Home > Search Results: Bachiller, M.
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Articles, 3 records found
Articles 3 records found  
1.
20 p, 5.5 MB Il-15 enhances the persistence and function of bcma-targeting car-t cells compared to il-2 or il-15/il-7 by limiting car-t cell dysfunction and differentiation / Battram, Anthony M. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Bachiller, Mireia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Lopez, Victor (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Fernandez de Larrea Rodriguez, Carlos (Universitat de Barcelona. Departament de Medicina) ; Urbano-Ispizua, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Martín-Antonio, B (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Chimeric antigen receptor (CAR)-T cell immunotherapy has revolutionized the treatment of B-lymphoid malignancies. For multiple myeloma (MM), B-cell maturation antigen (BCMA)-targeted CAR-T cells have achieved outstanding complete response rates, but unfortunately, patients often relapse within a year of receiving the therapy. [...]
2021 - 10.3390/cancers13143534
Cancers, Vol. 13 Núm. 14 (february 2021) , art. 3534  
Detailed record - Creative Commons
2.
21 p, 12.7 MB NK cells enhance CAR-T cell antitumor efficacy by enhancing immune/tumor cells cluster formation and improving CAR-T cell fitness / Bachiller, Mireia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Pérez-Amill, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Battram, Anthony M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Carné, Sebastian Ciro (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Najjar, Amer (The University of Texas MD Anderson Cancer Center) ; Verhoeyen, Els (Université Côte d'Azur) ; Juan, Manel (Universitat de Barcelona. Departament de Medicina) ; Urbano-Ispizua, Alvaro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Martín-Antonio, B (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ; Universitat Autònoma de Barcelona
Background Chimeric antigen receptor (CAR)-T cell immunotherapy has modified the concept of treatment in hematological malignancies. In comparison with pediatric patients, where responses are maintained over many years, older patients, such as those with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM), present lower persistence of CAR-T cells that might be due to decreased fitness of T cells acquired with aging. [...]
2021 - 10.1136/jitc-2021-002866
Journal for immunotherapy of cancer, Vol. 9 Núm. 8 (25 2021) , p. 2866  
Detailed record - Creative Commons
3.
31 p, 1.0 MB Senescence in the development and response to cancer with immunotherapy : A double-edged sword / Battram, Anthony M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Bachiller, Mireia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Martín-Antonio, B. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
Cellular senescence was first described as a physiological tumor cell suppressor mechanism that leads to cell growth arrest with production of the senescence-associated secretory phenotype known as SASP. [...]
2020 - 10.3390/ijms21124346
International journal of molecular sciences, Vol. 21 Núm. 12 (february 2020) , p. 1-31  
Detailed record - Creative Commons

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