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14 p, 12.6 MB |
Rational Design of Hydrogels for Cationic Antimicrobial Peptide Delivery : A Molecular Modeling Approach
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Pereira, Alfredo (Universidad de Chile) ;
Valdés-Muñoz, Elizabeth (Universidad Católica del Maule) ;
Marican, Adolfo (Universidad de Talca) ;
Cabrera-Barjas, Gustavo (Universidad de Concepción) ;
Vijayakumar, Sekar (Shandong University) ;
Valdés, Oscar (Universidad Católica del Maule) ;
Rafael, Diana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrade, Fernanda (Universitat de Barcelona. Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica) ;
Abaca, Paulina (Universidad de Talca. Instituto Ciencias Biologicas) ;
Bustos, Daniel (Universidad Católica del Maule) ;
Durán-Lara, Esteban F. (Universidad de Talca) ;
Universitat Autònoma de Barcelona
In light of the growing bacterial resistance to antibiotics and in the absence of the development of new antimicrobial agents, numerous antimicrobial delivery systems over the past decades have been developed with the aim to provide new alternatives to the antimicrobial treatment of infections. [...]
2023 -  10.3390/pharmaceutics15020474
Pharmaceutics, Vol. 15 (january 2023)
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12 p, 2.8 MB |
Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells
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Gener, Petra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Callejo, Patricia González (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrade, Fernanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rafael, Diana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez, Francesc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montero, Sara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sayós, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. [...]
2018 - 10.1155/2018/4516454
Stem Cells International, Vol. 2018 (october 2018)
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20 p, 1.8 MB |
Extracellular Vesicles as Drug Delivery Systems in Cancer
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Hernandez-Oller, Laia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrade, Fernanda (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Rafael, Diana (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Abasolo, Ibane (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Gener, Petra (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Schwartz, Simon (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Universitat Autònoma de Barcelona
Within tumors, Cancer Stem Cell (CSC) subpopulation has an important role in maintaining growth and dissemination while preserving high resistance against current treatments. It has been shown that, when CSCs are eliminated, the surrounding Differentiated Cancer Cells (DCCs) may reverse their phenotype and gain CSC-like features to preserve tumor progression and ensure tumor survival. [...]
2020 - 10.3390/pharmaceutics12121146
Pharmaceutics, Vol. 12 (november 2020)
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20 p, 2.7 MB |
Intracellular Delivery of Anti-SMC2 Antibodies against Cancer Stem Cells
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Montero, Sara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrade, Fernanda (Universidade do Porto) ;
Martinez-Trucharte, Francesc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vilar-Hernández, Mireia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Quesada, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Xandri Monje, Helena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rafael, Diana (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Schwartz, Simon (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Universitat Autònoma de Barcelona
Structural maintenance of chromosomes protein 2 (SMC2) is a central component of the condensin complex involved in DNA supercoiling, an essential process for embryonic stem cell survival. SMC2 over-expression has been related with tumorigenesis and cancer malignancy and its inhibition is regarded as a potential therapeutic strategy even though no drugs are currently available. [...]
2020 - 10.3390/pharmaceutics12020185
Pharmaceutics, Vol. 12 (february 2020)
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1.9 MB |
AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells
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Rafael, Diana (Universitat Autònoma de Barcelona) ;
Gener, Petra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrade, Fernanda (Instituto de Salud Carlos III) ;
Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montero, Sara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández Caparrós, Yolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hidalgo, Manuel (Rosenberg Clinical Cancer Center Beth Israel Deaconess Medical Center) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Florindo, Helena F. (Universidade de Lisboa) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schwartz, Simon (Instituto de Salud Carlos III) ;
Videira, Mafalda (Universidade de Lisboa) ;
Universitat Autònoma de Barcelona
Development of RNA interference-based therapies with appropriate therapeutic window remains a challenge for advanced cancers. Because cancer stem cells (CSC) are responsible of sustaining the metastatic spread of the disease to distal organs and the progressive gain of resistance of advanced cancers, new anticancer therapies should be validated specifically for this subpopulation of cells. [...]
2018 - 10.1080/10717544.2018.1461276
Drug Delivery, Vol. 25 (april 2018) , p. 961-972
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12 p, 2.9 MB |
The biological potential hidden in inclusion bodies
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Gifre-Renom, Laia (Institut de Recerca i Tecnologia Agroalimentàries) ;
Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rafael, Diana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrade, Fernanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cano-Garrido, Olivia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Martinez-Trucharte, Francesc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ugarte-Berzal, Estefanía (Katholieke Universiteit Leuven. Department of Microbiology, Immunology and Transplantation) ;
Martens, Erik (Katholieke Universiteit Leuven. Department of Microbiology, Immunology and Transplantation) ;
Boon, Lise (Katholieke Universiteit Leuven. Department of Microbiology, Immunology and Transplantation) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Opdenakker, Ghislain (Katholieke Universiteit Leuven. Department of Microbiology, Immunology and Transplantation) ;
Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arís i Giralt, Anna (Institut de Recerca i Tecnologia Agroalimentàries) ;
Garcia-Fruitos, Elena (Institut de Recerca i Tecnologia Agroalimentàries)
Inclusion bodies (IBs) are protein nanoclusters obtained during recombinant protein production processes, and several studies have demonstrated their potential as biomaterials for therapeutic protein delivery. [...]
2020 - 10.3390/pharmaceutics12020157
Pharmaceutics, Vol. 12, issue 2 (2020) , art. 157
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14 p, 3.9 MB |
Sterilization procedure for temperature-sensitive hydrogels loaded with silver nanoparticles for clinical applications
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Rafael, Diana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrade, Fernanda (INEB-Instituto Nacional de Engenharia Biomédica. Universidade do Porto) ;
Martinez-Trucharte, Francesc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Basas Satorras, Jana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Palau Gauthier, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gomis, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pérez-Burgos, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Blanco, Alberto (Hospital Universitari Vall d'Hebron) ;
López-Fernández, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vélez, Roberto (Hospital Universitari Vall d'Hebron) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Aguirre Cañadell, M. (Màrius) (Màrius) (Hospital Universitari Vall d'Hebron) ;
Gavaldà, Joan (Hospital Universitari Vall d'Hebron) ;
Schwartz, Simó (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Hydrogels (HG) have recognized benefits as drug delivery platforms for biomedical applications. Their high sensitivity to sterilization processes is however one of the greatest challenges regarding their clinical translation. [...]
2019 - 10.3390/nano9030380
Nanomaterials, Vol. 9 Núm. 3 (march 2019) , p. 380
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8 p, 96.9 KB |
Agroecologia, pedagogia da alternância e a indissociabilidade entre ensino, pesquisa e extensão na formação de educadores do campo
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Coutinho de Andrade, Fernanda Maria (Universidade Federal de Viçosa) ;
Nogueira Bello Simas, Felipe (Universidade Federal de Viçosa) ;
Gomes da Silva, Márcio (Universidade Federal de Viçosa) ;
Pires Barrella, Tatiana (Universidade Federal de Viçosa)
Este estudo visa refletir como os princípios e práticas da agroecologia e da pedagogia da alternância contribuem para a indissociabilidade entre ensino, pesquisa e extensão na formação de educadores do campo. [...]
2017
Enseñanza de las ciencias, Núm. Extra (2017) , p. 3299-3306
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