Resultados globales: 2 registros encontrados en 0.01 segundos.
Artículos, Encontrados 2 registros
Artículos Encontrados 2 registros  
1.
39 p, 4.7 MB mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer / Zabala Letona, Amaia (CIBERONC) ; Arruabarrena Aristorena, Amaia (CIC bioGUNE) ; Martín Martín, Natalia (CIBERONC) ; Fernández Ruiz, Sonia (CIBERONC) ; Sutherland, James D. (CIC bioGUNE) ; Clasquin, Michelle (AGIOS Pharmaceuticals) ; Tomás Cortázar, Julen (CIC bioGUNE) ; Jiménez, José (Hospital Universitari Vall d'Hebron) ; Torres Ramírez, Inés Ma. de (Hospital Universitari Vall d'Hebron) ; Quang, Phong (AGIOS Pharmaceuticals) ; Ximénez Embun, Pilar (Spanish National Cancer Research Centre) ; Bago, Ruzica (MRC Protein Phosphorylation and Ubiquitylation Unit) ; Ugalde Olano, Aitziber (Basurto University Hospital) ; Loizaga Iriarte, Ana (Basurto University Hospital) ; Lacasa Viscasillas, Isabel (Basurto University Hospital) ; Unda, Miguel (Basurto University Hospital) ; Torrano, Verónica (CIBERONC) ; Cabrera, Diana (CIC bioGUNE) ; van Liempd, Sebastiaan M. (CIC bioGUNE) ; Cendon, Ylenia (Universidad Autónoma de Madrid) ; Castro, Elena (Spanish National Cancer Research Centre) ; Murray, Stuart (AGIOS Pharmaceuticals) ; Revandkar, Ajinkya (University of Lausanne) ; Alimonti, Andrea (University of Lausanne) ; Zhang, Yinan (Harvard School of Public Health) ; Barnett, Amelia (AGIOS Pharmaceuticals) ; Lein, Gina (AGIOS Pharmaceuticals) ; Pirman, David (AGIOS Pharmaceuticals) ; Cortázar, Ana R. (CIC bioGUNE) ; Arreal, Leire (CIC bioGUNE) ; Prudkin, Ludmila (Hospital Universitari Vall d'Hebron) ; Astobiza, Ianire (CIC bioGUNE) ; Valcárcel Jiménez, Lorea (CIC bioGUNE) ; Zúñiga García, Patricia (CIC bioGUNE) ; Fernández Domínguez, Itziar (CIC bioGUNE) ; Piva, Marco (CIC bioGUNE) ; Caro Maldonado, Alfredo (CIC bioGUNE) ; Sánchez Mosquera, Pilar (CIC bioGUNE) ; Castillo Martín, Mireia (Fundação Champalimaud) ; Serra, Violeta (Hospital Universitari Vall d'Hebron) ; Beraza, Naiara (CIC bioGUNE) ; Gentilella, Antonio (Catalan Institute of Oncology) ; Thomas, George (Catalan Institute of Oncology) ; Azkargorta, Mikel (Carlos III Networked Proteomics Platform) ; Elortza, Felix (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Farràs, Rosa (Centro de Investigación Príncipe Felipe) ; Olmos, David (Hospitales Universitarios Virgen de la Victoria y Regional de Málaga) ; Efeyan, Alejo (Spanish National Cancer Research Centre) ; Anguita, Juan (Ikerbasque) ; Muñoz, Javier (Carlos III Networked Proteomics Platform) ; Falcón Pérez, Juan M. (Ikerbasque) ; Barrio, Rosa (CIC bioGUNE) ; Macarulla Mercadé, Teresa (Hospital Universitari Vall d'Hebron) ; Mato, José M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Martínez Chantar, Maria L. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Cordon Cardo, Carlos (Icahn School of Medicine at Mount Sinai) ; Aransay, Ana M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Marks, Kevin (AGIOS Pharmaceuticals) ; Baselga Torres, Josep, 1959-, (Memorial Sloan-Kettering Cancer Center) ; Taberneroo, J (Hospital Universitari Vall d'Hebron) ; Nuciforo, Paolo (Hospital Universitari Vall d'Hebron) ; Manning, Brendan D. (Harvard School of Public Health) ; Marjon, Katya (AGIOS Pharmaceuticals) ; Carracedo, Arkaitz (University of the Basque Country) ; Universitat Autònoma de Barcelona
Activation of the PTEN-PI3K-mTORC1 pathway consolidates metabolic programs that sustain cancer cell growth and proliferation,. Here we show that mTORC1 regulates polyamine dynamics, a metabolic route that is essential for oncogenicity. [...]
2017 - 10.1038/nature22964
Nature, Vol. 547 (July 2017) , p. 109-113  
2.
7 p, 1018.1 KB Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients / Sadovnick, A. Dessa (Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ; Traboulsee, Anthony L. (Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ; Bernales, Cecily Q. (Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ; Ross, Jay P. (Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ; Forwell, Amanda L. (Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ; Yee, Irene M. (Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ; Guillot-Noel, Lena (Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, France) ; Fontaine, Bertrand (Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, France) ; Cournu-Rebeix, Isabelle (Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, France) ; Alcina, Antonio (Department of Cell Biology and Immunology, Instituto de Parasitología y Biomedicina López Neyra (IPBLN), CSIC, 18100 Granada, Spain) ; Fedetz, Maria (Unidad de Esclerosis Múltiple, Hospital Universitario Virgen Macarena, 41071 Sevilla, Spain) ; Izquierdo, Guillermo (Unidad de Esclerosis Múltiple, Hospital Universitario Virgen Macarena, 41071 Sevilla, Spain) ; Matesanz, Fuencisla (Department of Cell Biology and Immunology, Instituto de Parasitología y Biomedicina López Neyra (IPBLN), CSIC, 18100 Granada, Spain) ; Hilven, Kelly (Laboratory for Neuroimmunology, Neurosciences, University of Leuven, 1022, Belgium) ; Dubois, Bénédicte (Department of Neurology, University Hospitals Leuven, University of Leuven, Belgium) ; Goris, An (Laboratory for Neuroimmunology, Neurosciences, University of Leuven, 1022, Belgium) ; Astobiza, Ianire (Achucarro Basque Center for Neuroscience, 48170 Spain) ; Alloza, Iraide (IKERBASQUE, Basque Foundation for Science, 48011 Spain) ; Antigüedad, Alfredo (Servicio de Neurología, Hospital Universitario Basurto-Osakidetza, 48940 Bilbao, Spain) ; Vandenbroeck, Koen (IKERBASQUE, Basque Foundation for Science, 48011 Spain) ; Akkad, Denis A. (Department of Human Genetics, Ruhr University, 44801 Bochum, Germany) ; Aktas, Orhan (Department of Neurology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany) ; Blaschke, Paul (Department of Neurology, University of Rostock, 18059 Germany) ; Buttmann, Mathias (Department of Neurology, University of Würzburg, 97080 Würzburg, Germany) ; Chan, Andrew (Department of Neurology, University Hospital Bern and University of Bern, 3010 Bern, Switzerland) ; Epplen, Joerg T. (Department of Human Genetics, Ruhr University, 44801 Bochum, Germany) ; Gerdes, Lisa-Ann (Institute for Clinical Neuroimmunology, Ludwig Maximilian University, 80539 Munich, Germany) ; Kroner, Antje (Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226) ; Kubisch, Christian (Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany) ; Kümpfel, Tania (Institute for Clinical Neuroimmunology, Ludwig Maximilian University, 80539 Munich, Germany) ; Lohse, Peter (Institute of Laboratory Medicine and Human Genetics, 78224 Singen, Germany) ; Rieckmann, Peter (Department of Neurology, Sozialstiftung Bamberg Hospital, 96049 Germany) ; Zettl, Uwe K. (Department of Neurology, University of Rostock, 18059 Germany) ; Zipp, Frauke (Department of Neurology, Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg-University Mainz, 55122 Germany) ; Bertram, Lars (School of Public Health, Medicine, Imperial College London, SW7 2AZ, UK) ; Lill, Christina M (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fernandez, Oscar (Department of Neurology, UGC Neurociencias Clínicas. IBIMA-Hospital Regional Universitario de Málaga, 29010 Spain) ; Urbaneja, Patricia (Department of Neurology, UGC Neurociencias Clínicas. IBIMA-Hospital Regional Universitario de Málaga, 29010 Spain) ; Leyva, Laura (Research Laboratory, UGC Neurociencias Clínicas. IBIMA-Hospital Regional Universitario de Málaga, 29010 Spain) ; Alvarez-Cermeño, Jose Carlos (Immunology and Neurology Service, Multiple Sclerosis Unit, Ramón y Cajal University Hospital-IRYCIS, 28034 Madrid, Spain) ; Arroyo, Rafael (Department of Neurology, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC, 28040 Madrid, Spain) ; Garagorri, Aroa M. (Department of Immunology, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC, Madrid, Spain) ; García-Martínez, Angel (Department of Immunology, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC, Madrid, Spain) ; Villar, Luisa M. (Immunology and Neurology Service, Multiple Sclerosis Unit, Ramón y Cajal University Hospital-IRYCIS, 28034 Madrid, Spain) ; Urcelay, Elena (Department of Immunology, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC, Madrid, Spain) ; Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Berger, Thomas (Department of Clinical Neurology, Medical University of Innsbruck, 6020 Austria) ; Fazekas, Franz (Department of Neurology, Medical University of Graz, 8010 Austria) ; Reindl, Markus (Department of Clinical Neurology, Medical University of Innsbruck, 6020 Austria) ; Schmied, Mascha C. (Department of Neurology, Medical University of Vienna, 1090 Austria) ; Zimprich, Alexander (Department of Neurology, Medical University of Vienna, 1090 Austria) ; Vilariño-Güell, Carles (Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ; Universitat Autònoma de Barcelona
Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p. G420D) in plasminogen (PLG) as a putative genetic risk factor for MS. [...]
2016 - 10.1534/g3.116.030841
G3, enomes  

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