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15 p, 14.5 MB |
Roadmap for Postnatal Brain Maturation : Changes in Gray and White Matter Composition during Development Measured by Fourier Transformed Infrared Microspectroscopy
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Peris, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Benseny Cases, Núria (Universitat Autònoma de Barcelona) ;
Manich, Gemma (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Zerpa, Oriana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Almolda Ardid, Beatriz (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona.) ;
González, Berta (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Castellano López, Bernardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Key events in postnatal brain development, such as neuronal migration, synaptogenesis, and myelination, shape the adult brain. These events are reflected in changes in gray and white matter (GM and WM) occurring during this period. [...]
2023 -  10.1021/acschemneuro.3c00237
ACS Chemical Neuroscience, Vol. 14 (08 2023) , p. 3088-3102
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13 p, 4.6 MB |
Aβ40 Aggregation under Changeable Conditions
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Curto, Jofre Seira (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Fernández Gallegos, María Rosario (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Benseny Cases, Núria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Homeostasis is crucial for cell function, and disturbances in homeostasis can lead to health disorders. Under normal conditions, intracellular pH is maintained between 7. 35 and 7. 45. Altered endosomal and lysosomal pH together with a general drop in brain pH are associated with the aggregation of amyloid-β-peptide (Aβ) and the development of Alzheimer's disease. [...]
2023 - 10.3390/ijms24098408
International journal of molecular sciences, Vol. 24, Issue 9 (May 2023) , art. 8408
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9 p, 1.5 MB |
In situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer's disease transgenic mice using synchrotron-based infrared imaging
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Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró) ;
Álvarez-Marimon, Elena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Aso, Ester (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Carmona, Margarita (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Klementieva, Oxana (Lund University. Department of Experimental Medical Science) ;
Appelhans, Dietmar (Leibniz Institute of Polymer Research) ;
Ferrer, Isidro (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer Disease. In situ identification of early-stage amyloid aggregates in Alzheimer's disease is relevant for their importance as potential targets for effective drugs. [...]
2021 - 10.1038/s41598-021-96379-4
Scientific reports, Vol. 11 (September 2021) , art. 18368
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1 p, 745.1 KB |
Retraction Note : In situ structural characterization of early amyloid aggregates in Alzheimer's disease transgenic mice and Octodon degus
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Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró) ;
Álvarez-Marimon, Elena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Aso, Ester (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Carmona, Margarita (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Klementieva, Oxana (Lund University. Medical Microspectroscopy Research Group, Department of Experimental Medical Science) ;
Appelhans, Dietmar (Leibniz Institute of Polymer Research) ;
Ferrer, Isidro (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
2020 - 10.1038/s41598-020-76208-w
Scientific reports, Vol. 10 (november 2020)
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10 p, 2.4 MB |
In situ structural characterization of early amyloid aggregates in Alzheimer's disease transgenic mice and Octodon degus
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Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró) ;
Álvarez Marimon, Elena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Aso, Ester (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Carmona, Margarita (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Klementieva, Oxana (Lund University) ;
Appelhans, Dietmar (Leibniz Institute of Polymer Research) ;
Ferrer, Isidro (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer's disease. In situ identification of early-stage amyloid aggregates in Alzheimer's disease is relevant for their importance as potential targets for effective drugs. [...]
2020 - 10.1038/s41598-020-62708-2
Scientific reports, Vol. 10 (april 2020)
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14 p, 6.6 MB |
From Mouse To Human : Comparative Analysis Between Grey And White Matter By Synchrotron-Fourier Transformed Infrared Microspectroscopy
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Sanchez-Molina, Paula (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Valente, Tony (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Almolda Ardid, Beatriz (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
González, Berta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Castellano López, Bernardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Kreuzer, Martin (ALBA Laboratori de Llum de Sincrotró) ;
Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró)
Fourier Transform Infrared microspectroscopy (μFTIR) is a very useful method to analyze the biochemical properties of biological samples in situ. Many diseases affecting the central nervous system (CNS) have been studied using this method, to elucidate alterations in lipid oxidation or protein aggregation, among others. [...]
2020 - 10.3390/biom10081099
Biomolecules, Vol. 10, Núm. 8 (August 2020) , art. 1099
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12 p, 3.3 MB |
Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection
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Aso, Ester (ALBA Laboratori de Llum de Sincrotró) ;
Martinsson, Isak (Wallenberg Neuroscience Center) ;
Appelhans, Dietmar (Leibniz Institute of Polymer Research Dresden) ;
Effenberg, Christiane (Leibniz Institute of Polymer Research Dresden) ;
Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró) ;
Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Gouras, Gunnar (Wallenberg Neuroscience Center) ;
Ferrer, Isidro (Hospital Universitari de Bellvitge) ;
Klementieva, Oxana (Wallenberg Neuroscience Center)
Poly(propylene imine) dendrimers have been shown to be promising 3-dimensional polymers for the use in the pharmaceutical and biomedical applications. Our aims of this study were first, to synthesize a novel type of dendrimer with poly(propylene imine) core and maltose-histidine shell (G4HisMal) assessing if maltose-histidine shell can improve the biocompatibility and the ability to cross the blood-brain barrier, and second, to investigate the potential of G4HisMal to protect Alzheimer disease transgenic mice from memory impairment. [...]
2019 - 10.1016/j.nano.2019.01.010
Nanomedicine, Vol. 17 (April 2019) , p. 198-209
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14 p, 2.6 MB |
Myoglobinopathy is an adult-onset autosomal dominant myopathy with characteristic sarcoplasmic inclusions
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Olive, Montse (Institut d'Investigació Biomèdica de Bellvitge) ;
Engvall, Martin (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Ravenscroft, Gianina (University of Western Australia. Harry Perkins Institute of Medical Research) ;
Cabrera-Serrano, Macarena (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Jiao, Hong (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Bortolotti, Carlo Augusto (University of Modena and Reggio Emilia) ;
Pignataro, Marcello (University of Modena and Reggio Emilia) ;
Lambrughi, Matteo (University of Modena and Reggio Emilia) ;
Jiang, Haibo (The University of Western Australia) ;
Forrest, Alistair R. R. (University of Western Australia. Harry Perkins Institute of Medical Research) ;
Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró) ;
Hofbauer, Stefan (BOKU-University of Natural Resources and Life Sciences) ;
Obinger, Christian (BOKU-University of Natural Resources and Life Sciences) ;
Battistuzzi, Gianantonio (University of Modena and Reggio Emilia) ;
Bellei, Marzia (University of Modena and Reggio Emilia) ;
Borsari, Marco (University of Modena and Reggio Emilia) ;
Di Rocco, Giulia (University of Modena and Reggio Emilia) ;
Viola, Helena M. (The University of Western Australia) ;
Hool, Livia C. (Victor Chang Cardiac Research Institute) ;
Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Lagerstedt-Robinson, Kristina (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Xiang, Fengqing (Karolinska Institutet (Estocolm, Suècia)) ;
Wredenberg, Anna (Karolinska Institutet (Estocolm, Suècia)) ;
Miralles, Francesc (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Baiges, Juanjo (Hospital de Tortosa Verge de la Cinta) ;
Malfatti, Edoardo (Centre de Référence de Pathologie Neuromusculaire Paris-Est) ;
Romero, Norma B. (Centre de Référence de Pathologie Neuromusculaire Paris-Est) ;
Streichenberger, Nathalie (Université Claude Bernard Lyon) ;
Vial, Christophe (Electromyographie-Groupement Hospitalier Est) ;
Claeys, Kristl G. (KU Leuven-University of Leuven) ;
Straathof, Chiara S. M. (Leiden University Medical Center) ;
Goris, An (KU Leuven-University of Leuven) ;
Freyer, Christoph (Karolinska Institutet (Estocolm, Suècia)) ;
Lammens, Martin (Radboud University Medical Center) ;
Bassez, Guillaume (East-Paris University (UPEC)) ;
Kere, Juha (King's College London) ;
Clemente, Paula (Karolinska Institutet (Estocolm, Suècia)) ;
Sejersen, Thomas (Karolinska Institutet (Estocolm, Suècia)) ;
Udd, Bjarne (Tampere University Hospital) ;
Vidal, Noemí (Institut d'Investigació Biomèdica de Bellvitge) ;
Ferrer, Isidro (Universitat de Barcelona) ;
Edström, Lars (Karolinska Institutet (Estocolm, Suècia)) ;
Wedell, Anna (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Laing, Nigel G. (University of Western Australia. Harry Perkins Institute of Medical Research)
Myoglobin, encoded by MB, is a small cytoplasmic globular hemoprotein highly expressed in cardiac myocytes and oxidative skeletal myofibers. Myoglobin binds O facilitates its intracellular transport and serves as a controller of nitric oxide and reactive oxygen species. [...]
2019 - 10.1038/s41467-019-09111-2
Nature communications, Vol. 10 (March 2019) , art. 1396
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