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The safety of agomelatine in standard medical practice in depressed patients : A 26-week international multicentre cohort study / Gorwood, Philip (Université de Paris & INSERM U1266) ; Benichou, Jacques (Unité de Biostatistiques. Centre Hospitalier Universitaire de Rouen) ; Moore, Nicholas (Bordeaux PharmacoEpi CIC Bordeaux CIC1401 INSERM U1219 Hôpital Pellegrin) ; Álvarez, Enrique (Álvarez Martínez) (Institut d'Investigació Biomèdica Sant Pau) ; Mertens, Joost (De Velse GGZ) ; Aguglia, Eugenio (AOU Policlinico Vittorio-Emanuele. Clinica Psichiatrica) ; Figueira, Maria-Luisa (University of Lisbon) ; Falkai, Peter (University of Munich) ; Olivier, Valérie (Institut de Recherches Internationales Servier (IRIS)) ; Wattez, Marine (Institut de Recherches Internationales Servier (IRIS)) ; Picarel-Blanchot, Françoise (Institut de Recherches Internationales Servier (IRIS)) ; de Bodinat, Christian (Institut de Recherches Internationales Servier (IRIS)) ; Universitat Autònoma de Barcelona
The present observational cohort study documented the safety of agomelatine in current medical practice in out-patients suffering from major depressive disorder. The 6-month evolution of agomelatine-treated patients was assessed with a focus on safety (emergent adverse events, liver acceptability), severity of depression using the Clinical Global Impression Severity (CGI-S) score, and functioning measured by the Sheehan Disability Scale (SDS). [...]
2020 - DOI (Digital Object Identifier)

10.1002/hup.2759
Human Psychopharmacology, Vol. 36 (september 2020)

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