Home > Search Results: Balboni, G.
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Articles, 4 records found
Articles 4 records found  
1.
16 p, 2.4 MB The Impact of UFP-512 in Mice with Osteoarthritis Pain : The Role of Hydrogen Sulfide / Batallé Melgarejo, Gerard (Institut de Recerca Sant Pau) ; Bai, Xue (Institut de Recerca Sant Pau) ; Balboni, Gianfranco (Universitá di Cagliari. Dipartimento della Vita e dell'Ambiente) ; Pol, Olga (Universitat Autònoma de Barcelona. Institut de Neurociències)
The pain-relieving properties of opioids in inflammatory and neuropathic pain are heightened by hydrogen sulfide (HS). However, whether allodynia and functional and/or emotional impairments related to osteoarthritis (OA) could be reduced by activating δ-opioid receptors (DOR) and the plausible influence of HS on these actions has not been completely established. [...]
2023 - 10.3390/antiox12122085
Antioxidants, Vol. 12, Num. 12 (december 2023)  
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2.
17 p, 5.0 MB Hydrogen Sulfide Increases the Analgesic Effects of μ- and δ-Opioid Receptors during Neuropathic Pain : Pathways Implicated / Bai, Xue (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Batallé Melgarejo, Gerard (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Balboni, Gianfranco (University of Cagliari. Department of Life and Environmental Sciences) ; Pol, Olga (Universitat Autònoma de Barcelona. Institut de Neurociències)
Recent studies have revealed that hydrogen sulfide (H2S) increases the analgesic actions of the δ-opioid receptor (DOR) in inflammatory pain. However, the possible improvement of the analgesia of μ-opioid receptor (MOR) and DOR agonists during neuropathic pain, through pretreat-ment with two slow-releasing H2S donors-DADS (diallyl disulfide) and GYY4137 (morpholin-4- ium 4-methoxyphenyl(morpholino) phosphinodithioate dichloromethane complex)-is still un-known. [...]
2022 - 10.3390/antiox11071321
Antioxidants, Vol. 11 Núm. 7 (july 2022) , p. 1321  
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3.
21 p, 3.3 MB Hydrogen sulfide inhibits inflammatory pain and enhances the analgesic properties of delta opioid receptors / Porta, Aina (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rodríguez, Laura (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bai, Xue (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Batallé Melgarejo, Gerard (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Roch, Gerard (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pouso-Vázquez, Enric (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Balboni, Gianfranco (University of Cagliari. Department of Life and Environmental Sciences) ; Pol, Olga (Universitat Autònoma de Barcelona. Institut de Neurociències)
Chronic inflammatory pain is present in many pathologies and diminishes the patient's quality of life. Moreover, most current treatments have a low efficacy and significant side effects. Recent studies demonstrate the analgesic properties of slow-releasing hydrogen sulfide (HS) donors in animals with osteoarthritis or neuropathic pain, but their effects in inflammatory pain and related pathways are not completely understood. [...]
2021 - 10.3390/antiox10121977
Antioxidants, Vol. 10 Núm. 12 (december 2021) , p. 1977  
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4.
16 p, 2.7 MB Treatment with the delta opioid agonist UFP-512 alleviates chronic inflammatory and neuropathic pain : Mechanisms implicated / Polo, S. (Institut d'Investigació Biomèdica Sant Pau) ; Díaz, Andrés Felipe (Institut d'Investigació Biomèdica Sant Pau) ; Gallardo, Núria (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Leánez, Sergi (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Balboni, Gianfranco (University of Cagliari. Department of Life and Environmental Sciences) ; Pol, Olga (Universitat Autònoma de Barcelona. Institut de Neurociències)
We investigated whether administration of the δ-opioid receptor (DOR) agonist H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), which also activates nuclear factor erythroid 2-related factor 2 (Nrf2), alleviated chronic inflammatory and/or neuropathic pain and inhibited the depressive-like behaviors associated with persistent neuropathic pain. [...]
2019 - 10.3389/fphar.2019.00283
Frontiers in Pharmacology, Vol. 10 Núm. MAR (2019) , p. 283  
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4 Balboni, Gianfranco
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