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14 p, 4.6 MB Genetic heterogeneity and actionable mutations in HER2-positive primary breast cancers and their brain metastases / De Mattos-Arruda, Leticia (Department of Pathology, Memorial Sloan Kettering Cancer Center) ; Ng, Charlotte K. Y. (Department of Biomedicine, University of Basel, Basel, Switzerland) ; Piscuoglio, Salvatore (Institute of Pathology, University Hospital Basel) ; Gonzalez-Cao, Maria (Hospital Universitari Quirón Dexeus) ; Lim, Raymond S. (Department of Pathology, Memorial Sloan Kettering Cancer Center) ; De Filippo, Maria R. (Department of Pathology, Memorial Sloan Kettering Cancer Center) ; Fusco, Nicola (Department of Pathology, Memorial Sloan Kettering Cancer Center) ; Schultheis, Anne M. (Department of Pathology, Memorial Sloan Kettering Cancer Center) ; Ortiz, Carolina (Vall d'Hebron Institut d'Oncologia) ; Viteri, Santiago (Hospital Universitari Quirón Dexeus) ; Arias, Alexandra (Vall d'Hebron Institut d'Oncologia) ; Macedo, Gabriel S. (Department of Pathology, Memorial Sloan Kettering Cancer Center) ; Oliveira, Mafalda (Vall d'Hebron Institut d'Oncologia) ; Gomez, Patricia (Vall d'Hebron Institut d'Oncologia) ; Teixidó, Cristina (Hospital Universitari Quirón Dexeus) ; Nuciforo, Paolo (Vall d'Hebron Institut d'Oncologia) ; Peg, Vicente (Vall d'Hebron Institut de Recerca) ; Saura, Cristina (Vall d'Hebron Institut d'Oncologia) ; Ramon y Cajal, Santiago (Vall d'Hebron Institut de Recerca) ; Tresserra Casas, Francesc (Hospital Universitari Quirón Dexeus) ; Weigelt, Britta (Department of Pathology, Memorial Sloan Kettering Cancer Center) ; Cortes, Javier (Universitat Autònoma de Barcelona. Departament de Medicina) ; Seoane Suárez, Joan (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Reis-Filho, Jorge S. (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)
Brain metastases constitute a challenge in the management of patients with HER2-positive breast cancer treated with anti-HER2 systemic therapies. Here we sought to define the repertoire of mutations private to or enriched for in HER2-positive brain metastases. [...]
2018 - 10.18632/oncotarget.25041
Oncotarget, Vol. 9 (april 2018) , p. 20617-20630  

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