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14 p, 690.6 KB |
The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy : a review from the ESGMYC study group
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Melkie, Solomon Tibebu (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Arias, Lilibeth (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Farroni, Chiara (National Institute for Infectious Diseases-IRCCS L. Spallanzani) ;
Jankovic Makek, Mateja (University Clinical Centre Zagreb) ;
Goletti, Delia (National Institute for Infectious Diseases-IRCCS L. Spallanzani) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Tuberculosis (TB) is still responsible for the deaths of >1 million people yearly worldwide, and therefore its correct diagnosis is one of the key components of any TB eradication programme. However, current TB diagnostic tests have many limitations, and improved diagnostic accuracy is urgently needed. [...]
2022 -  10.1183/16000617.0218-2021
European Respiratory Review, Vol. 31 (march 2022)
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2.
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10 p, 1.8 MB |
Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
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Garrido-Amaro, Cristina (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ;
Cardona, Paula (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Gassó, Diana (Universitat de Lleida. Escola Tècnica Superior d'Enginyeria Agrària) ;
Arias, Lilibeth (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Velarde, Roser (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ;
Tvarijonaviciute, Asta (Universidad de Murcia. Interlab-UMU) ;
Serrano Ferron, Emmanuel (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ;
Cardona, Pere-Joan (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Tuberculosis (TB) is still a major challenge for humankind. Because regions with the highest incidence also have a high prevalence of helminthiasis and nutritional scarcity, we wanted to understand the impact of these on TB progression. [...]
2021 - 10.3389/fimmu.2021.627638
Frontiers in immunology, Vol. 12 (april 2021)
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3.
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26 p, 5.0 MB |
A multi-antigenic MVA vaccine increases efficacy of combination chemotherapy against Mycobacterium tuberculosis
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Infectious Diseases department, Centre d'Infectiologie, Bât Domilyon, Lyon ;
Coupet, Charles-Antoine (Infectious Diseases department, Centre d'Infectiologie, Bât Domilyon, Lyon) ;
Gouanvic, Marie (Infectious Diseases department, Centre d'Infectiologie, Bât Domilyon, Lyon) ;
Schmitt, Doris (Boulevard Gonthier d'Andernach, Parc d'innovation, Illkirch-Graffenstaden) ;
Ray, Aurélie (Infectious Diseases department, Centre d'Infectiologie, Bât Domilyon, Lyon) ;
Hoffmann, Chantal (Boulevard Gonthier d'Andernach, Parc d'innovation, Illkirch-Graffenstaden) ;
Schultz, Huguette (Boulevard Gonthier d'Andernach, Parc d'innovation, Illkirch-Graffenstaden) ;
Tyagi, Sandeep (Johns Hopkins University, Baltimore) ;
Soni, Heena (Johns Hopkins University, Baltimore) ;
Converse, Paul J. (Johns Hopkins University, Baltimore) ;
Arias, Lilibeth (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Kleinpeter, Patricia (Boulevard Gonthier d'Andernach, Parc d'innovation, Illkirch-Graffenstaden) ;
Sansas, Benoît (Boulevard Gonthier d'Andernach, Parc d'innovation, Illkirch-Graffenstaden) ;
Mdluli, Khisimuzi (Global Alliance for Tuberculosis Drug Development, New York) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cardona, Pere-Joan (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Nuermberger, Eric (Johns Hopkins University, Baltimore, Maryland) ;
Marchand, Jean-Baptiste (Boulevard Gonthier d'Andernach, Parc d'innovation, Illkirch-Graffenstaden) ;
Silvestre, Nathalie (Boulevard Gonthier d'Andernach, Parc d'innovation, Illkirch-Graffenstaden) ;
Inchauspé, Geneviève (Infectious Diseases department, Centre d'Infectiologie, Bât Domilyon, Lyon)
Despite the existence of the prophylactic Bacille Calmette-Guérin (BCG) vaccine, infection by Mycobacterium tuberculosis (Mtb) remains a major public health issue causing up to 1. 8 million annual deaths worldwide. [...]
2018 - 10.1371/journal.pone.0196815
PloS one, Vol. 13 (may 2018)
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4.
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17 p, 2.5 MB |
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles
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Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Drobniewski, Francis (Imperial College) ;
Kontsevaya, Irina (N.V. Postnikov Samara Region Clinical Tuberculosis Dispensary) ;
Arias, Lilibeth (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Monguió-Tortajada, Marta (Universitat Autònoma de Barcelona) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ong, Ruo-Yan (University of Dundee) ;
Luquín Fernández, Marina (Marina) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Dupont, Maeva (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Chojnacki, Jakub (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cardona, Paula (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Neyrolles, Olivier (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Lugo-Villarino, Geanncarlo (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Vérollet, Christel (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Furrer, Hansjakob (University of Bern) ;
Günthard, Huldrych F. (University of Zurich) ;
Crocker, Paul R. (University of Dundee) ;
Tapia, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fellay, Jacques (Lausanne University Hospital) ;
McLaren, Paul J. (University of Manitoba) ;
Telenti, Amalio (The Scripps Research Institute) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non-functional variant in SIGLEC1, which encodes the myeloid-cell receptor Siglec-1/CD169 implicated in HIV-1 cell-to-cell transmission. [...]
2021 - 10.1002/jev2.12046
Journal of extracellular vesicles, Vol. 10 (january 2021)
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5.
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14 p, 3.2 MB |
Cording Mycobacterium tuberculosis Bacilli Have a Key Role in the Progression towards Active Tuberculosis, Which is Stopped by Previous Immune Response
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Arias, Lilibeth (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cardona, Paula (Institut Germans Trias i Pujol) ;
Català, Martí (Centre de Medicina Comparativa i Bioimatge de Catalunya (CMCiB)) ;
Campo Pérez, Víctor (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Prats, Clara (Universitat Politècnica de Catalunya. Escola Superior d'Agricultura de Barcelona) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Cardona, Pere-Joan (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Cording was the first virulence factor identified in Mycobacterium tuberculosis (Mtb). We aimed to ascertain its role in the induction of active tuberculosis (TB) in the mouse strain C3HeB/FeJ by testing the immunopathogenic capacity of the H37Rv strain. [...]
2020 - 10.3390/microorganisms8020228
Microorganisms, Vol. 8, Num. 2 (February 2020) , art. 228
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6.
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18 p, 5.0 MB |
Influence of Gut Microbiota on Progression to Tuberculosis Generated by High Fat Diet-Induced Obesity in C3HeB/FeJ Mice
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Arias, Lilibeth (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Goig, Galo A. (Instituto de Biomedicina de Valencia (IBV-CSIC)) ;
Cardona, Paula (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Torres-Puente, Manuela (Instituto de Biomedicina de Valencia (IBV-CSIC)) ;
Díaz, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rosales, Yaiza (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García, Eric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tapia, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Comas, I (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Vilaplana, Cristina (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Cardona, Pere-Joan (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The administration of a high fat content diet is an accelerating factor for metabolic syndrome, impaired glucose tolerance, and early type 2 diabetes. The present study aims to assess the impact of a high fat diet on tuberculosis progression and microbiota composition in an experimental animal model using a C3HeB/FeJ mouse strain submitted to single or multiple consecutive aerosol infections. [...]
2019 - 10.3389/fimmu.2019.02464
Frontiers in immunology, Vol. 10 (October 2019) , art. 2464
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