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14 p, 3.9 MB Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome / Bereshchenko, O. (Department of Medicine. Department of Philosophy. Social Sciences and Education. University of Perugia) ; Lo Re, O. (Department of Biology. Faculty of Medicine. Masaryk University) ; Nikulenkov, F. (Department of Biology. Faculty of Medicine. Masaryk University) ; Flamini, S. (Department of Medicine. Department of Philosophy. Social Sciences and Education. University of Perugia) ; Kotaskova, J. (University Hospital Brno (República Txeca)) ; Mazza, T. (IRCCS Casa Sollievo della Sofferenza. Bioinformatics Unit) ; Le Pannérer, Marguerite Marie (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Giallongo, C. (Division of Hematology. A.O.U. Policlinico-OVE. University of Catania) ; Palumbo, G. (Department of Medical and Surgical Sciences and Advanced Technologies GF Ingrassia. University of Catania) ; Li Volti, G. (Department of Biomedical and Biotechnological Sciences. University of Catania) ; Pazienza, V. (Gastroenterology Unit. IRCCS Casa Sollievo della Sofferenza) ; Cervinek, L. (University Hospital Brno (República Txeca)) ; Riccardi, C. (Department of Medicine. Department of Philosophy. Social Sciences and Education. University of Perugia) ; Krejci, L. (Department of Biology. Faculty of Medicine. Masaryk University) ; Pospisilova, S. (University Hospital Brno (República Txeca)) ; Stewart, A. F. (Genomics. Biotechnology Center. Center for Molecular and Cellular Bioengineering. Technische Universität Dresden) ; Vinciguerra, M. (International Clinical Research Center. St'Anne University Hospital) ; Universitat Autònoma de Barcelona
Background: Epigenetic regulation is important in hematopoiesis, but the involvement of histone variants is poorly understood. Myelodysplastic syndromes (MDS) are heterogeneous clonal hematopoietic stem cell (HSC) disorders characterized by ineffective hematopoiesis. [...]
2019 - 10.1186/s13148-019-0724-z
Clinical Epigenetics, Vol. 11 Núm. 1 (22 2019) , p. 121  
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