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Human Genotoxic Study Carried Out Two Years after Oil Exposure during the Clean-up Activities Using Two Different Biomarkers / Biern, Gloria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Zock, Jan-Paul (Centre de Recerca en Epidemiologia Ambiental) ; Monyarch Gros, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Espinosa, Ana (Centre de Recerca en Epidemiologia Ambiental) ; Rodriguez-Trigo, Gema (Hospital Clínico San Carlos (Madrid)) ; Gómez, Federico (Centro de Investigaciones Biomédicas en Red) ; Pozo Rodriguez, Francisco (Centro de Investigaciones Biomédicas en Red) ; Barberà i Mir, Joan Albert (Centro de Investigaciones Biomédicas en Red) ; Fuster i Marquès, Carme (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Micronuclei, comet and chromosome alterations assays are the most widely used biomarkers for determining the genotoxic damage in a population exposed to genotoxic chemicals. While chromosome alterations are an excellent biomarker to detect short- and long-term genotoxic effects, the comet assay only measures early biological effects, and furthermore it is unknown whether nuclear abnormalies, such as those measured in the micronucleus test, remain detectable long-term after an acute exposure. [...]
2015 - DOI (Digital Object Identifier)

10.3390/jmse3041334
Journal of marine science and engineering, Vol. 3 (2015) , p. 1334-1348

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