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Articles, 2 records found
Articles 2 records found  
1.
12 p, 4.6 MB Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis / Betancor, Gilberto (Centro de Biología Molecular Severo Ochoa) ; Álvarez, Mar (Centro de Biología Molecular Severo Ochoa) ; Marcelli, Bárbara (Centro de Biología Molecular Severo Ochoa) ; Andrés, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martínez, Miguel Ángel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Menéndez Arias, Luis (Centro de Biología Molecular Severo Ochoa)
HIV-1 reverse transcriptase (RT) connection subdomain mutations at positions 348, 369 and 376 have been associated with resistance to non-nucleoside RT inhibitors (NNRTIs). N348I may interfere with the initiation of (+)-strand DNA synthesis by reducing polypurine tract (PPT) removal in the presence of nevirapine. [...]
2015 - 10.1093/nar/gkv077
Nucleic acids research, Vol. 43 Núm. 4 (february 2015) , p. 2259  
2.
17 p, 1.3 MB Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy / Betancor, Gilberto (Centro de Biología Molecular "Severo Ochoa") ; Garriga, César (Instituto de Salud Carlos III. Centro Nacional de Epidemiología) ; Puertas, Maria C. (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Nevot, Maria (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Anta, Lourdes (Hospital Carlos III (Madrid)) ; Blanco, José L. (Hospital Clínic i Provincial de Barcelona) ; Pérez Elías, M. Jesús (Hospital Ramón y Cajal (Madrid)) ; Mendoza, Carmen de (Hospital Carlos III (Madrid)) ; Martínez, Miguel A. (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Martínez Picado, Francisco Javier (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Menéndez-Arias, Luis (Centro de Biología Molecular "Severo Ochoa") ; Spanish AIDS Research Network (ResRIS)
Background: Thymidine analogue resistance mutations (TAMs) selected under treatment with nucleoside analogues generate two distinct genotypic profiles in the HIV-1 reverse transcriptase (RT): (i) TAM1: M41L, L210W and T215Y, and (ii) TAM2: D67N, K70R and K219E/Q, and sometimes T215F. [...]
2012 - 10.1186/1742-4690-9-68
Retrovirology, Vol. 9, N. 68 (13 August 2012) , p. 1-17
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