Resultados globales: 2 registros encontrados en 0.01 segundos.
Artículos, Encontrados 2 registros
Artículos Encontrados 2 registros  
12 p, 3.3 MB Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection / Aso, Ester (ALBA Laboratori de Llum de Sincrotró) ; Martinsson, Isak (Wallenberg Neuroscience Center) ; Appelhans, Dietmar (Leibniz Institute of Polymer Research Dresden) ; Effenberg, Christiane (Leibniz Institute of Polymer Research Dresden) ; Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró) ; Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Gouras, Gunnar (Wallenberg Neuroscience Center) ; Ferrer, Isidre (Hospital Universitari de Bellvitge) ; Klementieva, Oxana (Wallenberg Neuroscience Center)
Poly(propylene imine) dendrimers have been shown to be promising 3-dimensional polymers for the use in the pharmaceutical and biomedical applications. Our aims of this study were first, to synthesize a novel type of dendrimer with poly(propylene imine) core and maltose-histidine shell (G4HisMal) assessing if maltose-histidine shell can improve the biocompatibility and the ability to cross the blood-brain barrier, and second, to investigate the potential of G4HisMal to protect Alzheimer disease transgenic mice from memory impairment. [...]
2019 - 10.1016/j.nano.2019.01.010
Nanomedicine, Vol. 17 (April 2019) , p. 198-209  
2 p, 188.6 KB Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds / Pérez-Areales, Francisco Javier (Universitat de Barcelona) ; Garrido, María (Instituto de Química Avanzada de) ; Catalunya (IQAC-CSIC) ; Aso, Ester (Universitat de Barcelona) ; Bartolini, Manuela (Department of Pharmacy and Biotechnology. Alma Mater Studiorum University of Bologna) ; De Simone, Angela (University of Bologna. Department for Life Quality Studies) ; Espargaró Colomé, Alba (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ginex, Tiziana (Universitat de Barcelona) ; Sabate, Raimon (Universitat de Barcelona) ; Pérez, Belén (Autonomous University of Barcelona. Therapeutics and Toxicology) ; Andrisano, Vincenza (University of Bologna. Department for Life Quality Studies) ; Luque, Francisco Javier (Universitat de Barcelona) ; Ferrer, Isidro (Universitat de Barcelona. Unitat de Neuropatologia Experimental) ; Ciruela, Francisco (Universitat de Barcelona) ; Messeguer, Àngel (Instituto de Química Avanzada de) ; Catalunya (IQAC-CSIC) ; Muñoz Torrero, Diego (Universitat de Barcelona. Laboratori de Química Farmacèutica)
Simultaneous modulation of several targets or athological events with a key pathogenic role is a promising strategy to tackle thus far difficult-to-cure or incurable multifactorial diseases, such as Alzheimer's disease (AD). [...]
2019 - 10.3390/proceedings2019022071
Proceedings, Vol. 22 (2019) , p. 1-2  

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1 Aso, Elena
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