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11 p, 519.8 KB |
Prevalence and clinical impact of alcohol withdrawal syndrome in alcohol-associated hepatitis and the potential role of prophylaxis : a multinational, retrospective cohort study
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Marti-Aguado, David (Institut d'Investigació Biomèdica (INCLIVA)) ;
Gougol, Amir (University of California) ;
Gomez-Medina, Concepcion (Institut d'Investigació Biomèdica (INCLIVA)) ;
Jamali, Arsia (University of Pittsburgh Medical Center) ;
Abo-Zed, Abdelrhman (University of Pittsburgh Medical Center) ;
Morales-Arraez, Dalia (Hospital Universitario de Canarias (La Laguna)) ;
Jimenez-Sosa, Alejandro (Hospital Universitario de Canarias (La Laguna)) ;
Burns, Keith (University of Pittsburgh Medical Center) ;
Bawa, Aditi (University of Pittsburgh Medical Center) ;
Hernández, Anjara (Hospital Universitario de Canarias (La Laguna)) ;
Pujol, Claudia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Alvarado-Tapias, Edilmar (Institut d'Investigació Biomèdica Sant Pau) ;
Szafranska, Justyna (Institut d'Investigació Biomèdica Sant Pau) ;
Chiu, Wai Kan (University of Pittsburgh Medical Center) ;
Villagrasa, Ares (Hospital Universitari Vall d'Hebron) ;
Ventura-Cots, Meritxell (Hospital Universitari Vall d'Hebron) ;
Gandicheruvu, Haritha (University of Pittsburgh Medical Center) ;
Lluch, Paloma (Institut d'Investigació Biomèdica (INCLIVA)) ;
Chen, Hui-Wei (Allegheny General Hospital) ;
Rachakonda, Vikrant (University of California) ;
Duarte-Rojo, Andres (University of Pittsburgh Medical Center) ;
Bataller, Ramon (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
The prevalence and impact of alcohol withdrawal syndrome (AWS) in patients with alcohol-associated hepatitis (AH) are unknown. In this study, we aimed to investigate the prevalence, predictors, management, and clinical impact of AWS in patients hospitalized with AH. [...]
2023 -  10.1016/j.eclinm.2023.102046
EClinicalMedicine, Vol. 61 (june 2023)
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12 p, 1022.2 KB |
Bariatric Surgery Is Associated with Alcohol-Related Liver Disease and Psychiatric Disorders Associated with AUD
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Alvarado-Tapias, Edilmar (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Marti-Aguado, David (Institut d'Investigació Biomèdica INCLIVA) ;
Kennedy, Kevin (Kansas City) ;
Fernández-Carrillo, Carlos (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Ventura-Cots, Meritxell (Hospital Universitari Vall d'Hebron) ;
Morales-Arraez, Dalia (Hospital Universitario de Canarias (La Laguna)) ;
Atkinson, Stephen R. (Imperial College London) ;
Clemente-Sanchez, Ana (Hospital General Universitario Gregorio Marañón) ;
Argemi, Josepmaria (Clínica Universidad de Navarra) ;
Bataller, Ramon (Universitat de Barcelona) ;
Universitat Autònoma de Barcelona
Bariatric surgery can increase the risk of addictive disorders and nutritional deficiencies. The aim of this study was to evaluate the association between bariatric surgery and alcohol use disorder (AUD), alcohol-related liver disease (ALD), and psychiatric disorders associated with AUD. [...]
2023 - 10.1007/s11695-023-06490-w
Obesity Surgery, Vol. 33 (march 2023) , p. 1494-1505
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12 p, 1.0 MB |
Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis : A pilot study (RIFA-AH)
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Jiménez, Cesar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ventura-Cots, Meritxell (University of Pittsburgh Medical Center) ;
Sala Llinas, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Calafat, Margalida (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Garcia-Retortillo, M. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cirera, Isabel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cañete Hidalgo, Nuria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Soriano, German (Institut d'Investigació Biomèdica Sant Pau) ;
Poca Sans, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Simon-Talero, Macarena (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Altamirano, José (Hospital Quirónsalud Barcelona) ;
Lucey, Michael (University of Wisconsin) ;
Garcia-Tsao, Guadalupe (Yale University) ;
Brown, R. S. (Weill Cornell Medical College) ;
Schwabe, R. F. (Department of Medicine. Columbia University) ;
Verna, Elizabeth (Columbia University Irving Medical Center) ;
Schnabl, Bernd (University of California San Diego) ;
Bosques, Francisco (Universidad Autónoma de Nuevo León (Mèxic)) ;
Mathurin, Philippe (Hospital Clínic i Provincial de Barcelona) ;
Louvet, Alexandre (Service des Maladies de L'appareil Digestif et Unité INSERM U995) ;
Shawcross, Debbie (King's College London) ;
Abraldes, Juan G. (University of Alberta) ;
Genescà Ferrer, Joan (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Bataller, Ramon (University of Pittsburgh) ;
Vargas, V. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Universitat Autònoma de Barcelona
Background & Aims: Alcoholic hepatitis (AH) is associated with a high incidence of infection and mortality. Rifaximin reduces bacterial overgrowth and translocation. We aimed to study whether the administration of rifaximin as an adjuvant treatment to corticosteroids decreases the number of bacterial infections at 90 days in patients with severe AH compared to a control cohort. [...]
2022 - 10.1111/liv.15207
Liver International, Vol. 42 Núm. 5 (may 2022) , p. 1109-1120
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7 p, 1.1 MB |
Prevalence and associations of metabolic syndrome in patients with alcohol use disorder
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Hernandez-Rubio, Anna (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Sanvisens, Arantza (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bolao, Ferran (Institut d'Investigació Biomèdica de Bellvitge) ;
Cachón-Suárez, Isabel (Institut d'Investigació Biomèdica de Bellvitge) ;
Garcia-Martín, Carme (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Short, Antoni (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Bataller, Ramon (University of Pittsburgh. Department of Medicine) ;
Muga, Roberto (Universitat Autònoma de Barcelona. Departament de Medicina)
Excessive alcohol consumption has been associated with different components of the metabolic syndrome (MetS) such as arterial hypertension, dyslipidemia, type 2 diabetes or obesity. We aimed to analyze the prevalence and associations of MetS in patients with Alcohol Use Disorder (AUD). [...]
2022 - 10.1038/s41598-022-06010-3
Scientific reports, Vol. 12 (february 2022)
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19 p, 2.5 MB |
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
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Argemi, Josepmaria (Universidad de Navarra) ;
Latasa, M. U. (Hepatology Program. Center for Applied Medical Research (CIMA). University of Navarra) ;
Atkinson, Stephen R (Imperial College London) ;
Blokhin, I. O. (CUniversity of Miami Miller School of Medicine) ;
Massey, V. (University of North Carolina at Chapel Hill) ;
Gue, J. P. (University of Pittsburgh Medical Center) ;
Cabezas González, Joaquín (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Lozano, Juan José (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Van Booven, D. (University of Miami) ;
Bell, Aaron (University of Pittsburgh School of Medicine) ;
Cao, S. (Mayo Clinic) ;
Vernetti, L. A. (University of Pittsburgh) ;
Arab, J. P. (Pontificia Universidad Católica de Chile) ;
Ventura-Cots, Meritxell (University of Pittsburgh Medical Center) ;
Edmunds, L. R. (University of Pittsburgh) ;
Fondevilla, C. (Hospital Clínic i Provincial de Barcelona) ;
Stärkel, P. (Université Catholique de Louvain) ;
Dubuquoy, L. (University of Lille) ;
Louvet, Alexandre (University of Lille) ;
Òdena Garcia, Gemma (University of North Carolina at Chapel Hill) ;
Gomez, J. L. (University of Pittsburgh School of Medicine) ;
Aragon, T. (Universidad de Navarra) ;
Altamirano, José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Caballería, J (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Jurczak, M. J. (University of Pittsburgh) ;
Taylor, D. L. (University of Pittsburgh) ;
Berasain, Carmen (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Wahlestedt, C. (University of Miami Miller School of Medicine) ;
Monga, S. P. (University of Pittsburgh School of Medicine) ;
Morgan, M. Y. (University College London) ;
Sancho-Bru, P. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Mathurin, Philippe (University of Lille) ;
Furuya, S. (Texas A&M University) ;
Lackner, C. (Medical University of Graz) ;
Rusyn, I. (Texas A&M University) ;
Shah, V. H. (Mayo Clinic) ;
Thursz, M. R. (Imperial College London) ;
Mann, J. (Newcastle University) ;
Avila, Matias A (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Bataller, Ramon (University of North Carolina at Chapel Hill) ;
Universitat Autònoma de Barcelona
Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. [...]
2019 - 10.1038/s41467-019-11004-3
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 3126
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