-2
3 documents
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