Resultados globales: 2 registros encontrados en 0.02 segundos.
Artículos, Encontrados 2 registros
Artículos Encontrados 2 registros  
1.
13 p, 3.3 MB Hydroxylamine derivatives as a new paradigm in the search of antibacterial agents / Miret-Casals, Laia (Universitat de Barcelona. Departament de Química Orgànica) ; Baelo, Aida (Institut de Ciència i Tecnologia de Barcelona) ; Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Astola, Josep (Institut de Ciència i Tecnologia de Barcelona) ; Lobo-Ruiz, Ariadna (Universitat de Barcelona. Departament de Química Orgànica) ; Albericio, Fernando (University of Kwazulu-Natal. School of Chemistry & Physics) ; Torrents, Eduard (Institut de Ciència i Tecnologia de Barcelona)
Serious infections caused by bacteria that are resistant to commonly used antibiotics have become a major global healthcare problem in the 21st century. Multidrug-resistant bacteria causing severe infections mainly grow in complex bacterial communities known as biofilms, in which bacterial resistance to antibacterial agents and to the host immune system is strengthened. [...]
2018 - 10.1021/acsomega.8b01384
ACS omega, Vol. 3, Issue 12 (December 2018) , p. 17057-17069  
2.
20 p, 8.9 MB Methyl-hydroxylamine as an efficacious antibacterial agent that targets the ribonucleotide reductase enzyme / Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Baelo, Aida (Institut de Bioenginyeria de Catalunya) ; Gavaldà, Joan (Hospital Universitari Vall d'Hebron) ; Torrents Serra, Eduard (Institut de Bioenginyeria de Catalunya)
The emergence of multidrug-resistant bacteria has encouraged vigorous efforts to develop antimicrobial agents with new mechanisms of action. Ribonucleotide reductase (RNR) is a key enzyme in DNA replication that acts by converting ribonucleotides into the corresponding deoxyribonucleotides, which are the building blocks of DNA replication and repair. [...]
2015 - 10.1371/journal.pone.0122049
PloS one, Vol. 10, Issue. 3 (March 2015) , p. e0122049  

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