Results overview: Found 17 records in 0.02 seconds.
Articles, 14 records found
Research literature, 3 records found
Articles 14 records found  1 - 10next  jump to record:
1.
13 p, 1.3 MB Identification of ZBTB18 as a novel colorectal tumor suppressor gene through genome-wide promoter hypermethylation analysis / Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez-Barriocanal, Águeda (IRBLleida. Group of Molecular Oncology) ; Anguita, Estefanía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Li, Jing (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Garcia-Vidal, Elia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Maggio, Valentina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Aaltonen, Lauri A. (University of Helsinki) ; Sánchez, Alex (Universitat de Barcelona. Departament d'Estadística) ; Mariadason, John M. (La Trobe University. School of Cancer Medicine) ; Arango, Diego (IRBLleida. Group of Molecular Oncology)
Cancer initiation and progression are driven by genetic and epigenetic changes. Although genome/exome sequencing has significantly contributed to the characterization of the genetic driver alterations, further investigation is required to systematically identify cancer driver genes regulated by promoter hypermethylation. [...]
2021 - 10.1186/s13148-021-01070-0
Clinical Epigenetics, Vol. 13 (april 2021)  
2.
10 p, 2.5 MB Myo5b knockout mice as a model of microvillus inclusion disease / Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Overeem, Arend W. (University Medical Center Groningen) ; Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ; Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ; Schwartz, Simo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ; van Ijzendoorn, Sven C. D. (University Medical Center Groningen) ; Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Inherited MYO5B mutations have recently been associated with microvillus inclusion disease (MVID), an autosomal recessive syndrome characterized by intractable, life-threatening, watery diarrhea appearing shortly after birth. [...]
2015 - 10.1038/srep12312
Scientific reports (Nature Publishing Group), Vol. 5 (07 2015)  
3.
12 p, 2.3 MB Loss of the EPH receptor B6 contributes to colorectal cancer metastasis / Mateo-Lozano, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Mazzolini, Rocco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Andretta, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fernández, Yolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; del Llano, Edgar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Suárez-López, Lucía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Jimenez-Flores, Lizbeth M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nuñez, Yaiza (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Afonso, Elsa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cacci, Karina (Hospital Universitari Vall d'Hebron) ; Hernández-Losa, Javier (Hospital Universitari Vall d'Hebron) ; Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ; Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ; Mariadason, John M. (La Trobe University) ; Schwartz, Simo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Matsui, Toshimitsu (Kobe University Graduate School of Medicine) ; Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Although deregulation of EPHB signaling has been shown to be an important step in colorectal tumorigenesis, the role of EPHB6 in this process has not been investigated. We found here that manipulation of EPHB6 levels in colon cancer cell lines has no effect on their motility and growth on a solid substrate, soft agar or in a xenograft mouse model. [...]
2017 - 10.1038/srep43702
Scientific reports (Nature Publishing Group), Vol. 7 (03 2017)  
4.
14 p, 2.1 MB Investigation of the role of tyrosine kinase receptor EPHA3 in colorectal cancer / Andretta, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez-Barriocanal, Águeda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Jimenez-Flores, Lizbeth M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nieto, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ; Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ; Schwartz, Simo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Brown, Arthur (Robarts Research Institute) ; Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
EPH signaling deregulation has been shown to be important for colorectal carcinogenesis and genome-wide sequencing efforts have identified EPHA3 as one of the most frequently mutated genes in these tumors. [...]
2017 - 10.1038/srep41576
Scientific reports (Nature Publishing Group), Vol. 7 (02 2017)  
5.
12 p, 2.8 MB Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells / Gener, Petra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Callejo, Patricia González (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Andrade, Fernanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rafael, Diana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez, Francesc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montero, Sara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sayós, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. [...]
2018 - 10.1155/2018/4516454
Stem Cells International, Vol. 2018 (october 2018)  
6.
11 p, 6.9 MB DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis / Tögel, Lars (La Trobe University School of Cancer Medicine) ; Nightingale, Rebecca (La Trobe University School of Cancer Medicine) ; Wu, Rui (Ludwig Institute for Cancer Research) ; Chüeh, Anderly C. (Ludwig Institute for Cancer Research) ; Al-Obaidi, Sheren (Ludwig Institute for Cancer Research) ; Luk, Ian (La Trobe University School of Cancer Medicine) ; Dávalos-Salas, Mercedes (La Trobe University School of Cancer Medicine) ; Chionh, Fiona (La Trobe University School of Cancer Medicine) ; Murone, Carmel (La Trobe University School of Cancer Medicine) ; Buchanan, Daniel D. (The University of Melbourne) ; Chatterton, Zac (The University of Melbourne) ; Sieber, Oliver M. (The Walter and Eliza Hall Institute of Medical Research) ; Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Tebbutt, Niall C. (La Trobe University School of Cancer Medicine) ; Williams, David (La Trobe University School of Cancer Medicine) ; Dhillon, Amardeep S. (La Trobe University School of Cancer Medicine) ; Mariadason, John M. (Ludwig Institute for Cancer Research) ; Universitat Autònoma de Barcelona
The ERK signalling pathway regulates key cell fate decisions in the intestinal epithelium and is frequently dysregulated in colorectal cancers (CRCs). Variations in the dynamics of ERK activation can induce different biological outcomes and are regulated by multiple mechanisms, including activation of negative feedback loops involving transcriptional induction of dual-specificity phosphatases (DUSPs). [...]
2018 - 10.1038/s41598-018-20176-9
Scientific reports (Nature Publishing Group), Vol. 8 (january 2018)  
7.
17 p, 2.5 MB A Molecular Mechanism Underlying Genotype-Specific Intrahepatic Cholestasis Resulting From MYO5B Mutations / Overeem, Arend W. (University Medical Center Groningen) ; Li, Qinghong (University Medical Center Groningen) ; Qiu, Yi-Ling (Children's Hospital of Fudan University, Shanghai) ; Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Leng, Changsen (University Medical Center Groningen) ; Klappe, Karin (University Medical Center Groningen) ; Dronkers, Just (University Medical Center Groningen) ; Hsiao, Nai-Hua (University Medical Center Groningen) ; Wang, Jian-She (Children's Hospital of Fudan University, Shanghai) ; Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; van Ijzendoorn, Sven C.D. (University Medical Center Groningen) ; Universitat Autònoma de Barcelona
Progressive familial intrahepatic cholestasis (PFIC) 6 has been associated with missense but not biallelic nonsense or frameshift mutations in MYO5B, encoding the motor protein myosin Vb (myoVb). This genotype-phenotype correlation and the mechanism through which MYO5B mutations give rise to PFIC are not understood. [...]
2020 - 10.1002/hep.31002
Hepatology, Vol. 72 (april 2020) , p. 213-229  
8.
15 p, 1.9 MB Silencing of adaptor protein 32 reduces / receptors expression and impairs gastrointestinal stromal tumors growth / Serrano-Candelas, Eva (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Ainsua-Enrich, Erola (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Navinés-Ferrer, Arnau (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; García-Valverde, Alfonso (Vall d'Hebron Institut d'Oncologia) ; Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; García-Valverde, Alfonso (Vall d'Hebron Institut d'Oncologia) ; Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; García-Valverde, Alfonso (Vall d'Hebron Institut d'Oncologia) ; Arribas, Joaquín V (Universitat Autònoma de Barcelona) ; Serrano, César (Hospital Universitari Vall d'Hebron) ; Sayós, Joan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martin, Margarita (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Gastrointestinal stromal tumors (s) represent about 80% of the mesenchymal neoplasms of the gastrointestinal tract. Most s contain oncogenic (85%) or (5%) receptors. The kinase inhibitor imatinib mesylate is the preferential treatment for these tumors; however, the development of drug resistance has highlighted the need for novel therapeutic strategies. [...]
2018 - 10.1002/1878-0261.12332
Molecular Oncology, Vol. 12 (june 2018) , p. 1383-1397  
9.
1.9 MB AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells / Rafael, Diana (Universitat Autònoma de Barcelona) ; Gener, Petra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Andrade, Fernanda (Instituto de Salud Carlos III) ; Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montero, Sara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fernández Caparrós, Yolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hidalgo, Manuel (Rosenberg Clinical Cancer Center Beth Israel Deaconess Medical Center) ; Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Florindo, Helena F. (Universidade de Lisboa) ; Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Schwartz, Simon (Instituto de Salud Carlos III) ; Videira, Mafalda (Universidade de Lisboa) ; Universitat Autònoma de Barcelona
Development of RNA interference-based therapies with appropriate therapeutic window remains a challenge for advanced cancers. Because cancer stem cells (CSC) are responsible of sustaining the metastatic spread of the disease to distal organs and the progressive gain of resistance of advanced cancers, new anticancer therapies should be validated specifically for this subpopulation of cells. [...]
2018 - 10.1080/10717544.2018.1461276
Drug Delivery, Vol. 25 (april 2018) , p. 961-972  
10.
29 p, 6.1 MB Loss of MYO5B expression deregulates late endosome size which hinders mitotic spindle orientation / Leng, Changsen (Department of Biomedical Sciences of Cells and Systems, section Molecular Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands) ; Overeem, Arend W. (Department of Biomedical Sciences of Cells and Systems, section Molecular Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands) ; Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Li, Qinghong (Department of Biomedical Sciences of Cells and Systems, section Molecular Cell Biology, University of Groningen, University Medical Center Groningen) ; Klappe, Karin (Department of Biomedical Sciences of Cells and Systems, section Molecular Cell Biology, University of Groningen, University Medical Center Groningen) ; Kuipers, Jeroen (Department of Biomedical Sciences of Cells and Systems, section Molecular Cell Biology, University of Groningen, University Medical Center Groningen) ; Cui, Yingying (Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen) ; Zuhorn, Inge S. (Department of Biomedical Engineering, University of Groningen, University Medical Center Groningen) ; Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; van IJzendoorn, Sven C. D. (Department of Biomedical Sciences of Cells and Systems, section Molecular Cell Biology, University of Groningen, University Medical Center Groningen) ; Universitat Autònoma de Barcelona
Recycling endosomes regulate plasma membrane recycling. Recently, recycling endosome-associated proteins have been implicated in the positioning and orientation of the mitotic spindle and cytokinesis. [...]
2019 - 10.1371/journal.pbio.3000531
PLoS biology, Vol. 17 (november 2019)  

Articles : 14 records found   1 - 10next  jump to record:
Research literature 3 records found  
1.
186 p, 5.8 MB Role of myosin VI in colorectal cancer / Macaya Erro, Irati ; Arango, Diego, dir. ; Meseguer Navarro, Anna, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
La miosina VI (MYO6) es un motor molecular que puede anclar moléculas o proporcionar tráfico de corto alcance a lo largo del citoesqueleto de actina valiéndose de la energía obtenida de la hidrólisis de ATP. [...]
Myosin VI (MYO6) is a molecular motor that can provide short range trafficking along the actin cytoskeleton by using the energy from ATP hydrolysis or anchor cargoes to actin filaments. Myosin VI moves towards the minus-end of actin filaments, in the opposite direction to the rest of myosins. [...]

[Bellaterra] : Universitat Autònoma de Barcelona, 2018.  
2.
189 p, 4.9 MB Myosin VB in intestinal pathogenesis / Cartón-Garcia, Fernando ; Arango, Diego, dir. ; Seoane Suárez, Joan, dir. ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Miosina VB es una proteína que actúa como un motor molecular usando la energía del ATP para moverse a lo largo de filamentos de actina. Participa en el trafico intracelular de endosomas de reciclaje en la parte subapical de células polarizadas y no polarizadas. [...]
Myosin VB is a molecular motor protein that uses the energy of ATP to move along actin filaments. It participates in the recycling endosomes trafficking in the subapical cytoplasmic region of non-polarized and polarized cells. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2017.  
3.
138 p, 4.9 MB Role of EPHA3 in colorectal cancer / Andretta, Elena ; Arango, Diego, dir. ; Schwartz Navarro, Simó, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
Los receptores EPH (receptores de efrina) constituyen la subfamilia más grande de los receptores tirosina quinasas en mamífero. Se unen a las efrinas, ancladas a las membranas celulares mediante un enlace glicosilfosfatidilinositol (GPI) (efrinas de tipo A) o mediante una dominio transmembrana seguido por un dominio citoplasmático (efrinas de tipo B). [...]
EPHs, which make up the largest family of mammalian receptor tyrosine kinases, bind cell surface-associated Ephrins that have either a glycosylphosphatidylinositol (GPI) membrane anchor (A-type Ephrins) or a transmembrane region followed by a conserved cytoplasmatic tail (B-type Ephrins). [...]

Bellaterra : Universitat Autònoma de Barcelona, 2015  

See also: similar author names
2 Arango, D.
3 Arango, Diego,
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