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1.
1.2 MB Molecular landscape and prognostic impact of FLT3 -ITD insertion site in acute myeloid leukemia : RATIFY study results / Rücker, Frank G. (University Hospital of Ulm (Alemanya)) ; Du, Ling (Novartis Pharmaceuticals, Cambridge) ; Luck, Tamara J. (Charité University, Berlin) ; Benner, Axel (German Cancer Research Center, Heidelberg) ; Krzykalla, Julia (German Cancer Research Center, Heidelberg) ; Gathmann, Insa (Novartis Pharmaceuticals, Basel) ; Voso, Maria Teresa (Università di Roma "Tor Vergata", Rome) ; Amadori, Sergio (Università di Roma "Tor Vergata", Rome) ; Prior, Thomas W. (The Ohio State University Comprehensive Cancer Center, Columbus) ; Brandwein, Joseph M. (University of Alberta, Edmonton) ; Appelbaum, Frederick (Fred Hutchinson Cancer Research Center, Seattle) ; Medeiros, Bruno (Stanford University) ; Tallman, Martin S. (Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York) ; Savoie, Lynn (University of Calgary, Calgary) ; Sierra, Jorge (Institut d'Investigació Biomèdica Sant Pau) ; Pallaud, Celine (Novartis Pharmaceuticals, Basel) ; Sanz, Miguel A.. (Hospital Universitari i Politècnic La Fe (València)) ; Jansen, Joop H. (Radboud University Medical Center, Nijmegen) ; Niederwieser, Dietger (Hematology and Oncology, University of Leipzig, Leipzig) ; Fischer, Thomas (Otto-von-Guericke University Magdeburg, Magdeburg) ; Ehninger, Gerhard (Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der TU Dresden) ; Heuser, Michael (Hannover Medical School, Hannover) ; Ganser, Arnold (Oncology and Stem Cell Transplantation, Hannover) ; Bullinger, Lars (Charité University, Berlin) ; Larson, Richard A. (University of Chicago, Chicago) ; Bloomfield, Clara D. (The Ohio State University Comprehensive Cancer Center, Columbus) ; Stone, Richard M. (Dana-Farber/Partners CancerCare, Boston) ; Döhner, Hartmut (University Hospital of Ulm (Alemanya)) ; Thiede, Christian (Universitätsklinikum Carl Gustav Carus der TU Dresden, Dresden) ; Döhner, Konstanze (University Hospital of Ulm (Alemanya)) ; Universitat Autònoma de Barcelona
In acute myeloid leukemia (AML) internal tandem duplications of the FLT3 gene (FLT3- ITD) are associated with poor prognosis. Retrospectively, we investigated the prognostic and predictive impact of FLT3 -ITD insertion site (IS) in 452 patients randomized within the RATIFY trial, which evaluated midostaurin additionally to intensive chemotherapy. [...]
2021 - 10.1038/s41375-021-01323-0
Leukemia, Vol. 36 (july 2021) , p. 90-99  
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2.
13 p, 1.0 MB Genome-Wide DNA Methylation Profiling in Early Stage I Lung Adenocarcinoma Reveals Predictive Aberrant Methylation in the Promoter Region of the Long Noncoding RNA PLUT : An Exploratory Study / Kim-Wanner, S. Z. (German Red Cross Blood Donor Service. Institute of Transfusion Medicine and Immune Hematology of the Goethe University Medical School) ; Assenov, Y. (Division of Epigenomics. German Cancer Research Center (Deutsches Krebsforschungszentrum [DKFZ])) ; Nair, M. B. (Division of Epigenomics. German Cancer Research Center (Deutsches Krebsforschungszentrum [DKFZ])) ; Weichenhan, D. (Division of Epigenomics. German Cancer Research Center (Deutsches Krebsforschungszentrum [DKFZ])) ; Benner, Axel (Division of Biostatistics. German Cancer Research Center (DKFZ)) ; Becker, N. (Division of Biostatistics. German Cancer Research Center (DKFZ)) ; Landwehr, K. (German Red Cross Blood Donor Service. Institute of Transfusion Medicine and Immune Hematology of the Goethe University Medical School) ; Kuner, R. (Translational Oncology at the University Medical Center of Johannes Gutenberg University) ; Sültmann, H. (Translational Lung Research Centre Heidelberg. Member of the German Centre for Lung Research (Deutsches Zentrum für Lungenforschung)) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Koch, I. (Center of Thoracic Surgery. Asklepios Fachkliniken München-Gauting. Ludwig Maximilians University. Gauting; Comprehensive Pneumology Centre Munich. German Centre for Lung Research (Deutsches Zentrum für Lungenforschung)) ; Lindner, M. (Center of Thoracic Surgery. Asklepios Fachkliniken München-Gauting. Ludwig Maximilians University. Gauting; Comprehensive Pneumology Centre Munich. German Centre for Lung Research (Deutsches Zentrum für Lungenforschung)) ; Meister, M. (Translational Research Unit. Thoraxklinik at University Hospital Heidelberg) ; Thomas, M. (Translational Research Unit. Thoraxklinik at University Hospital Heidelberg) ; Bieg, M. (Division of Theoretical Bioinformatics. and Heidelberg Center for Personalized Oncology. German Cancer Research Center (DKFZ)) ; Klingmüller, U. (Division Systems Biology of Signal Transduction. German Cancer Research Center (DKFZ)) ; Schlesner, M. (Bioinformatics and Omics Data Analytics. German Cancer Research Center (DKFZ)) ; Warth, A. (Heidelberg University Hospital (Alemanya)) ; Brors, Benedikt (Division of Applied Bioinformatics. German Cancer Research Center (DKFZ)) ; Seifried, E. (German Red Cross Blood Donor Service. Institute of Transfusion Medicine and Immune Hematology of the Goethe University Medical School) ; Bönig, H. (German Red Cross Blood Donor Service. Institute of Transfusion Medicine and Immune Hematology of the Goethe University Medical School) ; Plass, C. (Translational Lung Research Centre Heidelberg. Member of the German Centre for Lung Research (Deutsches Zentrum für Lungenforschung)) ; Risch, A. (Universität Salzburg. Cancer Cluster Salzburg) ; Muley, T. (Translational Research Unit. Thoraxklinik at University Hospital Heidelberg) ; Universitat Autònoma de Barcelona
Introduction: Surgical procedure is the treatment of choice in early stage I lung adenocarcinoma. However, a considerable number of patients experience recurrence within the first 2 years after complete resection. [...]
2020 - 10.1016/j.jtho.2020.03.023
Journal of Thoracic Oncology, Vol. 15 Núm. 8 (august 2020) , p. 1338-1350  
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