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34 p, 16.2 MB Stroke genetics informs drug discovery and risk prediction across ancestries / Mishra, Aniket (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Malik, Rainer (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ; Hachiya, Tsuyoshi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Jürgenson, Tuuli (University of Tartu. Institute of Mathematics and Statistics) ; Namba, Shinichi (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ; Posner, Daniel C. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Kamanu, Frederick K. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Koido, Masaru (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; Le Grand, Quentin (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Shi, Mingyang (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; He, Yunye (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; Georgakis, Marios K. (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ; Caro, Ilana (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Krebs, Kristi (University of Tartu. Estonian Genome Centre, Institute of Genomics) ; Liaw, Yi-Ching (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ; Vaura, Felix C. (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ; Lin, Kuang (University of Oxford. Nuffield Department of Population Health) ; Winsvold, Bendik Slagsvold (Oslo University Hospital (Oslo, Noruega)) ; Srinivasasainagendra, Vinodh (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ; Parodi, Livia (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ; Bae, Hee-Joon (Seoul National University Bundang Hospital, Seoul National University College of Medicine. Department of Neurology and Cerebrovascular Disease Center) ; Chauhan, Ganesh (Rajendra Institute of Medical Sciences) ; Chong, Michael R. (McMaster University. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine) ; Tomppo, Liisa (Helsinki University Hospital) ; Akinyemi, Rufus (University of Ibadan. Neuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training, College of Medicine) ; Roshchupkin, Gennady V. (Erasmus MC University Medical Center Rotterdam. Department of Radiology and Nuclear Medicine) ; Habib, Naomi (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ; Jee, Yon Ho (Harvard T. H. Chan School of Public Health. Department of Epidemiology) ; Thomassen, Jesper Qvist (Copenhagen University Hospital-Rigshospitalet. Department of Clinical Biochemistry) ; Abedi, Vida (The Pennsylvania State University. Department of Public Health Sciences, College of Medicine) ; Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ; Nygaard, Marianne (Odense University Hospital (Dinamarca)) ; Leonard, Hampton L. (Data Tecnica International) ; Yang, Chaojie (University of Virginia. Department of Biochemistry and Molecular Genetics) ; Yonova-Doing, Ekaterina (Novo Nordisk Research Centre Oxford. Department of Genetics) ; Knol, Maria J. (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ; Lewis, Adam J. (Vanderbilt University Medical Center. Department of Biomedical Informatics) ; Judy, Renae L. (University of Pennsylvania. Department of Surgery) ; Ago, Tetsuro (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ; Amouyel, Philippe (Institut Pasteur de Lille) ; Armstrong, Nicole D. (University of Alabama at Birmingham. Department of Epidemiology) ; Bakker, Mark K. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ; Bartz, Traci M. (University of Washington. Department of Biostatistics) ; Bennett, David A. (Rush University Medical Center. Rush Alzheimer's Disease Center) ; Bis, Joshua C (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ; Bordes, Constance (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Børte, Sigrid (Oslo University Hospital. Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research and Innovation, Division of Clinical Neuroscience) ; Cain, Anael (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ; Ridker, Paul M. (Harvard Medical School) ; Cho, Kelly (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Chen, Zhengming (University of Oxford. MRC Population Health Research Unit) ; Cruchaga, Carlos (Washington University School of Medicine. NeuroGenomics and Informatics Center) ; Cole, John W. (University of Maryland School of Medicine. Department of Neurology) ; De Jager, Philip L (Columbia University Medical Center. Center for Translational and Computational Neuroimmunology, Department of Neurology) ; de Cid, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Endres, Matthias (partner site Berlin. German Centre for Cardiovascular Research (DZHK)) ; Ferreira, Leslie E. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ; Geerlings, Mirjam I. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ; Gasca, Natalie C. (University of Washington. Department of Biostatistics) ; Gudnason, Vilmundur (University of Iceland. Faculty of Medicine) ; Hata, Jun (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ; He, Jing (Vanderbilt University Medical Center. Department of Biomedical Informatics) ; Heath, Alicia K. (Imperial College London. Department of Epidemiology and Biostatistics, School of Public Health) ; Ho, Yuk-Lam (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Havulinna, Aki S (FIMM-HiLIFE. Institute for Molecular Medicine Finland) ; Hopewell, Jemma C. (University of Oxford. Clinical Trial Service and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health) ; Hyacinth, Hyacinth I. (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ; Inouye, Michael (University of Cambridge. British Heart Foundation Centre of Research Excellence) ; Jacob, Mina A. (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ; Jeon, Christina E. (Los Angeles County Department of Public Health) ; Jern, Christina (Sahlgrenska University Hospital (Suècia)) ; Kamouchi, Masahiro (Kyushu University. Department of Health Care Administration and Management, Graduate School of Medical Sciences) ; Keene, Keith L. (East Carolina University. Department of Biology, Brody School of Medicine Center for Health Disparities) ; Kitazono, Takanari (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ; Kittner, Steven J. (VA Maryland Health Care System. Department of Neurology and Geriatric Research and Education Clinical Center) ; Konuma, Takahiro (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ; Kumar, Amit (Rajendra Institute of Medical Sciences) ; Lacaze, Paul (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ; Launer, Lenore Joy (National Institute on Aging, NIH. Intramural Research Program) ; Lee, Keon-Joo (Korea University Guro Hospital. Department of Neurology) ; Lepik, Kaido (University Center for Primary Care and Public Health, Lausanne, Switzerland) ; Li, Jiang (Geisinger Health System. Department of Molecular and Functional Genomics, Weis Center for Research) ; Li, Liming (Peking University Health Science Center. Department of Epidemiology and Biostatistics, School of Public Health) ; Manichaikul, Ani (University of Virginia. Center for Public Health Genomics) ; Markus, Hugh S. (University of Cambridge. Stroke Research Group, Department of Clinical Neurosciences) ; Marston, Nicholas A. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Meitinger, Thomas (German Research Center for Environmental Health. Institute of Human Genetics, Helmholtz Zentrum München) ; Mitchell, Braxton D. (Baltimore Veterans Administration Medical Center. Geriatrics Research and Education Clinical Center) ; Montellano, Felipe A. (University Hospital Würzburg. Department of Neurology) ; Morisaki, Takayuki (The University of Tokyo. Division of Molecular Pathology, Institute of Medical Sciences) ; Mosley, Thomas H. (University of Mississippi Medical Center. The MIND Center) ; Nalls, Mike A. (Data Tecnica International) ; Nordestgaard, Børge G. (University of Copenhagen. Department of Clinical Medicine) ; O'Donnell, Martin J. (NUI Galway. College of Medicine Nursing and Health Science) ; Okada, Yukinori (Osaka University. Center for Infectious Disease Education and Research (CiDER)) ; Onland-Moret, N. Charlotte (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ; Ovbiagele, Bruce (University of California, San Francisco. Weill Institute for Neurosciences) ; Peters, Annette (German Centre for Cardiovascular Research (DZHK), partner site Munich) ; Psaty, Bruce M. (University of Washington. Department of Health Systems and Population Health) ; Rich, Stephen S. (University of Virginia. Center for Public Health Genomics) ; Rosand, Jonathan (Massachusetts General Hospital. McCance Center for Brain Health) ; Sabatine, Marc S. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Sacco, Ralph L. (Evelyn F. McKnight Brain Institute) ; Saleheen, Danish (Columbia University. Division of Cardiology, Department of Medicine) ; Sandset, Else Charlotte (The Norwegian Air Ambulance Foundation. Research and Development) ; Salomaa, Veikko (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ; Sargurupremraj, Muralidharan (University of Texas Health Sciences Center. Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Sasaki, Makoto (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Satizabal, Claudia L. (Framingham Heart Study) ; Schmidt, Carsten O. (University Medicine Greifswald, Institute for Community Medicine, SHIP/KEF) ; Shimizu, Atsushi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Smith, Nicholas L. (Seattle Epidemiologic Research and Information Center. Department of Veterans Affairs Office of Research and Development) ; Sloane, Kelly L. (University of Pennsylvania. Department of Neurology) ; Sutoh, Yoichi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Sun, Yan V. (Emory University Rollins School of Public Health. Department of Epidemiology) ; Tanno, Kozo (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Tiedt, Steffen (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ; Tatlisumak, Turgut (Sahlgrenska University Hospital (Suècia)) ; Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ; Tiwari, Hemant K. (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ; Trégouët, David-Alexandre (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Trompet, Stella (Leiden University Medical Center. Department of Cardiology) ; Tuladhar, Anil Man (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ; Tybjærg-Hansen, Anne (University of Copenhagen. Department of Clinical Medicine) ; van Vugt, Marion (University Medical Center Utrecht, Utrecht University. Division Heart & Lungs, Department of Cardiology) ; Vibo, Riina (University of Tartu. Department of Neurology and Neurosurgery) ; Verma, Shefali S. (University of Pennsylvania. Department of Pathology and Laboratory Medicine) ; Wiggins, Kerri L. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ; Wennberg, Patrik (Umeå University. Department of Public Health and Clinical Medicine) ; Woo, Daniel (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ; Wilson, Peter W. F. (Emory University School of Medicine. Department of Medicine, Division of Cardiovascular Disease) ; Xu, Huichun (University of Maryland School of Medicine. Department of Medicine) ; Yang, Qiong (Boston University School of Public Health. Department of Biostatistics) ; Yoon, Kyungheon (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ; Millwood, Iona Y. (University of Oxford. MRC Population Health Research Unit) ; Gieger, Christian (German Research Center for Environmental Health. Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München) ; Ninomiya, Toshiharu (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ; Grabe, Hans J. (German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald) ; Jukema, J. Wouter (LUMC. Einthoven Laboratory for Experimental Vascular Medicine) ; Rissanen, Ina L. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ; Strbian, Daniel (Helsinki University Hospital) ; Kim, Young Jin (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ; Chen, Pei-Hsin (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ; Mayerhofer, Ernst (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ; Howson, Joanna M. M. (Novo Nordisk Research Centre Oxford. Department of Genetics) ; Irvin, Marguerite R. (University of Alabama at Birmingham. Department of Epidemiology) ; Adams, Hieab (Universidad Adolfo Ibáñez. Latin American Brain Health (BrainLat)) ; Wassertheil-Smoller, Sylvia (Albert Einstein College of Medicine. Department of Epidemiology and Population Health) ; Christensen, Kaare (Odense University Hospital (Dinamarca)) ; Ikram, M. Arfan (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ; Rundek, Tatjana (Evelyn F. McKnight Brain Institute) ; Worrall, Bradford B. (University of Virginia. Department of Public Health Science) ; Lathrop, G. Mark (McGill Genome Centre) ; Riaz, Moeen (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ; Simonsick, Eleanor M. (National Institute on Aging. Longitudinal Studies Section, Translational Gerontology Branch) ; Kõrv, Janika (University of Tartu. Department of Neurology and Neurosurgery) ; França, Paulo H. C. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ; Zand, Ramin (The Pennsylvania State University. Department of Neurology, College of Medicine) ; Prasad, Kameshwar (Rajendra Institute of Medical Sciences) ; Frikke-Schmidt, Ruth (University of Copenhagen. Department of Clinical Medicine) ; de Leeuw, Frank-Erik (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ; Liman, Thomas (Carl von Ossietzky University of Oldenburg. Klinik für Neurologie) ; Haeusler, Karl Georg (University Hospital Würzburg. Department of Neurology) ; Ruigrok, Ynte M. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ; Heuschmann, Peter Ulrich (University Hospital Würzburg. Clinical Trial Center) ; Longstreth, W. T. (University of Washington. Department of Neurology) ; Jung, Keum Ji (Yonsei University. Institute for Health Promotion, Graduate School of Public Health) ; Bastarache, Lisa (Vanderbilt University Medical Center. Department of Biomedical Informatics) ; Paré, Guillaume (David Braley Cardiac, Vascular and Stroke Research Institute. Population Health Research Institute) ; Damrauer, Scott M. (Corporal Michael Crescenz VA Medical Center) ; Chasman, Daniel I. (Harvard Medical School) ; Rotter, Jerome I. (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics) ; Anderson, Christopher D. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Zwart, John-Anker (University of Oslo. Institute of Clinical Medicine, Faculty of Medicine) ; Niiranen, Teemu J. (Turku University Hospital. Division of Medicine) ; Fornage, Myriam (University of Texas Health Science Center at Houston. Human Genetics Center, School of Public Health) ; Liaw, Yung-Po (Chung Shan Medical University Hospital. Department of Medical Imaging) ; Seshadri, Sudha (Boston University School of Medicine. Department of Neurology) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Walters, Robin G. (University of Oxford. MRC Population Health Research Unit) ; Ruff, Christian T. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Owolabi, Mayowa O. (University of Ibadan. Department of Medicine) ; Huffman, Jennifer E. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Milani, Lili (University of Tartu. Estonian Genome Centre, Institute of Genomics) ; Kamatani, Yoichiro (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; Dichgans, Martin (German Center for Neurodegenerative Diseases (DZNE)) ; Debette, Stéphanie (CHU de Bordeaux. Department of Neurology, Institute for Neurodegenerative Diseases) ; Universitat Autònoma de Barcelona
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry ,. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. [...]
2022 - 10.1038/s41586-022-05165-3
Nature, september 2022, p. 1-15  
2.
42 p, 2.1 MB Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis / Kanoni, Stavroula (Queen Mary University of London) ; Graham, Sarah E. (University of Michigan) ; Wang, Yuxuan (Boston University School of Public Health) ; Surakka, Ida (University of Michigan) ; Ramdas, Shweta (University of Pennsylvania) ; Zhu, Xiang (Stanford University) ; Clarke, Shoa L. (Stanford University School of Medicine) ; Bhatti, Konain Fatima (Queen Mary University of London) ; Vedantam, Sailaja (Broad Institute of MIT and Harvard) ; Winkler, Thomas W. (University of Regensburg) ; Locke, Adam E. (Washington University) ; Marouli, Eirini (Queen Mary University of London) ; Zajac, Greg J. M. (University of Michigan) ; Wu, Kuan-Han H. (University of Michigan) ; Ntalla, Ioanna (Queen Mary University of London) ; Hui, Qin (Atlanta VA Health Care System) ; Klarin, Derek (Stanford University School of Medicine) ; Hilliard, Austin T. (VA Palo Alto Health Care Systems) ; Wang, Zeyuan (Atlanta VA Health Care System) ; Xue, Chao (University of Michigan) ; Thorleifsson, Gudmar (deCODE Genetics/Amgen) ; Helgadottir, Anna (deCODE Genetics/Amgen) ; Gudbjartsson, Daniel F. (University of Iceland) ; Holm, Hilma (deCODE Genetics/Amgen) ; Olafsson, Isleifur (Landspitali - National University Hospital of Iceland) ; Hwang, Mi Yeong (National Institute of Health) ; Han, Sohee (National Institute of Health) ; Akiyama, Masato (Kyushu University) ; Sakaue, Saori (The University of Tokyo) ; Terao, Chikashi (RIKEN Center for Integrative Medical Sciences) ; Kanai, Masahiro (Harvard Medical School) ; Zhou, Wei (Massachusetts General Hospital) ; Brumpton, Ben M. (St Olav's University Hospital) ; Rasheed, Humaira (University of Oslo) ; Havulinna, Aki S. (Finnish Institute for Health and Welfare) ; Veturi, Yogasudha (University of Pennsylvania) ; Pacheco, Jennifer Allen (Northwestern University) ; Rosenthal, Elisabeth A. (University of Washington) ; Lingren, Todd (Cincinnati Children's Hospital Medical Center) ; Feng, QiPing (Vanderbilt University Medical Center) ; Kullo, Iftikhar J. (Mayo Clinic) ; Narita, Akira (Tohoku Medical Megabank Organization) ; Takayama, Jun (Tohoku Medical Megabank Organization) ; Martin, Hilary C. (Wellcome Trust Sanger Institute (Regne Unit)) ; Hunt, Karen A. (Queen Mary University of London) ; Trivedi, Bhavi (Queen Mary University of London) ; Haessler, Jeffrey (Fred Hutchinson Cancer Center) ; Giulianini, Franco (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Bradford, Yuki (University of Pennsylvania) ; Miller, Jason E. (University of Pennsylvania) ; Campbell, Archie (University of Edinburgh) ; Lin, Kuang (University of Oxford) ; Millwood, Iona Y. (University of Oxford) ; Rasheed, Asif (Center for Non-Communicable Diseases) ; Hindy, George (Qatar University College of Medicine) ; Faul, Jessica D. (University of Michigan) ; Zhao, Wei (University of Michigan) ; Weir, David R. (University of Michigan) ; Turman, Constance (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ; Huang, Hongyan (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ; Graff, Mariaelisa (University of North Carolina) ; Choudhury, Ananyo (University of the Witwatersrand) ; Sengupta, Dhriti (University of the Witwatersrand) ; Mahajan, Anubha (University of Oxford) ; Brown, Michael R. (The University of Texas Health Science Center at Houston) ; Zhang, Weihua (London North West University Healthcare NHS Trust) ; Yu, Ketian (University of Michigan) ; Schmidt, Ellen M. (University of Michigan) ; Pandit, Anita (University of Michigan) ; Gustafsson, S (Uppsala University) ; Yin, Xianyong (University of Michigan) ; Luan, Jian'an (University of Cambridge School of Clinical Medicine) ; Zhao, Jing-Hua (University of Cambridge) ; Matsuda, Fumihiko (Kyoto University Graduate School of Medicine) ; Jang, Hye-Mi (National Institute of Health) ; Yoon, Kyungheon (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ; Medina-Gomez, Carolina (University Medical Center Rotterdam) ; Pitsillides, Achilleas (Boston University School of Public Health) ; Hottenga, Jouke Jan (Amsterdam Public Health Research Institute) ; Wood, Andrew R. (University of Exeter Medical School) ; Ji, Yingji (University of Exeter Medical School) ; Gao, Zishan (German Research Center for Environmental Health) ; Haworth, Simon (University of Bristol) ; Yousri, Noha A. (Alexandria University) ; Mitchell, Ruth E. (University of Bristol) ; Chai, Jin Fang (National University of Singapore and National University Health System) ; Aadahl, Mette (University of Copenhagen) ; Bjerregaard, Anne A. (Bispebjerg and Frederiksberg Hospital) ; Yao, Jie (Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center) ; Manichaikul, Ani (University of Virginia) ; Hwu, Chii-Min (Taipei Veterans General Hospital) ; Hung, Yi-Jen (National Defense Medical Center) ; Warren, Helen R. (Queen Mary University of London) ; Ramirez, Julia (Universidad de Zaragoza) ; Bork-Jensen, Jette (University of Copenhagen) ; Kårhus, Line L. (Bispebjerg and Frederiksberg Hospital) ; Goel, Anuj (University of Oxford) ; Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ; Noordam, Raymond (Leiden University Medical Center) ; Mauro, Pala (Consiglio Nazionale Delle Ricerche) ; Matteo, Floris (Università Degli Studi Di Sassari) ; McDaid, Aaron F. (Swiss Institute of Bioinformatics) ; Marques-Vidal, Pedro (Lausanne University Hospital) ; Wielscher, Matthias (Imperial College London) ; Trompet, Stella (Leiden University Medical Center) ; Sattar, Naveed (BHF Glasgow Cardiovascular Research Centre) ; Møllehave, Line T. (Bispebjerg and Frederiksberg Hospital) ; Munz, Matthias (University of Lübeck) ; Zeng, Lingyao (Partner Site Munich Heart Alliance) ; Huang, Jianfeng (Fuwai Hospital) ; Yang, Bin (Fuwai Hospital) ; Poveda, Alaitz (Lund University Diabetes Center) ; Kurbasic, Azra (Lund University Diabetes Center) ; Lamina, Claudia (German Chronic Kidney Disease Study) ; Forer, Lukas (German Chronic Kidney Disease Study) ; Scholz, Markus (University of Leipzig) ; Galesloot, Tessel E. (Radboud University Medical Center) ; Bradfield, Jonathan Paul (Quantinuum Research LLC) ; Ruotsalainen, Sanni E. (University of Helsinki) ; Daw, E. Warwick (Washington University School of Medicine) ; Zmuda, Joseph M. (University of Pittsburgh) ; Mitchell, Jonathan S. (Affiliated Institute of the University of Lübeck) ; Fuchsberger, Christian (Affiliated Institute of the University of Lübeck) ; Christensen, Henry (Lillebaelt Hospital) ; Brody, Jennifer A. (University of Washington) ; Vazquez-Moreno, Miguel (Centro Medico Nacional Siglo XXI) ; Feitosa, Mary F. (Washington University School of Medicine) ; Wojczynski, Mary K. (Washington University School of Medicine) ; Wang, Zhe (The Charles Bronfman Institute for Personalized Medicine) ; Preuss, Michael H. (The Charles Bronfman Institute for Personalized Medicine) ; Mangino, Massimo (NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust) ; Christofidou, Paraskevi (King's College London) ; Verweij, Niek (University of Groningen) ; Benjamins, Jan W. (University of Groningen) ; Engmann, Jorgen (University College London) ; Tsao, Noah L. (University of Pennsylvania) ; Verma, Anurag (University of Pennsylvania) ; Slieker, Roderick C. (Leiden University Medical Center) ; Lo, Ken Sin (Montreal Université de Montréal) ; Zilhao, Nuno R. (Icelandic Heart Association) ; Le, Phuong (University of Toronto at Mississauga) ; Kleber, Marcus E. (SYNLAB MVZ Humangenetik Mannheim GmbH) ; Delgado, Graciela E. (Heidelberg University) ; Huo, Shaofeng (University of Chinese Academy of Sciences) ; Ikeda, Daisuke D. (Tokushima Research Institute) ; Iha, Hiroyuki (Tokushima Research Institute) ; Yang, Jian (The University of Queensland) ; Liu, Jun (University Medical Center Rotterdam) ; Demirkan, Ayşe (University of Surrey) ; Leonard, Hampton L. (Data Tecnica International) ; Marten, Jonathan (University of Edinburgh) ; Frank, Mirjam (University of Duisburg-Essen) ; Schmidt, Börge (University of Duisburg-Essen) ; Smyth, Laura J. (Queen's University of Belfast) ; Cañadas-Garre, Marisa (Instituto de Investigación Biosanitaria de Granada) ; Wang, Chaolong (Genome Institute of Singapore) ; Nakatochi, Masahiro (Nagoya University Graduate School of Medicine) ; Wong, Andrew (MRC Unit for Lifelong Health and Ageing at UCL) ; Hutri-Kähönen, Nina (Tampere University) ; Sim, Xueling (National University of Singapore and National University Health System) ; Xia, Rui (University of Texas Health Science Center at Houston) ; Huerta-Chagoya, Alicia (Instituto de Investigaciones Biomédicas (Mèxic)) ; Fernandez-Lopez, Juan Carlos (Instituto Nacional de Medicina Genómica) ; Lyssenko, Valeriya (University of Bergen) ; Nongmaithem, Suraj S. (Academy of Scientific and Innovative Research (AcSIR)) ; Bayyana, Swati (Academy of Scientific and Innovative Research (AcSIR)) ; Stringham, Heather M. (University of Michigan.) ; Irvin, Marguerite R. (University of Alabama at Birmingham) ; Oldmeadow, Christopher (Hunter Medical Research Institute) ; Kim, Han-Na (SAIHST, Sungkyunkwan University) ; Ryu, Seungho (Kangbuk Samsung Hospital) ; Timmers, Paul R. H. J. (University of Edinburgh) ; Arbeeva, Liubov (University of North Carolina) ; Dorajoo, Rajkumar (Duke-NUS Medical School) ; Lange, Leslie A. (University of Colorado) ; Prasad, Gauri (CSIR-Human Resource Development Centre) ; Lorés-Motta, Laura (Radboud University Nijmegen Medical Center) ; Pauper, Marc (Radboud University Nijmegen Medical Center) ; Long, Jirong (Vanderbilt University Medical Center) ; Li, Xiaohui (Harbor-UCLA Medical Center) ; Theusch, Elizabeth (University of California San Francisco) ; Takeuchi, Fumihiko (National Center for Global Health and Medicine) ; Spracklen, Cassandra N. (University of Massachusetts-Amherst) ; Loukola, Anu (University of Helsinki) ; Bollepalli, Sailalitha (University of Helsinki) ; Warner, Sophie C. (Glenfield Hospital) ; Wang, Ya Xing (Beijing Institute of Ophthalmology) ; Wei, Wen B. (Beijing Tongren Eye Center) ; Nutile, Teresa (Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" - CNR) ; Ruggiero, Daniela (IRCCS Neuromed) ; Sung, Yun Ju (Washington University) ; Chen, Shufeng (Fuwai Hospital) ; Liu, Fangchao (Fuwai Hospital) ; Yang, Jingyun (Rush University Medical Center) ; Kentistou, Katherine A. (University of Edinburgh) ; Banas, Bernhard (University Hospital Regensburg) ; Nardone, Giuseppe Giovanni (IRCCS Burlo Garofolo) ; Meidtner, Karina (German Center for Diabetes Research (DZD)) ; Bielak, Lawrence F. (University of Michigan) ; Smith, Jennifer A. (University of Michigan) ; Hebbar, Prashantha (Dasman Diabetes Institute) ; Farmaki, Aliki-Eleni (University College London) ; Hofer, Edith (Medical University of Graz) ; Lin, Maoxuan (Massachusetts General Hospital Cancer Center) ; Concas, Maria Pina (IRCCS Burlo Garofolo) ; Vaccargiu, Simona (Institute of Genetic and Biomedical Research) ; van der Most, Peter J (University of Groningen) ; Pitkänen, Niina (University of Turku and Turku University Hospital) ; Cade, Brian E. (Harvard Medical School) ; van der Laan, Sander W (University Medical Center Utrecht) ; Chitrala, Kumaraswamy Naidu (University of Houston-Sugarland) ; Weiss, Stefan (University of Greifswald and University Medicine Greifswald) ; Bentley, Amy R. (National Human Genome Research Institute) ; Doumatey, Ayo P. (National Human Genome Research Institute) ; Adeyemo, Adebowale A. (National Human Genome Research Institute) ; Lee, Jong Young (Soonchunhyang Mirai Medical Center 173) ; Petersen, Eva R. B. (Hospital of Southern Jutlandy and Immunology) ; Nielsen, Aneta A. (Lillebaelt Hospital) ; Choi, Hyeok Sun (Hallym University) ; Nethander, Maria (University of Gothenburg) ; Freitag-Wolf, Sandra (Kiel University) ; Southam, Lorraine (Institute of Translational Genomics) ; Rayner, Nigel W. (University of Oxford) ; Wang, Carol A (University of Newcastle) ; Lin, Shih-Yi (National Defense Medical Center) ; Wang, Jun-Sing (National Yang Ming Chiao Tung University) ; Couture, Christian (Université Laval) ; Lyytikäinen, Leo-Pekka (Finnish Cardiovascular Research Center - Tampere) ; Nikus, Kjell (Finnish Cardiovascular Research Center - Tampere) ; Cuellar-Partida, Gabriel (University of Queensland Diamantina Institute) ; Vestergaard, Henrik (Bornholms Hospital) ; Hidalgo, Bertha (University of Alabama at Birmingham) ; Giannakopoulou, Olga (Queen Mary University of London) ; Cai, Qiuyin (Vanderbilt University Medical Center) ; Obura, Morgan O. (Amsterdam Public Health Research Institute) ; van Setten, Jessica (University Medical Center Utrecht) ; Li, Xiaoyin (Case Western Reserve University) ; Liang, Jingjing (Case Western Reserve University) ; Tang, Hua (Stanford University School of Medicine Stanford) ; Terzikhan, Natalie (University Medical Center Rotterdam) ; Shin, Jae Hun (Hallym University) ; Jackson, Rebecca D. (Ohio State University) ; Reiner, Alexander P. (University of Washington) ; Martin, Lisa Warsinger (George Washington University) ; Chen, Zhengming (University of Oxford) ; Li, Liming (Peking University Health Science Center) ; Kawaguchi, Takahisa (Kyoto University Graduate School of Medicine) ; Thiery, Joachim (University Hospital Leipzig) ; Bis, Joshua C (University of Washington) ; Launer, Lenore J. (National Institute On Aging) ; Li, Huaixing (University of Chinese Academy of Sciences) ; Nalls, Mike A. (Data Tecnica International) ; Raitakari, Olli T. (Turku University Hospital (Finlàndia)) ; Ichihara, Sahoko (Jichi Medical University School of Medicine) ; Wild, Sarah H. (University of Edinburgh) ; Nelson, Christopher P. (NIHR Leicester Biomedical Research Centre) ; Campbell, Harry (University of Edinburgh) ; Jäger, Susanne (German Center for Diabetes Research (DZD)) ; Nabika, Toru (Shimane University School of Medicine) ; Al-Mulla, Fahd (Dasman Diabetes Institute) ; Niinikoski, Harri (University of Turku) ; Braund, Peter S. (NIHR Leicester Biomedical Research Centre) ; Kolcic, Ivana (University of Split School of Medicine) ; Kovacs, Peter (University of Leipzig Medical Center) ; Giardoglou, Tota (Harokopio University) ; Katsuya, Tomohiro (Osaka University Graduate School of Medicine) ; de Kleijn, Dominique (University Medical Center Utrecht) ; de Borst, Gert J. (University Medical Center Utrecht) ; Kim, Eung Kweon (Yonsei University College of Medicine) ; Adams, Hieab H. H. (Universidad Adolfo Ibáñez) ; Ikram, M. Arfan (University Medical Center Rotterdam) ; Zhu, X (Case Western Reserve University) ; Asselbergs, Folkert W. (University Medical Center Utrecht) ; Kraaijeveld, Adriaan O. (University Medical Center Utrecht) ; Beulens, Joline W. J. (University Medical Centre Utrecht) ; Shu, Xiao-Ou (Vanderbilt University Medical Center) ; Rallidis, Loukianos S. (National and Kapodistrian University of Athens) ; Pedersen, Oluf (University of Copenhagen) ; Hansen, Torben (University of Copenhagen) ; Mitchell, Paul (University of Sydney) ; Hewitt, Alex W. (University of Melbourne) ; Kähönen, Mika (Tampere University) ; Pérusse, Louis (Institute of Nutrition and Functional Foods (INAF)) ; Bouchard, Claude (Pennington Biomedical Research Center) ; Tönjes, Anke (University of Leipzig Medical Center) ; Chen, Yii Der Ida (Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center) ; Pennell, Craig E. (University of Newcastle) ; Mori, Trevor A. (The University of Western Australia) ; Lieb, Wolfgang (Kiel University) ; Franke, Andre (Kiel University) ; Ohlsson, Claes (Sahlgrenska University Hospital (Suècia)) ; Mellström, Dan (University of Gothenburg) ; Cho, Yoon Shin (Hallym University) ; Lee, Hyejin (EwhaWomans University School of Medicine) ; Yuan, Jian-Min (University of Pittsburgh) ; Koh, Woon-Puay (Singapore Institute for Clinical Sciences) ; Rhee, Sang Youl (Kyung Hee University School of Medicine) ; Woo, Jeong-Taek (Kyung Hee University School of Medicine) ; Heid, Iris M. (University of Regensburg) ; Stark, Klaus J. (University of Regensburg) ; Zimmermann, Martina E. (University of Regensburg) ; Völzke, Henry (University Medicine Greifswald) ; Homuth, Georg (University of Greifswald and University Medicine Greifswald) ; Evans, Michele K. (National Institute On Aging Intramural Research Program) ; Zonderman, Alan B. (National Institute On Aging Intramural Research Program) ; Polasek, Ozren (Algebra University College) ; Pasterkamp, Gerard (University Medical Center Utrecht) ; Hoefer, Imo E. (University Medical Center Utrecht) ; Redline, Susan (Harvard Medical School) ; Pahkala, Katja (University of Turku) ; Oldehinkel, Albertine J. (University of Groningen) ; Snieder, Harold (University Medical Center Groningen) ; Biino, Ginevra (National Research Council of Italy) ; Schmidt, Reinhold (Medical University of Graz) ; Schmidt, Helena (Medical University of Graz) ; Bandinelli, Stefania (Local Health Unit Toscana Centro) ; Dedoussis, George (Harokopio University of Athens) ; Thanaraj, Thangavel Alphonse (Dasman Diabetes Institute. Department of Genetics and Bioinformatics) ; Kardia, Sharon L. R. (University of Michigan) ; Peyser, Patricia A. (University of Michigan) ; Kato, Norihiro (National Center for Global Health and Medicine) ; Schulze, Matthias B. (University of Potsdam) ; Girotto, Giorgia (University of Trieste) ; Böger, Carsten A. (KfH Kidney Center Traunstein) ; Jung, Bettina (KfH Kidney Center Traunstein) ; Joshi, Peter K. (University of Edinburgh) ; Bennett, David A. (Rush University Medical Center) ; De Jager, Philip L. (Columbia University Medical Center) ; Lu, Xiangfeng (Fuwai Hospital) ; Mamakou, Vasiliki (Dromokaiteio Psychiatric Hospital) ; Brown, Morris (Queen Mary University of London) ; Caulfield, Mark J. (Queen Mary University of London) ; Munroe, Patricia B. (Queen Mary University of London) ; Guo, Xiuqing (Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center) ; Ciullo, Marina (IRCCS Neuromed) ; Jonas, Jost B. (Privatpraxis Prof Jonas Und Dr Panda-Jonas) ; Samani, Nilesh J. (NIHR Leicester Biomedical Research Centre) ; Kaprio, Jaakko (University of Helsinki) ; Pajukanta, Päivi (University of California) ; Tusié-Luna, Teresa (Instituto de Investigaciones Biomédicas UNAM/ Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán) ; Aguilar-Salinas, Carlos Alberto (Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán) ; Adair, Linda S. (University of North Carolina) ; Bechayda, Sonny Augustin (University of San Carlos) ; de Silva, H. Janaka (University of Kelaniya) ; Wickremasinghe, Ananda R. (University of Kelaniya) ; Krauss, Ronald M. (Children's Hospital Oakland Research Institute) ; Wu, Jer-Yuarn (Institute of Biomedical Sciences) ; Zheng, Wei (Vanderbilt University Medical Center) ; Hollander, Anneke Iden (Radboud University Nijmegen Medical Center) ; Bharadwaj, Dwaipayan (Jawaharlal Nehru University) ; Correa, Adolfo (University of Mississippi Medical Center) ; Wilson, James G. (University of Mississippi Medical Center) ; Lind, Lars (Uppsala University) ; Heng, Chew-Kiat (Yong Loo Lin School of Medicine) ; Nelson, Amanda E. (University of North Carolina) ; Golightly, Yvonne M. (University of North Carolina) ; Wilson, James F. (University of Edinburgh) ; Penninx, Brenda (Vrije Universiteit Amsterdam) ; Kim, Hyung-Lae (Ewha Womans University) ; Attia, John (University of Newcastle) ; Scott, Rodney J. (University of Newcastle) ; Rao, D. C. (Washington University School of Medicine) ; Arnett, Donna K. (University of South Carolina) ; Hunt, Steven C. (University of Utah) ; Walker, Mark (Institute of Cellular Medicine (Diabetes)) ; Koistinen, Heikki A. (Minerva Foundation Institute for Medical Research) ; Chandak, Giriraj R. (JSS Academy of Higher Education and Research) ; Mercader, Josep M. (Harvard Medical School) ; Costanzo, Maria C. (Broad Institute of MIT and Harvard) ; Jang, Dongkeun (Broad Institute of MIT and Harvard) ; Burtt, Noël P. (Broad Institute of MIT and Harvard) ; Villalpando, Clicerio Gonzalez (InstitutoNacional de Salud Publica Y Centro de Estudios en Diabetes (Mèxic)) ; Orozco, Lorena (Instituto Nacional de Medicina Genómica) ; Fornage, Myriam (University of Texas Health Science at Houston) ; Tai, EShyong (Yong Loo Lin School of Medicine) ; van Dam, Rob M. (Milken Institute School of Public Health) ; Lehtimäki, Terho (Finnish Cardiovascular Research Center - Tampere) ; Chaturvedi, Nish (MRC Unit for Lifelong Health and Ageing at UCL) ; Yokota, Mitsuhiro (Kurume University School of Medicine) ; Liu, Jianjun (Genome Institute of Singapore) ; Reilly, Dermot F. (Merck Sharp & Dohme Corp.. Genetics) ; McKnight, Amy Jayne (Queen's University of Belfast) ; Kee, Frank (Queen's University of Belfast) ; Jöckel, Karl-Heinz (University of Duisburg-Essen) ; McCarthy, Mark I. (University of Oxford) ; Palmer, Colin N. A. (University of Dundee) ; Vitart, Veronique (University of Edinburgh) ; Hayward, Caroline (University of Edinburgh) ; Simonsick, Eleanor (National Institute On Aging) ; van Duijn, Cornelia M. (University Medical Center Rotterdam) ; Jin, Zi-Bing (Wenzhou Medical University) ; Qu, Jia (Wenzhou Medical University) ; Hishigaki, Haretsugu (Tokushima Research Institute) ; Lin, Xu (University of Chinese Academy of Sciences) ; März, Winfried (Medical University of Graz) ; Gudnason, Vilmundur (University of Iceland) ; Tardif, Jean-Claude (Université de Montréal) ; Lettre, Guillaume (Université de Montréal) ; Hart, Leen M.'t (Amsterdam Public Health Research Institute) ; Elders, Petra J. M. (Amsterdam Public Health Research Institute) ; Damrauer, Scott M. (Corporal Michael Crescenz VA Medical Center) ; Kumari, Meena (University of Essex) ; Kivimaki, Mika (University College London) ; van der Harst, Pim (Utrecht University) ; Spector, Tim D. (King's College London) ; Loos, Ruth J. F. (Icahn School of Medicine at Mount Sinai) ; Province, Michael A. (Washington University School of Medicine) ; Parra, Esteban J. (University of Toronto at Mississauga) ; Cruz, Miguel (Centro Medico Nacional Siglo XXI) ; Psaty, Bruce M. (University of Washington) ; Brandslund, Ivan (University of Southern Denmark) ; Pramstaller, Peter P. (Affiliated Institute of the University of Lübeck) ; Rotimi, Charles N. (Center for Research On Genomics and Global Health) ; Christensen, Kaare (University of Southern Denmark) ; Ripatti, Samuli (Broad Institute of MIT and Harvard) ; Widén, Elisabeth (University of Helsinki) ; Hakonarson, Hakon (The University of Pennsylvania Perelman School of Medicine) ; Grant, Struan F. A. (Children's Hospital of Philadelphia (Pennsilvània)) ; Kiemeney, Lambertus A. L. M. (Radboud University Medical Center) ; de Graaf, Jacqueline (Radboud University Medical Center) ; Loeffler, Markus (University of Leipzig) ; Kronenberg, Florian (German Chronic Kidney Disease Study (Alemanya)) ; Gu, Dongfeng (Southern University of Science and Technology) ; Erdmann, Jeanette (University Heart Center Lübeck) ; Schunkert, Heribert (Partner Site Munich Heart Alliance) ; Franks, Paul W. (Lund University Diabetes Centre) ; Linneberg, Allan (University of Copenhagen) ; Jukema, J. Wouter (Netherlands Heart Institute) ; Khera, Amit V. (Verve Therapeutics) ; Männikkö, Minna (Northern Finland Birth Cohorts) ; Jarvelin, Marjo-Riitta (University of Oulu) ; Kutalik, Zoltan (Swiss Institute of Bioinformatics) ; Francesco, Cucca (University of Sassari) ; Mook-Kanamori, Dennis O. (Leiden University Medical Center) ; van Dijk, Ko Willems (Leiden University Medical Center) ; Watkins, Hugh (University of Oxford) ; Strachan, David P. (University of London) ; Grarup, Niels (University of Copenhagen) ; Sever, Peter (Imperial College London) ; Poulter, Neil (Imperial College London) ; Chuang, Lee-Ming (National Taiwan University Hospital (Taipei, Taiwan)) ; Rotter, Jerome I. (Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center) ; Dantoft, Thomas M. (Bispebjerg and Frederiksberg Hospital) ; Karpe, Fredrik (NIHR Oxford Biomedical Research Centre) ; Neville, Matt J. (NIHR Oxford Biomedical Research Centre) ; Timpson, Nicholas J. (University of Bristol) ; Cheng, Ching-Yu (Duke-NUS Medical School) ; Wong, Tien-Yin (Duke-NUS Medical School) ; Khor, Chiea Chuen (Genome Institute of Singapore) ; Li, Hengtong (Singapore Eye Research Institute) ; Sabanayagam, Charumathi (Duke-NUS Medical School) ; Peters, Annette (German Center for Diabetes Research (DZD)) ; Gieger, Christian (German Center for Diabetes Research (DZD)) ; Hattersley, Andrew T. (University of Exeter) ; Pedersen, Nancy L. (Karolinska Institutet (Estocolm, Suècia)) ; Magnusson, Patrik K. E. (Karolinska Institutet (Estocolm, Suècia)) ; Boomsma, Dorret I. (Amsterdam Public Health Research Institute) ; Willemsen, Allegonda H. M. (Amsterdam Public Health Research Institute) ; Cupples, LAdrienne (US National Institutes of Health) ; van Meurs, Joyce B. J. (University Medical Center Rotterdam) ; Ghanbari, Mohsen (Mashhad University of Medical Sciences) ; Gordon-Larsen, Penny (University of North Carolina) ; Huang, Wei (Chinese National Human Genome Center at Shanghai) ; Kim, Young Jin (National Institute of Health) ; Tabara, Yasuharu (Kyoto University Graduate School of Medicine) ; Wareham, Nicholas J. (University of Cambridge School of Clinical Medicine) ; Langenberg, Claudia (Berlin Institute of Health at Charité - Universitätsmedizin) ; Zeggini, Eleftheria (Helmholtz Zentrum München - German Research Center for Environmental Health) ; Kuusisto, Johanna (University of Eastern Finland and Kuopio University Hospital) ; Laakso, Markku (University of Eastern Finland and Kuopio University Hospital) ; Ingelsson, Erik (Stanford University) ; Abecasis, Goncalo (Regeneron Pharmaceuticals) ; Chambers, John C. (Imperial College London) ; Kooner, Jaspal S. (Imperial College London) ; de Vries, Paul S. (The University of Texas Health Science Center at Houston) ; Morrison, Alanna C. (The University of Texas Health Science Center at Houston) ; Hazelhurst, Scott (University of the Witwatersrand) ; Ramsay, Michèle (University of the Witwatersrand) ; North, Kari E. (University of North Carolina) ; Daviglus, Martha (University of Illinois College of Medicine) ; Kraft, Peter (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ; Martin, Nicholas G. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Whitfield, John B. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Abbas, Shahid (Faisalabad Institute of Cardiology) ; Saleheen, Danish (Columbia University Irving Medical Center) ; Walters, Robin G. (University of Oxford) ; Holmes, Michael V. (Oxford University Hospitals) ; Black, Corri (University of Aberdeen) ; Smith, Blair H. (University of Dundee) ; Baras, Aris (Regeneron Pharmaceuticals) ; Justice, Anne E. (Geisinger Health) ; Buring, Julie E. (Harvard Medical School) ; Ridker, Paul M. (Harvard Medical School) ; Chasman, Daniel I. (Harvard Medical School) ; Kooperberg, Charles (Fred Hutchinson Cancer Center) ; Tamiya, Gen (Tohoku University) ; Yamamoto, Masayuki (Tohoku University) ; van Heel, David A (Queen Mary University of London) ; Trembath, Richard C. (King's College London) ; Wei, Wei-Qi (Vanderbilt University Medical Center) ; Jarvik, Gail P. (University of Washington) ; Namjou, Bahram (Cincinnati Children's Hospital Medical Center) ; Hayes, M. Geoffrey (Northwestern University) ; Ritchie, Marylyn D. (University of Pennsylvania) ; Jousilahti, Pekka (Finnish Institute for Health and Welfare) ; Salomaa, Veikko (Finnish Institute for Health and Welfare) ; Hveem, Kristian (St Olav's University Hospital) ; Åsvold, Bjørn Olav (St Olav's University Hospital) ; Kubo, Michiaki (RIKEN Center for Integrative Medical Sciences) ; Kamatani, Yoichiro (The University of Tokyo) ; Okada, Yukinori (The University of Tokyo) ; Murakami, Yoshinori (The University of Tokyo) ; Kim, Bong-Jo (National Institute of Health) ; Thorsteinsdottir, Unnur (University of Iceland) ; Stefansson, Kari (The University of Manchester) ; Zhang, Jifeng (University of Michigan) ; Chen, YEugene (University of Michigan) ; Ho, Yuk-Lam (VA Boston Healthcare System) ; Lynch, Julie A. (University of Massachusetts) ; Rader, Daniel J. (University of Pennsylvania) ; Tsao, Philip S. (Stanford University School of Medicine) ; Chang, Kyong-Mi (University of Pennsylvania Perelman School of Medicine) ; Cho, Kelly (Brigham Women's Hospital) ; O'Donnell, Christopher J. (Brigham Women's Hospital) ; Gaziano, John M. (Brigham Women's Hospital) ; Wilson, Peter W. F. (Emory University School of Medicine) ; Frayling, Timothy M. (University of Exeter Medical School) ; Hirschhorn, Joel N. (Harvard Medical School) ; Kathiresan, Sekar (Harvard Medical School) ; Mohlke, Karen L. (University of North Carolina) ; Sun, Yan V. (Atlanta VA Health Care System) ; Morris, Andrew P. (The University of Manchester) ; Boehnke, Michael (University of Michigan) ; Brown, Christopher D. (University of Pennsylvania) ; Natarajan, Pradeep (Massachusetts General Hospital) ; Deloukas, Panos (King Abdulaziz University) ; Willer, Cristen J. (University of Michigan) ; Assimes, Themistocles (Stanford University School of Medicine. Cardiovascular Institute) ; Peloso, Gina M (Boston University School of Public Health. Department of Biostatistics) ; Universitat Autònoma de Barcelona
Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. [...]
2022 - 10.1186/s13059-022-02837-1
Genome biology, Vol. 23 (december 2022)  
3.
2 p, 2.0 MB Author Correction : Common variants in Alzheimer's disease and risk stratification by polygenic risk scores / De Rojas, Itziar (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Moreno-Grau, Sonia (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Tesi, Niccolo (Delft Univeristy of Technology) ; Grenier-Boley, Benjamin (Institut Pasteur de Lille) ; Andrade, Victor (University Clinic Bonn) ; Jansen, Iris E. (VU University) ; Pedersen, Nancy L. (Karolinska Institutet (Estocolm, Suècia)) ; Stringa, Najada (Amsterdam Public Health Research Institute) ; Zettergren, Anna (University of Gothenburg) ; Hernández, Isabel (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Montrreal, Laura (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Antúnez, Carmen (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Antonell, Anna (Hospital Clínic i Provincial de Barcelona) ; Tankard, Rick M. (Murdoch University) ; Bis, Joshua C (University of Washington) ; Sims, Rebecca (Cardiff University) ; Bellenguez, Céline (Institut Pasteur de Lille) ; Quintela, Inés (Universidade de Santiago de Compostela) ; González-Perez, Antonio (Centro Andaluz de Estudios Bioinformáticos) ; Calero, Miguel (Fundación Reina Sofía) ; Franco-Macías, Emilio (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Macías, Juan (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Cervera Carles, Laura (Institut d'Investigació Biomèdica Sant Pau) ; Mendez-Gonzalez, Manuel (Universidad de Oviedo) ; Frank-García, Ana (Universidad Autónoma de Madrid) ; Royo, Jose Luís (Universidad de Málaga) ; Moreno, Fermin (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Huerto Vilas, Raquel (Institut de Recerca Biomedica de Lleida (IRBLLeida)) ; Baquero, Miquel (Hospital Universitari i Politècnic La Fe (València)) ; Diez-Fairen, Monica (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Lage, Carmen (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; García-Madrona, Sebastián (Hospital Universitario Ramón y Cajal (Madrid)) ; García-González, Pablo (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Alarcón-Martín, Emilio (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Valero, Sergi (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Sotolongo Grau, Oscar (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Ullgren, Abbe (Karolinska University Hospital and Karolinska Institutet (Suecia)) ; Naj, Adam C. (University of Pennsylvania Perelman School of Medicine) ; Lemstra, Afina W. (Vrije Universiteit Amsterdam) ; Benaque, Alba (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Pérez-Cordón, Alba (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Benussi, Alberto (University of Brescia) ; Rábano, Alberto (BT-CIEN) ; Padovani, Alessandro (University of Brescia) ; Squassina, Alessio (University of Cagliari) ; de Mendonça, Alexandre (University of Lisbon) ; Arias Pastor, Alfonso (Institut de Recerca Biomedica de Lleida (IRBLLeida)) ; Kok, Almar A. L. (Amsterdam Public Health Research Institute) ; Meggy, Alun (Cardiff University) ; Pastor, Ana Belén (BT-CIEN) ; Espinosa, Ana (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Corma-Gómez, Anaïs (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Martín Montes, Angel (Hospital Universitario La Paz (Madrid)) ; Sanabria, Ángela (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; DeStefano, Anita L. (Boston University School of Public Health) ; Schneider, Anja (German Center for Neurodegenerative Diseases (DZNE)) ; Haapasalo, Annakaisa (University of Eastern Finland) ; Kinhult Ståhlbom, Anne (Karolinska University Hospital and Karolinska Institutet (Suecia)) ; Tybjærg-Hansen, Anne (University of Copenhagen) ; Hartmann, Annette M. (Martin-Luther-University Halle-Wittenberg) ; Spottke, Annika (University of Bonn) ; Corbatón-Anchuelo, Arturo (Hospital Clínico San Carlos (Madrid)) ; Rongve, Arvid (University of Bergen) ; Borroni, Barbara (University of Brescia) ; Arosio, Beatrice (IRCCS Ospedale Maggiore Policlinico) ; Nacmias, Benedetta (IRCCS Fondazione Don Carlo Gnocchi) ; Nordestgaard, Børge G. (Herlev Gentofte Hospital) ; Kunkle, Brian W. (University of Miami Miller School of Medicine) ; Charbonnier, Camille (Normandie Univ) ; Abdelnour, Carla (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Masullo, Carlo (Catholic University of the Sacred Heart) ; Martínez Rodríguez, Carmen (Hospital Universitario de Cabueñes (Gijón)) ; Muñoz-Fernandez, Carmen (Hospital Universitario de Gran Canaria Dr.Negrín) ; Dufouil, Carole (CHU de Bordeaux) ; Graff, Caroline (Karolinska University Hospital and Karolinska Institutet (Suecia)) ; Ferreira, Catarina B. (Universidade de Lisboa) ; Chillotti, Caterina (University Hospital of Cagliari) ; Reynolds, Chandra A. (University of California-Riverside) ; Fenoglio, Chiara (University of Milan) ; Van Broeckhoven, Christine (University of Antwerp) ; Clark, Christopher (University of Zürich) ; Pisanu, Claudia (University of Cagliari) ; Satizabal, Claudia L. (UT Health San Antonio) ; Holmes, Clive (University of Southampton) ; Buiza-Rueda, Dolores (Instituto de Biomedicina de Sevilla) ; Aarsland, Dag (Stavanger University Hospital) ; Rujescu, Dan (Martin-Luther-University Halle-Wittenberg) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Galimberti, Daniela (Ospedale Policlinico) ; Wallon, David (Normandie Univ) ; Seripa, Davide (Complex Structure of Geriatrics) ; Grünblatt, Edna (University of Zurich) ; Dardiotis, Efthimios (University of Thessaly) ; Düzel, Emrah (Otto-von-Guericke University) ; Scarpini, Elio (Ospedale Policlinico, Milan, Italy) ; Conti, Elisa (University of Milano-Bicocca and Milan Center for Neuroscience) ; Rubino, Elisa (AOU Città della Salute e della Scienza di Torino) ; Gelpi, Ellen (Medical University of Vienna) ; Rodríguez-Rodríguez, Eloy (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Duron, Emmanuelle (Hôpital Broca) ; Boerwinkle, Eric (Baylor College of Medicine) ; Ferri, Evelyn (IRCCS Ospedale Maggiore Policlinico) ; Tagliavini, Fabrizio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Küçükali, Fahri (University of Antwerp) ; Pasquier, Florence (CHU CNR-MAJ) ; Sanchez-Garcia, Florentino (Hospital Universitario de Gran Canaria Dr. Negrín) ; Mangialasche, Francesca (Karolinska Institutet (Estocolm, Suècia)) ; Jessen, Frank (University of Cologne) ; Nicolas, Gaël (Hospital Universitario de Cabueñes (Gijón)) ; Selbæk, Geir (University of Oslo) ; Ortega, Gemma (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Chêne, Geneviève (CHU de Bordeaux) ; Hadjigeorgiou, Georgios (University of Cyprus) ; Rossi, Giacomina (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Spalletta, Gianfranco (Baylor College of Medicine) ; Giaccone, Giorgio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Grande, Giulia (Karolinska Institutet and Stockholm University) ; Binetti, Giuliano (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Papenberg, Goran (Karolinska Institutet and Stockholm University) ; Hampel, Harald (Sorbonne University) ; Bailly, Henri (Université Paris Descartes) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ; Soininen, Hilkka (Kuopio University Hospital ( Finlàndia)) ; Karlsson, Ida K. (Jönköping University) ; Alvarez, Ignacio (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Appollonio, Ildebrando (Ospedale San Gerardo (Itàlia)) ; Giegling, Ina (Martin-Luther-University Halle-Wittenberg) ; Skoog, Ingmar (University of Gothenburg) ; Saltvedt, Ingvild (Norwegian University of Science and Technhology) ; Rainero, Innocenzo (University of Torino) ; Rosas Allende, Irene (Hospital Universitario Central de Asturias) ; Hort, Jakub (St. Anne's University Hospital Brno) ; Diehl-Schmid, Janine (Technical University of Munich) ; Van Dongen, Jasper (Institute Born-Bunge) ; Vidal, Jean-Sébastien (Université Paris Descartes) ; Lehtisalo, Jenni (Finnish Institute for Health and Welfare) ; Wiltfang, Jens (University of Aveiro) ; Thomassen, Jesper Qvist (Copenhagen University Hospital Rigshospitalet) ; Kornhuber, Johannes (Friedrich-Alexander Universität Erlangen-Nürnberg) ; Haines, Jonathan L. (Case Western Reserve University) ; Vogelgsang, Jonathan (Harvard Medical School) ; Pineda, Juan A. (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Popp, Julius (Lausanne University Hospital) ; Deckert, Jürgen (University Hospital) ; Buerger, Katharina (German Center for Neurodegenerative Diseases) ; Morgan, Kevin (University of Nottingham) ; Fließbach, Klaus (University Clinic Bonn) ; Sleegers, Kristel (University of Antwerp) ; Molina-Porcel, Laura (Hospital Clínic i Provincial de Barcelona) ; Kilander, Lena (Uppsala) ; Weinhold, Leonie (University Hospital of Bonn) ; Farrer, Lindsay A. (Boston University Schools of Medicine and Public Health) ; Wang, Li-San (University of Pennsylvania Perelman School of Medicine) ; Kleineidam, Luca (University Clinic Bonn) ; Farotti, Lucia (University of Perugia) ; Parnetti, Lucilla (University of Perugia) ; Tremolizzo, Lucio (Ospedale San Gerardo (Itàlia)) ; Hausner, Lucrezia (University of Heidelberg) ; Benussi, Luisa (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Froelich, Lutz (University of Heidelberg) ; Ikram, M. Arfan (Erasmus Medical Center) ; Deniz-Naranjo, M. Candida (Hospital Universitario de Gran Canaria Dr. Negrín) ; Tsolaki, Magda (1st Department of Neurology Aristotle University of Thessaloniki) ; Rosende-Roca, Maitée (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Löwenmark, Malin (Uppsala) ; Hulsman, Marc (Vrije Universiteit Amsterdam) ; Spallazzi, Marco (Azienda Ospedaliero-Universitaria) ; Pericak-Vance, Margaret A (University of Miami Miller School of Medicine) ; Esiri, Margaret (Nuffield Department of Clinical Neurosciences) ; Bernal Sánchez-Arjona, María (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Dalmasso, Maria Carolina (University of Cologne) ; Martínez-Larrad, María Teresa (Hospital Clínico San Carlos (Madrid)) ; Arcaro, Marina (Ospedale Policlinico) ; Nöthen, Markus M. (University of Bonn) ; Fernández-Fuertes, Marta (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Dichgans, Martin (Munich Cluster for Systems Neurology (SyNergy)) ; Ingelsson, Martin (Uppsala) ; Herrmann, Martin J. (University Hospital) ; Scherer, Martin (University Medical Centre Hamburg-Eppendorf) ; Vyhnalek, Martin (St. Anne's University Hospital Brno) ; Kosmidis, Mary H. (Aristotle University of Thessaloniki) ; Yannakoulia, Mary (Harokopio University) ; Schmid, Matthias (University Hospital of Bonn) ; Ewers, Michael (German Center for Neurodegenerative Diseases (DZNE)) ; Heneka, Michael T. (German Center for Neurodegenerative Diseases (DZNE)) ; Wagner, Michael (German Center for Neurodegenerative Diseases (DZNE)) ; Scamosci, Michela (University of Perugia) ; Kivipelto, Miia (Stockholms Sjukhem) ; Hiltunen, Mikko (University of Eastern Finland) ; Zulaica, Miren (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Alegret, Montserrat (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Fornage, Myriam (University of Texas Health Sciences Center at Houston) ; Roberto, Natalia (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; van Schoor, Natasja M. (Amsterdam Public Health Research Institute) ; Seidu, Nazib M. (University of Gothenburg) ; Banaj, Nerisa (IRCCS Santa Lucia Foundation) ; Armstrong, Nicola (Murdoch University) ; Scarmeas, Nikolaos (Columbia University) ; Scherbaum, Norbert (University of Duisburg-Essen) ; Goldhardt, Oliver (Technical University of Munich) ; Hanon, Olivier (Université Paris Descartes) ; Peters, Oliver (German Center for Neurodegenerative Diseases) ; Skrobot, Olivia Anna (Southmead Hospital) ; Quenez, Olivier (Normandie Univ) ; Lerch, Ondrej (St. Anne's University Hospital Brno) ; Bossù, Paola (IRCCS Santa Lucia Foundation) ; Caffarra, Paolo (University of Parma) ; Dionigi Rossi, Paolo (IRCCS Ospedale Maggiore Policlinico) ; Sakka, Paraskevi (Athens Association of Alzheimer's disease and Related Disorders) ; Mecocci, Patrizia (University of Perugia) ; Hoffmann, Per (University Hospital Basel (Basilea, Suïssa)) ; Holmans, Peter (Cardiff University) ; Fischer, Peter (Social Medicine Center East- Donauspital) ; Riederer, Peter (University Hospital of Würzburg) ; Yang, Qiong (Boston University School of Public Health) ; Marshall, Rachel (Cardiff University) ; Kalaria, Rajesh N. (Campus for Ageing anf Vitality) ; Mayeux, Richard (Columbia University) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; Cecchetti, Roberta (University of Perugia) ; Ghidoni, Roberta (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Frikke-Schmidt, Ruth (University of Copenhagen) ; Sorbi, Sandro (IRCCS Fondazione Don Carlo Gnocchi) ; Hägg, Sara (Karolinska Institutet (Estocolm, Suècia)) ; Engelborghs, Sebastiaan (VUB University Hospital Brussels) ; Helisalmi, Seppo (University of Eastern Finland) ; Botne Sando, Sigrid (Norwegian University of Science and Technology) ; Kern, Silke (University of Gothenburg) ; Archetti, Silvana (Brescia Hospital) ; Boschi, Silvia (University of Torino) ; Fostinelli, Silvia (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Gil, Silvia (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Mendoza, Silvia (Instituto Andaluz de Neurociencia) ; Mead, Simon (University College London. Institute of Prion Diseases) ; Ciccone, Simona (IRCCS Ospedale Maggiore Policlinico) ; Djurovic, Srdjan (University of Bergen) ; Heilmann-Heimbach, Stefanie (School of Medicine & University Hospital Bonn) ; Riedel-Heller, Steffi (University of Leipzig) ; Kuulasmaa, Teemu (University of Eastern Finland) ; del Ser, Teodoro (Fundación Reina Sofía) ; Lebouvier, Thibaud (CHU CNR-MAJ) ; Polak, Thomas (University Hospital) ; Ngandu, Tiia (Finnish Institute for Health and Welfare) ; Grimmer, Timo (Technical University of Munich) ; Bessi, Valentina (Azienda Ospedaliero-Universitaria Careggi Largo Brambilla) ; Escott-Price, Valentina (Cardiff University) ; Giedraitis, Vilmantas (Uppsala) ; Deramecourt, Vincent (CHU CNR-MAJ) ; Maier, Wolfgang (German Center for Neurodegenerative Diseases) ; Jian, Xueqiu (Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Pijnenburg, Yolande A. L. (Vrije Universiteit Amsterdam) ; Kehoe, Patrick Gavin (University of Bristol) ; García-Ribas, Guillermo (Hospital Universitario Ramón y Cajal (Madrid)) ; Sánchez-Juan, Pascual (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Pérez-Tur, Jordi (Instituto de Investigación Sanitaria La Fe) ; Piñol-Ripoll, Gerard (Institut de Recerca Biomedica de Lleida (IRBLLeida)) ; Lopez de Munain, Adolfo (Hospital de Donostia (Sant Sebastià, País Basc)) ; García-Alberca, Jose María (Instituto Andaluz de Neurociencia) ; Bullido, María J (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ; Álvarez, Victoria (Hospital Universitario Central de Asturias) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Real, Luis M. (Universidad de Málaga) ; Mir, Pablo (Instituto de Biomedicina de Sevilla) ; Medina, Miguel (Fundación Reina Sofía) ; Scheltens, Philip (Vrije Universiteit Amsterdam) ; Holstege, Henne (Vrije Universiteit Amsterdam) ; Marquié, Marta (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Sáez, María Eugenia (Centro Andaluz de Estudios Bioinformáticos) ; Carracedo, Ángel (Fundación Pública Galega de Medicina Xenómica) ; Amouyel, Philippe (Institut Pasteur de Lille) ; Schellenberg, Gerard D. (University of Pennsylvania Perelman School of Medicine) ; Williams, Julie (Cardiff University) ; Seshadri, Sudha (Framingham Heart Study) ; van Duijn, Cornelia M. (University of Oxford) ; Mather, Karen A (Neuroscience Research Australia) ; Sanchez-Valle, Raquel (Hospital Clínic i Provincial de Barcelona) ; Serrano-Ríos, Manuel (Hospital Clínico San Carlos (Madrid)) ; Orellana, Adelina (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Tárraga, Lluís (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Blennow, Kaj (Sahlgrenska Academy at the University of Gothenburg) ; Huisman, Martijn A (VU University) ; Andreassen, Ole A. (Oslo University Hospital (Oslo, Noruega)) ; Posthuma, Danielle (VU University) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Boada, Mercè (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; van der Flier, Wiesje M (Vrije Universiteit Amsterdam) ; Ramirez, Alfredo (Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Lambert, Jean-Charles (Institut Pasteur de Lille) ; van der Lee, Sven J. (Vrije Universiteit Amsterdam) ; Ruiz, Agustín (National Institute of Health Carlos III) ; Universitat Autònoma de Barcelona
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. [...]
2023 - 10.1038/s41467-023-36192-x
Nature communications, Vol. 14 (february 2023)  
4.
33 p, 4.9 MB New insights into the genetic etiology of Alzheimer's disease and related dementias / Bellenguez, Céline (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Küçükali, Fahri (University of Antwerp) ; Jansen, Iris E. (Department of Complex Trait Genetics. Center for Neurogenomics and Cognitive Research. Amsterdam Neuroscience. Vrije University) ; Kleineidam, Luca (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Moreno-Grau, Sonia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Amin, Najaf (Nuffield Department of Population Health. Oxford University) ; Naj, Adam C. (University of Pennsylvania Perelman School of Medicine) ; Campos-Martin, Rafael (Universität zu Köln (Colònia, Alemaya). Department of Psychiatry and Psychotherapy) ; Grenier-Boley, Benjamin (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Andrade, Victor (Universität zu Köln (Colònia, Alemaya). Department of Psychiatry and Psychotherapy) ; Holmans, Peter (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Boland, Anne (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Damotte, Vincent (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; van der Lee, Sven J. (Vrije Universiteit Amsterdam) ; Costa, Marcos R. (Brain Institute. Federal University of Rio Grande do Norte) ; Kuulasmaa, Teemu (Institute of Biomedicine. University of Eastern Finland) ; Yang, Qiong (Framingham Heart Study) ; De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Bis, Joshua C (Cardiovascular Health Research Unit. Department of Medicine. University of Washington) ; Yaqub, Amber (Department of Epidemiology. Erasmus MC) ; Prokic, Ivana (Department of Epidemiology. Erasmus MC) ; Chapuis, Julien (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Ahmad, Shahzad (LACDR) ; Giedraitis, Vilmantas (Department of Public Health and Carins Sciences/Geriatrics. Uppsala University) ; Aarsland, Dag (Institute of Psychiatry. Psychology & Neuroscience) ; Garcia-Gonzalez, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Abdelnour, Carla (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Alarcón-Martín, Emilio (Department of Surgery. Biochemistry and Molecular Biology. School of Medicine. University of Málaga) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Alvarez, Ignacio (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Alvarez, Victoria (Hospital Universitario Central de Asturias) ; Armstrong, Nicola (Curtin University) ; Tsolaki, Anthoula (Alzheimer Hellas) ; Antúnez, Carmen (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Appollonio, Ildebrando (Neurology Unit. San Gerardo Hospital) ; Arcaro, Marina (Fondazione IRCCS Ca'Granda. Ospedale Policlinico) ; Archetti, Silvana (Department of Laboratory Diagnostics. III Laboratory of Analysis. Brescia Hospital) ; Pastor, Alfonso A. (Institut de Recerca Biomedica de Lleida (IRBLLeida)) ; Arosio, Beatrice (Geriatic Unit. Fondazione Cà Granda. IRCCS Ospedale Maggiore Policlinico) ; Athanasiu, Lavinia (NORMENT Centre. University of Oslo) ; Bailly, Henri (EA 4468. Université de Paris. APHP. Hôpital Broca) ; Banaj, Nerisa (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Baquero, Miquel (Hospital Universitari i Politècnic La Fe (València)) ; Barral, Sandra (Gertrude H. Sergievsky Center. Columbia University) ; Beiser, Alexa (Boston University and the NHLBI's Framingham Heart Study) ; Pastor, Ana Belén (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Below, Jennifer E. (Human Genetics Center. Department of Epidemiology. Human Genetics. and Environmental Sciences. School of Public Health. The University of Texas Health Science Center at Houston) ; Benchek, Penelope (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Benussi, Luisa (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Berr, Claudine (Université Montpellier, INSERM, Institute for Neurosciences of Montpellier) ; Besse, Céline (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Bessi, Valentina (Azienda Ospedaliero-Universitaria Careggi) ; Binetti, Giuliano (MAC - Memory Clinic. IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Bizarro, Alessandra (Geriatrics Unit. Fondazione Policlinico A. Gemelli IRCCS) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Boerwinkle, Eric (Baylor College of Medicine) ; Borroni, Barbara (Centre for Neurodegenerative Disorders. Department of Clinical and Experimental Sciences. University of Brescia) ; Boschi, Silvia (Department of Neuroscience "Rita Levi Montalcini". University of Torino) ; Bossù, Paola (Experimental Neuro-psychobiology Laboratory. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Bråthen, Geir (Department of Neuromedicine and Movement Science. Norwegian University of Science and Technology) ; Bressler, Jan (School of Public Health. University of Texas Health Science Center at Houston) ; Bresner, Catherine (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Brodaty, Henry (Dementia Centre for Research Collaboration. School of Psychiatry. University of New South Wales) ; Brookes, Keeley J. (Biosciences. School of Science and Technology. Nottingham Trent University) ; Brusco, Luis Ignacio (Hospital Interzonal General de Agudos Eva Perón. San Martín) ; Buiza-Rueda, Dolores (Department of Neurology. Erasmus MC) ; Bûrger, Katharina (German Center for Neurodegenerative Diseases (DZNE. Munich)) ; Burholt, Vanessa (Wales Centre for Ageing & Dementia Research. Swansea University) ; Bush, William S. (Department of Population & Quantitative Health Sciences. Case Western Reserve University) ; Calero, Miguel (UFIEC. Instituto de Salud Carlos III) ; Cantwell, Laura B (Department of Pathology and Laboratory Medicine. University of Pennsylvania) ; Chene, Geneviève (Pole Santé Publique. CHU de Bordeaux) ; Chung, Jaeyoon (Department of Medicine (Biomedical Genetics). Boston University School of Medicine) ; Cuccaro, MichaelL. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Carracedo, Ángel (Fundación Pública Galega de Medicina Xenómica- CIBERER-IDIS. University of Santiago de Compostela) ; Cecchetti, Roberta (Institute of Gerontology and Geriatrics. Department of Medicine and Surgery. University of Perugia) ; Cervera Carles, Laura (Institut d'Investigació Biomèdica Sant Pau) ; Charbonnier, Camille (Department of Genetics and CNR-MAJ. Normandie University. UNIROUEN. INSERM U1245. CHU Rouen) ; Chen, Hung-Hsin (Division of Genetic Medicine. Vanderbilt University) ; Chillotti, Caterina (Unit of Clinical Pharmacology. University Hospital of Cagliari) ; Ciccone, Simona (Geriatic Unit. Fondazione Cà Granda. IRCCS Ospedale Maggiore Policlinico) ; Claassen, Jurgen A.H.R. (Radboudumc Alzheimer Center. Department of Geriatrics. Radboud University Medical Center) ; Clark, Christopher (Institute for Regenerative Medicine. University of Zürich) ; Conti, Elisa (School of Medicine and Surgery. University of Milano-Bicocca) ; Corma-Gómez, Anaïs (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Costantini, Emanuele (Department of Neuroscience. Catholic University of Sacred Heart. Fondazione Policlinico Universitario A. Gemelli IRCCS) ; Custodero, Carlo (University of Bari. "A. Moro") ; Daian, Delphine (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Dalmasso, Maria Carolina (Universität zu Köln (Colònia, Alemaya). Department of Psychiatry and Psychotherapy) ; Daniele, Antonio (Department of Neuroscience. Catholic University of Sacred Heart. Fondazione Policlinico Universitario A. Gemelli IRCCS) ; Dardiotis, Efthimios (School of Medicine. University of Thessaly) ; Dartigues, Jean-François (Bordeaux Population Health Research Center. University Bordeaux. INSERM) ; de Deyn, Peter Paul (Department of Neurology. University Medical Center Groningen) ; de Paiva Lopes, Katia (Department of Psychiatry. Icahn School of Medicine at Mount Sinai) ; de Witte, Lot D. (Department of Psychiatry. Icahn School of Medicine at Mount Sinai) ; Debette, Stéphanie (Bordeaux Population Health Research Center. University Bordeaux. INSERM) ; Deckert, Jürgen (Department of Psychiatry. Psychosomatics and Psychotherapy. Center of Mental Health. University Hospital) ; del Ser, Teodoro (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Denning, Nicola (UKDRI@ Cardiff. School of Medicine. Cardiff University) ; DeStefano, Anita (Department of Neurology. Boston University School of Medicine) ; Dichgans, Martin (Munich Cluster for Systems Neurology (SyNergy)) ; Diehl-Schmid, Janine (Klinikum rechts der Isar. Department of Psychiatry and Psychotherapy. Technical University of Munich. School of Medicine) ; Diez-Fairen, Mónica (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Rossi, Paolo Dionigi (Geriatic Unit. Fondazione Cà Granda. IRCCS Ospedale Maggiore Policlinico) ; Djurovic, Srdjan (NORMENT Centre. University of Oslo) ; Duron, Emmanuelle (EA 4468. Université de Paris. APHP. Hôpital Broca) ; Düzel, Emrah (German Center for Neurodegenerative Diseases (DZNE)) ; Dufouil, Carole (Pole Santé Publique. CHU de Bordeaux) ; Eiriksdottir, Gundy (Icelandic Heart Association) ; Engelborghs, Sebastiaan (Department of Neurology. UZ Brussel) ; Escott-Price, Valentina (UKDRI@ Cardiff. School of Medicine. Cardiff University) ; Espinosa, Ana (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Ewers, Michael (German Center for Neurodegenerative Diseases (DZNE. Munich)) ; Faber, Kelley M. (Department of Medical and Molecular Genetics. Indiana University) ; Fabrizio, Tagliavini (Fondazione IRCCS. Istituto Neurologico Carlo Besta) ; Nielsen, Sune Fallgaard (Department of Clinical Biochemistry. Herlev and Gentofte Hospital) ; Fardo, David W. (Sanders-Brown Center on Aging. Department of Biostatistics. University of Kentucky) ; Farotti, Lucia (Centre for Memory Disturbances. Lab of Clinical Neurochemistry. Section of Neurology. University of Perugia) ; Fenoglio, Chiara (University of Milan) ; Fernández-Fuertes, Marta (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Ferrari, Raffaele (UCL Institute of Neurology (Regne Unit)) ; Ferreira, Catarina B. (Faculty of Medicine. University of Lisbon) ; Ferri, Evelyn (Geriatic Unit. Fondazione Cà Granda. IRCCS Ospedale Maggiore Policlinico) ; Fin, Bertrand (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Fischer, Peter (Department of Psychiatry. Social Medicine Center East- Donauspital) ; Fladby, Tormod (Institute of Clinical Medicine. University of Oslo) ; Fließbach, Klaus (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Fongang, Bernard (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Fornage, Myriam (School of Public Health. University of Texas Health Science Center at Houston) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Foroud, Tatiana M. (Department of Medical and Molecular Genetics. Indiana University) ; Fostinelli, Silvia (Molecular Markers Laboratory. IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Fox, Nick C. (Dementia Research Centre. UCL Queen Square Institute of Neurology) ; Franco-Macías, Emilio (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Bullido, María J. (Centro de Biología Molecular Severo Ochoa (UAM-CSIC)) ; Frank-García, Ana (Hospital Universitario La Paz (Madrid)) ; Froelich, Lutz (Department of Geriatric Psychiatry. Central Institute for Mental Health. Mannheim. University of Heidelberg) ; Fulton-Howard, Brian (Department of Neuroscience. Ronald M. Loeb Center for Alzheimer's Disease. Icahn School of Medicine at Mount Sinai) ; Galimberti, Daniela (University of Milan) ; García-Alberca, Jose Maria (Instituto Andaluz de Neurociencia) ; García-González, Pablo (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Garcia-Madrona, Sebastian (Hospital Universitario Ramón y Cajal (Madrid)) ; Garcia-Ribas, Guillermo (Hospital Universitario Ramón y Cajal (Madrid)) ; Ghidoni, Roberta (Molecular Markers Laboratory. IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Giegling, Ina (Department of Psychiatry and Psychotherapy. Medical University of Vienna) ; Giorgio, Giaccone (Fondazione IRCCS. Istituto Neurologico Carlo Besta) ; Goate, Alison M. (Department of Genetics and Genomic Sciences. Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai) ; Goldhardt, Oliver (Klinikum rechts der Isar. Department of Psychiatry and Psychotherapy. Technical University of Munich. School of Medicine) ; Gomez-Fonseca, Duber (Department of Biostatistics. Epidemiology. and Informatics Perelman School of Medicine. University of Pennsylvania) ; González-Pérez, Antonio (CAEBI. Centro Andaluz de Estudios Bioinformáticos) ; Graff, Caroline (Unit for Hereditary Dementias. Karolinska University Hospital-Solna) ; Grande, Giulia (Aging Research Center. Department of Neurobiology. Care Sciences and Society. Karolinska Institutet and Stockholm University) ; Green, Emma (Institute of Public Health. University of Cambridge) ; Grimmer, Timo (Klinikum rechts der Isar. Department of Psychiatry and Psychotherapy. Technical University of Munich. School of Medicine) ; Grünblatt, Edna (Zurich Center for Integrative Human Physiology. University of Zurich) ; Grunin, Michelle (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Gudnason, Vilmundur (Icelandic Heart Association. Faculty of Medicine. University of Iceland) ; Guetta-Baranes, Tamar (Human Genetics. School of Life Sciences. Life Sciences Building. University Park. University of Nottingham) ; Haapasalo, Annakaisa (AI Virtanen Institute for Molecular Sciences. University of Eastern Finland) ; Hadjigeorgiou, Georgios (Department of Neurology. Medical School. University of Cyprus) ; Haines, Jonathan L. (Department of Population & Quantitative Health Sciences. Case Western Reserve University) ; Hamilton-Nelson, Kara L. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Hampel, Harald (GRC 21. Alzheimer Precision Medicine Initiative (APMI). Sorbonne University. AP-HP. Pitié-Salpêtrière Hospital) ; Hanon, Olivier (EA 4468. Université de Paris. APHP. Hôpital Broca) ; Hardy, John (UCL Institute of Neurology (Regne Unit)) ; Hartmann, Annette M. (Department of Psychiatry and Psychotherapy. Medical University of Vienna) ; Hausner, Lucrezia (Department of Geriatric Psychiatry. Central Institute for Mental Health. Mannheim. University of Heidelberg) ; Harwood, Janet (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Heilmann-Heimbach, Stefanie (Institute of Human Genetics. University of Bonn. School of Medicine & University Hospital Bonn) ; Helisalmi, Seppo (Institute of Clinical Medicine. Internal Medicine. University of Eastern Finland) ; Heneka, Michael T. (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Hernández, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Herrmann, Martin J. (Department of Psychiatry. Psychosomatics and Psychotherapy. Center of Mental Health. University Hospital) ; Hoffmann, Per (Institute of Human Genetics. University of Bonn. School of Medicine & University Hospital Bonn) ; Holmes, Clive (Clinical and Experimental Science. Faculty of Medicine. University of Southampton) ; Holstege, Henne (Section Genomics of Neurodegenerative Diseases and Aging. Department of Human Genetics Amsterdam UMC. Vrije Universiteit Amsterdam. Amsterdam UMC) ; Huerto Vilas, Raquel (Institut de Recerca Biomedica de Lleida (IRBLLeida)) ; Hulsman, Marc (Section Genomics of Neurodegenerative Diseases and Aging. Department of Human Genetics Amsterdam UMC. Vrije Universiteit Amsterdam. Amsterdam UMC) ; Humphrey, Jack (Nash Family Department of Neuroscience & Friedman Brain Institute. Icahn School of Medicine at Mount Sinai) ; Biessels, Geert Jan (Department of Neurology. UMC Utrecht Brain Center) ; Jian, Xueqiu (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Johansson, Charlotte (Center for Alzheimer Research. Department NVS. Division of Neurogeriatrics. Karolinska Institutet) ; Jun, Gyungah R. (Medicine Biomedical Genetics Boston University School of Medicine) ; Kastumata, Yuriko (Biostatistics. University of Kentucky College of Public Health) ; Kauwe, John (Department of Biology. Brigham Young University) ; Kehoe, Patrick G. (Translational Health Sciences. Bristol Medical School. University of Bristol) ; Kilander, Lena (Department of Biostatistics. Boston University School of Public Health) ; Ståhlbom, Anne Kinhult (Center for Alzheimer Research. Department NVS. Division of Neurogeriatrics. Karolinska Institutet) ; Kivipelto, Miia (Research & Development. UnitStockholms Sjukhem) ; Koivisto, Anne (Department of Neurosciences. University of Helsinki and Department of Geriatrics. Helsinki University Hospital) ; Kornhuber, Johannes (Department of Psychiatry and Psychotherapy. Universitätsklinikum Erlangen. and Friedrich-Alexander Universität Erlangen-Nürnberg) ; Kosmidis, Mary H. (Laboratory of Cognitive Neuroscience. School of Psychology. Aristotle University of Thessaloniki) ; Kukull, Walter A. (Department of Epidemiology. University of Washington) ; Kuksa, Pavel P. (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; Kunkle, Brian W. (Department of Neurology. Medical School. University of Cyprus) ; Kuzma, Amanda B. (Department of Pathology and Laboratory Medicine. University of Pennsylvania) ; Lage, Carmen (Service of Neurology. University Hospital Marqués de Valdecilla. IDIVAL. University of Cantabria) ; Laukka, Erika J. (Stockholm Gerontology Research Center) ; Launer, Lenore (Intramural Research Program/National Institute on Aging/National Institutes of Health) ; Lauria, Alessandra (Geriatrics Unit. Fondazione Policlinico A. Gemelli IRCCS) ; Lee, Chien-Yueh (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; Lehtisalo, Jenni (Public Health Promotion Unit. Finnish Institute for Health and Welfare) ; Lerch, Ondrej (International Clinical Research Center. St. Anne's University Hospital Brno) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Longstreth, William (Departments of Neurology and Epidemiology. University of Washington) ; Lopez, Oscar (Framingham Heart Study) ; Lopez de Munain, Adolfo (Department of Neurology. Hospital Universitario Donostia. OSAKIDETZA-Servicio Vasco de Salud) ; Love, Seth (Translational Health Sciences. Bristol Medical School. University of Bristol) ; Löwemark, Malin (Department of Biostatistics. Boston University School of Public Health) ; Luckcuck, Lauren (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Lunetta, Kathryn L. (Institute of Biomedicine. University of Eastern Finland) ; Ma, Yiyi (Department of Neurology. Columbia University) ; Macías, Juan (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; MacLeod, Catherine A. (School of Health Sciences. Bangor University) ; Maier, Wolfgang (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Mangialasche, Francesca (Division of Clinical Geriatrics. Center for Alzheimer Research. Care Sciences and Society (NVS). Karolinska Institutet) ; Spallazzi, Marco (Unit of Neurology. University of Parma and AOU) ; Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Marshall, Rachel (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Martin, Eden R. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Martín Montes, Angel (Hospital Universitario La Paz (Madrid)) ; Martínez Rodríguez, Carmen (Servicio de Neurología. Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias) ; Masullo, Carlo (Institute of Neurology. Catholic University of the Sacred Heart) ; Mayeux, Richard (Gertrude H. Sergievsky Center. Columbia University) ; Mead, Simon (MRC Prion Unit at UCL. UCL Institute of Prion Diseases) ; Mecocci, Patrizia (Institute of Gerontology and Geriatrics. Department of Medicine and Surgery. University of Perugia) ; Medina, Miguel (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Meggy, Alun (UKDRI@ Cardiff. School of Medicine. Cardiff University) ; Mehrabian, Shima (Clinic of Neurology. UH 'Alexandrovska'. Medical University - Sofia) ; Mendoza, Silvia (Instituto Andaluz de Neurociencia) ; Menéndez-González, Manuel (Servicio de Neurología. Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias) ; Mir, Pablo (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Moebus, Susanne (Institute for Urban Public Health. University Hospital of University Duisburg-Essen) ; Mol, Merel (Department of Neurology. Erasmus MC) ; Molina-Porcel, Laura (Alzheimer's Disease and Other Cognitive Disorders Unit. Neurology Department. Hospital Clinic) ; Montrreal, Laura (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Morelli, Laura (Laboratory of Brain Aging and Neurodegeneration. FIL-CONICET) ; Moreno, Fermin (Department of Neurology. Hospital Universitario Donostia. OSAKIDETZA-Servicio Vasco de Salud) ; Morgan, Kevin (Human Genetics. School of Life Sciences. University of Nottingham) ; Mosley, Thomas (Memory Impairment and Neurodegenerative Dementia (MIND) Center. University of Mississippi Medical Center) ; Nöthen, Markus M. (Institute of Human Genetics. University of Bonn. School of Medicine & University Hospital Bonn) ; Muchnik, Carolina (Instituto de Investigaciones Médicas Alfredo Lanari (Buenos Aires, Argentina)) ; Mukherjee, Shubhabrata (Department of Medicine. University of Washington) ; Nacmias, Benedetta (IRCCS Fondazione Don Carlo Gnocchi) ; Ngandu, Tiia (Public Health Promotion Unit. Finnish Institute for Health and Welfare) ; Nicolas, Gael (Department of Genetics and CNR-MAJ. Normandie University. UNIROUEN. INSERM U1245. CHU Rouen) ; Nordestgaard, Børge G. (Department of Clinical Medicine. University of Copenhagen) ; Olaso, Robert (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Orsini, Michela (Department of Neuroscience. Catholic University of Sacred Heart. Fondazione Policlinico Universitario A. Gemelli IRCCS) ; Ortega, Gemma (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Padovani, Alessandro (Human Genome Sequencing Center. Baylor College of Medicine) ; Paolo, Caffarra (DIMEC. University of Parma) ; Papenberg, Goran (Aging Research Center. Department of Neurobiology. Care Sciences and Society. Karolinska Institutet and Stockholm University) ; Parnetti, Lucilla (Centre for Memory Disturbances. Lab of Clinical Neurochemistry. Section of Neurology. University of Perugia) ; Pasquier, Florence (Resources and Research Memory Center (MRRC) of Distalz. LicendUniversity of Lille. INSERM. CHU Lille. UMR1172) ; Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Peloso, Gina (Boston University and the NHLBI's Framingham Heart Study) ; Pérez-Cordón, Alba (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Pérez-Tur, Jordi (Unitat Mixta de de Neurología y Genética. Institut d'Investigació Sanitària La Fe) ; Pericard, Pierre (US 41-UMS 2014-PLBS. bilille. Université de Lille. CNRS. INSERM. CHU Lille. Institut Pasteur de Lille) ; Peters, Oliver (German Center for Neurodegenerative Diseases (DZNE)) ; Pijnenburg, Yolande A.L. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Vrije Universiteit Amsterdam. Amsterdam UMC) ; Pineda, Juan A. (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Piñol-Ripoll, Gerard (Institut de Recerca Biomedica de Lleida (IRBLLeida)) ; Pisanu, Claudia (Department of Biomedical Sciences. University of Cagliari) ; Polak, Thomas (Department of Psychiatry. Psychosomatics and Psychotherapy. Center of Mental Health. University Hospital) ; Popp, Julius (Department of Geriatric Psychiatry. University Hospital of Psychiatry Zürich) ; Posthuma, Danielle (Department of Complex Trait Genetics. Center for Neurogenomics and Cognitive Research. Amsterdam Neuroscience. Vrije University) ; Priller, Josef (Department of Neuropsychiatry and Laboratory of Molecular Psychiatry. Charité. Charitéplatz 1) ; Puerta, Raquel (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Quenez, Olivier (Department of Genetics and CNR-MAJ. Normandie University. UNIROUEN. INSERM U1245. CHU Rouen) ; Quintela, Inés (Grupo de Medicina Xenómica. Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII). Universidade de Santiago de Compostela) ; Thomassen, Jesper Qvist (Department of Clinical Biochemistry. Rigshospitalet) ; Rábano, Alberto (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Rainero, Innocenzo (Centre for Neurodegenerative Disorders. Department of Clinical and Experimental Sciences. University of Brescia) ; Rajabli, Farid (The John P. Hussman Institute for Human Genomics. University of Miami) ; Ramakers, Inez (Department of Psychiatry & Neuropsychologie. Maastricht University. Alzheimer Center Limburg) ; Real, Luis M. (Depatamento de Especialidades Quirúrgicas Bioquímica e Inmunología. Facultad de Medicina. Universidad de Málaga) ; Reinders, Marcel J.T. (Delft Bioinformatics Lab. Delft University of Technology) ; Reitz, Christiane (Taub Institute. Columbia University) ; Reyes-Dumeyer, Dolly (Taub Institute. Columbia University) ; Ridge, Perry (Bioinformatics. College of Life Sciences. Brigham Young University) ; Riedel-Heller, Steffi (Institute of Social Medicine. Occupational Health and Public Health. University of Leipzig) ; Riederer, Peter (Center of Mental Health. Clinic and Policlinic of Psychiatry. Psychosomatics and Psychotherapy. University Hospital of Würzburg) ; Roberto, Natalia (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Rodriguez-Rodriguez, Eloy (Instituto de Investigación Sanitaria Valdecilla (Santander, País Basc)) ; Rongve, Arvid (Institute of Clinical Medicine (K1). The University of Bergen) ; Rosas Allende, Irene (Servicio de Neurología. Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias) ; Rosende-Roca, Maitée (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Royo, Jose Luis (Departamento de Especialidades Quirúrgicas. Bioquímicas e Inmunología. School of Medicine. University of Málaga) ; Rubino, Elisa (Department of Neuroscience and Mental Health. AOU Città della Salute e della Scienza di Torino) ; Rujescu, Dan (Department of Psychiatry and Psychotherapy. Medical University of Vienna) ; Sáez, María Eugenia (CAEBI. Centro Andaluz de Estudios Bioinformáticos) ; Sakka, Paraskevi (Athens Association of Alzheimer's Disease and Related Disorders) ; Saltvedt, Ingvild (Department of Geriatrics. St. Olav's Hospital. Trondheim University Hospital) ; Sanabria, Ángela (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Sánchez-Arjona, Maria B. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Sanchez-Garcia, Florentino (Department of Immunology. Hospital Universitario Doctor Negrín. Las Palmas de Gran Canaria) ; Sánchez Juan, Pacual (Instituto de Investigación Sanitaria Valdecilla (Santander, País Basc)) ; Sánchez-Valle, Raquel (Neurology Department-Hospital Clínic. IDIBAPS. Universitat de Barcelona) ; Sando, Sigrid B. (Department of Neurology and Clinical Neurophysiology. University Hospital of Trondheim) ; Sarnowski, Chloé (Human Genetics Center. School of Public Health. University of Texas Health Science Center at Houston) ; Satizabal, Claudia L. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Scamosci, Michela (Institute of Gerontology and Geriatrics. Department of Medicine and Surgery. University of Perugia) ; Scarmeas, Nikolaos (First Department of Neurology. Aiginition Hospital. National and Kapodistrian University of Athens. Medical School) ; Scarpini, Elio (University of Milan) ; Scheltens, Philip (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Vrije Universiteit Amsterdam. Amsterdam UMC) ; Scherbaum, Norbert (LVR-Hospital Essen. Department of Psychiatry and Psychotherapy. Medical Faculty. University of Duisburg-Essen) ; Scherer, Martin (Department of Primary Medical Care. University Medical Centre Hamburg-Eppendorf) ; Schmid, Matthias (Institute of Medical Biometry. Informatics and Epidemiology. University Hospital of Bonn) ; Schneider, Anja (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Schott, Jonathan M. (Dementia Research Centre. UCL Queen Square Institute of Neurology) ; Selbæk, Geir (Department of Geriatric Medicine. Oslo University Hospital) ; Seripa, Davide (Laboratory for Advanced Hematological Diagnostics. Department of Hematology and Stem Cell Transplant. Vito Fazzi Hospital) ; Serrano, Manuel (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas. CIBERDEM. Hospital Clínico San Carlos) ; Sha, Jin (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Shadrin, Alexey A. (NORMENT Centre. University of Oslo) ; Skrobot, Olivia (Translational Health Sciences. Bristol Medical School. University of Bristol) ; Slifer, Susan H. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Snijders, Gijsje J.L. (Department of Psychiatry. Icahn School of Medicine at Mount Sinai) ; Soininen, Hilkka (Institute of Clinical Medicine. Neurology. University of Eastern) ; Solfrizzi, Vincenzo (University of Bari. "A. Moro") ; Solomon, Alina (Division of Clinical Geriatrics. Center for Alzheimer Research. Care Sciences and Society (NVS). Karolinska Institutet) ; Song, Yeunjoo (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Sorbi, Sandro (IRCCS Fondazione Don Carlo Gnocchi) ; Sotolongo Grau, Oscar (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Spalletta, Gianfranco (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Spottke, Annika (Department of Neurology. University of Bonn) ; Squassina, Alessio (Department of Biomedical Sciences. Section of Neuroscience and Clinical Pharmacology. University of Cagliari) ; Stordal, Eystein (Department of Psychiatry. Namsos Hospital) ; Tartan, Juan Pablo (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Tesí, Niccolo (Section Genomics of Neurodegenerative Diseases and Aging. Department of Human Genetics Amsterdam UMC. Vrije Universiteit Amsterdam. Amsterdam UMC) ; Thalamuthu, Anbupalam (Centre for Healthy Brain Ageing. School of Psychiatry. Faculty of Medicine. University of New South Wales) ; Thomas, Tegos (Alzheimer Hellas) ; Tosto, Giuseppe (Department of Neurology. Columbia University) ; Traykov, Latchezar (Clinic of Neurology. UH 'Alexandrovska'. Medical University - Sofia) ; Tremolizzo, Lucio (Neurology Unit. San Gerardo Hospital) ; Tybjærg-Hansen, Anne (Department of Clinical Biochemistry. Rigshospitalet) ; Uitterlinden, Andre (Department of Internal Medicine and Biostatistics. Erasmus MC) ; Ullgren, Abbe (Center for Alzheimer Research. Department NVS. Division of Neurogeriatrics. Karolinska Institutet) ; Ulstein, Ingun (Department of Geriatric Medicine. Oslo University Hospital) ; Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Valladares, Otto (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; Van Broeckhoven, Christine (Neurodegenerative Brain Diseases Group. VIB Center for Molecular Neurology. VIB) ; Vance, Jeffery (Dr. John T. Macdonald Foundation Department of Human Genetics. University of Miami) ; Vardarajan, Badri N. (Taub Institute on Alzheimer's Disease and the Aging Brain. Department of Neurology. Columbia University) ; van der Lugt, Aad (Department of Neurology. ErasmusMC) ; Van Dongen, Jasper (Department of Biomedical Sciences. University of Antwerp) ; van Rooij, Jeroen (Department of Neurology. ErasmusMC) ; van Swieten, John (Department of Neurology. Erasmus MC) ; Vandenberghe, Rik (Neurology Department. University Hospitals Leuven) ; Verhey, Frans (Department of Psychiatry & Neuropsychologie. Maastricht University. Alzheimer Center Limburg) ; Vidal, Jean-Sébastien (EA 4468. Université de Paris. APHP. Hôpital Broca) ; Vogelgsang, Jonathan (Department of Psychiatry. Harvard Medical School. McLean Hospital) ; Vyhnalek, Martin (International Clinical Research Center. St. Anne's University Hospital Brno) ; Wagner, Michael (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Wallon, David (Department of Neurology and CNR-MAJ. F 76000. Normandy Center for Genomic and Personalized Medicine. Normandie University. UNIROUEN. INSERM U1245. CHU Rouen) ; Wang, Li-San (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; Wang, Ruiqi (Department of Biostatistics. Boston University School of Public Health) ; Weinhold, Leonie (Institute of Medical Biometry. Informatics and Epidemiology. University Hospital of Bonn) ; Wiltfang, Jens (Medical Science Department. iBiMED) ; Windle, Gill (School of Health Sciences. Bangor University) ; Woods, Bob (School of Health Sciences. Bangor University) ; Yannakoulia, Mary (Department of Nutrition and Diatetics. Harokopio University) ; Zare, Habil (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Zhao, Yi (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Zhang, Xiaoling (Department of Medicine (Biomedical Genetics). Boston University School of Medicine) ; Zhu, Congcong (Department of Medicine (Biomedical Genetics). Boston University School of Medicine) ; Zulaica, Miren (Neurosciences Area. Instituto Biodonostia) ; Laczo, Jan (International Clinical Research Center. St. Anne's University Hospital Brno) ; Matoska, Vaclav (Department of Clinical Biochemistry. Hematology and Immunology. Na Homolce Hospital) ; Serpente, Maria (University of Milan) ; Assogna, Francesca (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Piras, Fabrizio (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Ciullo, Valentina (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Shofany, Jacob (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Ferrarese, Carlo (Neurology Unit. San Gerardo Hospital) ; Andreoni, Simona (School of Medicine and Surgery. University of Milano-Bicocca) ; Sala, Gessica (School of Medicine and Surgery. University of Milano-Bicocca) ; Zoia, Chiara Paola (School of Medicine and Surgery. University of Milano-Bicocca) ; Zompo, Maria del (Department of Biomedical Sciences. Section of Neuroscience and Clinical Pharmacology. University of Cagliari) ; Benussi, Alberto (Centre for Neurodegenerative Disorders. Department of Clinical and Experimental Sciences. University of Brescia) ; Bastiani, Patrizia (Institute of Gerontology and Geriatrics. Department of Medicine. University of Perugia) ; Takalo, Mari (Insitute of Biomedicine. University of Eastern Finland) ; Natunen, Teemu (Insitute of Biomedicine. University of Eastern Finland) ; Laatikainen, Tiina (Public Health Promotion Unit. Finnish Institute for Health and Welfare) ; Tuomilehto, Jaakko (Public Health Promotion Unit. Finnish Institute for Health and Welfare) ; Antikainen, Riitta (Medical Research Center Oulu. Oulu University Hospital) ; Strandberg, Timo (Helsinki University Hospital) ; Lindström, Jaana (Public Health Promotion Unit. Finnish Institute for Health and Welfare) ; Peltonen, Markku (Public Health Promotion Unit. Finnish Institute for Health and Welfare) ; Abraham, Richard (Division of Psychological Medicine and Clinial Neurosciences. MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University) ; Al-Chalabi, Ammar (Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ; Bass, Nicholas J. (Division of Psychiatry. University College London) ; Brayne, Carol (Institute of Public Health. University of Cambridge) ; Brown, Kristelle S. (Institute of Genetics. Queens Medical Centre. University of Nottingham) ; Collinge, John (MRC Prion Unit at UCL. UCL Institute of Prion Diseases) ; Craig, David (Ageing Group. Centre for Public Health. School of Medicine. Dentistry and Biomedical Sciences. Queen's University Belfast) ; Deloukas, Pangiotis (The Wellcome Trust Sanger Institute. Wellcome Trust Genome Campus. Hinxton) ; Fox, Nick (Dementia Research Centre. Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Gerrish, Amy (Dementia Research Centre. Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Gill, Michael (Mercer's Institute for Research on Ageing. St James' Hospital) ; Gwilliam, Rhian (The Wellcome Trust Sanger Institute. Wellcome Trust Genome Campus. Hinxton) ; Harold, Denise (School of Biotechnology. Dublin City University) ; Hollingworth, Paul (Division of Psychological Medicine and Clinial Neurosciences. MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University) ; Johnston, Jarret A. (Centre for Public Health. School of Medicine. Dentistry and Biomedical Sciences. Queens University) ; Jones, Lesley (Division of Psychological Medicine and Clinial Neurosciences. MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University) ; Lawlor, Brian (Mercer's Institute for Research on Ageing. St James' Hospital) ; Livingston, Gill (Division of Psychiatry. University College London) ; Lovestone, Simon (Department of Psychiatry. University of Oxford) ; Lupton, Michelle (Department of Basic and Clinical Neuroscience. Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ; Lynch, Aoibhinn (Mercer's Institute for Research on Ageing. St James' Hospital) ; Mann, David (Division of Neuroscience and Experimental Psychology. School of Biological Sciences. Faculty of Biology. Medicine and Health. University of Manchester. Manchester Academic Health Science Centre) ; McGuinness, Bernadette (Centre for Public Health. School of Medicine. Dentistry and Biomedical Sciences. Queens University) ; McQuillin, Andrew (Division of Psychiatry. University College London) ; O'Donovan, Michael C. (Division of Psychological Medicine and Clinial Neurosciences. MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University) ; Owen, Michael J. (Division of Psychological Medicine and Clinial Neurosciences. MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University) ; Passmore, Peter (Centre for Public Health. School of Medicine. Dentistry and Biomedical Sciences. Queens University) ; Powell, John F. (Department of Basic and Clinical Neuroscience. Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ; Proitsi, Petra (Department of Basic and Clinical Neuroscience. Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ; Rossor, Martin (Dementia Research Centre. Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Shaw, Christopher E. (Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ; Smith, A. David (Oxford Project to Investigate Memory and Ageing (OPTIMA). University of Oxford. Level 4. John Radcliffe Hospital) ; Gurling, Hugh (Department of Mental Health Sciences. University College London) ; Todd, Stephen (Ageing Group. Centre for Public Health. School of Medicine. Dentistry and Biomedical Sciences. Queen's University Belfast) ; Mummery, Catherine (Dementia Research Centre. UCL) ; Ryan, Nathalie (Dementia Research Centre. UCL) ; Lacidogna, Giordano (Department of Neuroscience. Catholic University of Sacred Heart. Fondazione Policlinico Universitario A. Gemelli IRCCS) ; Adarmes-Gómez, A.D (Department of Neurology. Erasmus MC) ; Mauleón, Ana (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Pancho, Ana (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Gailhajenet, Anna (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Lafuente, Asunción (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Macias-García, D. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Martín, Elvira (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Pelejá, Esther (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Carrillo, F. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Sastre Merlín, Isabel (Centro de Biología Molecular Severo Ochoa (UAM-CSIC)) ; Garrote-Espina, L. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Vargas, Liliana (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Carrión-Claro, M. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Marín, M. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Labrador, Ma (Department of Neurology. Erasmus MC) ; Buendia, Mar (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Alonso, María Dolores (Servei de Neurologia. Hospital Clínic Universitari de València) ; Guitart, Marina (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Moreno, Mariona (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Ibarria, Marta (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Periñán, Mt (Department of Neurology. Erasmus MC) ; Aguilera, Nuria (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Gómez-Garre, P. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Cañabate, Pilar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Escuela, R. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Pineda-Sánchez, R. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Vigo-Ortega, R. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Jesús, S. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Preckler, S. (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Rodrigo-Herrero, S. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Diego, Susana (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Vacca, Alessandro (Department of Neuroscience "Rita Levi Montalcini". University of Torino) ; Roveta, F. (Department of Neuroscience "Rita Levi Montalcini". University of Torino) ; Salvadori, N. (Institute of Cognitive Neurology and Dementia Research (IKND). Otto-Von-Guericke University) ; Chipi, E. (Institute of Cognitive Neurology and Dementia Research (IKND). Otto-Von-Guericke University) ; Boecker, H. (Department of Radiology. University Hospital Bonn) ; Laske, C. (Section for Dementia Research. Department of Psychiatry. Hertie Institute for Clinical Brain Research) ; Perneczky, R. (Department of Psychiatry and Psychotherapy. University Hospital. LMU Munich) ; Anastasiou, C. (Department of Nutrition and Diatetics. Harokopio University) ; Janowitz, D. (Institute for Stroke and Dementia Research. Klinikum der Universität München. Ludwig Maximilians Universität (LMU)) ; Malik, R. (Institute for Stroke and Dementia Research. Klinikum der Universität München. Ludwig Maximilians Universität (LMU)) ; Anastasiou, A. (First Department of Neurology. Medical School. Aristotle University of Thessaloniki) ; Parveen, K. (Department of Neurodegenerative Diseases and Geriatric Psychiatry. University Hospital Bonn) ; Lage, C. (Service of Neurology. University Hospital Marqués de Valdecilla. IDIVAL. University of Cantabria) ; López-García, S. (Service of Neurology. University Hospital Marqués de Valdecilla. IDIVAL. University of Cantabria) ; Antonell, A. (Neurology Department-Hospital Clínic. IDIBAPS. Universitat de Barcelona) ; Mihova, K.Y. (Molecular Medicine Center. Department of Medical chemistry and biochemistry. Medical University of Sofia) ; Belezhanska, D. (Clinic of Neurology. UH 'Alexandrovska'. Medical University - Sofia) ; Weber, H. (Department of Psychiatry. Psychosomatics and Psychotherapy. Center of Mental Health. University Hospital of Würzburg) ; Kochen, S. (ENYS (Estudio en Neurociencias y Sistemas Complejos) CONICET- Hospital El Cruce "Nestor Kirchner"- UNAJ) ; Solis, P. (ENYS (Estudio en Neurociencias y Sistemas Complejos) CONICET- Hospital El Cruce "Nestor Kirchner"- UNAJ) ; Medel, N. (ENYS (Estudio en Neurociencias y Sistemas Complejos) CONICET- Hospital El Cruce "Nestor Kirchner"- UNAJ) ; Lisso, J. (ENYS (Estudio en Neurociencias y Sistemas Complejos) CONICET- Hospital El Cruce "Nestor Kirchner"- UNAJ) ; Sevillano, Z. (ENYS (Estudio en Neurociencias y Sistemas Complejos) CONICET- Hospital El Cruce "Nestor Kirchner"- UNAJ) ; Politis, D.G. (HIGA Eva Perón) ; Cores, V. (HIGA Eva Perón) ; Cuesta, C. (HIGA Eva Perón) ; Ortiz, C. (Neurología Clinica) ; Bacha, J.I. (Neurología Clinica) ; Rios, M. (Dirección de Atención de Adultos Mayores del Min. Salud Desarrollo Social y Deportes de la Pcia. de Mendoza) ; Saenz, A. (Dirección de Atención de Adultos Mayores del Min. Salud Desarrollo Social y Deportes de la Pcia. de Mendoza) ; Abalos, M.S. (Laboratorio de Genética Forense del Ministerio Público de la Pcia de La Pampa) ; Kohler, E. (Fundacion Sinapsis) ; Palacio, D.L. (Hospital Dr. Lucio Molas. Santa Rosa; Fundacion Ayuda Enfermo Renal y Alta Complejidad (FERNAC)) ; Etchepareborda, I. (Hospital Dr. Lucio Molas. Santa Rosa; Fundacion Ayuda Enfermo Renal y Alta Complejidad (FERNAC)) ; Kohler, M. (Hospital Dr. Lucio Molas. Santa Rosa; Fundacion Ayuda Enfermo Renal y Alta Complejidad (FERNAC)) ; Novack, G. (Laboratory of Brain Aging and Neurodegeneration (FIL)) ; Prestia, F.A. (Laboratory of Brain Aging and Neurodegeneration (FIL)) ; Galeano, P. (Laboratory of Brain Aging and Neurodegeneration (FIL)) ; Castaño, E.M. (Laboratory of Brain Aging and Neurodegeneration (FIL)) ; Germani, S. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A.) ; Toso, C.R. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A.) ; Rojo, M. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A.) ; Ingino, C. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A.) ; Mangone, C. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A.) ; Rubinsztein, D.C. (Cambridge Institute for Medical Research and UK Dementia Research Institute. University of Cambridge) ; Teipel, S. (German Center for Neurodegenerative Diseases (DZNE)) ; Fievet, N. (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Deramerourt, V. (Resources and Research Memory Center (MRRC) of Distalz. LicendUniversity of Lille. INSERM. CHU Lille. UMR1172) ; Forsell, C. (Unit for Hereditary Dementias. Karolinska University Hospital-Solna) ; Thonberg, H. (Unit for Hereditary Dementias. Karolinska University Hospital-Solna) ; Bjerke, M. (Grupo de Medicina Xenómica. Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII). Universidade de Santiago de Compostela) ; Roeck, E.D. (Grupo de Medicina Xenómica. Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII). Universidade de Santiago de Compostela) ; Martínez-Larrad, M.T. (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas. CIBERDEM. Hospital Clínico San Carlos) ; Olivar, N. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A.) ; Aguilera, N. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Cano, A. (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Cañabate, P. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Macias, J. (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Maroñas, O. (Grupo de Medicina Xen'omica. Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII). Universidad de Santiago de Compostela) ; Nuñez-Llaves, R. (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Olivé, C. (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Pelejá, E. (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Adarmes-Gómez, A.D (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Alonso, M.D. (Servei de Neurologia. Hospital Clínic Universitari de València) ; Amer-Ferrer, G. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ; Antequera, M. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Burguera, J.A. (Hospital Universitari i Politècnic La Fe (València)) ; Carrillo, F. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Carrión-Claro, M. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Casajeros, M.J. (Hospital Universitario Ramón y Cajal (Madrid)) ; Martinez de Pancorbo, M. (BIOMICs. País Vasco; Centro de Investigación Lascaray. Universidad del País Vasco UPV/EHU) ; Escuela, R. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Garrote-Espina, L. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Gómez-Garre, P. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Hevilla, S. (Instituto Andaluz de Neurociencia) ; Jesús, S. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Espinosa, M.A.L. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Legaz, A. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; López-García, S. (Service of Neurology. University Hospital Marqués de Valdecilla. IDIVAL. University of Cantabria) ; Macias-García, D. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Manzanares, S. (Fundación para la Formación e Investigación Sanitarias de la Región de Murcia) ; Marín, M. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Marín-Muñoz, J. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Marín, T. (Instituto Andaluz de Neurociencia) ; Martínez, B. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Martínez, V. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Martínez-Lage Álvarez, P. (Centro de Investigación y Terapias Avanzadas. Fundación CITA-Alzheimer) ; Iriarte, M.M. (Navarrabiomed) ; Periñán-Tocino, M.T. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Pineda-Sánchez, R. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Real de Asúa, D. (Hospital Universitario de la Princesa (Madrid)) ; Rodrigo, S. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Sastre, I. (Centro de Biología Molecular Severo Ochoa (UAM-CSIC)) ; Vicente, M. P. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Vigo-Ortega, R. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Vivancos, L. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Epelbaum, J. (UMR 7179 CNRS/MNHN) ; Hannequin, D. (Department of Neurology and CNR-MAJ. F 76000. Normandy Center for Genomic and Personalized Medicine. Normandie University. UNIROUEN. INSERM U1245. CHU Rouen) ; campion, D. (Department of Genetics and CNR-MAJ. Normandie University. UNIROUEN. INSERM U1245. CHU Rouen) ; Deramecourt, V. (Resources and Research Memory Center (MRRC) of Distalz. LicendUniversity of Lille. INSERM. CHU Lille. UMR1172) ; Tzourio, C. (Bordeaux Population Health Research Center. University Bordeaux. INSERM) ; Brice, A. (Sorbonne Université. Paris Brain Institute. APHP. INSERM. CNRS) ; Dubois, B. (Department of Neurology. Institute of Memory and Alzheimer's Disease (IM2A). Pitié-Salpêtrière Hospital. AP-HP. Boulevard de l'Hôpital) ; Williams, A. (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Thomas, C. (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Davies, C. (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Nash, W. (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Dowzell, K. (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Morales, A.C. (UKDRI@ Cardiff. School of Medicine. Cardiff University) ; Bernardo-Harrington, M. (UKDRI@ Cardiff. School of Medicine. Cardiff University) ; Turton, J. (Institute of Genetics. Queen's Medical Centre. University of Nottingham) ; Lord, J. (Institute of Genetics. Queen's Medical Centre. University of Nottingham) ; Brown, K. (Institute of Genetics. Queens Medical Centre. University of Nottingham) ; Vardy, E. (Institute for Ageing and Health. Newcastle University. Campus for Ageing and Vitality) ; Fisher, E. (Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Warren, J.D. (Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Rossor, M. (Dementia Research Centre. Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Ryan, N.S. (Dementia Research Centre. UCL) ; Guerreiro, R. (Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Uphill, J. (MRC Prion Unit at UCL. UCL Institute of Prion Diseases) ; Bass, N. (Division of Psychiatry. University College London) ; Heun, R. (Department of Old Age Psychiatry. Institute of Psychiatry. Psychology and Neuroscience. King's College London) ; Kölsch, H. (Department of Psychiatry and Psychotherapy. University of Bonn) ; Schürmann, B. (Department of Psychiatry and Psychotherapy. University of Bonn) ; Lacour, A. (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Herold, C. (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Johnston, J.A. (Centre for Public Health. School of Medicine. Dentistry and Biomedical Sciences. Queens University) ; Passmore, P. (Centre for Public Health. School of Medicine. Dentistry and Biomedical Sciences. Queens University) ; Powell, J. (Department of Basic and Clinical Neuroscience. Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ; Patel, Y. (University of Toronto) ; Hodges, A. (Department of Old Age Psychiatry. Institute of Psychiatry. Psychology and Neuroscience. King's College London) ; Becker, T. (Institute for Medical Biometry. Informatics and Epidemiology. University of Bonn) ; Warden, D. (Oxford Project to Investigate Memory and Ageing (OPTIMA). University of Oxford. Level 4. John Radcliffe Hospital) ; Wilcock, G. (Oxford Project to Investigate Memory and Ageing (OPTIMA). University of Oxford. Level 4. John Radcliffe Hospital) ; Clarke, R. (Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Deloukas, P. (The Wellcome Trust Sanger Institute. Wellcome Trust Genome Campus. Hinxton) ; Ben-Shlomo, Y. (Population Health Sciences. Bristol Medical School. University of Bristol) ; Hooper, N.M. (Division of Neuroscience and Experimental Psychology. School of Biological Sciences. Faculty of Biology. Medicine and Health. University of Manchester. Manchester Academic Health Science Centre) ; Pickering-Brown, S. (University of Manchester. Manchester Academic Health Science Centre) ; Sussams, R. (Division of Clinical Neurosciences. School of Medicine. University of Southampton) ; Warner, N. (Somerset Partnership NHS Trust) ; Bayer, A. (Institute of Primary Care and Public Health. Cardiff University. University Hospital of Wales) ; Heuser, I. (Department of Psychiatry and Psychotherapy. Charité University Medicine) ; Drichel, D. (Universität zu Köln (Colònia, Alemaya). Cologne Center for Genomics) ; Klopp, N. (Institute of Epidemiology. Helmholtz Zentrum München. German Research Center for Environmental Health. Neuherberg) ; Mayhaus, M. (Department of Psychiatry and Psychotherapy. University Hospital) ; Riemenschneider, M. (Department of Psychiatry and Psychotherapy. University Hospital) ; Pinchler, S. (Department of Psychiatry and Psychotherapy. University Hospital) ; Feulner, T. (Department of Psychiatry and Psychotherapy. University Hospital) ; Gu, W. (Department of Psychiatry and Psychotherapy. University Hospital) ; van den Bussche, H. (Department of Primary Medical Care. University Medical Centre Hamburg-Eppendorf) ; Hüll, M. (Department of Psychiatry. University of Freiburg) ; Frölich, L. (Central Institute of Mental Health. Medical Faculty Mannheim. University of Heidelberg) ; Wichmann, H.E. (Institute of Epidemiology. Helmholtz Zentrum München. German Research Center for Environmental Health. Neuherberg) ; Jöckel, K.H. (Institute for Medical Informatics. Biometry and Epidemiology. University Hospital of Essen. University Duisburg-Essen) ; O'Donovan, M. (Division of Psychological Medicine and Clinial Neurosciences. MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University) ; Owen, M. (Division of Psychological Medicine and Clinial Neurosciences. MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University) ; Bahrami, S. (Division of Mental Health and Addiction. Oslo University Hospital) ; Bosnes, I. (Department of Psychiatry. Hospital Namsos. Nord-Trøndelag Health Trust) ; Selnes, P. (Department of Neurology. Akershus University Hospital) ; Bergh, S. (Centre for Old Age Psychiatry Research. Innlandet Hospital Trust) ; Palotie, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Daly, M. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Jacob, H. (AbbVie) ; Matakidou, A. (Astra Zeneca) ; Runz, H. (Biogen) ; John, S. (Biogen) ; Plenge, R. (Celgene) ; McCarthy, M. (Genentech) ; Hunkapiller, J. (Genentech) ; Ehm, M. (GlaxoSmithKline) ; Waterworth, D. (GlaxoSmithKline) ; Fox, C. (Merck) ; Malarstig, A. (Pfizer) ; Klinger, K. (Sanofi) ; Call, K. (Sanofi) ; Behrens, T. (Maze Therapeutics) ; Loerch, P. (Janssen Biotech) ; Mäkelä, T. (HiLIFE. University of Helsinki) ; Kaprio, Jaakko (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Virolainen, P. (Auria Biobank. University of Turku. Hospital District of Southwest Finland) ; Pulkki, K. (Auria Biobank. University of Turku. Hospital District of Southwest Finland) ; Kilpi, T. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Perola, M. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Partanen, J. (Finnish Red Cross Blood Service. Finnish Hematology Registry and Clinical Biobank) ; Pitkäranta, A. (Helsinki Biobank. Helsinki University and Hospital District of Helsinki and Uusimaa) ; Kaarteenaho, R. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Vainio, S. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Turpeinen, M. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Serpi, R. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Laitinen, T. (Oxford Healthy Aging Project. Clinical Trial Service Unit. University of Oxford) ; Mäkelä, J. (Finnish Clinical Biobank Tampere. University of Tampere. Pirkanmaa Hospital District) ; Kosma, V.M. (Biobank of Eastern Finland. University of Eastern Finland / Northern Savo Hospital District) ; Kujala, U. (Central Finland Biobank. University of Jyväskylä. Central Finland Health Care District) ; Tuovila, O. (Business Finland) ; Hendolin, M. (Business Finland) ; Pakkanen, R. (Business Finland) ; Waring, J. (AbbVie) ; Riley-Gillis, B. (AbbVie) ; Liu, J. (Biogen) ; Biswas, S. (Celgene) ; Diogo, D. (Merck) ; Marshall, C. (Pfizer) ; Hu, X. (Pfizer) ; Gossel, M. (Sanofi) ; Graham, R. (Maze Therapeutics) ; Cummings, B. (Janssen Biotech) ; Ripatti, Samuli (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Schleutker, J. (Auria Biobank. University of Turku. Hospital District of Southwest Finland) ; Arvas, M. (Finnish Red Cross Blood Service. Finnish Hematology Registry and Clinical Biobank) ; Carpén, O. (Helsinki Biobank. Helsinki University and Hospital District of Helsinki and Uusimaa) ; Hinttala, R. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Kettunen, J. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Mannermaa, A. (Biobank of Eastern Finland. University of Eastern Finland / Northern Savo Hospital District) ; Laukkanen, J. (Central Finland Biobank. University of Jyväskylä. Central Finland Health Care District) ; Julkunen, V. (Northern Savo Hospital District) ; Remes, A. (Northern Savo Hospital District) ; Kälviäinen, R. (Northern Savo Hospital District) ; Peltola, J. (Pirkanmaa Hospital District) ; Tienari, P. (Hospital District of Helsinki and Uusimaa) ; Rinne, J. (Hospital District of Southwest Finland) ; Ziemann, A. (AbbVie) ; Waring, J. (AbbVie) ; Esmaeeli, S. (AbbVie) ; Smaoui, N. (AbbVie) ; Lehtonen, A. (AbbVie) ; Eaton, S. (Biogen) ; Lahdenperä, S. (Biogen) ; van Adelsberg, J. (Celgene) ; Michon, J. (Genentech) ; Kerchner, G. (Genentech) ; Bowers, N. (Genentech) ; Teng, E. (Genentech) ; Eicher, J. (Genentech) ; Mehta, V. (Merck) ; Gormley, P. (Merck) ; Linden, K. (Pfizer) ; Whelan, C. (Pfizer) ; Xu, F. (GlaxoSmithKline) ; Pulford, D. (GlaxoSmithKline) ; Färkkilä, M. (Hospital District of Helsinki and Uusimaa) ; Pikkarainen, S. (Hospital District of Helsinki and Uusimaa) ; Jussila, A. (Pirkanmaa Hospital District) ; Blomster, T. (Northern Ostrobothnia Hospital District) ; Kiviniemi, M. (Northern Savo Hospital District) ; Voutilainen, M. (Hospital District of Southwest Finland) ; Georgantas, B. (AbbVie) ; Heap, G. (AbbVie) ; Rahimov, F. (AbbVie) ; Usiskin, K. (Celgene) ; Lu, T. (Department of Complex Trait Genetics. Center for Neurogenomics and Cognitive Research. Amsterdam Neuroscience. Vrije University) ; Oh, D. (Genentech) ; Kalpala, K. (Pfizer) ; Miller, M. (Pfizer) ; McCarthy, L. (GlaxoSmithKline) ; Eklund, K. (Hospital District of Helsinki and Uusimaa) ; Palomäki, A. (Hospital District of Southwest Finland) ; Isomäki, P. (Pirkanmaa Hospital District) ; Pirilä, L. (Hospital District of Southwest Finland) ; Kaipiainen-Seppänen, O. (Northern Savo Hospital District) ; Huhtakangas, J. (Northern Ostrobothnia Hospital District) ; Lertratanakul, A. (AbbVie) ; Hochfeld, M. (Celgene) ; Bing, N. (Pfizer) ; Gordillo, J.E. (GlaxoSmithKline) ; Mars, N. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Pelkonen, M. (Northern Savo Hospital District) ; Kauppi, P. (Hospital District of Helsinki and Uusimaa) ; Kankaanranta, H. (Pirkanmaa Hospital District) ; Harju, T. (Northern Ostrobothnia Hospital District) ; Close, D. (Astra Zeneca) ; Greenberg, S. (Celgene) ; Chen, H. (Genentech) ; Betts, J. (GlaxoSmithKline) ; Ghosh, S. (GlaxoSmithKline) ; Salomaa, V. (The National Institute of Health and Welfare Helsinki) ; Niiranen, T. (The National Institute of Health and Welfare Helsinki) ; Juonala, M. (Hospital District of Southwest Finland) ; Metsärinne, K. (Hospital District of Southwest Finland) ; Kähönen, M. (Pirkanmaa Hospital District) ; Junttila, J. (Northern Ostrobothnia Hospital District) ; Laakso, Markku (Northern Savo Hospital District) ; Pihlajamäki, J. (Northern Savo Hospital District) ; Sinisalo, J. (Hospital District of Helsinki and Uusimaa) ; Taskinen, M.R. (Hospital District of Helsinki and Uusimaa) ; Tuomi, T. (Hospital District of Helsinki and Uusimaa) ; Challis, B. (Astra Zeneca) ; Peterson, A. (Genentech) ; Chu, A. (Merck) ; Parkkinen, J. (Pfizer) ; Muslin, A. (Sanofi) ; Joensuu, H. (Hospital District of Helsinki and Uusimaa) ; Meretoja, T. (Hospital District of Helsinki and Uusimaa) ; Aaltonen, L. (Hospital District of Helsinki and Uusimaa) ; Mattson, J. (Hospital District of Helsinki and Uusimaa) ; Auranen, A. (Pirkanmaa Hospital District) ; Karihtala, P. (Northern Ostrobothnia Hospital District) ; Kauppila, S. (Northern Ostrobothnia Hospital District) ; Auvinen, P. (Northern Ostrobothnia Hospital District) ; Elenius, K. (Hospital District of Southwest Finland) ; Popovic, R. (AbbVie) ; Schutzman, J. (Genentech) ; Loboda, A. (Merck) ; Chhibber, A. (Merck) ; Lehtonen, H. (Pfizer) ; McDonough, S. (Pfizer Worldwide Research and Development) ; Crohns, M. (Sanofi) ; Kulkarni, D. (GlaxoSmithKline) ; Kaarniranta, K. (Northern Savo Hospital District) ; Turunen, J.A. (Hospital District of Helsinki and Uusimaa) ; Ollila, T. (Hospital District of Helsinki and Uusimaa) ; Seitsonen, S. (Hospital District of Helsinki and Uusimaa) ; Uusitalo, H. (Pirkanmaa Hospital District) ; Aaltonen, V. (Hospital District of Southwest Finland) ; Uusitalo-Järvinen, H. (Pirkanmaa Hospital District) ; Luodonpää, M. (Northern Ostrobothnia Hospital District) ; Hautala, N. (Northern Ostrobothnia Hospital District) ; Loomis, S. (Biogen) ; Strauss, E. (Genentech) ; Chen, H. (Genentech) ; Podgornaia, A. (Merck) ; Hoffman, J. (GlaxoSmithKline) ; Tasanen, K. (Northern Ostrobothnia Hospital District) ; Huilaja, L. (Northern Ostrobothnia Hospital District) ; Hannula-Jouppi, K. (Hospital District of Helsinki and Uusimaa) ; Salmi, T. (Pirkanmaa Hospital District) ; Peltonen, S. (Hospital District of Helsinki and Uusimaa) ; Koulu, L. (Hospital District of Helsinki and Uusimaa) ; Harvima, I. (Northern Savo Hospital District) ; Wu, Y. (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Choy, D. (Genentech) ; Pussinen, P. (Hospital District of Helsinki and Uusimaa) ; Salminen, A. (Hospital District of Helsinki and Uusimaa) ; Salo, T. (Hospital District of Helsinki and Uusimaa) ; Rice, D. (Hospital District of Helsinki and Uusimaa) ; Nieminen, P. (Hospital District of Helsinki and Uusimaa) ; Palotie, U. (Hospital District of Helsinki and Uusimaa) ; Siponen, M. (Northern Savo Hospital District) ; Suominen, L. (Northern Savo Hospital District) ; Mäntylä, P. (Northern Savo Hospital District) ; Gursoy, U. (Hospital District of Southwest Finland) ; Anttonen, V. (Northern Ostrobothnia Hospital District) ; Sipilä, K. (Northern Ostrobothnia Hospital District) ; Davis, J.W. (AbbVie) ; Quarless, D. (AbbVie) ; Petrovski, S. (Astra Zeneca) ; Wigmore, E. (Astra Zeneca) ; Chen, C.Y. (Biogen) ; Bronson, P. (Biogen) ; Tsai, E. (Biogen) ; Huang, Y. (Biogen) ; Maranville, J. (Celgene) ; Shaikho, E. (Celgene) ; Mohammed, E. (Celgene) ; Wadhawan, S. (Bristol Myers Squibb) ; Kvikstad, E. (Bristol Myers Squibb) ; Caliskan, M. (Bristol Myers Squibb) ; Chang, D. (Genentech) ; Bhangale, T. (Genentech) ; Pendergrass, S. (Genentech) ; Holzinger, E. (Merck) ; Chen, X. (Pfizer) ; Hedman, Å. (Pfizer) ; King, K.S. (GlaxoSmithKline) ; Wang, C. (Sanofi) ; Xu, E. (Sanofi) ; Auge, F. (Sanofi) ; Chatelain, C. (Sanofi) ; Rajpal, D. (Sanofi) ; Liu, D. (Population Health Sciences. German Center for Neurodegenerative Diseases (DZNE)) ; Call, K. (Sanofi) ; Xia, T.h. (Sanofi) ; Brauer, M. (Maze Therapeutics) ; Kurki, M. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Karjalainen, J. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Havulinna, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Jalanko, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Palta, P. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; della Briotta Parolo, P. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Zhou, W. (Broad Institute) ; Lemmelä, S. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Rivas, M. (University of Stanford) ; Harju, J. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Lehistö, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Ganna, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Llorens, V. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Laivuori, H. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Rüeger, S. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Niemi, M.E. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Tukiainen, T. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Reeve, M.P. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Heyne, H. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Palin, K. (University of Helsinki) ; Garcia-Tabuenca, J. (University of Tampere) ; Siirtola, H. (University of Tampere) ; Kiiskinen, T. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Lee, J. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Tsuo, K. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Elliott, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Kristiansson, K. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Hyvärinen, K. (Finnish Red Cross Blood Service) ; Ritari, J. (Finnish Red Cross Blood Service) ; Koskinen, M. (Helsinki Biobank. Helsinki University and Hospital District of Helsinki and Uusimaa) ; Pylkäs, K. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Kalaoja, M. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Karjalainen, M. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Mantere, T. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Kangasniemi, E. (Finnish Clinical Biobank Tampere. University of Tampere. Pirkanmaa Hospital District) ; Heikkinen, S. (Biobank of Eastern Finland. University of Eastern Finland / Northern Savo Hospital District) ; Laakkonen, E. (Central Finland Biobank. University of Jyväskylä. Central Finland Health Care District) ; Sipeky, C. (University of Turku) ; Heron, S. (University of Turku) ; Karlsson, A. (Auria Biobank. University of Turku. Hospital District of Southwest Finland) ; Jambulingam, D. (University of Turku) ; Rathinakannan, V.S. (University of Turku) ; Kajanne, R. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Aavikko, M. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Jiménez, M.G. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; della Briotta Parola, P. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Lehistö, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Kanai, M. (Broad Institute) ; Kaunisto, M. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Kilpeläinen, E. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Sipilä, T.P. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Brein, G. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Awaisa, G. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Shcherban, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Donner, K. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Loukola, A. (Helsinki Biobank. Helsinki University and Hospital District of Helsinki and Uusimaa) ; Laiho, P. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Sistonen, T. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Kaiharju, E. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Laukkanen, M. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Järvensivu, E. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Lähteenmäki, S. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Männikkö, L. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Wong, R. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Mattsson, H. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Hiekkalinna, T. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Paajanen, T. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Pärn, K. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Gracia-Tabuenca, J. (University of Tampere) ; Abner, E. (Sanders-Brown Center on Aging. Department of Epidemiology. College of Public Health. University of Kentucky) ; Adams, P.M. (Department of Psychiatry. University of Texas Southwestern Medical Center) ; Aguirre, A. (Department of Neurology. Dell Medical School. University of Texas at Austin) ; Albert, M.S. (Department of Neurology. Johns Hopkins University) ; Albin, R.L. (Michigan Alzheimer's Disease Center. University of Michigan) ; Allen, M. (Department of Neuroscience. Mayo Clinic) ; Alvarez, L. (Department of Pharmacology and Neuroscience. University of North Texas Health Science Center) ; Apostolova, L.G. (Indiana Alzheimer's Disease Research Center. Indiana University School of Medicine) ; Arnold, S.E. (Department of Psychiatry. Perelman School of Medicine. University of Pennsylvania) ; Asthana, S. (Wisconsin Alzheimer's Disease Research Center) ; Atwood, C.S. (Wisconsin Alzheimer's Disease Research Center) ; Ayres, G. (Department of Neurology. Dell Medical School. University of Texas at Austin) ; Baldwin, C.T. (Department of Medicine (Biomedical Genetics). Boston University School of Medicine) ; Barber, R.C. (Department of Pharmacology and Neuroscience. University of North Texas Health Science Center) ; Barnes, L.L. (Rush Alzheimer's Disease Center. Rush University Medical Center) ; Barral, S. (Gertrude H. Sergievsky Center. Columbia University) ; Beach, T.G. (Civin Laboratory for Neuropathology. Banner Sun Health Research Institute) ; Beecham, G.W. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Beekly, D. (National Alzheimer's Coordinating Center. University of Washington) ; Below, J.E. (Human Genetics Center. Department of Epidemiology. Human Genetics. and Environmental Sciences. School of Public Health. The University of Texas Health Science Center at Houston) ; Benchek, P. (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Benitez, B.A. (Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration. Washington University School of Medicine) ; Bennett, D. (Rush Alzheimer's Disease Center. Rush University Medical Center) ; Bertelson, J. (Department of Psychiatry. University of Texas at Austin/Dell Medical School) ; Margaret, F.E. (Cognitive Neurology and Alzheimer's Disease Center. Northwestern University Feinberg School of Medicine) ; Bird, T.D. (VA Puget Sound Health Care System/GRECC) ; Blacker, D. (Department of Psychiatry. Massachusetts General Hospital/Harvard Medical School) ; Boeve, B.F. (Department of Neurology. Mayo Clinic) ; Bowen, J.D. (Swedish Medical Center) ; Boxer, A. (Department of Neurology. University of California San Francisco) ; Brewer, J. (Department of Neurosciences. University of California San Diego) ; Burke, J.R. (Department of Medicine. Duke University) ; Burns, J.M. (University of Kansas Alzheimer's Disease Center. University of Kansas Medical Center) ; Bush, W.S. (Department of Population & Quantitative Health Sciences. Case Western Reserve University) ; Buxbaum, J.D. (Nash Family Department of Neuroscience & Friedman Brain Institute. Icahn School of Medicine at Mount Sinai) ; Cairns, N.J. (Department of Pathology and Immunology. Washington University) ; Cao, C. (USF Health Byrd Alzheimer's Institute. University of South Florida) ; Carlson, C.S. (Fred Hutchinson Cancer Research Center) ; Carlsson, C.M. (Wisconsin Alzheimer's Disease Research Center) ; Carney, R.M. (Mental Health and Behavioral Science Service. Bruce W. Carter VA Medical Center) ; Carrasquillo, M.M. (Department of Neuroscience. Mayo Clinic) ; Chasse, S. (Department of Genetics. University of North Carolina at Chapel Hill) ; Chesselet, M.F. (Neurogenetics Program. University of California. Los Angeles) ; Chesi, A. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Chin, N.A. (Department of Medicine. University of Wisconsin) ; Chui, H.C. (Department of Neurology. University of Southern California) ; Craft, S. (Section of Gerontology and Geriatric Medicine Research. Wake Forest School of Medicine) ; Crane, P.K. (Department of Medicine. University of Washington) ; Cribbs, D.H. (Department of Neurology. University of California. Irvine) ; Crocco, E.A. (Department of Psychiatry and Behavioral Sciences. Miller School of Medicine. University of Miami) ; Cruchaga, C. (Department of Psychiatry. Washington University in St. Louis) ; Cullum, M. (Department of Psychiatry. University of Texas Southwestern Medical Center) ; Darby, E. (Alzheimer's Disease and Memory Disorders Center. Baylor College of Medicine) ; Davis, B. (Department of Population and Data Sciences. University of Texas Southwestern Medical Center) ; De Jager, P.L. (Center for Translational and Computational Neuroimmunology. Department of Neurology. Columbia University Medical Center) ; DeCarli, C. (Department of Neurology. University of California. Davis) ; DeToledo, J. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center) ; Dick, M. (Institute for Memory Impairments and Neurological Disorders. University of California. Irvine) ; Dickson, D.W. (Department of Neuroscience. Mayo Clinic) ; Dombroski, B.A. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Doody, R.S. (Alzheimer's Disease and Memory Disorders Center. Baylor College of Medicine) ; Duara, R. (Wien Center for Alzheimer's Disease and Memory Disorders. Mount Sinai Medical Center) ; Ertekin-Taner, N. (Department of Neurology. Mayo Clinic) ; Evans, D.A. (Rush Institute for Healthy Aging. Department of Internal Medicine. Rush University Medical Center) ; Fairchild, T.J. (Office of Strategy and Measurement. University of North Texas Health Science Center) ; Fallon, K.B. (Department of Pathology. University of Alabama at Birmingham) ; Farlow, M.R. (Department of Neurology. Indiana University) ; Farrell, J.J. (Department of Medicine (Biomedical Genetics). Boston University School of Medicine) ; Fernandez-Hernandez, V. (Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration. Washington University School of Medicine) ; Ferris, S. (Department of Psychiatry. New York University) ; Frosch, M.P. (C.S. Kubik Laboratory for Neuropathology. Massachusetts General Hospital) ; Fulton-Howard, B. (Department of Neuroscience. Ronald M. Loeb Center for Alzheimer's Disease. Icahn School of Medicine at Mount Sinai) ; Galasko, D.R. (Department of Neurosciences. University of California San Diego) ; Gamboa, A. (Department of Health Management and Policy. School of Public Health. University of North Texas Health Science Center) ; Gearing, M. (Emory Alzheimer's Disease Center. Emory University) ; Geschwind, D.H. (NeuroGenomics and Informatics. Washington University in St. Louis) ; Ghetti, Bernardino (Department of Pathology and Laboratory Medicine. Indiana University) ; Gilbert, J.R. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Grabowski, T.J. (Department of Radiology. University of Washington) ; Graff-Radford, N.R. (Department of Neurology. Mayo Clinic) ; Grant, S.F.A. (Department of Genetics. Perelman School of Medicine. University of Pennsylvania) ; Green, R.C. (Division of Genetics. Department of Medicine and Partners Center for Personalized Genetic Medicine. Brigham and Women's Hospital and Harvard Medical School) ; Growdon, J.H. (Department of Neurology. Massachusetts General Hospital/Harvard Medical School) ; Haines, J.L. (Department of Population & Quantitative Health Sciences. Case Western Reserve University) ; Hakonarson, H. (Division of Human Genetics. Department of Pediatrics. Perelman School of Medicine. University of Pennsylvania) ; Hall, J. (Department of Pharmacology and Neuroscience. University of North Texas Health Science Center) ; Hamilton, R.L. (Department of Pathology (Neuropathology). University of Pittsburgh) ; Harari, O. (Department of Psychiatry. Washington University in St. Louis) ; Harrell, L.E. (Department of Neurology. University of Alabama at Birmingham) ; Haut, J. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Head, E. (Department of Pathology and Laboratory Medicine. University of California Irvine) ; Henderson, V.W. (Department of Neurology and Neurological Sciences. Stanford University) ; Hernandez, M. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center) ; Hohman, T. (Vanderbilt Memory and Alzheimer's Center. Department of Neurology. Vanderbilt University Medical Center) ; Honig, L.S. (Taub Institute on Alzheimer's Disease and the Aging Brain. Department of Neurology. Columbia University) ; Huebinger, R.M. (Department of Surgery. University of Texas Southwestern Medical Center) ; Huentelman, M.J. (Neurogenomics Division. Translational Genomics Research Institute) ; Hulette, C.M. (Department of Pathology. Duke University) ; Hyman, B.T. (Department of Neurology. Massachusetts General Hospital/Harvard Medical School) ; Hynan, L.S. (Department of Neurological Surgery. University of Texas Southwestern Medical Center) ; Ibanez, L. (Hope Center Program on Protein Aggregation and Neurodegeneration. Washington University School of Medicine) ; Jarvik, G.P. (Department of Genome Sciences. University of Washington) ; Jayadev, S. (Departments of Neurology and Epidemiology. University of Washington) ; Jin, L.W. (Department of Pathology and Laboratory Medicine. University of California. Davis) ; Johnson, K. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center) ; Johnson, L. (Department of Health Behavior and Health Systems. University of North Texas Health Science Center) ; Kamboh, M.I. (Alzheimer's Disease Research Center. University of Pittsburgh) ; Karydas, A.M. (Department of Neurology. University of California San Francisco) ; Katz, M.J. (Department of Neurology. Albert Einstein College of Medicine) ; Kaye, J.A. (Department of Neurology. Portland Veterans Affairs Medical Center) ; Keene, C.D. (Department of Laboratory Medicine and Pathology. University of Washington) ; Khaleeq, A. (Alzheimer's Disease and Memory Disorders Center. Baylor College of Medicine) ; Kim, R. (Department of Pathology and Laboratory Medicine. University of California Irvine) ; Knebl, J. (Department of Health Behavior and Health Systems. University of North Texas Health Science Center) ; Kowall, N.W. (Department of Pathology. Boston University) ; Kramer, J.H. (Department of Neuropsychology. University of California San Francisco) ; Kuksa, P.P. (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; LaFerla, F.M. (Department of Neurobiology and Behavior. University of California Irvine) ; Lah, J.J. (Department of Neurology. Emory University) ; Larson, E.B. (Kaiser Permanente Washington Health Research Institute) ; Lee, C.Y. (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; Lee, E.B. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Lerner, A. (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Leung, Y.Y. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Leverenz, J.B. (Cleveland Clinic Lou Ruvo Center for Brain Health. Cleveland Clinic) ; Levey, A.I. (Department of Neurology. Emory University) ; Li, M. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Lieberman, A.P. (Department of Pathology. University of Michigan) ; Lipton, R.B. (Department of Neurology. Albert Einstein College of Medicine) ; Logue, M. (National Center for PTSD at Boston VA Healthcare System) ; Lyketsos, C.G. (Department of Psychiatry. Johns Hopkins University) ; Malamon, J. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Mains, D. (Department of Health Management and Policy. School of Public Health. University of North Texas Health Science Center) ; Marson, D.C. (Department of Neurology. University of Alabama at Birmingham) ; Martiniuk, F. (Department of Medicine (Pulmonary). New York University) ; Mash, D.C. (Department of Neurology. Miller School of Medicine. University of Miami) ; Masliah, E. (Department of Pathology. University of California San Diego) ; Massman, P. (Alzheimer's Disease and Memory Disorders Center. Baylor College of Medicine) ; Masurkar, A. (Department of Psychiatry. New York University) ; McCormick, W.C. (Department of Medicine. University of Washington) ; McCurry, S.M. (School of Nursing Northwest Research Group on Aging. University of Washington) ; McDavid, A.N. (Fred Hutchinson Cancer Research Center) ; McDonough, S. (Pfizer Worldwide Research and Development) ; McKee, A.C. (Department of Pathology. Boston University) ; Mesulam, M. (Cognitive Neurology and Alzheimer's Disease Center. Northwestern University Feinberg School of Medicine) ; Mez, J. (Institute of Biomedicine. University of Eastern Finland) ; Miller, B.L. (Weill Institute for Neurosciences. Memory and Aging Center. University of California. San Francisco) ; Miller, C.A. (Department of Pathology. University of Southern California) ; Miller, J.W. (Department of Pathology and Laboratory Medicine. University of California. Davis) ; Montine, T.J. (Department of Pathology. Stanford University School of Medicine) ; Monuki, E.S. (Department of Pathology and Laboratory Medicine. University of California Irvine) ; Morris, J.C. (Department of Neurology. Washington University at St. Louis) ; Myers, A.J. (Department of Psychiatry and Behavioral Sciences. Miller School of Medicine. University of Miami) ; Nguyen, T. (Department of Neurology. University of Texas Southwestern Medical Center) ; O'Bryant, S. (Institute for Translational Research. University of North Texas Health Science Center) ; Olichney, J.M. (Center for Mind and Brain and Department of Neurology. University of California. Davis) ; Ory, M. (Center for Population Health and Aging. Texas A&M University Health Science Center) ; Palmer, R. (Department of Family and Community Medicine. University of Texas Health Science Center San Antonio) ; Parisi, J.E. (Department of Laboratory Medicine and Pathology. Mayo Clinic) ; Paulson, H.L. (Michigan Alzheimer's Disease Center. University of Michigan) ; Pavlik, V. (Alzheimer's Disease and Memory Disorders Center. Baylor College of Medicine) ; Paydarfar, D. (Department of Neurology. Dell Medical School. University of Texas at Austin) ; Perez, V. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center) ; Peskind, E. (Department of Psychiatry and Behavioral Sciences. University of Washington School of Medicine) ; Phillips-Cremins, J.E. (Department of Bioengineering. University of Pennsylvania) ; Pierce, A. (Department of Neurology. University of California. Irvine) ; Polk, M. (Alzheimer's Disease Center. New York University) ; Poon, W.W. (Institute for Memory Impairments and Neurological Disorders. University of California. Irvine) ; Potter, H. (Department of Neurology. University of Colorado School of Medicine) ; Qu, L. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Quiceno, M. (Department of Medical Education. TCU/UNTHSC School of Medicine) ; Quinn, J.F. (Department of Neurology. Portland Veterans Affairs Medical Center) ; Raj, A. (USF Health Byrd Alzheimer's Institute. University of South Florida) ; Raskind, M. (Department of Psychiatry and Behavioral Sciences. University of Washington School of Medicine) ; Reiman, E.M. (Department of Psychiatry. University of Arizona) ; Reisberg, B. (Alzheimer's Disease Center. New York University) ; Reisch, J.S. (Department of Population and Data Sciences. University of Texas Southwestern Medical Center) ; Ringman, J.M. (Department of Neurology. University of Southern California) ; Roberson, E.D. (Department of Neurology. University of Alabama at Birmingham) ; Rodriguear, M. (Alzheimer's Disease and Memory Disorders Center. Baylor College of Medicine) ; Rogaeva, E. (Tanz Centre for Research in Neurodegenerative Disease. University of Toronto) ; Rosen, H.J. (Department of Neurology. University of California San Francisco) ; Rosenberg, R.N. (Department of Neurology. University of Texas Southwestern Medical Center) ; Royall, D.R. (Department of Family and Community Medicine. University of Texas Health Science Center San Antonio) ; Sager, M.A. (Department of Medicine. University of Wisconsin) ; Sano, M. (Department of Psychiatry. Icahn School of Medicine at Mount Sinai) ; Saykin, A.J. (Department of Radiology and Imaging Sciences. Indiana University) ; Schneider, J.A. (Department of Pathology (Neuropathology). Rush University Medical Center) ; Schneider, L.S. (Department of Psychiatry. University of Southern California) ; Seeley, W.W. (Department of Neurology. University of California San Francisco) ; Slifer, S.H. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Small, S. (Gertrude H. Sergievsky Center. Columbia University) ; Smith, A.G. (USF Health Byrd Alzheimer's Institute. University of South Florida) ; Smith, J.P. (Department of Population and Data Sciences. University of Texas Southwestern Medical Center) ; Song, Y.E. (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Sonnen, J.A. (Department of Laboratory Medicine and Pathology. University of Washington) ; Spina, S. (Department of Pathology and Laboratory Medicine. Indiana University) ; St George Hyslop, Peter (University of Toronto) ; Stern, R.A. (Institute of Biomedicine. University of Eastern Finland) ; Stevens, A.B. (College of Medicine. Texas A&M University Health Science Center) ; Strittmatter, S.M. (Program in Cellular Neuroscience. Neurodegeneration and Repair. Yale University School of Medicine) ; Sultzer, D. (Department of Psychiatry and Human Behavior. University of California. Irvine) ; Swerdlow, R.H. (University of Kansas Alzheimer's Disease Center. University of Kansas Medical Center) ; Tanzi, R.E. (Department of Neurology. Massachusetts General Hospital/Harvard Medical School) ; Tilson, J.L. (Renaissance Computing Institute. University of North Carolina at Chapel Hill) ; Trojanowski, J.Q. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Troncoso, J.C. (Department of Pathology. Johns Hopkins University) ; Tsuang, D.W. (Department of Psychiatry and Behavioral Sciences. University of Washington School of Medicine) ; Valladares, Otto (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; Van Deerlin, V.M. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; van Eldik, L.J. (Sanders-Brown Center on Aging. Department of Biostatistics. University of Kentucky) ; Vassar, R. (Cognitive Neurology and Alzheimer's Disease Center. Northwestern University Feinberg School of Medicine) ; Vinters, H.V. (Department of Pathology and Laboratory Medicine. University of California. Los Angeles) ; Vonsattel, J.P. (Taub Institute on Alzheimer's Disease and the Aging Brain. Department of Neurology. Columbia University) ; Weintraub, S. (Department of Psychiatry and Behavioral Sciences. Northwestern University Feinberg School of Medicine) ; Welsh-Bohmer, K.A. (Department of Psychiatry and Behavioral Sciences. Duke University) ; Whitehead, P.L. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Wijsman, E.M. (Department of Biostatistics. University of Washington) ; Wilhelmsen, K.C. (Department of Genetics. University of North Carolina at Chapel Hill) ; Williams, B. (Section of Gerontology and Geriatric Medicine Research. Wake Forest School of Medicine) ; Williamson, J. (Taub Institute on Alzheimer's Disease and the Aging Brain. Department of Neurology. Columbia University) ; Wilms, H. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center) ; Wingo, T.S. (Department of Neurology. Emory University) ; Wisniewski, T. (Center for Cognitive Neurology and Departments of Neurology and Pathology. New York University Grossman School of Medicine) ; Woltjer, R.L. (Department of Pathology. Oregon Health and Science University) ; Woon, M. (Department of Psychiatry. University of Texas at Austin/Dell Medical School) ; Wright, C.B. (Evelyn F. McKnight Brain Institute. Department of Neurology. Miller School of Medicine. University of Miami) ; Wu, C.K. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center) ; Younkin, S.G. (Department of Neurology. Mayo Clinic) ; Yu, C.E. (Department of Medicine. University of Washington) ; Yu, L. (Rush Alzheimer's Disease Center. Rush University Medical Center) ; Zhang, Y. (Center for Applied Genomics. Children's Hospital of Philadelphia) ; Zhao, Y. (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Zhu, X. (Department of Pathology. Case Western Reserve University) ; Adams, Hieab (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Akinyemi, R.O. (Centre for Genomic and Precision Medicine. College of Medicine. UI) ; Ali, M. (Washington University at St. Louis) ; Aparicio, H.J. (Department of Neurology. Boston University School of Medicine) ; Bahadori, M. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Becker, James T. (University of Pittsburgh) ; Breteler, M. (Population Health Sciences. German Center for Neurodegenerative Diseases (DZNE)) ; Chasman, D. (Brigham and Women's Hospital. Harvard University) ; Chauhan, G. (INSERM U1219. University of Bordeaux) ; Comic, H. (Department of Epidemiology. Erasmus MC) ; Cox, S. (University of Edinburgh) ; Cupples, A.L. (Department of Biostatistics. Boston University School of Public Health) ; Davies, G. (Centre for Cognitive Ageing and Cognitive Epidemiology. University of Edinburgh) ; DeCarli, C.S. (Department of Neurology and Center for Neuroscience. University of California. Davis) ; Duperron, M.G. (Bordeaux Population Health Research Center. Team VIN-TAGE. UMR 1219. University of Bordeaux. INSERM) ; Dupuis, J. (Department of Biostatistics. Boston University School of Public Health) ; Evans, T. (Department of Epidemiology. Erasmus MC) ; Fan, F. (University of Pittsburgh) ; Fitzpatrick, A. (Department of Family Medicine. University of Washington) ; Fohner, A.E. (Cardiovascular Health Research Unit. Department of Medicine. University of Washington) ; Ganguli, M. (University of Pittsburgh) ; Geerlings, M. (University Medical Center Utrecht) ; Glatt, S.J. (Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab). Department of Psychiatry and Behavioral Sciences. SUNY Upstate Medical University) ; Gonzalez, H.M. (University of California. San Diego) ; Goss, M. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Grabe, H. (Department of Psychiatry and Psychotherapy. University Medicine Greifswald) ; Habes, M. (Department of Radiology. University of Texas Health Science Center at San Antonio) ; Heckbert, S.R. (School of Public Health. University of Texas Health Science Center at Houston) ; Hofer, E. (Clinical Division of Neurogeriatrics. Department of Neurology. Medical University of Graz) ; Hong, E. (University of Maryland) ; Hughes, T. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Kautz, T.F. (Department of General Medicine. University of Texas Health Science Center) ; Knol, M. (Department of Epidemiology. Erasmus MC) ; Kremen, W. (Department of Epidemiology. Erasmus MC) ; Lacaze, P. (Monash University Clayton Campus) ; Lahti, J. (University of Helsinki) ; Grand, Q.L. (Bordeaux Population Health Research Center. Team VIN-TAGE. UMR 1219. University of Bordeaux. INSERM) ; Litkowski, E. (University of Colorado Anschutz Medical Center) ; Li, S. (Department of Biostatistics. Boston University School of Public Health) ; Liu, D. (Population Health Sciences. German Center for Neurodegenerative Diseases (DZNE)) ; Liu, X. (Department of Biostatistics. Boston University School of Public Health) ; Loitfelder, M. (Medical University of Graz) ; Manning, A. (Massachusetts General Hospital. Harvard University) ; Maillard, P. (Imaging of Dementia and Aging (IDeA) Laboratory. Department of Neurology. University of California. Davis) ; Marioni, R. (University of Staffmail) ; Mazoyer, B. (University of Bordeaux. IMN) ; van Lent, D.M. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Mei, H. (University of Mississippi Medical Center) ; Mishra, Aniket (Université de Bordeaux) ; Nyquist, P. (Johns Hopkins University School of Medicine) ; O'Connell, J. (University of Maryland) ; Patel, Y. (University of Toronto) ; Paus, T. (University of Montreal. Centre Hospitalier Universitaire Saint-Justine) ; Pausova, Z. (Hospital for Sick Children. University of Toronto) ; Raikkonen-Talvitie, K. (University of Helsinki) ; Riaz, M. (Monash University Clayton Campus) ; Rich, S. (Monash University Clayton Campus) ; Harbor-UCLA Medical Center. Los Angeles Biomedical Research Institute and Pediatrics ; Romero, J. (Boston Medical Center) ; Roshchupkin, G. (Department of Epidemiology. Erasmus MC) ; Saba, Y. (Gottfried Schatz Research Center. Department of Molecular Biology and Biochemistry. Medical University of Graz) ; Sargurupremraj, M. (Gottfried Schatz Research Center. Department of Molecular Biology and Biochemistry. Medical University of Graz) ; Schmidt, H. (Gottfried Schatz Research Center. Department of Molecular Biology and Biochemistry. Medical University of Graz) ; Schmidt, R. (Clinical Division of Neurogeriatrics. Department of Neurology. Medical University of Graz) ; Shulman, J.M. (Departments of Neurology. Molecular & Human Genetics. and Neuroscience and Program in Developmental Biology. Baylor College of Medicine) ; Smith, J. (Department of Epidemiology. School of Public Health. University of Michigan) ; Sekhar, H. (Bordeaux Population Health Research Center. Team VIN-TAGE. UMR 1219. University of Bordeaux. INSERM) ; Rajula, R. (Bordeaux Population Health Research Center. Team VIN-TAGE. UMR 1219. University of Bordeaux. INSERM) ; Shin, J. (Hospital for Sick Children. University of Toronto) ; Simino, J. (University of Mississippi Medical Center) ; Sliz, E. (University of Mississippi Medical Center) ; Teumer, A. (Institute for Community Medicine. University Medicine Greifswald) ; Thomas, A. (University of North Carolina) ; Tin, A. (University of Mississippi Medical Center) ; Tucker-Drob, E. (University of Texas) ; Vojinovic, D. (Department of Epidemiology. Erasmus MC) ; Wang, Y. (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Weinstein, G. (Clinical Division of Neurogeriatrics. Department of Neurology. Medical University of Graz) ; Williams, D. (Karolinska Institutet (Estocolm, Suècia)) ; Wittfeld, K. (German Center for Neurodegenerative Diseases (DZNE). Site Rostock/Greifswald) ; Yanek, L. (GeneSTAR Research Program. Department of Neurology. Johns Hopkins University School of Medicine) ; Yang, Y. (Institute of Molecular Medicine. University of Texas Health Science Center at Houston McGovern Medical School) ; Farrer, L.A. (Department of Neurology. Boston University School of Medicine) ; Psaty, B.M. (Department of Health Service. University of Washington) ; Ghanbari, M. (Department of Epidemiology. Erasmus MC) ; Raj, T. (Nash Family Department of Neuroscience & Friedman Brain Institute. Icahn School of Medicine at Mount Sinai) ; Sachdev, Perminder S. (University of New South Wales) ; Mather, Karen A (Centre for Healthy Brain Ageing. School of Psychiatry. Faculty of Medicine. University of New South Wales) ; Jessen, F. (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Ikram, M. Arfan (Department of Epidemiology. Erasmus MC) ; de Mendonça, A. (Faculty of Medicine. University of Lisbon) ; Hort, J. (Memory Clinic. Department of Neurology. Charles University. 2nd Faculty of Medicine and Motol University Hospital) ; Tsolaki, M. (Alzheimer Hellas) ; Pericak-Vance, Margaret A (AI Virtanen Institute for Molecular Sciences. University of Eastern Finland) ; Amouyel, Philippe (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Williams, J. (UKDRI@ Cardiff. School of Medicine. Cardiff University) ; Frikke-Schmidt, R. (Department of Clinical Biochemistry. Rigshospitalet) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Deleuze, J.F. (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Rossi, G. (Fondazione IRCCS. Istituto Neurologico Carlo Besta) ; Seshadri, S. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Andreassen, Ole A. (NORMENT Centre. University of Oslo) ; Ingelsson, Martin (Department of Public Health and Carins Sciences/Geriatrics. Uppsala University) ; Hiltunen, M. (Brain Institute. Federal University of Rio Grande do Norte) ; Sleegers, Kristel (Department of Biomedical Sciences. University of Antwerp) ; Schellenberg, G.D. (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; van Duijn, C.M. (Nuffield Department of Population Health. Oxford University) ; Sims, Rebecca (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; van der Flier, Wiesje M (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Vrije Universiteit Amsterdam. Amsterdam UMC) ; Ruiz, A. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Ramirez, A. (Universität zu Köln (Colònia, Alemaya). Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)) ; Lambert, Jean-Charles (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Universitat Autònoma de Barcelona
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. [...]
2022 - 10.1038/s41588-022-01024-z
Nature genetics, Vol. 54 Núm. 4 (April 2022) , p. 412-436  
5.
17 p, 1.3 MB Genome-wide association study of circulating interleukin 6 levels identifies novel loci / Ahluwalia, Tarunveer Singh (University of Copenhagen) ; Prins, Bram Peter (University of Groningen) ; Abdollahi, Mohammadreza (University of Groningen) ; Armstrong, Nicola (Murdoch University) ; Aslibekyan, Stella (University of Alabama at Birmingham School of Public Health) ; Bain, Lisa J (Qimr Berghofer Medical Research Institute) ; Jefferis, Barbara (University College London) ; Baumert, Jens (Helmholtz Zentrum München-German Research Center for Environmental Health) ; Beekman, Marian (Leiden University Medical Center) ; Ben-Shlomo, Yoav (University of Bristol) ; Bis, Joshua C (University of Washington) ; Mitchell, Braxton D. (University of Maryland School of Medicine) ; de Geus, Eco J. C (Amsterdam UMC. University Medical Center) ; Delgado, Graciela E. (University of Heidelberg) ; Marek, Diana (Sib Swiss Institute of Bioinformatics) ; Eriksson, Joel (University of Gothenburg) ; Kajantie, Eero (Helsinki University Central Hospital and University of Helsinki) ; Kanoni, Stavroula (Queen Mary University of London) ; Kemp, John P. (University of Bristol) ; Lu, Chen (Boston University School of Public Health) ; Marioni, Riccardo E. (University of Edinburgh) ; McLachlan, Stela (University of Edinburgh) ; Milaneschi, Yuri (Amsterdam Umc. Vrije Universiteit) ; Nolte, Ilja M. (University of Groningen) ; Petrelis, Alexandros M. (Université de Lorraine) ; Porcu, Eleonora (Consiglio Nazionale Delle Ricerche) ; Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ; Naderi, Elnaz (University of Groningen) ; Seppälä, Ilkka (Tampere University) ; Shah, Tina (University College London) ; Singhal, Gaurav (University of Adelaide) ; Standl, Marie (Helmholtz Zentrum München-German Research Center for Environmental Health) ; Teumer, Alexander (University Medicine Greifswald) ; Thalamuthu, Anbupalam (University of New South Wales) ; Thiering, Elisabeth (Ludwig-Maximilians-University of Munich. Dr. von Hauner Children's Hospital) ; Trompet, Stella (Leiden University Medical Center) ; Ballantyne, Christie M. (Baylor College of Medicine) ; Benjamin, Emelia J. (Boston University School of Medicine) ; Casas, Juan P. (Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC). Va Boston Healthcare System) ; Toben, Catherine (University of Adelaide) ; Dedoussis, George (Harokopio University) ; Deelen, Joris (Max Planck Institute for Biology of Ageing) ; Durda, Peter (Larner College of Medicine. University of Vermont) ; Engmann, Jorgen (University College London) ; Feitosa, Mary (Washington University School of Medicine) ; Grallert, Harald (German Center for Diabetes Research (DZD)) ; Hammarstedt, Ann (Sahlgrenska Academy at the University of Gothenburg) ; Harris, Sarah E (University of Edinburgh) ; Homuth, Georg (University Medicine Greifswald) ; Hottenga, Jouke Jan (Amsterdam UMC. University Medical Center) ; Jalkanen, Sirpa (University of Turku) ; Jamshidi, Yalda (St George's University of London) ; Jawahar, Magdalene C. (University of Adelaide) ; Jess, Tine (Statens Serum Institute) ; Kivimaki, Mika (University College London) ; Kleber, Marcus E. (University of Heidelberg) ; Lahti, Jari (University of Helsinki) ; Liu, Yongmei (Wake Forest School of Medicine) ; Marques-Vidal, Pedro (University of Lausanne) ; Mellström, Dan (Sahlgrenska Academy at the University of Gothenburg. Centre for Bone and Arthritis Research) ; Mooijaart, Simon P. (Leiden University Medical Center) ; Müller-Nurasyid, Martina (Johhanes Gutenberg University) ; Penninx, Brenda WJH (Amsterdam Umc. Vrije Universiteit) ; Revez, Joana A. (Qimr Berghofer Medical Research Institute) ; Rossing, Peter (University of Copenhagen) ; Raïkkönen, Katri (University of Helsinki) ; Sattar, Naveed (Bhf Glasgow Cardiovascular Research Centre) ; Scharnagl, Hubert (Medical University of Graz) ; Sennblad, Bengt (Uppsala University) ; Silveira, Angela (Karolinska Institutet (Estocolm, Suècia)) ; Pourcain, Beate St (Radboud University) ; Timpson, Nicholas J. (University of Bristol) ; Trollor, Julian (University of New South Wales) ; Van Dongen, Jenny (Amsterdam UMC. University Medical Center) ; Van Heemst, Diana (Baylor College of Medicine) ; Visvikis-Siest, Sophie (Université de Lorraine. Inserm. IGE-PCV) ; Vollenweider, Peter (University of Lausanne) ; Völker, Uwe (University of Turku) ; Waldenberger, Melanie (Helmholtz Zentrum München-German Research Center for Environmental Health) ; Willemsen, Gonneke (Amsterdam UMC. University Medical Center) ; Zabaneh, Delilah (University College London Genetics Institute) ; Morris, Richard W. (Bristol Medical School. University of Bristol) ; Arnett, Donna K. (University of Kentucky) ; Baune, Bernhard T. (University of Melbourne) ; Boomsma, Dorret I. (Amsterdam UMC. University Medical Center) ; Chang, Yen-Pei C. (University of Maryland School of Medicine) ; Deary, Ian J. (University of Edinburgh) ; Deloukas, Panos (Queen Mary University of London) ; Eriksson, Johan G. (University of Helsinki) ; Evans, David M. (University of Bristol) ; Ferreira, Manuel A. (Qimr Berghofer Medical Research Institute) ; Gaunt, Tom (University of Bristol) ; Gudnason, Vilmundur (University of Iceland) ; Hamsten, Anders (Karolinska Institutet (Estocolm, Suècia)) ; Heinrich, Joachim (University of Melbourne) ; Hingorani, Aroon (University College London) ; Humphries, Steve E. (University College London) ; Jukema, J. Wouter (Durrer Center for Cardiogenetic Research) ; Koenig, Wolfgang (University of Ulm) ; Kumari, Meena (University of Essex) ; Kutalik, Zoltan (University of Lausanne) ; Lawlor, Deborah A. (University of Bristol) ; Lehtimäki, Terho (Tampere University) ; März, Winfried (Synlab Academy. Synalb Holding Deutschland GmbH) ; Mather, Karen A (Neuroscience Research Australia) ; Naitza, Silvia. (Consiglio Nazionale Delle Ricerche) ; Nauck, Matthias (Dzhk (German Center for Cardiovascular Research). Partner Site Greifswald) ; Ohlsson, Claes (University of Gothenburg) ; Price, Jackie F. (University of Edinburgh) ; Raitakari, Olli (Turku University Hospital (Finlàndia)) ; Rice, Ken (University of Washington) ; Sachdev, Perminder S. (Prince of Wales Hospital (Australia)) ; Slagboom, Pieternella Eline (Max Planck Institute for Biology of Ageing) ; Sørensen, Thorkild I.A. (University of Copenhagen. Department of Public Health. Section on Epidemiology) ; Spector, Tim (King's College London. Department of Twin Research and Genetic Epidemiology) ; Stacey, David (University of Cambridge) ; Stathopoulou, Maria G. (Université de Lorraine. Inserm. IGE-PCV) ; Tanaka, Toshiko (National Institute on Aging (Estats Units d'Amèrica)) ; Wannamethee, Sasiwarang Goya (University College London) ; Whincup, Peter (University of London) ; Rotter, Jerome I. (The Lundquist Institute at Harbor-UCLA Medical Center) ; Dehghan, Abbas (Erasmus Mc) ; Boerwinkle, Eric (Baylor College of Medicine) ; Psaty, Bruce M. (University of Washington) ; Snieder, Harold (University Medical Center Groningen) ; Alizadeh, Behrooz Ziad (University Medical Center Groningen)
Interleukin 6 (IL-6) is a multifunctional cytokine with both pro-A nd anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. [...]
2021 - 10.1093/hmg/ddab023
Human Molecular Genetics, Vol. 30 Núm. 5 (january 2021) , p. 393-409  
6.
1 p, 647.1 KB Publisher Correction : Stroke genetics informs drug discovery and risk prediction across ancestries / Mishra, Aniket (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Malik, Rainer (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ; Hachiya, Tsuyoshi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Jürgenson, Tuuli (University of Tartu. Institute of Mathematics and Statistics) ; Namba, Shinichi (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ; Posner, Daniel C. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Kamanu, Frederick K. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Koido, Masaru (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; Le Grand, Quentin (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Shi, Mingyang (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; He, Yunye (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; Georgakis, Marios K. (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ; Caro, Ilana (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Krebs, Kristi (University of Tartu. Estonian Genome Centre, Institute of Genomics) ; Liaw, Yi-Ching (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ; Vaura, Felix C. (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ; Lin, Kuang (University of Oxford. Nuffield Department of Population Health) ; Winsvold, Bendik Slagsvold (Oslo University Hospital (Oslo, Noruega)) ; Srinivasasainagendra, Vinodh (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ; Parodi, Livia (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ; Bae, Hee-Joon (Seoul National University Bundang Hospital, Seoul National University College of Medicine. Department of Neurology and Cerebrovascular Disease Center) ; Chauhan, Ganesh (Rajendra Institute of Medical Sciences) ; Chong, Michael R. (McMaster University. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine) ; Tomppo, Liisa (Helsinki University Hospital (Finlàndia)) ; Akinyemi, Rufus (University of Ibadan. Neuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training, College of Medicine) ; Roshchupkin, Gennady V. (Erasmus MC University Medical Center Rotterdam. Department of Radiology and Nuclear Medicine) ; Habib, Naomi (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ; Jee, Yon Ho (Harvard T. H. Chan School of Public Health. Department of Epidemiology) ; Thomassen, Jesper Qvist (Copenhagen University Hospital-Rigshospitalet. Department of Clinical Biochemistry) ; Abedi, Vida (The Pennsylvania State University. Department of Public Health Sciences, College of Medicine) ; Cárcel-Márquez, Jara (Universitat Autònoma de Barcelona. Departament de Medicina) ; Nygaard, Marianne (Odense University Hospital (Dinamarca)) ; Leonard, Hampton L. (Data Tecnica International) ; Yang, Chaojie (University of Virginia. Department of Biochemistry and Molecular Genetics) ; Yonova-Doing, Ekaterina (Novo Nordisk Research Centre Oxford. Department of Genetics) ; Knol, Maria J. (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ; Lewis, Adam J. (Vanderbilt University Medical Center. Department of Biomedical Informatics) ; Judy, Renae L. (University of Pennsylvania. Department of Surgery) ; Ago, Tetsuro (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ; Amouyel, Philippe (Institut Pasteur de Lille) ; Armstrong, Nicole D. (University of Alabama at Birmingham. Department of Epidemiology) ; Bakker, Mark K. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ; Bartz, Traci M. (University of Washington. Department of Biostatistics) ; Bennett, David A. (Rush University Medical Center. Rush Alzheimer's Disease Center) ; Bis, Joshua C. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ; Bordes, Constance (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Børte, Sigrid (Oslo University Hospital. Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research and Innovation, Division of Clinical Neuroscience) ; Cain, Anael (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ; Ridker, Paul M. (Harvard Medical School) ; Cho, Kelly (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Chen, Zhengming (University of Oxford. MRC Population Health Research Unit) ; Cruchaga, Carlos (Washington University School of Medicine. NeuroGenomics and Informatics Center) ; Cole, John W. (University of Maryland School of Medicine. Department of Neurology) ; De Jager, Philip L (Columbia University Medical Center. Center for Translational and Computational Neuroimmunology, Department of Neurology) ; de Cid, Rafael (Institut Germans Trias i Pujol) ; Endres, Matthias (partner site Berlin. German Centre for Cardiovascular Research (DZHK)) ; Ferreira, Leslie E. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ; Geerlings, Mirjam I. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ; Gasca, Natalie C. (University of Washington. Department of Biostatistics) ; Gudnason, Vilmundur (University of Iceland. Faculty of Medicine) ; Hata, Jun (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ; He, Jing (Vanderbilt University Medical Center. Department of Biomedical Informatics) ; Heath, Alicia K. (Imperial College London. Department of Epidemiology and Biostatistics, School of Public Health) ; Ho, Yuk-Lam (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Havulinna, Aki S. (FIMM-HiLIFE. Institute for Molecular Medicine Finland) ; Hopewell, Jemma C. (University of Oxford. Clinical Trial Service and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health) ; Hyacinth, Hyacinth I. (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ; Inouye, Michael (University of Cambridge. British Heart Foundation Centre of Research Excellence) ; Jacob, Mina A. (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ; Jeon, Christina E. (Los Angeles County Department of Public Health) ; Jern, Christina (Sahlgrenska University Hospital (Suècia)) ; Kamouchi, Masahiro (Kyushu University. Department of Health Care Administration and Management, Graduate School of Medical Sciences) ; Keene, Keith L. (East Carolina University. Department of Biology, Brody School of Medicine Center for Health Disparities) ; Kitazono, Takanari (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ; Kittner, Steven J. (VA Maryland Health Care System. Department of Neurology and Geriatric Research and Education Clinical Center) ; Konuma, Takahiro (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ; Kumar, Amit (Rajendra Institute of Medical Sciences) ; Lacaze, Paul (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ; Launer, Lenore Joy (National Institute on Aging, NIH. Intramural Research Program) ; Lee, Keon-Joo (Korea University Guro Hospital. Department of Neurology) ; Lepik, Kaido (University Center for Primary Care and Public Health, Lausanne, Switzerland) ; Li, Jiang (Geisinger Health System. Department of Molecular and Functional Genomics, Weis Center for Research) ; Li, Liming (Peking University Health Science Center. Department of Epidemiology and Biostatistics, School of Public Health) ; Manichaikul, Ani (University of Virginia. Center for Public Health Genomics) ; Markus, Hugh S. (University of Cambridge. Stroke Research Group, Department of Clinical Neurosciences) ; Marston, Nicholas A. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Meitinger, Thomas (German Research Center for Environmental Health. Institute of Human Genetics, Helmholtz Zentrum München) ; Mitchell, Braxton D. (Baltimore Veterans Administration Medical Center. Geriatrics Research and Education Clinical Center) ; Montellano, Felipe A. (University Hospital Würzburg. Department of Neurology) ; Morisaki, Takayuki (The University of Tokyo. Division of Molecular Pathology, Institute of Medical Sciences) ; Mosley, Thomas H. (University of Mississippi Medical Center. The MIND Center) ; Nalls, Mike A. (Data Tecnica International) ; Nordestgaard, Børge G. (University of Copenhagen. Department of Clinical Medicine) ; O'Donnell, Martin J. (NUI Galway. College of Medicine Nursing and Health Science) ; Okada, Yukinori (Osaka University. Center for Infectious Disease Education and Research (CiDER)) ; Onland-Moret, N. Charlotte (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ; Ovbiagele, Bruce (University of California, San Francisco. Weill Institute for Neurosciences) ; Peters, Annette (German Centre for Cardiovascular Research (DZHK), partner site Munich) ; Psaty, Bruce M. (University of Washington. Department of Health Systems and Population Health) ; Rich, Stephen S. (University of Virginia. Center for Public Health Genomics) ; Rosand, Jonathan (Massachusetts General Hospital. McCance Center for Brain Health) ; Sabatine, Marc S. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Sacco, Ralph L. (Evelyn F. McKnight Brain Institute) ; Saleheen, Danish (Columbia University. Division of Cardiology, Department of Medicine) ; Sandset, Else Charlotte (The Norwegian Air Ambulance Foundation. Research and Development) ; Salomaa, Veikko (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ; Sargurupremraj, Muralidharan (University of Texas Health Sciences Center. Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Sasaki, Makoto (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Satizabal, Claudia L. (Framingham Heart Study) ; Schmidt, Carsten O. (University Medicine Greifswald, Institute for Community Medicine, SHIP/KEF) ; Shimizu, Atsushi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Smith, Nicholas L. (Seattle Epidemiologic Research and Information Center. Department of Veterans Affairs Office of Research and Development) ; Sloane, Kelly L. (University of Pennsylvania. Department of Neurology) ; Sutoh, Yoichi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Sun, Yan V. (Emory University Rollins School of Public Health. Department of Epidemiology) ; Tanno, Kozo (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Tiedt, Steffen (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ; Tatlisumak, Turgut (Sahlgrenska University Hospital (Suècia)) ; Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ; Tiwari, Hemant K. (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ; Trégouët, David-Alexandre (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Trompet, Stella (Leiden University Medical Center. Department of Cardiology) ; Tuladhar, Anil Man (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ; Tybjærg-Hansen, Anne (University of Copenhagen. Department of Clinical Medicine) ; van Vugt, Marion (University Medical Center Utrecht, Utrecht University. Division Heart & Lungs, Department of Cardiology) ; Vibo, Riina (University of Tartu. Department of Neurology and Neurosurgery) ; Verma, Shefali S. (University of Pennsylvania. Department of Pathology and Laboratory Medicine) ; Wiggins, Kerri L. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ; Wennberg, Patrik (Umeå University. Department of Public Health and Clinical Medicine) ; Woo, Daniel (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ; Wilson, Peter W. F. (Emory University School of Medicine. Department of Medicine, Division of Cardiovascular Disease) ; Xu, Huichun (University of Maryland School of Medicine. Department of Medicine) ; Yang, Qiong (Boston University School of Public Health. Department of Biostatistics) ; Yoon, Kyungheon (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ; Millwood, Iona Y. (University of Oxford. MRC Population Health Research Unit) ; Gieger, Christian (German Research Center for Environmental Health. Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München) ; Ninomiya, Toshiharu (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ; Grabe, Hans J. (German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald) ; Jukema, J. Wouter (LUMC. Einthoven Laboratory for Experimental Vascular Medicine) ; Rissanen, Ina L. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ; Strbian, Daniel (Helsinki University Hospital (Finlàndia)) ; Kim, Young Jin (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ; Chen, Pei-Hsin (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ; Mayerhofer, Ernst (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ; Howson, Joanna M. M. (Novo Nordisk Research Centre Oxford. Department of Genetics) ; Irvin, Marguerite R. (University of Alabama at Birmingham. Department of Epidemiology) ; Adams, Hieab (Universidad Adolfo Ibáñez) ; Wassertheil-Smoller, Sylvia (Albert Einstein College of Medicine. Department of Epidemiology and Population Health) ; Christensen, Kaare (Odense University Hospital (Dinamarca)) ; Ikram, M. Arfan (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ; Rundek, Tatjana (Evelyn F. McKnight Brain Institute) ; Worrall, Bradford B. (University of Virginia. Department of Public Health Science) ; Lathrop, G. Mark (McGill Genome Centre) ; Riaz, Moeen (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ; Simonsick, Eleanor M. (National Institute on Aging. Longitudinal Studies Section, Translational Gerontology Branch) ; Kõrv, Janika (University of Tartu. Department of Neurology and Neurosurgery) ; França, Paulo H. C. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ; Zand, Ramin (The Pennsylvania State University. Department of Neurology, College of Medicine) ; Prasad, Kameshwar (Rajendra Institute of Medical Sciences) ; Frikke-Schmidt, Ruth (University of Copenhagen. Department of Clinical Medicine) ; de Leeuw, Frank-Erik (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ; Liman, Thomas (Carl von Ossietzky University of Oldenburg. Klinik für Neurologie) ; Haeusler, Karl Georg (University Hospital Würzburg. Department of Neurology) ; Ruigrok, Ynte M. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ; Heuschmann, Peter Ulrich (University Hospital Würzburg. Clinical Trial Center) ; Longstreth, W. T. (University of Washington. Department of Neurology) ; Jung, Keum Ji (Yonsei University. Institute for Health Promotion, Graduate School of Public Health) ; Bastarache, Lisa (Vanderbilt University Medical Center. Department of Biomedical Informatics) ; Paré, Guillaume (David Braley Cardiac, Vascular and Stroke Research Institute. Population Health Research Institute) ; Damrauer, Scott M. (Corporal Michael Crescenz VA Medical Center) ; Chasman, Daniel I. (Harvard Medical School) ; Rotter, Jerome I. (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics) ; Anderson, Christopher D. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Zwart, John-Anker (University of Oslo. Institute of Clinical Medicine, Faculty of Medicine) ; Niiranen, Teemu J. (Turku University Hospital. Division of Medicine) ; Fornage, Myriam (University of Texas Health Science Center at Houston. Human Genetics Center, School of Public Health) ; Liaw, Yung-Po (Chung Shan Medical University Hospital. Department of Medical Imaging) ; Seshadri, Sudha (Boston University School of Medicine. Department of Neurology) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Walters, Robin G. (University of Oxford. MRC Population Health Research Unit) ; Ruff, Christian T. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Owolabi, Mayowa O. (University of Ibadan. Department of Medicine) ; Huffman, Jennifer E. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Milani, Lili (University of Tartu. Estonian Genome Centre, Institute of Genomics) ; Kamatani, Yoichiro (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; Dichgans, Martin (German Center for Neurodegenerative Diseases (DZNE)) ; Debette, Stéphanie (CHU de Bordeaux. Department of Neurology, Institute for Neurodegenerative Disease) ; Universitat Autònoma de Barcelona
2022 - 10.1038/s41586-022-05492-5
Nature, Vol. 612 (november 2022) , p. E7  
7.
23 p, 7.9 MB Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease / Holstege, Henne (Delft Bioinformatics Lab, Delft University of Technology) ; Hulsman, Marc (Delft Bioinformatics Lab, Delft University of Technology) ; Charbonnier, Camille (Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Genetics and CNRMAJ) ; Grenier-Boley, Benjamin (Université Lille, INSERM, Centre Hospitalier Universitaire Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Quenez, Olivier (Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Genetics and CNRMAJ) ; Grozeva, Detelina (Cardiff University. Medical Research Council Centre for Neuropsychiatric Genetics and Genomics,, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine) ; van Rooij, Jeroen G. J. (Erasmus Medical Centre. Department of Internal Medicine) ; Sims, Rebecca (Cardiff University. Medical Research Council Centre for Neuropsychiatric Genetics and Genomics,, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine) ; Ahmad, Shahzad (Leiden Academic Centre for Drug Research) ; Amin, Najaf (Nuffield Department of Population Health Oxford University) ; Norsworthy, Penny J. (Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases) ; Dols Icardo, Oriol (Institut d'Investigació Biomèdica Sant Pau) ; Hummerich, Holger (Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases) ; Kawalia, Amit (Faculty of Medicine and University Hospital Cologne, University of Cologne. Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy) ; Amouyel, Philippe (Université Lille, INSERM, Centre Hospitalier Universitaire Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Beecham, Gary W. (The John P. Hussman Institute for Human Genomics, University of Miami) ; Berr, Claudine (Université Montpellier, INSERM, Institute for Neurosciences of Montpellier) ; Bis, Joshua C. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ; Boland, Anne (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Bossù, Paola (Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation. Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology) ; Bouwman, Femke (Amsterdam Neuroscience, Neurodegeneration) ; Bras, Jose (Michigan State University College of Human Medicine. Division of Psychiatry and Behavioral Medicine) ; Campion, Dominique (Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Genetics and CNRMAJ) ; Cochran, J. Nicholas (HudsonAlpha Institute for Biotechnology) ; Daniele, Antonio (Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico. Department of Neuroscience) ; Dartigues, Jean-François (Université Bordeaux, INSERM, Bordeaux Population Health Research Center) ; Debette, Stéphanie (Bordeaux University Hospital. Department of Neurology) ; Deleuze, Jean-François (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Denning, Nicola (Cardiff University. UKDRI Cardiff, School of Medicine) ; DeStefano, Anita L. (Boston University School of Medicine. Department of Neurology) ; Farrer, Lindsay A. (Boston University. Department of Medicine (Biomedical Genetics)) ; Fernández, Maria Victoria (Washington University School of Medicine. Hope Center for Neurological Disorders) ; Fox, Nick C. (University College London Queen Square Institute of Neurology. Dementia Research Centre) ; Galimberti, Daniela (University of Milan) ; Genin, Emmanuelle (Université Brest, INSERM, Etablissement Français du Sang, Centre Hospitalier Universitaire Brest, Unité Mixte de Recherche 1078, GGB, Brest, France) ; Gille, Johan J. P. (VU University, AmsterdamUMC (location VUmc). Genome Diagnostics, Department of Human Genetics) ; Le Guen, Yann (Stanford University. Department of Neurology and Neurological Sciences) ; Guerreiro, Rita (Michigan State University College of Human Medicine. Division of Psychiatry and Behavioral Medicine) ; Haines, Jonathan L. (Case Western Reserve University. Department of Epidemiology and Biostatistics) ; Holmes, Clive (University of Southampton. Clinical and Experimental Science, Faculty of Medicine) ; Ikram, M. Arfan (Erasmus Medical Centre. Department of Epidemiology) ; Ikram, M. Kamran (Erasmus Medical Centre. Department of Epidemiology) ; Jansen, Iris E. (Vrije University. Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience) ; Kraaij, Robert (Erasmus Medical Centre. Department of Internal Medicine) ; Lathrop, Marc (McGill University and Genome Quebec Innovation Centre) ; Lemstra, Afina W. (Amsterdam Neuroscience, Neurodegeneration) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Luckcuck, Lauren (Cardiff University. Medical Research Council Centre for Neuropsychiatric Genetics and Genomics) ; Mannens, Marcel M. A. M. (University of Amsterdam, Amsterdam Reproduction and Development Research Institute. Department of Human Genetics, Amsterdam UMC) ; Marshall, Rachel (Cardiff University. Medical Research Council Centre for Neuropsychiatric Genetics and Genomics,, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine) ; Martin, Eden R. (University of Miami. Dr. John T. Macdonald Foundation Department of Human Genetics) ; Masullo, Carlo (Institute of Neurology, Catholic University of the Sacred Heart) ; Mayeux, Richard (Columbia University. Gertrude H. Sergievsky Center) ; Mecocci, Patrizia (University of Perugia. Institute of Gerontology and Geriatrics, Department of Medicine and Surgery) ; Meggy, Alun (Cardiff University. UKDRI Cardiff, School of Medicine) ; Mol, Merel O. (Erasmus Medical Centre. Department of Neurology) ; Morgan, Kevin (University of Nottingham. Human Genetics, School of Life Sciences) ; Myers, Richard M. (HudsonAlpha Institute for Biotechnology) ; Nacmias, Benedetta (IRCCS Fondazione Don Carlo Gnocchi) ; Naj, Adam C. (University of Pennsylvania Perelman School of Medicine. Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine) ; Napolioni, Valerio (Genomic and Molecular Epidemiology Laboratory, School of Biosciences and Veterinary Medicine, University of Camerino) ; Pasquier, Florence (Université Lille, INSERM, Centre Hospitalier Universitaire Lille, UMR1172, Resources and Research Memory Center (MRRC) of Distalz, Licend) ; Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Pericak-Vance, Margaret A. (University of Miami. Dr. John T. Macdonald Foundation Department of Human Genetics) ; Raybould, Rachel (Cardiff University. UKDRI Cardiff, School of Medicine) ; Redon, Richard (Université de Nantes, Centre Hospitalier Universitaire Nantes, Centre National de la Recherche Scientifique, INSERM, l'institut du Thorax) ; Reinders, Marcel J. T. (Delft Bioinformatics Lab, Delft University of Technology) ; Richard, Anne-Claire (Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Genetics and CNRMAJ) ; Riedel-Heller, Steffi G. (Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig) ; Rivadeneira, Fernando (Erasmus Medical Centre. Department of Internal Medicine) ; Rousseau, Stéphane (Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Genetics and CNRMAJ) ; Ryan, Natalie S. (University College London Queen Square Institute of Neurology. Dementia Research Centre) ; Saad, Salha (Cardiff University. Medical Research Council Centre for Neuropsychiatric Genetics and Genomics,, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine) ; Sánchez-Juan, Pascual (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria)) ; Schellenberg, Gerard D. (University of Pennsylvania Perelman School of Medicine. Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine) ; Scheltens, Philip (Amsterdam Neuroscience, Neurodegeneration) ; Schott, Jonathan M. (University College London Queen Square Institute of Neurology. Dementia Research Centre) ; Seripa, Davide (Laboratory for Advanced Hematological Diagnostics, Department of Hematology and Stem Cell Transplant, Lecce, Italy) ; Seshadri, Sudha (Department of Psychiatry and Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX USA) ; Sie, Daoud (VU University, AmsterdamUMC (location VUmc). Genome Diagnostics, Department of Human Genetics) ; Sistermans, Erik A. (VU University, AmsterdamUMC (location VUmc). Genome Diagnostics, Department of Human Genetics) ; Sorbi, Sandro (IRCCS Fondazione Don Carlo Gnocchi) ; van Spaendonk, Resie (VU University, AmsterdamUMC (location VUmc). Genome Diagnostics, Department of Human Genetics) ; Spalletta, Gianfranco (Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation. Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology) ; Tesi, Niccolo (Delft Bioinformatics Lab, Delft University of Technology) ; Tijms, Betty (Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc. Alzheimer Center Amsterdam, Neurology) ; Uitterlinden, André G. (Erasmus Medical Centre. Department of Internal Medicine) ; van der Lee, Sven J. (Delft Bioinformatics Lab, Delft University of Technology) ; Visser, Pieter Jelle (Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc. Alzheimer Center Amsterdam, Neurology) ; Wagner, Michael (German Center for Neurodegenerative Diseases) ; Wallon, David (Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Neurology and CNRMAJ) ; Wang, Li-San (University of Pennsylvania Perelman School of Medicine. Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine) ; Zarea, Aline (Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Neurology and CNRMAJ) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; van Swieten, John C. (Erasmus Medical Centre. Department of Neurology) ; Greicius, Michael D. (Stanford University. Department of Neurology and Neurological Sciences) ; Yokoyama, Jennifer S. (University of California. Memory and Aging Center, Department of Neurology) ; Cruchaga, Carlos (Washington University School of Medicine. Hope Center for Neurological Disorders) ; Hardy, John (University College London Institute of Neurology. Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience) ; Ramirez, Alfredo (University of Cologne. Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases) ; Mead, Simon (University College London. Institute of Prion Diseases) ; van der Flier, Wiesje M. (Amsterdam Neuroscience, Neurodegeneration) ; van Duijn, Cornelia M. (Nuffield Department of Population Health Oxford University) ; Williams, Julie (Cardiff University. Medical Research Council Centre for Neuropsychiatric Genetics and Genomics,, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine) ; Nicolas, Gaël (Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Genetics and CNRMAJ) ; Bellenguez, Céline (Université Lille, INSERM, Centre Hospitalier Universitaire Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Lambert, Jean-Charles (Université Lille, INSERM, Centre Hospitalier Universitaire Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Universitat Autònoma de Barcelona
Alzheimer's disease (AD), the leading cause of dementia, has an estimated heritability of approximately 70% . The genetic component of AD has been mainly assessed using genome-wide association studies, which do not capture the risk contributed by rare variants . [...]
2022 - 10.1038/s41588-022-01208-7
Nature genetics, Vol. 54 (november 2022) , p. 1786-1794  
8.
58 p, 1.4 MB The power of genetic diversity in genome-wide association studies of lipids / Graham, Sarah E. (University of Michigan. Department of Internal Medicine) ; Chang, Kyong-Mi (Corporal Michael J. Crescenz VA Medical Center) ; Cho, Kelly (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; O'Donnell, Christopher J. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Gaziano, John M. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Wilson, Peter (Emory University School of Medicine) ; Rotimi, Charles (Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health) ; Hazelhurst, Scott (University of the Witwatersrand. School of Electrical and Information Engineering) ; Ramsay, Michele (University of the Witwatersrand) ; Trembath, Richard C. (King's College London) ; van Heel, David A (Queen Mary University of London) ; Tamiya, Gen (Tohoku Medical Megabank Organization. Tohoku University) ; Yamamoto, Masayuki (Tohoku Medical Megabank Organization. Tohoku University) ; Kim, Bong-Jo (Department of Precision Medicine. Division of Genome Science. National Institute of Health) ; Mohlke, Karen L (Department of Genetics. University of North Carolina) ; Frayling, Timothy M. (Genetics of Complex Traits. University of Exeter Medical School. University of Exeter) ; Hirschhorn, Joel N. (Departments of Pediatrics and Genetics. Harvard Medical School) ; Kathiresan, Sekar (Center for Genomic Medicine. Department of Medicine. Massachusetts General Hospital) ; Boehnke, Michael (Department of Biostatistics and Center for Statistics Genetics. University of Michigan) ; Natarajan, Pradeep (Cardiovascular Research Center and Center for Genomic Medicine. Massachusetts General Hospital) ; Peloso, Gina M (Department of Biostatistics. Boston University School of Public Health) ; Brown, Christopher D. (Department of Genetics. Perelman School of Medicine. University of Pennsylvania) ; Morris, Andrew P. (University College London. Centre for Adolescent Rheumatology Versus Arthritis) ; Assimes, Themistocles (Stanford University School of Medicine. Cardiovascular Institute) ; Deloukas, Panos (King Abdulaziz University) ; Sun, Yan V. (Atlanta VA Health Care System) ; Willer, Cristen J. (Department of Human Genetics. University of Michigan) ; Clarke, Shoa L. (Department of Medicine. Division of Cardiovascular Medicine. Stanford University School of Medicine) ; Wu, Kuan-Han H. (Department of Computational Medicine and Bioinformatics. University of Michigan) ; Kanoni, Stavroula (Queen Mary University of London) ; Zajac, Greg J. M. (University of Michigan) ; Ramdas, Shweta (University of Pennsylvania) ; Surakka, Ida (University of Michigan) ; Ntalla, Ioanna (Queen Mary University of London) ; Vedantam, Sailaja (Medical and Population Genetics. Broad Institute) ; Winkler, Thomas W. (Department of Genetic Epidemiology. University of Regensburg) ; Locke, Adam E. (McDonnell Genome Institute and Department of Medicine. Washington University) ; Marouli, Eirini (Queen Mary University of London) ; Hwang, Mi Yeong (Department of Precision Medicine. Division of Genome Science. National Institute of Health) ; Han, Sohee (Department of Precision Medicine. Division of Genome Science. National Institute of Health) ; Narita, Akira (Tohoku Medical Megabank Organization. Tohoku University) ; Choudhury, Ananyo (Sydney Brenner Institute for Molecular Bioscience. Faculty of Health Sciences. University of the Witwatersrand) ; Bentley, Amy R (Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health) ; Ekoru, Kenneth (Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health) ; Verma, Anurag (Department of Genetics. Perelman School of Medicine. University of Pennsylvania) ; Trivedi, Bhavi (Blizard Institute. Barts and the London School of Medicine and Dentistry. Queen Mary University of London) ; Martin, Hilary C. (Wellcome Trust Sanger Institute (Regne Unit)) ; Hunt, Karen A. (Blizard Institute. Barts and the London School of Medicine and Dentistry. Queen Mary University of London) ; Hui, Qin (Atlanta VA Health Care System) ; Klarin, Derek (Program in Medical and Population Genetics. Broad Institute of MIT and Harvard) ; Zhu, Xiang (Stanford University. Department of Statistics) ; Thorleifsson, Gudmar (deCODE genetics/Amgen) ; Helgadottir, Anna (deCODE genetics/Amgen) ; Gudbjartsson, Daniel F. (School of Engineering and Natural Sciences. University of Iceland) ; Holm, Hilma (deCODE genetics/Amgen) ; Olafsson, Isleifur (Department of Clinical Biochemistry. Landspitali-National University Hospital of Iceland) ; Akiyama, Masato (Kyushu University) ; Sakaue, Saori (Department of Allergy and Rheumatology. Graduate School of Medicine. The University of Tokyo) ; Terao, Chikashi (Laboratory for Statistical and Translational Genetics. RIKEN Center for Integrative Medical Sciences) ; Kanai, Masahiro (Harvard Medical School. Department of Biomedical Informatics) ; Zhou, Wei (Broad Institute of MIT and Harvard) ; Brumpton, Ben M. (St Olavs Hospital. Trondheim University Hospital) ; Rasheed, Humaira (MRC Integrative Epidemiology Unit. University of Bristol) ; Ruotsalainen, Sanni E. (University of Helsinki) ; Havulinna, Aki S. (Finnish Institute for Health and Welfare) ; Veturi, Yogasudha (University of Pennsylvania. Perelman School of Medicine) ; Feng, QiPing (Vanderbilt University Medical Center) ; Rosenthal, Elisabeth A. (University of Washington. Department of Medicine) ; Lingren, Todd (Cincinnati Children's Hospital Medical Center) ; Pacheco, Jennifer Allen (Center for Genetic Medicine. Northwestern University) ; Pendergrass, Sarah A. (Genentech) ; Haessler, Jeffrey (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ; Giulianini, Franco (Division of Preventive Medicine. Brigham and Women's Hospital) ; Bradford, Yuki (Department of Genetics. Institute for Biomedical Informatics. Perelman School of Medicine. University of Pennsylvania) ; Miller, Jason E. (Department of Genetics. Institute for Biomedical Informatics. Perelman School of Medicine. University of Pennsylvania) ; Campbell, Archie (University of Edinburgh) ; Lin, Kuang (University of Oxford. Nuffield Department of Population Health) ; Millwood, Iona Y. (University of Oxford. Nuffield Department of Population Health) ; Hindy, George (Qatar University College of Medicine) ; Rasheed, Asif (Center for Non-Communicable Diseases) ; Faul, Jessica D. (University of Michigan. Institute for Social Research) ; Zhao, Wei (University of Michigan. School of Public Health) ; Weir, David R (University of Michigan. Institute for Social Research) ; Turman, Constance (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ; Huang, Hongyan (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ; Graff, Mariaelisa (University of North Carolina. Department of Epidemiology) ; Mahajan, Anubha (University of Oxford. Wellcome Centre for Human Genetics) ; Brown, Michael R. (The University of Texas Health Science Center at Houston) ; Zhang, Weihua (Imperial College Healthcare NHS Trust) ; Yu, Ketian (Department of Biostatistics. Center for Statistical Genetics. University of Michigan) ; Schmidt, Ellen M. (Department of Biostatistics. Center for Statistical Genetics. University of Michigan) ; Pandit, Anita (Department of Biostatistics. Center for Statistical Genetics. University of Michigan) ; Gustafsson, Stefan (Department of Medical Sciences. Molecular Epidemiology and Science for Life Laboratory. Uppsala University) ; Yin, Xianyong (Department of Biostatistics. Center for Statistical Genetics. University of Michigan) ; Luan, Jian'an (MRC Epidemiology Unit. University of Cambridge School of Clinical Medicine) ; Zhao, Jing-Hua (Cardiovascular Epidemiology Unit. Department of Public Health and Primary Care. University of Cambridge Strangeways Research Laboratory) ; Matsuda, Fumihiko (Center for Genomic Medicine. Kyoto University Graduate School of Medicine) ; Jang, Hye-Mi (Department of Precision Medicine. Division of Genome Science. National Institute of Health) ; Yoon, Kyungheon (Department of Precision Medicine. Division of Genome Science. National Institute of Health) ; Medina-Gomez, Carolina (Department of Epidemiology. Erasmus MC. University Medical Center Rotterdam) ; Pitsillides, Achilleas (Department of Biostatistics. Boston University School of Public Health) ; Hottenga, Jouke Jan (Amsterdam Public Health. VU Medical Center Amsterdam) ; Willemsen, Gonneke (Amsterdam Public Health Research Institute. VU Medical Center Amsterdam) ; Wood, Andrew R. (Genetics of Complex Traits. University of Exeter Medical School. University of Exeter) ; Ji, Yingji (Genetics of Complex Traits. University of Exeter Medical School. University of Exeter) ; Gao, Zishan (Institute of Epidemiology. Helmholtz Zentrum München. German Research Center for Environmental Health) ; Haworth, Simon (Bristol Dental School. University of Bristol) ; Mitchell, Ruth E. (Population Health Sciences. Bristol Medical School. University of Bristol) ; Chai, Jin-Fang (Saw Swee Hock School of Public Health. National University of Singapore and National University Health System) ; Aadahl, Mette (Center for Clinical Research and Prevention. Bispebjerg and Frederiksberg Hospital) ; Yao, Jie (The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center) ; Manichaikul, Ani (University of Virginia. Center for Public Health Genomics) ; Warren, Helen R. (NIHR Barts Cardiovascular Biomedical Research Centre. Barts and The London School of Medicine and Dentistry. Queen Mary University of London) ; Ramírez, Julia (William Harvey Research Institute. Barts and The London School of Medicine and Dentistry. John Vane Science Centre. Queen Mary University of London) ; Bork-Jensen, Jette (University of Copenhagen) ; Kårhus, Line L. (Center for Clinical Research and Prevention. Bispebjerg and Frederiksberg Hospital) ; Goel, Anuj (University of Oxford. Radcliffe Department of Medicine) ; Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ; Noordam, Raymond (Leiden University Medical Center) ; Sidore, Carlo (Institute for Genetic and Biomedical Research. Italian National Council of Research (IRGB CNR)) ; Fiorillo, Edoardo (Institute for Genetic and Biomedical Research. Italian National Council of Research (IRGB CNR)) ; McDaid, Aaron F. (Swiss Institute of Bioinformatics) ; Marques-Vidal, Pedro (Lausanne University Hospital) ; Wielscher, Matthias (Department of Epidemiology and Biostatistics. MRC-PHE Centre for Environment and Health. School of Public Health. Imperial College London) ; Trompet, Stella (Leiden University Medical Center) ; Sattar, Naveed (BHF Glasgow Cardiovascular Research Centre. Faculty of Medicine) ; Møllehave, Line T. (Center for Clinical Research and Prevention. Bispebjerg and Frederiksberg Hospital) ; Thuesen, Betina H. (Center for Clinical Research and Prevention. Bispebjerg and Frederiksberg Hospital) ; Munz, Matthias (Department of Periodontology and Synoptic Dentistry. Berlin Institute of Health. Institute for Dental and Craniofacial Sciences) ; Zeng, Lingyao (Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK). Partner site Munich Heart Alliance) ; Huang, Jianfeng (Chinese Academy of Medical Sciences) ; Yang, Bin (Chinese Academy of Medical Sciences) ; Poveda, Alaitz (Lund University Diabetes Centre) ; Kurbasic, Azra (Lund University Diabetes Centre) ; Lamina, Claudia (German Chronic Kidney Disease Study) ; Forer, Lukas (German Chronic Kidney Disease Study) ; Scholz, Markus (LIFE Research Centre for Civilization Diseases. University of Leipzig) ; Galesloot, Tessel E (Radboud University Medical Center. Radboud Institute for Health Sciences) ; Bradfield, Jonathan Paul (Quantinuum Research) ; Daw, E. Warwick (Division of Statistical Genomics. Department of Genetics. Washington University School of Medicine) ; Zmuda, Joseph M (Department of Epidemiology. University of Pittsburgh) ; Mitchell, Jonathan S. (Institute for Biomedicine. Eurac Research. Affiliated Institute of the University of Lübeck) ; Fuchsberger, Christian (Institute for Biomedicine. Eurac Research. Affiliated Institute of the University of Lübeck) ; Christensen, Henry (Department of Clinical Biochemistry. Lillebaelt Hospital) ; Brody, Jennifer A. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ; Feitosa, Mary (Division of Statistical Genomics. Department of Genetics. Washington University School of Medicine) ; Wojczynski, Mary K. (Division of Statistical Genomics. Department of Genetics. Washington University School of Medicine) ; Preuss, Michael (The Charles Bronfman Institute for Personalized Medicine. Icahn School of Medicine at Mount Sinai) ; Mangino, Massimo (NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust) ; Christofidou, Paraskevi (Department of Twin Research and Genetic Epidemiology. King's College London) ; Verweij, Niek (Department of Cardiology. University Medical Center Groningen. University of Groningen) ; Benjamins, Jan W (Department of Cardiology. University Medical Center Groningen. University of Groningen) ; Engmann, Jorgen (Department of Epidemiology and Public Health. University College London) ; Kember, Rachel L. (Department of Psychiatry. University of Pennsylvania) ; Slieker, Roderick C. (Department of Cell and Chemical Biology. Leiden University Medical Center) ; Lo, Ken S. (Montreal Heart Institute) ; Zilhao, Nuno R. (Icelandic Heart Association) ; Le, Phuong (Department of Anthropology. University of Toronto at Mississauga) ; Kleber, Marcus E. (Synlab MVZ Humangenetik Mannheim) ; Delgado, Graciela E. (University of Heidelberg. Vth Department of Medicine) ; Huo, Shsofeng (Shanghai Institute of Nutrition and Health. University of Chinese Academy of Sciences. Chinese Academy of Sciences) ; Ikeda, Daisuke D. (Biomedical Technology Research Center. Tokushima Research Institute. Otsuka Pharmaceutical) ; Iha, Hiroyuki (Biomedical Technology Research Center. Tokushima Research Institute. Otsuka Pharmaceutical) ; Yang, Jian (Department of Neurological Sciences. Rush University Medical Center) ; Liu, Jun (Genome Institute of Singapore. Agency for Science. Technology and Research) ; Leonard, Hampton L. (Data Tecnica International) ; Marten, Jonathan (MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital) ; Schmidt, Börge (Institute for Medical Informatics. Biometrie and Epidemiology. University of Duisburg-Essen) ; Arendt, Marina (Department of Computer Science. University of Applied Sciences and Arts Dortmund) ; Smyth, Laura J. (Centre for Public Health. Queen's University of Belfast) ; Cañadas-Garre, Marisa (Centre for Public Health. Queen's University of Belfast) ; Wang, Chaolong (Genome Institute of Singapore. Agency for Science. Technology and Research) ; Nakatochi, Masahiro (Public Health Informatics Unit. Department of Integrated Health Sciences. Nagoya University Graduate School of Medicine) ; Wong, Andrew (MRC Unit for Lifelong Health and Ageing at UCL) ; Hutri-Kähönen, Nina (Department of Pediatrics. Faculty of Medicine and Health Technology. Tampere University) ; Sim, Xueling (Saw Swee Hock School of Public Health. National University of Singapore and National University Health System) ; Xia, Rui (Brown Foundation Institute of Molecular Medicine. McGovern Medical School. University of Texas Health Science Center at Houston) ; Huerta-Chagoya, Alicia (Departamento de Medicina Genómica y Toxicología Ambiental. Instituto de Investigaciones Biomédicas. UNAM. Ciudad de Mexico) ; Fernandez-Lopez, Juan Carlos (Departamento de Genómica Computacional. Instituto Nacional de Medicina Genómica. Ciudad de Mexico) ; Lyssenko, Valeriya (Lund University Diabetes Center. Lund University) ; Ahmed, Meraj (Genomic Research on Complex Diseases (GRC Group). CSIR-Centre for Cellular and Molecular Biology) ; Jackson, Anne U. (Department of Biostatistics and Center for Statistics Genetics. University of Michigan) ; Irvin, Marguerite R. (Epidemiology. School of Public Health. University of Alabama at Birmingham) ; Oldmeadow, Christopher (Hunter Medical Research Institute) ; Kim, Han-Na (Department of Clinical Research Design and Evaluation. SAIHST. Sungkyunkwan University) ; Ryu, Seungho (Sungkyunkwan University School of Medicine) ; Timmers, Paul R. H. J. (Centre for Global Health Research. Usher Institute. University of Edinburgh) ; Arbeeva, Liubov (University of North Carolina. Thurston Arthritis Research Center) ; Dorajoo, Rajkumar (Genome Institute of Singapore. Agency for Science. Technology and Research) ; Lange, Leslie A. (Division of Biomedical Informatics and Personalized Medicine. Department of Medicine. Anschutz Medical Campus. University of Colorado. Denver) ; Chai, Xiaoran (Department of Ophthalmology. National University of Singapore and National University Health System) ; Prasad, Gauri (Academy of Scientific and Innovative Research. CSIR-Institute of Genomics and Integrative Biology Campus) ; Lorés-Motta, Laura (Departments of Ophthalmology and Human Genetics. Radboud University Nijmegen Medical Center) ; Pauper, Marc (Departments of Ophthalmology and Human Genetics. Radboud University Nijmegen Medical Center) ; Long, Jirong (Vanderbilt Epidemiology Center. Division of Epidemiology. Vanderbilt University Medical Center) ; Li, Xiaohui (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Theusch, Elisabeth (Department of Pediatrics. University of California. San Francisco) ; Takeuchi, Fumihiko (National Center for Global Health and Medicine) ; Spracklen, Cassandra N. (Department of Biostatistics and Epidemiology. University of Massachusetts-Amherst) ; Loukola, Anu (Institute for Molecular Medicine Finland (FIMM). HiLIFE. University of Helsinki) ; Bollepalli, Sailalitha (Institute for Molecular Medicine Finland (FIMM). HiLIFE. University of Helsinki) ; Warner, Sophie C. (NIHR Leicester Biomedical Research Centre. Glenfield Hospital) ; Wang, Ya Xing (Beijing Tongren Eye Center. Beijing Tongren Hospital. Capital Medical University) ; Wei, Wen B. (Beijing Tongren Eye Center. Beijing Tongren Hospital. Capital Medical University) ; Nutile, Teresa (Institute of Genetics and Biophysics "Adriano Buzzati-Traverso"-CNR) ; Ruggiero, Daniela (IRCCS Neuromed. Pozzilli) ; Sung, Yun Ju (Department of Psychiatry. Washington University) ; Hung, Yi-Jen (Division of Endocrinology and Metabolism. Tri-Service General Hospital Songshan Branch) ; Chen, Shufeng (Chinese Academy of Medical Sciences) ; Liu, Fangchao (Chinese Academy of Medical Sciences) ; Yang, Jingyun (Department of Neurological Sciences. Rush University Medical Center) ; Kentistou, Katherine A. (Centre for Global Health Research. Usher Institute. University of Edinburgh) ; Gorski, Mathias (Department of Nephrology. University Hospital Regensburg) ; Brumat, Marco (Department of Medicine. Surgery and Health Sciences. University of Trieste) ; Meidtner, Karina (German Center for Diabetes Research (DZD)) ; Bielak, Lawrence F. (Department of Epidemiology. School of Public Health. University of Michigan) ; Smith, Jennifer A. (Department of Epidemiology. School of Public Health. University of Michigan) ; Hebbar, Prashantha (Dasman Diabetes Institute. Department of Genetics and Bioinformatics) ; Farmaki, Aliki-Eleni (Department of Population Science and Experimental Medicine. University College London) ; Hofer, Edith (Institute for Medical Informatics. Statistics and Documentation. Medical University of Graz) ; Lin, Maoxuan (Department of Bioinformatics and Genomics. University of North Carolina at Charlotte) ; Xue, Chao (Department of Internal Medicine. Division of Cardiology. University of Michigan) ; Zhang, Jifeng (Department of Internal Medicine. Division of Cardiology. University of Michigan) ; Concas, Maria Pina (Institute for Maternal and Child Health. IRCCS Burlo Garofolo) ; Vaccargiu, Simona (Institute of Genetic and Biomedical Research. National Research Council of Italy. UOS of Sassari) ; van der Most, Peter J (Department of Epidemiology. University Medical Center Groningen. University of Groningen) ; Pitkänen, Niina (Centre for Population Health Research. University of Turku and Turku University Hospital) ; Cade, Brian E (Division of Sleep Medicine. Harvard Medical School) ; Lee, Jiwon (Sleep Medicine and Circadian Disorders. Brigham and Women's Hospital) ; van der Laan, Sander W (University Medical Center Utrecht) ; Chitrala, Kumaraswamy Naidu (Laboratory of Epidemiology and Population Science. National Institute on Aging Intramural Research Program. NIH Biomedical Research Center. NIA) ; Weiss, Stefan (University Medicine Greifswald) ; Zimmermann, Martina E (University of Regensburg. Department of Genetic Epidemiology) ; Lee, Jong Young (Oneomics) ; Choi, Hyeok Sun (Department of Biomedical Science. Hallym University) ; Nethander, Maria (Bioinformatics Core Facility. Sahlgrenska Academy. University of Gothenburg) ; Freitag-Wolf, Sandra (Institute of Medical Informatics and Statistics. Kiel University) ; Southam, Lorraine (Wellcome Trust Sanger Institute (Regne Unit)) ; Rayner, Nigel W. (Oxford Centre for Diabetes Endocrinology and Metabolism) ; Wang, Carol A (School of Medicine and Public Health. College of Health. Medicine and Wellbeing. University of Newcastle) ; Lin, Shih Yi (School of Medicine. National Defense Medical Center) ; Wang, Jun-Sing (Department of Medicine. School of Medicine. National Yang-Ming University) ; Couture, Christian (Department of Kinesiology. Université Laval) ; Lyytikäinen, Leo-Pekka (Department of Clinical Chemistry. Finnish Cardiovascular Research Center-Tampere. Faculty of Medicine and Health Technology. Tampere University) ; Nikus, Kjell (Department of Cardiology. Finnish Cardiovascular Research Center-Tampere. Faculty of Medicine and Health Technology. Tampere University) ; Cuellar-Partida, Gabriel (University of Queensland Diamantina Institute. Translational Research Institute) ; Vestergaard, Henrik (Department of Medicine. Bornholms Hospital) ; Hildalgo, Bertha (School of Public Health. University of Alabama at Birmingham) ; Giannakopoulou, Olga (William Harvey Research Institute. Barts and the London School of Medicine and Dentistry. Queen Mary University of London) ; Cai, Qiuyin (Vanderbilt Epidemiology Center. Division of Epidemiology. Vanderbilt University Medical Center) ; Obura, Morgan O. (Amsterdam UMC. Department of Epidemiology and Biostatistics. Amsterdam Public Health Research Institute) ; van Setten, Jessica (University Medical Center Utrecht) ; Li, Xiaoyin (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Schwander, Karen (Division of Statistical Genomics. Department of Genetics. Washington University School of Medicine) ; Terzikhan, Natalie (Department of Epidemiology. Erasmus MC. University Medical Center Rotterdam) ; Shin, Jae Hun (Department of Biomedical Science. Hallym University) ; Jackson, Rebecca D. (Division of Endocrinology. Ohio State University) ; Reiner, Alewxander P. (Department of Epidemiology. University of Washington) ; Martin, Lisa W. (School of Medicine and Health Sciences. George Washington University) ; Chen, Zhengming (Medical Research Council Population Health Research Unit. Nuffield Department of Population Health. University of Oxford) ; Li, Liming (Peking University Health Science Center) ; Highland, Heather M. (Department of Epidemiology. University of North Carolina) ; Young, Kristin L. (Department of Epidemiology. University of North Carolina) ; Kawaguchi, Takahisa (Center for Genomic Medicine. Kyoto University Graduate School of Medicine) ; Thiery, Joachim (Institute for Laboratory Medicine. University Hospital Leipzig) ; Bis, Joshua C (Cardiovascular Health Research Unit. Department of Medicine. University of Washington) ; Nadkarni, Girish N. (The Charles Bronfman Institute for Personalized Medicine. Icahn School of Medicine at Mount Sinai) ; Launer, Lenore Joy (Laboratory of Epidemiology and Population Sciences. National Institute on Aging. NIH) ; Li, Huaixing (Shanghai Institute of Nutrition and Health. University of Chinese Academy of Sciences. Chinese Academy of Sciences) ; Nalls, Mike A. (Data Tecnica International) ; Raitakari, Olli T. (Department of Clinical Physiology and Nuclear Medicine. Turku University Hospital) ; Ichihara, Sahoko (Department of Environmental and Preventive Medicine. Jichi Medical University School of Medicine) ; Wild, Sarah (Centre for Population Health Sciences. Usher Institute. University of Edinburgh) ; Nelson, Christopher P. (NIHR Leicester Biomedical Research Centre. Glenfield Hospital) ; Campbell, Harry (Centre for Global Health Research. Usher Institute. University of Edinburgh) ; Jäger, Susanne (German Center for Diabetes Research (DZD)) ; Nabika, Toru (Department of Functional Pathology. Shimane University School of Medicine) ; Al-Mulla, Fahd (Dasman Diabetes Institute. Department of Genetics and Bioinformatics) ; Niinikoski, Harri (Department of Physiology. University of Turku) ; Braund, Peter S. (NIHR Leicester Biomedical Research Centre. Glenfield Hospital) ; Kolcic, Ivana (Faculty of Medicine. University of Split) ; Kovacs, Peter (Medical Department III-Endocrinology. Nephrology. Rheumatology. University of Leipzig Medical Center) ; Giardoglou, Tota (Department of Nutrition-Dietetics. Harokopio University. Eleftheriou Venizelou) ; Katsuya, Tomohiro (Department of Geriatric and General Medicine. Osaka University Graduate School of Medicine) ; Bhatti, Konain Fatima (William Harvey Research Institute. Barts and the London School of Medicine and Dentistry. Queen Mary University of London) ; de Kleijn, Dominique (University Medical Center Utrecht) ; de Borst, Gert J. (University Medical Center Utrecht) ; Kim, Eung Kweon (Corneal Dystrophy Research Institute. Department of Ophthalmology. Yonsei University College of Medicine) ; Adams, Hieab H. H. (Department of Radiology and Nuclear Medicine. Erasmus MC. University Medical Center Rotterdam) ; Ikram, M. Arfan (Erasmus University Medical Center. Department of Epidemiology) ; Zhu, Xiaofeng (Case Western Reserve University. Department of Population and Quantitative Health Sciences) ; Asselbergs, Folkert W (University Medical Center Utrecht) ; Kraaijeveld, Adriaan O. (University Medical Center Utrecht) ; Beulens, Joline W. J. (University Medical Center Utrecht) ; Shu, Xiao-Ou (Vanderbilt Epidemiology Center. Division of Epidemiology. Vanderbilt University Medical Center) ; Rallidis, Loukianos S. (Kapodistrian University of Athens) ; Pedersen, Oluf (University of Copenhagen) ; Hansen, Torben (University of Copenhagen) ; Mitchell, Paul (University of Sydney) ; Hewitt, Alex W. (University of Melbourne) ; Kähönen, Mika (Tampere University) ; Pérusse, Louis (Institute of Nutrition and Functional Foods (INAF). Université Laval) ; Bouchard, Claude (Pennington Biomedical Research Center) ; Tönjes, Anke (Medical Department III-Endocrinology. Nephrology. Rheumatology. University of Leipzig Medical Center) ; Chen, Yii Der Ida (The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center) ; Pennell, Craig E. (School of Medicine and Public Health. College of Health. Medicine and Wellbeing. University of Newcastle) ; Mori, Trevor A (Medical School. Faculty of Health and Medical Sciences. University of Western Australia) ; Lieb, Wolfgang (Institute of Epidemiology. Kiel University) ; Franke, Andre (Christian-Albrechts-University of Kiel. Institute of Clinical Molecular Biology) ; Ohlsson, Claes (Department of Drug Treatment. Sahlgrenska University Hospital) ; Mellström, Dan (Geriatric Medicine. Institute of Medicine. Sahlgrenska Academy. University of Gothenburg) ; Cho, Yoon Shin (Department of Biomedical Science. Hallym University) ; Lee, Hyejin (Department of Internal Medicine. Ewha Womans University School of Medicine) ; Yuan, Jan-Min (Department of Epidemiology. Graduate School of Public Health. University of Pittsburgh) ; Koh, Woon-Puay (Singapore Institute for Clinical Sciences. Agency for Science Technology and Research (A*STAR)) ; Rhee, Sang Youl (Department of Endocrinology and Metabolism. Kyung Hee University School of Medicine) ; Woo, Jeong-Taek (Department of Endocrinology and Metabolism. Kyung Hee University School of Medicine) ; Heid, Iris M. (Department of Genetic Epidemiology. University of Regensburg) ; Stark, Klaus J. (Department of Genetic Epidemiology. University of Regensburg) ; Völzke, Henry (Institute for Community Medicine. University Medicine Greifswald) ; Homuth, Georg (Department of Functional Genomics. Interfaculty Institute for Genetics and Functional Genomics. University of Greifswald and University Medicine Greifswald) ; Evans, Michele K. (Laboratory of Epidemiology and Population Science. National Institute on Aging Intramural Research Program. NIH Biomedical Research Center) ; Zonderman, Alan B (Laboratory of Epidemiology and Population Science. National Institute on Aging Intramural Research Program. NIH Biomedical Research Center) ; Polasek, Ozren (Faculty of Medicine. University of Split) ; Pasterkamp, Gerard (University Medical Center Utrecht) ; Hoefer, Imo E. (University Medical Center Utrecht) ; Redline, Susan (Harvard Medical School) ; Pahkala, Katja (University of Turku) ; Oldehinkel, Albertine J (Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE). University of Groningen. University Medical Center Groningen) ; Snieder, Harold (Department of Epidemiology. University Medical Center Groningen. University of Groningen) ; Biino, Ginevra (National Research Council of Italy. Institute of Molecular Genetics) ; Schmidt, Reinhold (Department of Neurology. Clinical Division of Neurogeriatrics. Medical University of Graz) ; Schmidt, Helena (Medical University Graz) ; Chen, Y. Eugene (Department of Internal Medicine. Division of Cardiology. University of Michigan) ; Bandinelli, Stefania (Local Health Unit Toscana Centro) ; Dedoussis, George (Harokopio University of Athens) ; Thanaraj, Thangavel Alphonse (Dasman Diabetes Institute. Department of Genetics and Bioinformatics) ; Kardia, Sharon L. R. (Department of Epidemiology. School of Public Health. University of Michigan) ; Kato, Norihiro (National Center for Global Health and Medicine) ; Schulze, Matthias B. (Institute of Nutritional Science. University of Potsdam) ; Girotto, Giorgia (Institute for Maternal and Child Health IRCCS "Burlo Garofolo") ; Jung, Bettina (Department of Nephrology. University Hospital Regensburg) ; Böger, Carsten A. (KfH Kidney Center Traunstein) ; Joshi, Peter K. (Centre for Global Health Research. Usher Institute. University of Edinburgh) ; Bennett, David A. (Department of Neurological Sciences. Rush University Medical Center) ; De Jager, Philip L. (Program in Medical and Population Genetics. Broad Institute) ; Lu, Xiangfeng (Chinese Academy of Medical Sciences) ; Mamakou, Vasiliki (Dromokaiteio Psychiatric Hospital) ; Brown, Morris (Clinical Pharmacology. William Harvey Research Institute. Queen Mary University of London) ; Caulfield, Mark (Queen Mary University of London. William Harvey Research Institute) ; Munroe, Patricia B. (Queen Mary University of London. Barts and The London School of Medicine and Dentistry) ; Guo, Xiuqing (The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center) ; Ciullo, Marina (IRCCS Neuromed. Pozzilli) ; Jonas, Jost B. (Institute of Molecular and Clinical Ophthalmology Basel) ; Samani, Nilesh J. (NIHR Leicester Biomedical Research Centre. Glenfield Hospital) ; Kaprio, Jaakko (Institute for Molecular Medicine Finland (FIMM). HiLIFE. University of Helsinki) ; Pajukanta, Päivi (University of California. David Geffen School of Medicine at UCLA.) ; Adair, Linda S (Carolina Population Center. University of North Carolina) ; Bechayda, Sonny Augustin (Department of Anthropology. Sociology. and History. University of San Carlos) ; de Silva, H. Janaka (Department of Medicine. Faculty of Medicine. University of Kelaniya) ; Wickremasinghe, Ananda R. (Department of Public Health. Faculty of Medicine. University of Kelaniya) ; Krauss, Ronald M. (Departments of Pediatrics and Medicine. University of California. San Francisco) ; Wu, Jer-Yuarn (Institute of Biomedical Sciences. Academia Sinica) ; Zheng, Wei (Vanderbilt Epidemiology Center. Division of Epidemiology. Vanderbilt University Medical Center) ; den Hollander, Anneke I. (Departments of Ophthalmology and Human Genetics. Radboud University Nijmegen Medical Center) ; Bharadwaj, Dwaipayan (Systems Genomics Laboratory. School of Biotechnology. Jawaharlal Nehru University) ; Correa, Adolfo (University of Mississippi Medical Center) ; Wilson, James G. (University of Mississippi Medical Center) ; Lind, Lars (Uppsala University. Department of Medical Sciences) ; Heng, Chew-Kiat (Khoo Teck Puat-National University Children's Medical Institute. National University Health System) ; Nelson, Amanda E. (Department of Medicine. University of North Carolina) ; Golightly, Yvonne M. (Division of Physical Therapy. University of North Carolina) ; Wilson, James F. (Centre for Global Health Research. Usher Institute. University of Edinburgh) ; Penninx, Brenda WJH (Amsterdam Public Health Research Institute. VU Medical Center Amsterdam) ; Kim, Hyung-Lae (Department of Biochemistry. College of Medicine. Ewha Womans University) ; Attia, John (University of Newcastle. Faculty of Health and Medicine) ; Scott, Rodney J. (University of Newcastle. Faculty of Health and Medicine) ; Rao, D. C. (Washington University School of Medicine) ; Arnett, Donna K. (University of Kentucky. College of Public Health) ; Walker, Mark (Institute of Cellular Medicine (Diabetes). The Medical School. Newcastle University) ; Koistinen, Heikki A. (Minerva Foundation Institute for Medical Research) ; Chandak, Giriraj Ratan (Academy of Scientific and Innovative Research (AcSIR)) ; Yajnik, Chittaranjan S. (Diabetology Research Centre. KEM Hospital and Research Centre) ; Mercader, Josep M. (Diabetes Unit and Center for Genomic Medicine. Massachusetts General Hospital) ; Tusié-Luna, Teresa (Unidad de Biología Molecular y Medicina Genómica. Instituto de Investigaciones Bimédicas UNAM/ Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán) ; Aguilar-Salinas, Carlos Alberto (Dirección de Nutrición and Unidad de Estudios de Enfermedades Metabólicas. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán) ; Gonzalez Villalpando, Clicerio (Instituto Nacional de Salud Publica y Centro de Estudios en Diabetes) ; Orozco, Lorena (Instituto Nacional de Medicina Genómica) ; Fornage, Myriam (University of Texas Health Science at Houston) ; Tai, E. Shyong (Yong Loo Lin School of Medicine. National University of Singapore and National University Health System) ; van Dam, Rob M. (Yong Loo Lin School of Medicine. National University of Singapore and National University Health System) ; Lehtimäki, Terho (Department of Clinical Chemistry. Finnish Cardiovascular Research Center-Tampere. Faculty of Medicine and Health Technology. Tampere University) ; Chaturvedi, Nish (MRC Unit for Lifelong Health and Ageing at UCL) ; Yokota, Mitsuhiro (Kurume University School of Medicine) ; Liu, Jianjun (Genome Institute of Singapore. Agency for Science. Technology and Research) ; Reilly, Dermot F. (Genetics. Merck Sharp & Dohme) ; McKnight, Amy Jayne (Centre for Public Health. Queen's University of Belfast) ; Kee, Frank (Queen's University Belfast) ; Jöckel, Karl-Heinz (University of Duisburg-Essen) ; McCarthy, Mark I. (University of Oxford) ; Palmer, Colin N. A. (University of Dundee. Ninwells Hospital and Medical School) ; Vitart, Veronique (University of Edinburgh. Western General Hospital) ; Hayward, Caroline (University of Edinburgh. Western General Hospital) ; Simonsick, Eleanor (Intramural Research Program. National Institute on Aging) ; van Duijn, Cornelia M. (Nuffield Department of Population Health. University of Oxford) ; Lu, Fan (The Eye Hospital. School of Ophthalmology and Optometry. Wenzhou Medical University) ; Qu, Jia (The Eye Hospital. School of Ophthalmology and Optometry. Wenzhou Medical University) ; Hishigaki, Haretsugu (Biomedical Technology Research Center. Tokushima Research Institute. Otsuka Pharmaceutical) ; Lin, Xu (Shanghai Chinese Academy of Sciences) ; März, Winfried (Medical University of Graz) ; Parra, Esteban J. (Department of Anthropology. University of Toronto at Mississauga) ; Cruz, Miguel (Instituto Mexicano del Seguro Social) ; Gudnason, Vilmundur (Faculty of Medicine. University of Iceland) ; Tardif, Jean-Claude (Department of Medicine. Faculty of Medecine. Université de Montréal) ; Lettre, Guillaume (Department of Medicine. Faculty of Medicine. Université de Montréal) ; 't Hart, Leen M. (Department of Biomedical Data Sciences. Section Molecular Epidemiology. Leiden University Medical Center) ; Elders, Petra J. M. (Amsterdam UMC. Department of General Practice and Elderly Care. Amsterdam Public Health Research Institute) ; Damrauer, Scott M. (Corporal Michael Crescenz VA Medical Center) ; Kumari, Meena (Institute of Social and Economic Research. University of Essex) ; Kivimaki, Mika (Department of Epidemiology and Public Health. University College London) ; van der Harst, Pim (Department of Cardiology. University Medical Center Groningen. University of Groningen) ; Spector, Tim (Department of Twin Research and Genetic Epidemiology. King's College London) ; Loos, Ruth J. F. (The Mindich Child Health and Development Institute. Icahn School of Medicine at Mount Sinai) ; Province, Michael A. (Division of Statistical Genomics. Department of Genetics. Washington University School of Medicine) ; Psaty, Bruce M. (Kaiser Permanent Washington Health Research Institute) ; Brandslund, Ivan (Institute of Regional Health Research. University of Southern Denmark) ; Pramstaller, Peter P. (Institute for Biomedicine. Eurac Research. Affiliated Institute of the University of Lübeck) ; Christensen, Kaare (Danish Aging Research Center. University of Southern Denmark) ; Ripatti, Samuli (Broad Institute of MIT and Harvard) ; Widén, Elisabeth (Institute for Molecular Medicine Finland (FIMM). HiLIFE. University of Helsinki) ; Hakonarson, Hakon (Department of Pediatrics. Perelman School of Medicine. The University of Pennsylvania) ; Grant, Struan F. A. (Children's Hospital of Philadelphia (Pennsilvània)) ; Kiemeney, Lambertus A. L. M. (Radboud University Medical Center. Radboud Institute for Health Sciences) ; de Graaf, Jacqueline (Radboud University Medical Center. Radboud Institute for Health Sciences) ; Loeffler, Markus (LIFE Research Centre for Civilization Diseases. University of Leipzig) ; Kronenberg, Florian (Institute of Genetic Epidemiology. Department of Genetics and Pharmacology. Medical University of Innsbruck) ; Gu, Dongfeng (School of Medicine. Southern University of Science and Technology) ; Erdmann, Jeanette (University of Lübeck. Institute for Cardiogenetics) ; Schunkert, Heribert (Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) e.V.. Partner site Munich Heart Alliance) ; Franks, Paul W. (Lund University Diabetes Centre) ; Linneberg, Allan (University of Copenhagen. Department of Clinical Medicine) ; Jukema, J. Wouter (Netherlands Heart Institute) ; Khera, Amit V. (Department of Medicine. Harvard Medical School) ; Männikkö, Minna (University of Oulu) ; Jarvelin, Marjo-Riitta (University of Oulu. Biocenter of Oulu) ; Kutalik, Zoltan (University Center for Primary Care and Public Health) ; Cucca, Francesco (University of Sassari) ; Mook-Kanamori, Dennis O. (Department of Public Health and Primary Care. Leiden University Medical Center) ; van Dijk, Ko Willems (Department of Human Genetics. Leiden University Medical Center) ; Watkins, Hugh (Division of Cardiovascular Medicine. Radcliffe Department of Medicine. John Radcliffe Hospital. University of Oxford) ; Strachan, David P. (Population Health Research Institute. St George's University of London) ; Grarup, Niels (Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen) ; Sever, Peter (National Heart and Lung Institute. Imperial College London) ; Poulter, Neil (Imperial College London) ; Rotter, Jerome I. (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics) ; Dantoft, Thomas M. (Center for Clinical Research and Prevention. Bispebjerg and Frederiksberg Hospital) ; Karpe, Fredrik (NIHR Oxford Biomedical Research Centre. Churchill Hospital) ; Neville, Matt J. (NIHR Oxford Biomedical Research Centre. Churchill Hospital) ; Timpson, Nicholas J. (University of Bristol) ; Cheng, Ching-Yu (Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP). Duke-NUS Medical School) ; Wong, Tien-Yin (Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP). Duke-NUS Medical School) ; Khor, Chiea Chuen (Genome Institute of Singapore. Agency for Science. Technology and Research) ; Sabanayagam, Charumathi (Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP). Duke-NUS Medical School) ; Peters, Annette (DZHK (German Centre for Cardiovascular Research). Munich Heart Alliance Partner Site) ; Gieger, Christian (German Center for Diabetes Research (DZD)) ; Hattersley, Andrew T. (University of Exeter Medical School. University of Exeter) ; Pedersen, Nancy L. (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Magnusson, Patrik K. E. (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Boomsma, Dorret I. (Amsterdam Reproduction and Development Research Institute. VU Medical Center Amsterdam) ; de Geus, Eco J. C. (Amsterdam Public Health Research Institute. VU Medical Center Amsterdam) ; Cupples, L. Adrienne (Framingham Heart Study. National Heart. Lung. and Blood Institute. US National Institutes of Health) ; van Meurs, Joyce B. J. (Department of Epidemiology. Erasmus MC. University Medical Center Rotterdam) ; Ghanbari, Mohsen (Department of Genetics. School of Medicine. Mashhad University of Medical Sciences) ; Gordon-Larsen, Penny (Carolina Population Center. University of North Carolina) ; Huang, Wei (Department of Genetics. Shanghai-MOST Key Laboratory of Health and Disease Genomics. Chinese National Human Genome Center at Shanghai) ; Kim, Young Jin (Department of Precision Medicine. Division of Genome Science. National Institute of Health) ; Tabara, Yasuharu (Center for Genomic Medicine. Kyoto University Graduate School of Medicine) ; Wareham, Nicholas J. (University of Cambridge (Regne Unit). School of Clinical Medicine) ; Langenberg, Claudia (University of Cambridge (Regne Unit). School of Clinical Medicine) ; Zeggini, Eleftheria (TUM School of Medicine. Technical University of Munich (TUM) and Klinikum Rechts der Isar) ; Kuusisto, Johanna (Institute of Clinical Medicine. Internal Medicine. University of Eastern Finland and Kuopio University Hospital) ; Laakso, Markku (Institute of Clinical Medicine. Internal Medicine. University of Eastern Finland and Kuopio University Hospital) ; Ingelsson, Erik (Stanford Diabetes Research Center. Stanford University) ; Abecasis, Goncalo (Regeneron Pharmaceuticals) ; Chambers, John C. (Imperial College Healthcare NHS Trust. Imperial College London) ; Kooner, Jaspal S. (National Heart and Lung Institute. Imperial College London) ; de Vries, Paul S. (Human Genetics Center. Department of Epidemiology. Human Genetics. and Environmental Sciences. School of Public Health. The University of Texas Health Science Center at Houston) ; Morrison, Alanna (Human Genetics Center. Department of Epidemiology. Human Genetics. and Environmental Sciences. School of Public Health. The University of Texas Health Science Center at Houston) ; North, Kari E. (Department of Epidemiology. University of North Carolina) ; Daviglus, Martha (Institute for Minority Health Research. University of Illinois College of Medicine) ; Kraft, Peter (Department of Biostatistics. Harvard T. H. Chan School of Public Health) ; Martin, Nicholas G (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Whitfield, John B (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Abbas, Shahid (Faisalabad Institute of Cardiology) ; Saleheen, Danish (Department of Cardiology. Columbia University Irving Medical Center) ; Walters, Robin G. (Big Data Institute. University of Oxford) ; Holmes, Michael V (National Institute for Health Research Oxford Biomedical Research Centre. Oxford University Hospitals) ; Black, Corri (Aberdeen Centre for Health Data Science (Aberdeen, Regne Unit)) ; Smith, Blair H (Division of Population Health and Genomics. Ninewells Hospital and Medical School. University of Dundee) ; Justice, Anne E. (Biomedical and Translational Informatics. Geisinger Health) ; Baras, Aris (Regeneron Pharmaceuticals) ; Buring, Julie E. (Harvard Medical School) ; Ridker, Paul M. (Harvard Medical School) ; Chasman, Daniel I. (Harvard Medical School) ; Kooperberg, Charles (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ; Wei, Wei-Qi (Department of Biomedical Informatics. Vanderbilt University Medical Center) ; Jarvik, Gail P. (Departments of Medicine (Medical Genetics) and Genome Sciences. University of Washington Medical Center) ; Namjou, Bahram (Center for Autoimmune Genomics and Etiology. Cincinnati Children's Hospital Medical Center (CCHMC)) ; Hayes, M. Geoffrey (Center for Genetic Medicine. Northwestern University. Feinberg School of Medicine) ; Ritchie, Marylyn D. (Department of Genetics. Institute for Biomedical Informatics. Perelman School of Medicine. University of Pennsylvania) ; Jousilahti, Pekka (Department of Public Health and Welfare. Finnish Institute for Health and Welfare) ; Salomaa, Veikko (Department of Public Health and Welfare. Finnish Institute for Health and Welfare) ; Hveem, Kristian (Department of Medicine. Levanger Hospital. Nord-Trøndelag Hospital Trust) ; Åsvold, Bjørn Olav (Department of Endocrinology. St Olavs Hospital. Trondheim University Hospital) ; Kubo, Michiaki (RIKEN Center for Integrative Medical Sciences) ; Kamatani, Yoichiro (The University of Tokyo. Department of Computational Biology and Medical Sciences) ; Okada, Yukinori (Integrated Frontier Research for Medical Science Division. Institute for Open and Transdisciplinary Research Initiatives. Osaka University) ; Murakami, Yoshinori (The University of Tokyo. Institute of Medical Science) ; Thorsteinsdottir, Unnur (Faculty of Medicine. University of Iceland) ; Stefansson, Kari (Faculty of Medicine. University of Iceland) ; Ho, Yuk-Lam (VA Boston Healthcare System) ; Lynch, Julie A. (University of Massachusetts) ; Rader, Daniel J. (Department of Medicine. Perelman School of Medicine. University of Pennsylvania) ; Tsao, Philip S. (Cardiovascular Institute. Stanford University School of Medicine)
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use. Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels, heart disease remains the leading cause of death worldwide. [...]
2021 - 10.1038/s41586-021-04064-3
Nature, Vol. 600 Núm. 7890 (12 2021) , p. 675-679  
9.
16 p, 4.3 MB Common variants in Alzheimer's disease and risk stratification by polygenic risk scores / De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Moreno-Grau, Sonia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Tesi, Niccolo (Delft Univeristy of Technology) ; Grenier-Boley, Benjamin (Institut Pasteur de Lille) ; Andrade, Victor (University Clinic Bonn) ; Jansen, Iris E. (Vrije Universiteit Amsterdam) ; Pedersen, Nancy L. (Karolinska Institutet (Estocolm, Suècia)) ; Stringa, Najada (Amsterdam UMC-Vrije Universiteit Amsterdam) ; Zettergren, Anna (University of Gothenburg) ; Hernández, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Montrreal, Laura (Universitat Internacional de Catalunya) ; Antúnez, Carmen (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Antonell, Anna (Universitat de Barcelona) ; Tankard, Rick M. (Murdoch University) ; Bis, Joshua C. (University of Washington) ; Sims, Rebecca (Cardiff University) ; Bellenguez, Céline (Institut Pasteur de Lille) ; Quintela, Inés (Universidade de Santiago de Compostela) ; González-Perez, Antonio (Centro Andaluz de Estudios Bioinformáticos, Sevilla) ; Calero, Miguel (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Franco-Macías, Emilio (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Macías, Juan (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Cervera Carles, Laura (Institut d'Investigació Biomèdica Sant Pau) ; Mendez-Gonzalez, Manuel (Universidad de Oviedo) ; Frank-García, Ana (Universidad Autónoma de Madrid) ; Royo, Jose Luís (Universidad de Málaga) ; Moreno, Fermin (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Huerto Vilas, Raquel (Institut de Recerca Biomèdica) ; Baquero, Miquel (Hospital Universitari i Politècnic La Fe (València)) ; Diez-Fairen, Monica (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Lage, Carmen (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; García-Madrona, Sebastián (Hospital Universitario Ramón y Cajal (Madrid)) ; García-González, Pablo (Universitat Internacional de Catalunya) ; Alarcón-Martín, Emilio (Universidad de Málaga) ; Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Sotolongo Grau, Oscar (Universitat Internacional de Catalunya) ; Ullgren, Abbe (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Naj, Adam C. (University of Pennsylvania) ; Lemstra, Afina W. (Vrije Universiteit Amsterdam) ; Benaque, Alba (Universitat Internacional de Catalunya) ; Pérez-Cordón, Alba (Universitat Internacional de Catalunya) ; Benussi, Alberto (University of Brescia) ; Rábano, Alberto (BT-CIEN, Madrid, Spain) ; Padovani, Alessandro (University of Brescia) ; Squassina, Alessio (University of Cagliari) ; de Mendonça, Alexandre (University of Lisbon) ; Arias Pastor, Alfonso (Institut de Recerca Biomèdica) ; Kok, Almar A. L. (Vrije Universiteit Amsterdam) ; Meggy, Alun (Cardiff University) ; Pastor, Ana Belén (BT-CIEN, Madrid, Spain) ; Espinosa, Ana (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Corma-Gómez, Anaïs (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Martín Montes, Angel (Hospital Universitario La Paz (Madrid)) ; Sanabria, Ángela (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; DeStefano, Anita L. (Boston University) ; Schneider, Anja (German Center for Neurodegenerative Diseases (DZNE)) ; Haapasalo, Annakaisa (University of Eastern Finland) ; Kinhult Ståhlbom, Anne (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Tybjærg-Hansen, Anne (University of Copenhagen) ; Hartmann, Annette M. (Martin-Luther-University Halle-Wittenberg) ; Spottke, Annika (University of Bonn) ; Corbatón-Anchuelo, Arturo (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Rongve, Arvid (University of Bergen) ; Borroni, Barbara (University of Brescia) ; Arosio, Beatrice (IRCCS Ospedale Maggiore Policlinico) ; Nacmias, Benedetta (IRCCS Fondazione Don Carlo Gnocchi) ; Nordestgaard, Børge G. (Herlev Gentofte Hospital) ; Kunkle, Brian W. (University of Miami) ; Charbonnier, Camille (Normandie Univ, UNIROUEN) ; Abdelnour, Carla (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Masullo, Carlo (Catholic University of the Sacred Heart) ; Martínez Rodríguez, Carmen (Hospital Universitario de Cabueñes (Gijón)) ; Muñoz-Fernandez, Carmen (Hospital Universitario de Gran Canaria Dr. Negrín) ; Dufouil, Carole (CHU de Bordeaux) ; Graff, Caroline (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Ferreira, Catarina B. (Universidade de Lisboa) ; Chillotti, Caterina (University Hospital of Cagliari) ; Reynolds, Chandra A. (University of California-Riverside) ; Fenoglio, Chiara (Dino Ferrari Center. University of Milan) ; Van Broeckhoven, Christine (University of Antwerp) ; Clark, Christopher (University of Zürich) ; Pisanu, Claudia (University of Cagliari) ; Satizabal, Claudia L. (UT Health San Antonio) ; Holmes, Clive (University of Southampton) ; Buiza-Rueda, Dolores (Universidad de Sevilla) ; Aarsland, Dag (Stavanger University Hospital) ; Rujescu, Dan (Martin-Luther-University Halle-Wittenberg) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Galimberti, Daniela (Fondazione IRCCS Ca' Granda, Ospedale Policlinico) ; Wallon, David (Normandie Univ, UNIROUEN) ; Seripa, Davide (Fondazione IRCCS Casa Sollievo della Sofferenza) ; Grünblatt, Edna (University of Zurich) ; Dardiotis, Efthimios (University of Thessaly. School of Medicine) ; Düzel, Emrah (Otto-von-Guericke University) ; Scarpini, Elio (Fondazione IRCCS Ca' Granda, Ospedale Policlinico) ; Conti, Elisa (University of Milano-Bicocca) ; Rubino, Elisa (AOU Città della Salute e della Scienza di Torino) ; Gelpi, Ellen (Medical University of Vienna) ; Rodríguez-Rodríguez, Eloy (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Duron, Emmanuelle (APHP, Hôpital Broca) ; Boerwinkle, Eric (Baylor College of Medicine) ; Ferri, Evelyn (IRCCS Ospedale Maggiore Policlinico) ; Tagliavini, Fabrizio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Küçükali, Fahri (University of Antwerp) ; Pasquier, Florence (CHU CNR-MAJ, Lille) ; Sanchez-Garcia, Florentino (Hospital Universitario de Gran Canaria Dr. Negrín) ; Mangialasche, Francesca (Karolinska Institutet (Estocolm, Suècia)) ; Jessen, Frank (University of Cologne) ; Nicolas, Gaël (Hospital Universitario de Cabueñes (Gijón)) ; Selbæk, Geir (University of Oslo) ; Ortega, Gemma (National Institute of Health Carlos III) ; Chêne, Geneviève (CHU de Bordeaux, Pole de Santé Publique) ; Hadjigeorgiou, Georgios (University of Cyprus) ; Rossi, Giacomina (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Spalletta, Gianfranco (Baylor College of Medicine) ; Giaccone, Giorgio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Grande, Giulia (Karolinska Institutet and Stockholm University) ; Binetti, Giuliano (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Papenberg, Goran (Karolinska Institutet and Stockholm University) ; Hampel, Harald (Pitié-Salpêtrière Hospital) ; Bailly, Henri (Université Paris Descartes) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit). UK Dementia Research Institute) ; Soininen, Hilkka (Kuopio University Hospital ( Finlàndia)) ; Karlsson, Ida K. (Jönköping University) ; Alvarez, Ignacio (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Appollonio, Ildebrando (San Gerardo hospital) ; Giegling, Ina (Martin-Luther-University Halle-Wittenberg) ; Skoog, Ingmar (University of Gothenburg) ; Saltvedt, Ingvild (Norwegian University of Science and Technhology) ; Rainero, Innocenzo (University of Torino) ; Rosas Allende, Irene (Hospital Universitario Central de Asturias) ; Hort, Jakub (St. Anne's University Hospital Brno) ; Diehl-Schmid, Janine (Technical University of Munich) ; Van Dongen, Jasper (Institute Born-Bunge) ; Vidal, Jean-Sébastien (Université Paris Descartes) ; Lehtisalo, Jenni (Finnish Institute for Health and Welfare) ; Wiltfang, Jens (University of Aveiro) ; Thomassen, Jesper Qvist (Copenhagen University Hospital Rigshospitalet) ; Kornhuber, Johannes (Friedrich-Alexander Universität Erlangen-Nürnberg) ; Haines, Jonathan L. (Case Western Reserve University) ; Vogelgsang, Jonathan (Harvard Medical School) ; Pineda, Juan A. (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Popp, Julius (Lausanne University Hospital) ; Deckert, Jürgen (University Hospital, Wuerzburg) ; Buerger, Katharina (German Center for Neurodegenerative Diseases) ; Morgan, Kevin (University of Nottingham) ; Fließbach, Klaus (University Clinic Bonn) ; Sleegers, Kristel (University of Antwerp) ; Molina-Porcel, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Kilander, Lena (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Weinhold, Leonie (University Hospital of Bonn) ; Farrer, Lindsay A. (Boston University) ; Wang, Li-San (University of Pennsylvania) ; Kleineidam, Luca (University Clinic Bonn) ; Farotti, Lucia (University of Perugia) ; Parnetti, Lucilla (University of Perugia) ; Tremolizzo, Lucio (Ospedale San Gerardo (Itàlia)) ; Hausner, Lucrezia (University of Heidelberg) ; Benussi, Luisa (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Froelich, Lutz (University of Heidelberg) ; Ikram, M. Arfan (Erasmus Medical Center) ; Deniz-Naranjo, M. Candida (Hospital Universitario de Gran Canaria Dr. Negrín) ; Tsolaki, Magda (University of Thessaloniki) ; Rosende-Roca, Maitée (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Löwenmark, Malin (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Hulsman, Marc (Vrije Universiteit Amsterdam) ; Spallazzi, Marco (Azienda Ospedaliero-Universitaria) ; Pericak-Vance, Margaret A. (University of Miami) ; Esiri, Margaret (Nuffield Department of Clinical Neurosciences) ; Bernal Sánchez-Arjona, María (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Dalmasso, Maria Carolina (University of Cologne) ; Martínez-Larrad, María Teresa (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Arcaro, Marina (Fondazione IRCCS Ca' Granda, Ospedale Policlinico) ; Nöthen, Markus M. (University of Bonn) ; Fernández-Fuertes, Marta (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Dichgans, Martin (Munich Cluster for Systems Neurology) ; Ingelsson, Martin (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Herrmann, Martin J. (University Hospital, Wuerzburg) ; Scherer, Martin (University Medical Centre Hamburg-Eppendorf) ; Vyhnalek, Martin (St. Anne's University Hospital Brno) ; Kosmidis, Mary H. (Aristotle University of Thessaloniki) ; Yannakoulia, Mary (Harokopio University) ; Schmid, Matthias (University Hospital of Bonn) ; Ewers, Michael (German Center for Neurodegenerative Diseases) ; Heneka, Michael T. (German Center for Neurodegenerative Diseases) ; Wagner, Michael (German Center for Neurodegenerative Diseases) ; Scamosci, Michela (University of Perugia) ; Kivipelto, Miia (Stockholms Sjukhem, Research & Development Unit, Stockholm, Sweden) ; Hiltunen, Mikko (University of Eastern Finland. Institute of Biomedicine) ; Zulaica, Miren (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Fornage, Myriam (University of Texas) ; Roberto, Natalia (Universitat Internacional de Catalunya) ; van Schoor, Natasja M. (Vrije Universiteit Amsterdam) ; Seidu, Nazib M. (University of Gothenburg) ; Banaj, Nerisa (IRCCS Santa Lucia Foundation) ; Armstrong, Nicola (Murdoch University) ; Scarmeas, Nikolaos (Columbia University) ; Scherbaum, Norbert (University of Duisburg-Essen) ; Goldhardt, Oliver (Technical University of Munich) ; Hanon, Olivier (Université Paris Descartes) ; Peters, Oliver (German Center for Neurodegenerative Diseases) ; Skrobot, Olivia Anna (University of Bristol) ; Quenez, Olivier (FHU G4 Génomique. Normandie Univ) ; Lerch, Ondrej (St. Anne's University Hospital Brno) ; Bossù, Paola (IRCCS Santa Lucia Foundation) ; Caffarra, Paolo (University of Parma) ; Dionigi Rossi, Paolo (IRCCS Ospedale Maggiore Policlinico) ; Sakka, Paraskevi (Athens Association of Alzheimer's disease and Related Disorders) ; Hoffmann, Per (University Hospital Basel (Basilea, Suïssa)) ; Holmans, Peter (Cardiff University) ; Fischer, Peter (Social Medicine Center East- Donauspital) ; Riederer, Peter (University Hospital of Würzburg) ; Yang, Qiong (Boston University) ; Marshall, Rachel (Cardiff University) ; Kalaria, Rajesh N. (Campus for Ageing anf Vitality, Newcastle upon Tyne) ; Mayeux, Richard (Columbia University) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; Cecchetti, Roberta (University of Perugia) ; Ghidoni, Roberta (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Frikke-Schmidt, Ruth (University of Copenhagen) ; Sorbi, Sandro (IRCCS Fondazione Don Carlo Gnocchi) ; Hägg, Sara (Karolinska Institutet (Estocolm, Suècia)) ; Engelborghs, Sebastiaan (VUB University Hospital Brussels) ; Helisalmi, Seppo (University of Eastern Finland) ; Botne Sando, Sigrid (Norwegian University of Science and Technology) ; Kern, Silke (University of Gothenburg) ; Archetti, Silvana (Brescia Hospital) ; Boschi, Silvia (University of Torino) ; Fostinelli, Silvia (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Gil, Silvia (Universitat Internacional de Catalunya) ; Mendoza, Silvia (Instituto Andaluz de Neurociencia) ; Mead, Simon (University College London. Institute of Prion Diseases) ; Ciccone, Simona (IRCCS Ospedale Maggiore Policlinico) ; Djurovic, Srdjan (University of Bergen) ; Heilmann-Heimbach, Stefanie (University of Bonn) ; Riedel-Heller, Steffi (University of Leipzig) ; Kuulasmaa, Teemu (University of Eastern Finland) ; del Ser, Teodoro (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Lebouvier, Thibaud (CHU CNR-MAJ, Lille, France) ; Polak, Thomas (University Hospital, Wuerzburg) ; Ngandu, Tiia (Finnish Institute for Health and Welfare. Population Health Unit) ; Grimmer, Timo (Technical University of Munich) ; Bessi, Valentina (Azienda Ospedaliero-Universitaria Careggi Largo Brambilla) ; Escott-Price, Valentina (Cardiff University) ; Giedraitis, Vilmantas (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Deramecourt, Vincent (CHU CNR-MAJ, Lille, France) ; Maier, Wolfgang (German Center for Neurodegenerative Diseases) ; Jian, Xueqiu (Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Pijnenburg, Yolande (Vrije Universiteit Amsterdam) ; Kehoe, Patrick Gavin (German Center for Neurodegenerative Diseases) ; García-Ribas, Guillermo (Hospital Universitario Ramón y Cajal (Madrid)) ; Sánchez-Juan, Pascual (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Pérez-Tur, Jordi (Instituto de Investigación Sanitaria La Fe) ; Piñol-Ripoll, Gerard (Institut de Recerca Biomèdica) ; Lopez de Munain, Adolfo (Universidad del País Vasco) ; García-Alberca, Jose María (Instituto Andaluz de Neurociencia) ; Bullido, María J. (Hospital Universitario La Paz (Madrid)) ; Álvarez, Victoria (Hospital Universitario Central de Asturias) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Real, Luis M. (Universidad de Málaga) ; Mir, Pablo (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Medina, Miguel (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Scheltens, Philip (Vrije Universiteit Amsterdam) ; Holstege, Henne (Vrije Universiteit Amsterdam) ; Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Sáez, María Eugenia (Centro Andaluz de Estudios Bioinformáticos, Sevilla) ; Carracedo, Ángel (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Amouyel, Philippe (Institut Pasteur de Lille) ; Schellenberg, Gerard D. (University of Pennsylvania) ; Williams, Julie (Cardiff University) ; Seshadri, Sudha (Framingham Heart Study) ; van Duijn, Cornelia M. (University of Oxford) ; Mather, Karen A. (Neuroscience Research Australia) ; Sanchez-Valle, Raquel (Universitat de Barcelona) ; Serrano-Ríos, Manuel (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Blennow, Kaj (University of Gothenburg) ; Huisman, Martijn A (Vrije Universiteit Amsterdam) ; Andreassen, Ole A. (Oslo University Hospital (Oslo, Noruega)) ; Posthuma, Danielle (Vrije Universiteit Amsterdam) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; van der Flier, Wiesje M. (Vrije Universiteit Amsterdam) ; Ramirez, Alfredo (Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Lambert, Jean-Charles (Institut Pasteur de Lille) ; van der Lee, Sven J. (Vrije Universiteit Amsterdam) ; Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Universitat Autònoma de Barcelona
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. [...]
2021 - 10.1038/s41467-021-22491-8
Nature communications, Vol. 12 (june 2021)  
10.
13 p, 1.3 MB Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease / Escott-Price, Valentina (Clinical Cardiff University) ; Bellenguez, Céline (Institut Pasteur de Lille, Lille, France) ; Wang, Li-San (Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Choi, Seung-Hoan (Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America) ; Harold, Denise (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Jones, Lesley (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Holmans, Peter (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Gerrish, Amy (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Vedernikov, Alexey (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Richards, Alexander (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; DeStefano, Anita L. (Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America) ; Lambert, Jean-Charles (Institut Pasteur de Lille, Lille, France) ; Ibrahim-Verbaas, Carla A. (Department of Epidemiology and Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands) ; Naj, Adam C. (University of Pennsylvania Perelman School of Medicine. Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine) ; Sims, Rebecca (Cardiff University. Institute of Psychological Medicine and Clinical Neurosciences) ; Jun, Gyungah (Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America) ; Bis, Joshua C. (Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America) ; Beecham, Gary W. (Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America) ; Grenier-Boley, Benjamin (Institut Pasteur de Lille, Lille, France) ; Russo, Giancarlo (Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland) ; Thornton-Wells, Tricia A. (Vanderbilt University (Nashville, Estats Units d'Amèrica)) ; Denning, Nicola (Cardiff University) ; Smith, Albert V. (Icelandic Heart Association, Kopavogur, Iceland) ; Chouraki, Vincent (Boston University School of Medicine) ; Thomas, Charlene (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Ikram, M. Arfan (Netherlands Consortium for Healthy Aging, Leiden, The Netherlands) ; Zelenika, Diana (Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France) ; Vardarajan, Badri N. (Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America) ; Kamatani, Yoichiro (Fondation Jean Dausset- CEPH, Paris, France) ; Lin, Chiao-Feng (Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Schmidt, Helena (Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria) ; Kunkle, Brian (The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America) ; Dunstan, Melanie L. (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Vronskaya, Maria (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Johnson, Andrew D. (NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, Massachusetts, United States of America) ; Ruiz, Agustin (Fundació ACE) ; Bihoreau, Marie-Thérèse (Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France) ; Reitz, Christiane (Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America) ; Pasquier, Florence (CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France) ; Hollingworth, Paul (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Hanon, Olivier (University Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics department, Paris, France) ; Fitzpatrick, Annette L. (Departments of Epidemiology and Global Health, University of Washington, Seattle, Washington, United States of America) ; Buxbaum, Joseph D (Icahn School of Medicine at Mount Sinai) ; Campion, Dominique (CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France) ; Crane, Paul K. (Department of Medicine, University of Washington, Seattle, Washington, United States of America) ; Baldwin, Clinton (Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America) ; Becker, Tim (German Center for Neurodegenerative Diseases (DZNE), Bonn, and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany) ; Gudnason, Vilmundur (Icelandic Heart Association, Kopavogur, Iceland) ; Cruchaga, Carlos (Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America) ; Craig, David (Queen's University Belfast. Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences) ; Amin, Najaf (Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands) ; Berr, Claudine (Université Montpellier, INSERM, Institute for Neurosciences of Montpellier) ; Lopez, Oscar L. (Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America) ; De Jager, Philip L. (Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts, United States of America) ; Deramecourt, Vincent (CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France) ; Johnston, Janet A. (Queen's University Belfast. Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences) ; Evans, Denis (Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America) ; Lovestone, Simon (King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom) ; Letenneur, Luc (Inserm U897, Victor Segalen University, F-33076, Bordeaux, France) ; Hernández, Isabel (Fundació ACE) ; Rubinsztein, David C. (Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom) ; Eiriksdottir, Gudny (Icelandic Heart Association, Kopavogur, Iceland) ; Sleegers, Kristel (Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Goate, Alison M. (Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America) ; Fiévet, Nathalie (Institut Pasteur de Lille, Lille, France) ; Huentelman, Matthew J. (Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America) ; Gill, Michael (Discipline of Psychiatry, Trinity College, Dublin, Ireland) ; Brown, Kristelle (Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom) ; Kamboh, M. Ilyas (Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America) ; Keller, Lina (Aging Reasearch Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden) ; Barberger-Gateau, Pascale (King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom) ; McGuinness, Bernadette (Queen's University Belfast. Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences) ; Larson, Eric B. (Group Health Research Institute, Group Health, Seattle, Washington, United States of America) ; Myers, Amanda J. (Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, United States of America) ; Dufouil, Carole (Inserm U897, Victor Segalen University, F-33076, Bordeaux, France) ; Todd, Stephen (Queen's University Belfast. Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences) ; Wallon, David (CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France) ; Love, Seth (University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, United Kingdom) ; Rogaeva, Ekaterina (Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada) ; Gallacher, John (Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom) ; St George Hyslop, Peter (Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom) ; Clarimón, Jordi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Lleo, Alberto (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Bayer, Anthony (Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom) ; Tsuang, Debby W. (Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America) ; Yu, Lei (Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America) ; Tsolaki, Magda (3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece) ; Bossù, Paola (Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy) ; Spalletta, Gianfranco (Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy) ; Proitsi, Petra (King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom) ; Collinge, John (MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom) ; Sorbi, Sandro (Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy) ; Garcia, Florentino Sanchez (Hospital Universitario de Gran Canaria Dr. Negrín) ; Fox, Nick C. (University College London Queen Square Institute of Neurology. Dementia Research Centre) ; Hardy, John (Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, United Kingdom) ; Naranjo, Maria Candida Deniz (Hospital Universitario de Gran Canaria Dr. Negrín) ; Bosco, Paolo (IRCCS Associazione Oasi Maria SS, Troina, Italy) ; Clarke, Robert (Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom) ; Brayne, Carol (Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge, United Kingdom) ; Galimberti, Daniela (University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy) ; Scarpini, Elio (University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy) ; Bonuccelli, Ubaldo (Neurological Clinic, University of Pisa, Pisa, Italy) ; Mancuso, Michelangelo (Neurological Clinic, University of Pisa, Pisa, Italy) ; Siciliano, Gabriele (Neurological Clinic, University of Pisa, Pisa, Italy) ; Moebus, Susanne (Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany) ; Mecocci, Patrizia (University of Perugia (Itàlia)) ; Zompo, Maria Del (Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy) ; Maier, Wolfgang (Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany) ; Hampel, Harald (Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany) ; Pilotto, Alberto (Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy) ; Frank-García, Ana (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ; Panza, F. (University of Bari Aldo Moro) ; Solfrizzi, Vincenzo (Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy) ; Caffarra, Paolo (Center for Cognitive Disorders AUSL, Parma, Italy) ; Nacmias, Benedetta (Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy) ; Perry, William (Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America) ; Mayhaus, Manuel (Department Of Psychiatry, University Hospital, Saarland, Germany) ; Lannfelt, Lars (Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden) ; Hakonarson, Hakon (Children's Hospital of Philadelphia (Pennsilvània)) ; Pichler, Sabrina (Department Of Psychiatry, University Hospital, Saarland, Germany) ; Carrasquillo, Minerva M. (Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America) ; Ingelsson, Martin (Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden) ; Beekly, Duane (National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, United States of America) ; Alvarez, Victoria (Genetica molecular-Huca-Oviedo, Oviedo, Spain) ; Zou, Fanggeng (Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America) ; Valladares, Otto (University of Pennsylvania Perelman School of Medicine) ; Younkin, Steven G. (Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America) ; Coto, Eliecer (Genetica molecular-Huca-Oviedo, Oviedo, Spain) ; Hamilton-Nelson, Kara L. (The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America) ; Gu, Wei (Department of Psychiatry, University Hospital, Saarland, Germany) ; Razquin, Cristina (Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain) ; Pastor, Pau (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Mateo, Ignacio (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Owen, Michael J. (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Faber, Kelley M. (Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America) ; Jonsson, Palmi V. (Landspitali University Hospital (Reykjavík, Islàndia)) ; Combarros, Onofre (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; O'Donovan, Michael C. (Cardiff University) ; Cantwell, Laura B. (Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Soininen, Hilkka (Kuopio University Hospital ( Finlàndia)) ; Blacker, Deborah (Massachusetts General Hospital (Boston)) ; Mead, Simon (University College London. Institute of Neurology) ; Mosley, Thomas H. (Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, United States of America) ; Bennett, David A. (Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America) ; Harris, Tamara B. (Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America) ; Fratiglioni, Laura (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Holmes, Clive (Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, United Kingdom) ; de Bruijn, Renee F. A. G. (Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands) ; Passmore, Peter (Queen's University Belfast. Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences) ; Montine, Thomas J. (Department of Pathology, University of Washington, Seattle, Washington, United States of America) ; Bettens, Karolien (Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Rotter, Jerome I. (Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America) ; Brice, Alexis (AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France) ; Morgan, Kevin (Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom) ; Foroud, Tatiana M. (Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America) ; Kukull, Walter A. (Department of Epidemiology, University of Washington, Seattle, Washington, United States of America) ; Hannequin, Didier (CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France) ; Powell, John F. (King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom) ; Nalls, Michael A.. (Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America) ; Ritchie, Karen (Imperial College, London, United Kingdom) ; Lunetta, Kathryn L. (Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America) ; Kauwe, John S. K. (Department of Biology, Brigham Young University, Provo, Utah, United States of America) ; Boerwinkle, Eric (Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas, United States of America) ; Riemenschneider, Matthias (Department of Psychiatry, University Hospital, Saarland, Germany) ; Boada, Mercè (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hiltunen, Mikko (Kuopio University Hospital ( Finlàndia)) ; Martin, Eden R. (Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America) ; Schmidt, Reinhold (Department of Neurology, Medical University Graz, Graz, Austria) ; Rujescu, Dan (Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany) ; Dartigues, Jean-François (Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France) ; Mayeux, Richard (Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America) ; Tzourio, Christophe (Inserm U708, Victor Segalen University, Bordeaux, France) ; Hofman, Albert (Netherlands Consortium for Healthy Aging, Leiden, The Netherlands) ; Nöthen, Markus M. (University of Bonn. Life and Brain Center) ; Graff, Caroline (Karolinska Institutet (Estocolm, Suècia). Department of Neurobiology, Care Sciences and Society) ; Psaty, Bruce M. (Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America) ; Haines, Jonathan L. (Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America) ; Lathrop, Mark (McGill University and Génome Québec Innovation Centre, Montreal, Canada) ; Pericak-Vance, Margaret A. (Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America) ; Launer, Lenore J. (Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America) ; Van Broeckhoven, Christine (Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Farrer, Lindsay A. (Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America) ; van Duijn, Cornelia M. (Center for Medical Systems Biology, Leiden, The Netherlands) ; Ramirez, Alfredo (Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn, Germany) ; Seshadri, Sudha (The Framingham Heart Study, Framingham, Massachusetts, United States of America) ; Schellenberg, Gerard D. (Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Amouyel, Philippe (Centre Hospitalier Régional Universitaire de Lille, Lille, France) ; Williams, Julie (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Universitat Autònoma de Barcelona
Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. [...]
2014 - 10.1371/journal.pone.0094661
PloS one, Vol. 9 (june 2014)  

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1 Bis, J.
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5 Bis, Joshua C.
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