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8 p, 826.6 KB |
Levodopa-carbidopa intestinal gel in advanced Parkinson's : Final results of the GLORIA registry
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Antonini, Angelo (University of Padua) ;
Poewe, Werner (Medical University of Innsbruck) ;
Chaudhuri, K.Ray (King's College and King's College Hospital) ;
Jech, Robert (General University Hospital in Prague) ;
Pickut, Barbara (Michigan State University) ;
Pirtošek, Zvezdan (University Medical Center Ljubljana) ;
Szasz, Jozsef (University of Medicine and Pharmacy Tirgu-Mures) ;
Valldeoriola, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Winkler, Christian (Lindenbrunn Hospital) ;
Bergmann, Lars (AbbVie Inc.) ;
Yegin, Ashley (AbbVie Inc.) ;
Onuk, Koray (AbbVie Inc.) ;
Barch, David (AbbVie Inc.) ;
Odin, Per (Lund University) ;
Amalia, Ene (University Emergency Hospital) ;
Arnold, Guy (Sindelfingen Hospital) ;
Bajenaru, Ovidiu (University of Medicine and Pharmacy "Carol Davila") ;
Bergmans, Bruno (AZ St-Jan Brugge-Oostende AV) ;
Bjornara, Kari Anne (Drammen Hospital) ;
Blackie, Jeff (John Hunter Hospital) ;
Bode, Matthias (Odense University Hospital (Dinamarca)) ;
Bourgeois, Paul (Department of Neurology AZ Groeninge) ;
Bohlhalter, Stephan (Neurology and Neurorehabilitation Center) ;
Buraga, Ioan (Colentina Hospital) ;
Burkhard, Pierre R. (Geneva University Hospitals) ;
Busson, Philippe (Centre Hospitalier Avranches Granvilles) ;
Calopa, Matilde (Hospital Universitari de Bellvitge) ;
Clausen, Jesper (Rigshospitalet/Glostup) ;
Danielsen, Erik Hvid (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Defebvre, Luc (Université of Lille) ;
Delvaux, Valerie (University of Liege) ;
Dethy, Sophie (Chu-Tivoli) ;
Dietrichs, Espen (University of Oslo) ;
Fàbregues-Boixar i Nebot, Oriol de (Hospital Universitari Vall d'Hebron) ;
Gerhard, Ransmayr (Kepler University Hospital) ;
Gusmaroli, Graziano (Ospedale degli Infermi di Biella) ;
Hahn, Kirsten ;
Hauptmann, Björn (Neurologisches Zentrum) ;
Henriksen, Tove (University Hospital of Bispebjerg) ;
Hernández-Vara, Jorge (Hospital Universitari Vall d'Hebron) ;
Jeanjean, A. (Université catholique de Louvain) ;
Kaiserova, Michaela (Palacky University) ;
Kassubek, Jan (University of Ulm) ;
Kimber, Thomas (University of Adelaide) ;
Konitsiotis, Spyridon (University of Ioannina) ;
Krüger, Rejko (University of Tübingen) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Leenders, Jo (Sint-Dimpa Ziekenhuis) ;
Lundqvist, Christofer (Akershus University Hospital) ;
Ory Magne, F. (Toulouse University Hospital) ;
Marano, Pietro (Nuova Casa di Cura D'Anna) ;
Milanov, Ivan (University Neurological Hospital "St. Naum") ;
Modugno, Nicola (IRCCS Neuromed) ;
Misbahuddin, Anjum (Essex Centre for Neurological Sciences) ;
Nevrly, Martin (University Hospital and Faculty of Medicine and Dentistry of Palacky University) ;
Panayiotis, Zikos (251 Hellenic Air Force Hospital) ;
Pedersen, Kenn Freddy (Stavanger University Hospital) ;
Pedersen, Stephen W. (Glostrup Hospital University of Copenhagen) ;
Perju-Dumbrava, Lacramioara (University of Medicine and Pharmacy "Iuliu Hatieganu") ;
Ponsen, M.M. (Meander Medical Center) ;
Popescu, Bogdan O. (Carol Davila University of Medicine and Pharmacy) ;
Rijntjes, Michel (University Clinic Freiburg) ;
Puente, V. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Redecker, Christoph (Jena University Hospital (Alemania)) ;
Schrader, Christoph (Hannover Medical School) ;
Sensi, Mariachiara (Arcispedale S.Anna) ;
Simu, Michaela (UMF"Victor Babes") ;
Spanaki, Cleanthe (University of Crete) ;
Storch, Alexander (University of Rostock) ;
Storstein, Anette (Haukeland University Hospital (Bergen, Noruega)) ;
Tomantschger, Volker (Gailtal-Klinik Hermagor) ;
van der Linden, Chris (St. Lucas Hospital Ghent) ;
van Laar, T. (University Medical Center Groningen) ;
Viallet, F. (CH du pays d'Aix) ;
Witjas, Tatiana (University Hospital Timone) ;
Wolz, Martin (Elblandklinikum Meissen) ;
Zibetti, Maurizio (University of Torino) ;
Van Zandijcke, Michel (AZ Sint-Jan Brugge) ;
Universitat Autònoma de Barcelona
This registry evaluated the 24-month safety and efficacy of levodopa-carbidopa intestinal gel (LCIG) treatment in advanced Parkinson's disease (PD) patients under routine clinical care. Motor fluctuations, dyskinesia, non-motor symptoms, quality of life, and safety were evaluated. [...]
2017 -  10.1016/j.parkreldis.2017.09.018
Parkinsonism and Related Disorders, Vol. 45 (december 2017) , p. 13-20
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15 p, 294.1 KB |
The reliability of a deep learning model in clinical out-of-distribution MRI data : A multicohort study
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Mårtensson, G. (Karolinska Institutet (Estocolm, Suècia)) ;
Ferreira, D. (Karolinska Institutet (Estocolm, Suècia)) ;
Granberg, T. (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Cavallin, L. (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Oppedal, K. (University of Stavanger) ;
Padovani, A. (University of Brescia) ;
Rektorova, I. (Masaryk University) ;
Bonanni, Laura (University G d'Annunzio of Chieti-Pescara) ;
Pardini, M. (University of Genoa and Neurology Clinics) ;
Kramberger, M.G. (Univerza V Ljubljani) ;
Taylor, J.P. (Newcastle University) ;
Hort, J. (Charles University) ;
Snædal, J. (Landspitali University Hospital (Reykjavík, Islàndia)) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Blanc, F. (University of Strasbourg and French National Centre for Scientific Research (CNRS)) ;
Antonini, Angelo (University of Padua) ;
Mecocci, Patrizia (University of Perugia) ;
Vellas, B. (University of Toulouse) ;
Tsolaki, Magda (3rd Aristotle University of Thessaloniki) ;
Kłoszewska, Iwona (Medical University of Lodz) ;
Soininen, H. (Kuopio University Hospital ( Finlàndia)) ;
Lovestone, S. (University of Oxford) ;
Simmons, A. (King's College London) ;
Aarsland, Dag (King's College London) ;
Westman, E. (King's College London) ;
Universitat Autònoma de Barcelona
Deep learning (DL) methods have in recent years yielded impressive results in medical imaging, with the potential to function as clinical aid to radiologists. However, DL models in medical imaging are often trained on public research cohorts with images acquired with a single scanner or with strict protocol harmonization, which is not representative of a clinical setting. [...]
2020 - 10.1016/j.media.2020.101714
Medical Image Analysis, Vol. 66 (december 2020) , p. 101714
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9 p, 1.0 MB |
Safinamide in the treatment pathway of Parkinson's Disease : a European Delphi Consensus
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Stocchi, Fabrizio (University and IRCCS San Raffaele Pisana) ;
Antonini, Angelo (University of Padua) ;
Berg, Daniela (Hertie-Institute of Clinical Brain Research Tübingen) ;
Bergmans, Bruno (Ghent University Hospital. (Bèlgica)) ;
Jost, Wolfgang (Parkinson-Klinik Ortenau) ;
Katzenschlager, Regina (Neurodegenerative Disorders Klinik Donaustadt) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Odin, Per (Lund University) ;
Valldeoriola, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Ray Chaudhuri, K. (King's College Hospital NHS Foundation Trust) ;
Universitat Autònoma de Barcelona
Safinamide is a highly selective, reversible MAO B-inhibitor recently marketed in European and North American countries. To better define clinical indications regarding motor and non-motor symptoms, targeted population and safety of this compound, ten movement disorders specialists, experts in their field, convened and developed a panel of statements on: the role of glutamate in Parkinson's disease, introduction to fluctuations, efficacy of safinamide on motor symptoms, motor complications and non-motor symptoms, quality of life, safety of safinamide and target population for use. [...]
2022 - 10.1038/s41531-022-00277-z
NPJ Parkinson's disease, Vol. 8 (february 2022)
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7 p, 823.4 KB |
Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease
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Jost, Stefanie Theresa (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Neurology) ;
Visser-Vandewalle, Veerle (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Stereotaxy and Functional Neurosurgery) ;
Rizos, Alexandra Marianne (King's College London. Parkinson Foundation International Centre of Excellence) ;
Loehrer, Philipp Alexander (Department of Neurology. University Hospital Giessen and Marburg. Campus Marburg) ;
Silverdale, Monty (Department of Neurology and Neurosurgery. Salford Royal NHS Foundation Trust. Manchester Academic Health Science Centre. University of Manchester) ;
Evans, Julian (Department of Neurology and Neurosurgery. Salford Royal NHS Foundation Trust. Manchester Academic Health Science Centre. University of Manchester) ;
Samuel, Michael (King's College London. Parkinson Foundation International Centre of Excellence) ;
Petry-Schmelzer, Jan Niklas (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Neurology) ;
Sauerbier, Anna (Institute of Psychiatry. Psychology and Neuroscience. King's College London) ;
Gronostay, Alexandra (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Neurology) ;
Barbe, Michael T. (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Neurology) ;
Fink, Gereon R. (Cognitive Neuroscience. Institute of Neuroscience and Medicine (INM-3). Research Centre Jülich) ;
Ashkan, Keyoumars (King's College London. Parkinson Foundation International Centre of Excellence) ;
Antonini, Angelo (Padova University. Department of Neurosciences (DNS)) ;
Martinez-Martin, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Chaudhuri, Kallol Ray (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Timmermann, Lars (University Hospital Giessen and Marburg) ;
Dafsari, Haidar S. (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Neurology) ;
Bhidayasiri, Roongroj (Chulalongkorn Centre of Excellence for Parkinson's Disease & Related Disorders. Department of Medicine. Faculty of Medicine. Chulalongkorn University and King Chulalongkorn Memorial Hospital. Thai Red Cross Society) ;
Falup-Pecurariu, Cristian (Faculty of Medicine. Transilvania University of Brașov) ;
Jeon, Beomseok (Department of Neurology. Seoul National University College of Medicine) ;
Leta, Valentina (King's College London. Institute of Psychiatry. Psychology & Neuroscience) ;
Borghammer, Per (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Odin, Per (University of Lund. Faculty of Medicine) ;
Schrag, Anette (UCL Institute of Neurology (Regne Unit)) ;
Storch, Alexander (German Center for Neurodegenerative Diseases (DZNE). Research Site Dresden) ;
Rodríguez-Violante, Mayela (Movement Disorders Clinic. National Institute of Neurology and Neurosurgery) ;
Weintraub, Daniel (Parkinson's Disease and Mental Illness Research. Education and Clinical Centers. Philadelphia Veterans Affairs Medical Center) ;
Adler, Charles (The Parkinson's Disease and Movement Disorders Center. Department of Neurology. Mayo Clinic) ;
Barone, Paolo (Center for Neurodegenerative Diseases (CEMAND). Neuroscience Section. University of Salerno) ;
Brooks, David J. (Department of Nuclear Medicine and PET Centre. Aarhus University Hospital) ;
Brown, Richard (Department of Medicine. University of Birmingham Institute of Cardiovascular Sciences. City Hospital) ;
Cantillon, Marc (Reviva Pharmaceuticals. Inc) ;
Carroll, Camille (Faculty of Medicine and Dentistry. University of Plymouth) ;
Coelho, Miguel (FAS Center for Systems Biology. Harvard University) ;
Henriksen, Tove (Movement Disorder Clinic. University Hospital of Bispebjerg) ;
Hu, Michele (Nuffield Department of Clinical Neurosciences. University of Oxford) ;
Jenner, Peter (Neurodegenerative Diseases Research Group. Institute of Pharmaceutical Sciences. Faculty of Life Sciences and Medicine. King's College London) ;
Kramberger, Milica (Department of Neurology. University Medical Centre Ljubljana) ;
Kumar, Padma (Parkinson's Disease Service for the Older Person. Rankin Park Centre. John Hunter Hospital. HNELHD) ;
Kurtis, Monica M. (Functional Movement Disorders Unit. Movement Disorders Program. Neurology Department. Hospital Ruber Internacional) ;
Lewis, Simon (Brain and Mind Centre. University of Sydney) ;
Litvan, Irene (Department of Neurosciences Movement Disorders Center. University of California) ;
Lyons, Kelly (University of Kansas Medical Center) ;
Martino, Davide (Department of Clinical Neurosciences. University of Calgary & Hotchkiss Brain Institute) ;
Masellis, Mario (Hurvitz Brain Sciences Program. Sunnybrook Research Institute) ;
Mochizuki, Hideki (Department of Neurology. Osaka University Graduate School of Medicine) ;
Morley, James F. (Department of Neurology. University of Pennsylvania) ;
Nirenberg, Melissa (Department of Neurology. NYU School of Medicine) ;
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Panicker, Jalesh (Neurology. National Hospital for Neurology & Neurosurgery) ;
Pavese, Nicola (Newcastle Magnetic Resonance Centre & Positron Emission Tomography Centre. Newcastle University. Campus for Ageing & Vitality) ;
Pekkonen, Eero (Department of Neurology. Helsinki University Hospital. and Department of Neurological Sciences (Neurology). University of Helsinki) ;
Postuma, Ron (Research Institute of McGill University Health Centre) ;
Rosales, Raimon L. (Center for Neurodiagnostic and Therapeutic Services. Metropolitan Medical Center) ;
Schapira, Anthony (Department of Clinical Neurosciences. University College London (UCL) Institute of Neurology. Royal Free Campus. Rowland Hill Street) ;
Simuni, Tanya (Department of Neurology. Northwestern University. Feinberg School of Medicine) ;
Stocchi, Fabrizio (University and Institute for Research and Medical Care. IRCCS San Raffaele) ;
Subramanian, Indu (UCLA/West LA VA) ;
Tagliati, Michele (Cedars-Sinai Medical Center) ;
Tinazzi, Michele (Department of Neuroscience. Biomedicine. and Movement. University of Verona) ;
Toledo, Jon (Department of Neurology. Houston Methodist Hospital) ;
Tsuboi, Yoshio (Department of Neurology. Fukuoka University) ;
Walker, Richard (Northumbria Healthcare NHS Foundation Trust. North Tyneside General Hospital. Rake Lane)
To identify predictors of 36-month follow-up quality of life (QoL) outcome after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD). In this ongoing, prospective, multicenter international study (Cologne, Manchester, London) including 73 patients undergoing STN-DBS, we assessed the following scales preoperatively and at 6-month and 36-month follow-up: PD Questionnaire-8 (PDQ-8), NMSScale (NMSS), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). [...]
2021 - 10.1038/s41531-021-00174-x
NPJ Parkinson's disease, Vol. 7 Núm. 1 (december 2021) , p. 48
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10 p, 322.3 KB |
Can suitable candidates for levodopa/carbidopa intestinal gel therapy be identified using current evidence?
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Catalán Alonso, Maria José (Hospital Clínico San Carlos (Madrid)) ;
Antonini, Angelo (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS)) ;
Calopa, Matilde (Hospital Universitari de Bellvitge) ;
Băjenaru, Ovidiu (University of Medicine and Pharmacy "Carol Davila" Bucharest - University Emergency Hospital, Department of Neurology, Bucharest, Romania) ;
Fàbregues-Boixar i Nebot, Oriol de (Hospital Universitari Vall d'Hebron) ;
Mínguez-Castellanos, Adolfo (Instituto de Investigación Sanitaria de Granada) ;
Odin, Per (Klinikum-Bremerhaven, Bremerhaven, Germany) ;
García Moreno, José Manuel (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Pedersen, Stephen W. (University of Copenhagen) ;
Pirtošek, Zvezdan (University Medical Centre, Ljubljana, Slovenia) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Advanced Parkinson's disease (APD) is characterized by increased functional disability, caused by motor complications, the presence of axial symptoms, and emergent disease- and drug-related non-motor symptoms. [...]
2017 - 10.1016/j.ensci.2017.06.004
eNeurologicalSci, Vol. 8 (july 2017) , p. 44-53
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12 p, 671.7 KB |
An Observational Study of the Effect of Levodopa-Carbidopa Intestinal Gel on Activities of Daily Living and Quality of Life in Advanced Parkinson's Disease Patients
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Krüger, Rejko (Tübingen, Germany) ;
Lingor, Paul (Göttingen, Germany) ;
Doskas, Triantafyllos (Athens, Greece) ;
Henselmans, Johanna M. L. (Leiden, The Netherlands) ;
Danielsen, Erik H. (Aarhus, Denmark) ;
Fàbregues-Boixar i Nebot, Oriol de (Hospital Universitari Vall d'Hebron) ;
Stefani, Alessandro (Rome, Italy) ;
Sensken, Sven-Christian (Wiesbaden, Germany) ;
Parra, Juan Carlos (Waukegan Road, North Chicago, IL USA) ;
Onuk, Koray (Waukegan Road, North Chicago, IL USA) ;
Yegin, Ashley (Waukegan Road, North Chicago, IL USA) ;
Antonini, Angelo (University Hospital of Padova (Pàdua, Itàlia)) ;
Universitat Autònoma de Barcelona
Continuous delivery of levodopa-carbidopa intestinal gel (LCIG) by percutaneous endoscopic gastrojejunostomy (PEG-J) in advanced Parkinson's disease (PD) patients reduces variability in plasma levels, providing better control of motor fluctuations ("on" and "off" states). [...]
2017 - 10.1007/s12325-017-0571-2
Advances in Therapy, Vol. 34 (june 2017) , p. 1741-1752
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