Results overview: Found 2 records in 0.01 seconds.
Articles, 2 records found
Articles 2 records found  
1.
17.3 KB A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia / Robles-Valero, Javier (Centro de Investigación del Cáncer) ; Lorenzo-Martín, L. Francisco (Centro de Investigación del Cáncer) ; Menacho-Márquez, Mauricio (Centro de Investigación del Cáncer) ; Fernández-Pisonero, Isabel (Centro de Investigación del Cáncer) ; Abad, Antonio (Centro de Investigación del Cáncer) ; Camós, Mireia (Hospital Sant Joan de Déu (Esplugues de Llobregat)) ; Toribio, María L. (Centro de Biología Molecular Severo Ochoa) ; Espinosa, Lluis (Institut Hospital del Mar d'Investigacions Mèdiques (Barcelona)) ; Bigas Salvans, Anna (Institut Hospital del Mar d'Investigacions Mèdiques (Barcelona)) ; Bustelo, Xosé R. (Centro de Investigación del Cáncer) ; Universitat Autònoma de Barcelona
Rho guanine exchange factors (GEFs), the enzymes that stimulate Rho GTPases, are deemed as potential therapeutic targets owing to their protumorigenic functions. However, the understanding of the spectrum of their pathobiological roles in tumors is still very limited. [...]
2017 - 10.1016/j.ccell.2017.10.004
Cancer Cell, Vol. 32 (november 2017) , p. 608-623.e9  
2.
22 p, 1.4 MB Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression / Forn Bernaus, Marta (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Díez-Villanueva, Anna (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Merlos-Suárez, Anna (Institute for Research in Biomedicine (IRB Barcelona)) ; Muñoz, Mar (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Lois, Sergi (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Carrió Gaspar, Elvira (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Jordà Ramos, Mireia (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Bigas Salvans, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ; Batlle, Eduard (Institute for Research in Biomedicine (IRB Barcelona)) ; Peinado Morales, Miguel Á. (Miguel Ángel) (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
Mouse models of intestinal crypt cell differentiation and tumorigenesis have been used to characterize the molecular mechanisms underlying both processes. DNA methylation is a key epigenetic mark and plays an important role in cell identity and differentiation programs and cancer. [...]
2015 - 10.1371/journal.pone.0123263
PloS one, Vol. 10, No. 5 (May 2015) , p. e0123263  

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