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1.
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10 p, 2.3 MB |
Global and Regional Deep Learning Models for Multiple Sclerosis Stratification From MRI
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Coll, Llucia (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquin (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Alberich, Manel (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Oliver, Arnau (Universitat de Girona) ;
Montalban, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Lladó, Xavier (Universitat de Girona) ;
Tur, Carmen (Universitat Autònoma de Barcelona. Departament de Medicina)
Background: The combination of anatomical MRI and deep learning-based methods such as convolutional neural networks (CNNs) is a promising strategy to build predictive models of multiple sclerosis (MS) prognosis. [...]
2023 -  10.1002/jmri.29046
Journal of Magnetic Resonance Imaging
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2.
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12 p, 4.0 MB |
Deciphering multiple sclerosis disability with deep learning attention maps on clinical MRI
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Coll, Llucia (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Salerno, Annalaura (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Alberich, Manel (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Oliver, Arnau (Universitat de Girona. Institut de recerca en visió per computador i robòtica (VICOROB)) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Lladó, Xavier (Universitat de Girona. Institut de recerca en visió per computador i robòtica (VICOROB)) ;
Tur, Carmen (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
The application of convolutional neural networks (CNNs) to MRI data has emerged as a promising approach to achieving unprecedented levels of accuracy when predicting the course of neurological conditions, including multiple sclerosis, by means of extracting image features not detectable through conventional methods. [...]
2023 - 10.1016/j.nicl.2023.103376
NeuroImage, Vol. 38 (march 2023)
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3.
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8 p, 871.8 KB |
Oral contraceptives do not modify the risk of a second attack and disability accrual in a prospective cohort of women with a clinically isolated syndrome and early multiple sclerosis
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Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Zuluaga Rodas, María Isabel (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Rodríguez, Marta (Hospital Universitari Vall d'Hebron) ;
Tur, Carmen (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
To evaluate whether oral contraceptive (OC) use is associated with the risk of a second attack and disability accrual in women with a clinically isolated syndrome (CIS) and early multiple sclerosis (MS). [...]
2021 - 10.1177/13524585211053001
Multiple sclerosis, Vol. 28 (november 2021) , p. 950-957
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4.
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14 p, 2.2 MB |
Associations of with clinico-radiological measures in a large population
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Sotirchos, Elias S. (Johns Hopkins University School of Medicine) ;
Fitzgerald, Kathryn (Johns Hopkins University School of Medicine) ;
Singh, Carol (Biogen) ;
Smith, Matthew D. (Johns Hopkins University School of Medicine) ;
Reyes-Mantilla, Maria (Johns Hopkins University School of Medicine) ;
Hersh, Carrie (Cleveland Clinic) ;
Hyland, Megan H. (University of Rochester Medical Center) ;
Canissario, Ryan (University of Rochester Medical Center) ;
Simmons, Sarah B. (Mellen Center, Neurological Institute, Cleveland Clinic) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Naismith, Robert (Washington University in St. Louis) ;
Qiao, Min (Washington University in St. Louis) ;
Krupp, Lauren B. (New York University) ;
Nicholas, Jacqueline A. (Riverside Methodist Hospital) ;
Akgün, Katja (University Clinic Carl-Gustav Carus) ;
Ziemssen, Tjalf (University Clinic Carl-Gustav Carus) ;
Rudick, Richard ((formerly) Biogen) ;
Fisher, Elizabeth (Biogen) ;
Bermel, Robert (Mellen Center, Neurological Institute, Cleveland Clinic) ;
Mowry, Ellen (Johns Hopkins University School of Medicine) ;
Calabresi, Peter A. (Johns Hopkins University School of Medicine) ;
Universitat Autònoma de Barcelona
Evaluation of serum neurofilament light chain (sNfL), measured using high-throughput assays on widely accessible platforms in large, real-world MS populations, is a critical step for sNfL to be utilized in clinical practice. [...]
2022 - 10.1002/acn3.51704
Annals of Clinical and Translational Neurology, Vol. 10 (november 2022) , p. 84-97
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5.
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10 p, 509.3 KB |
Association of Early Progression Independent of Relapse Activity With Long-term Disability After a First Demyelinating Event in Multiple Sclerosis
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Tur, Carmen (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Salerno, Annalaura (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
This cohort study investigates the long-term outcomes of patients who develop progression independent of relapse activity after a first demyelinating event in multiple sclerosis. What are the long-term outcomes of patients developing progression independent of relapse activity (PIRA) after a first demyelinating event in multiple sclerosis? In this longitudinal cohort study including 1128 patients with a first demyelinating event in multiple sclerosis, presenting with PIRA was associated with significantly shorter times to developing severe disability compared with not presenting with PIRA. [...]
2022 - 10.1001/jamaneurol.2022.4655
JAMA Neurology, Vol. 80 (december 2022) , p. 151-160
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6.
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13 p, 1.9 MB |
Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis : A systematic review and meta-analysis
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Hegen, Harald (Medical University of Innsbruck) ;
Walde, Janette (University of Innsbruck) ;
Berek, Klaus (University of Innsbruck) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Gnanapavan, Sharmilee (Queen Mary University of London) ;
Kaplan, Batia (Sheba Medical Center (Israel)) ;
Khalil, Michael (Medical University of Graz) ;
Saadeh, Ruba (Clínica Mayo) ;
Teunissen, Charlotte E (Vrije Universiteit) ;
Tumani, Hayrettin (University of Ulm) ;
Villar, Luisa M (Hospital Universitario Ramón y Cajal (Madrid)) ;
Willrich, Maria Alice V (Clínica Mayo) ;
Zetterberg, Henrik (Sahlgrenska University Hospital (Suècia)) ;
Deisenhammer, Florian ;
Universitat Autònoma de Barcelona
Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detected by oligoclonal IgG bands (OCB) or by κ-free light chains (κ-FLC) in cerebrospinal fluid. To perform a systematic review and meta-analysis to evaluate whether κ-FLC index has similar diagnostic value to identify patients with clinically isolated syndrome (CIS) or MS compared to OCB, and to determine κ-FLC index cut-off. [...]
2022 - 10.1177/13524585221134213
Multiple sclerosis, Vol. 29 (december 2022) , p. 169-181
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7.
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14 p, 1.1 MB |
Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis : A consensus statement
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Hegen, Harald (Medical University of Innsbruck) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Gnanapavan, Sharmilee (Queen Mary University of London) ;
Kaplan, Batia (Sheba Medical Center) ;
Khalil, Michael (Medical University of Graz) ;
Saadeh, Ruba (Mayo Clinic (Rochester)) ;
Teunissen, Charlotte E (Amsterdam UMC) ;
Tumani, Hayrettin (University of Ulm) ;
Villar, Luisa Maria (Hospital Universitario Ramón y Cajal (Madrid)) ;
Willrich, Maria Alice V (Mayo Clinic) ;
Zetterberg, Henrik (Sahlgrenska University Hospital (Suècia)) ;
Deisenhammer, Florian (Medical University of Innsbruck) ;
Universitat Autònoma de Barcelona
Cerebrospinal fluid (CSF) analysis is of utmost importance for diagnosis and differential diagnosis of patients with suspected multiple sclerosis (MS). Evidence of intrathecal immunoglobulin G (IgG) synthesis proves the inflammatory nature of the disease, increases diagnostic certainty and substitutes for dissemination in time according to current diagnostic criteria. [...]
2022 - 10.1177/13524585221134217
Multiple sclerosis, Vol. 29 (december 2022) , p. 182-195
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8.
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12 p, 302.7 KB |
SARS-CoV-2 Infection in Multiple Sclerosis
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Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Llaneza-González, Miguel Ángel (Hospital Universitari Vall d'Hebron) ;
Costa-Frossard, Lucienne (Hospital Universitari Vall d'Hebron) ;
Meca-Lallana, Virginia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Díaz, Eva Fernández (Hospital Universitari Vall d'Hebron) ;
Moreno-Torres, Irene (Hospital Universitari Vall d'Hebron) ;
García-Domínguez, Jose Manuel (Hospital Universitari Vall d'Hebron) ;
Ortega-Suero, Gloria (Hospital Universitari Vall d'Hebron) ;
Ayuso-Peralta, Lucía (Hospital Universitari Vall d'Hebron) ;
Gómez-Moreno, Mayra (Hospital Universitari Vall d'Hebron) ;
Sotoca Fernández, Javier (Hospital Universitari Vall d'Hebron) ;
Caminero, Ana B (Hospital Universitari Vall d'Hebron) ;
Rodríguez de Antonio, Luis A. (Hospital Universitari Vall d'Hebron) ;
Corujo-Suárez, Marcial (Hospital Universitari Vall d'Hebron) ;
Otano-Martínez, María A. (Hospital Universitari Vall d'Hebron) ;
Pérez-Miralles, Francisco Carlos (Hospital Universitari Vall d'Hebron) ;
Reyes-Garrido, Virginia (Hospital Universitari Vall d'Hebron) ;
Ayuso-Blanco, Teresa (Hospital Universitari Vall d'Hebron) ;
Balseiro-Gómez, José (Hospital Universitari Vall d'Hebron) ;
Muñoz-Pasadas, Mercedes (Hospital Universitari Vall d'Hebron) ;
Pérez-Molina, Inmaculada (Hospital Universitari Vall d'Hebron) ;
Domingo-Santos, Ángela (Hospital Universitari Vall d'Hebron) ;
Guijarro-Castro, Cristina (Hospital Universitari Vall d'Hebron) ;
Íñiguez-Martínez, Cristina (Hospital Universitari Vall d'Hebron) ;
Téllez Lara, Nieves (Hospital Universitari Vall d'Hebron) ;
Castellanos-Pinedo, Fernando (Hospital Universitari Vall d'Hebron) ;
Castillo-Triviño, Tamara (Hospital Universitari Vall d'Hebron) ;
Cerdán-Santacruz, Debora María (Hospital Universitari Vall d'Hebron) ;
Torres, Berta Sebastián (Hospital Universitari Vall d'Hebron) ;
Álvarez de Arcaya, Amaya (Hospital Universitari Vall d'Hebron) ;
Costa-Arpín, Eva (Hospital Universitari Vall d'Hebron) ;
Durán-Ferreras, Eduardo (Hospital Universitari Vall d'Hebron) ;
González-Platas, Montserrat (Hospital Universitari Vall d'Hebron) ;
Landete Pascual, Lamberto (Hospital Universitari Vall d'Hebron) ;
Millán-Pascual, Jorge (Hospital Universitari Vall d'Hebron) ;
Oreja-Guevara, Celia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
To understand COVID-19 characteristics in people with multiple sclerosis (MS) and identify high-risk individuals due to their immunocompromised state resulting from the use of disease-modifying treatments. [...]
2021 - 10.1212/NXI.0000000000001024
Neurology® neuroimmunology & neuroinflammation, Vol. 8 (june 2021)
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9.
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8 p, 441.0 KB |
Serum Biomarker gMS-Classifier2 : Predicting Conversion to Clinically Definite Multiple Sclerosis
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Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron) ;
Yarden, Jennifer (Department of Research and Development, Glycominds, Modi'in, Israel) ;
Fire, Ella (Department of Research and Development, Glycominds, Modi'in, Israel) ;
Spector, Larissa (Department of Research and Development, Glycominds, Modi'in, Israel) ;
Dotan, Nir (Department of Research and Development, Glycominds, Modi'in, Israel) ;
Dukler, Avinoam (Department of Research and Development, Glycominds, Simi Valley, California, United States of America) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Anti-glycan antibodies can be found in autoimmune diseases. IgM against glycan P63 was identified in clinically isolated syndromes (CIS) and included in gMS-Classifier2, an algorithm designed with the aim of identifying patients at risk of a second demyelinating attack. [...]
2013 - 10.1371/journal.pone.0059953
PloS one, Vol. 8 (march 2013)
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10.
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13 p, 780.6 KB |
Humoral and Cellular Responses to SARS-CoV-2 in Convalescent COVID-19 Patients With Multiple Sclerosis
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Zabalza, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tagliani, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cárdenas-Robledo, Simón (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Otero-Romero, Susana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esperalba, Juliana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernandez-Naval, Candela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Trocoli Campuzano, Jesus (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castillo, Mireia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bonastre, Mercè (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Resina Sallés, Mireia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Beltran, Jordina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Barranco, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
López-Maza, Samuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Melgarejo Otálora, Pedro José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Ortiz, Mariano (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pappolla, Agustin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tur, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Río, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Information about humoral and cellular responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and antibody persistence in convalescent (COVID-19) patients with multiple sclerosis (PwMS) is scarce. [...]
2022 - 10.1212/NXI.0000000000001143
Neurology® neuroimmunology & neuroinflammation, Vol. 9 (february 2022)
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