Resultats globals: 7 registres trobats en 0.03 segons.
Articles, 7 registres trobats
Articles 7 registres trobats  
1.
21 p, 7.3 MB Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging / Piñeiro-Hermida, Sergio (Centro Nacional de Investigaciones Oncológicas) ; Autilio, Chiara (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ; Martínez, Paula (Centro Nacional de Investigaciones Oncológicas) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pérez-Gil, Jesús (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ; Blasco, María A (Centro Nacional de Investigaciones Oncológicas)
Here, we show that physiological aging in mice leads to degenerative and fibrotic-like pathologies in the lung and that telomerase gene therapy prevents the onset of these pathologies. Our findings highlight telomerase activation as a potential therapeutic strategy for lung degenerative pathologies associated with aging. [...]
2020 - 10.1083/jcb.202002120
The Journal of Cell Biology, Vol. 219 (august 2020)  
2.
18 p, 268.9 KB Predicting global e-entrepreneurship : an exploratory study / Torres Coronas, Teresa (Universitat Rovira i Virgili) ; Vidal-Blasco, María-Arántzazu (Universitat Rovira i Virgili)
Globalization provides international career opportunities and options, such as entrepreneurship. Entrepreneurship education is currently promoted in both national and European educational strategies. [...]
La globalització brinda oportunitats i opcions professionals internacionals, com l'emprenedoria global. L'educació en emprenedoria es promociona tant en les estratègies educatives nacionals com en les europees. [...]
La globalización brinda oportunidades y opciones profesionales internacionales, como el emprendimiento. La educación en emprendimiento se promociona en las estrategias educativas nacionales y europeas. [...]

2020 - 10.5565/rev/educar.1279
Educar, Vol. 57 Núm. 2 (2021) , p. 519-536 (Temas de investigación)  
3.
25 p, 24.0 MB AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer / Muñoz-Lorente, Miguel A. (Centro Nacional de Investigaciones Oncológicas) ; Martínez, Paula (Centro Nacional de Investigaciones Oncológicas) ; Tejera, Águeda (Centro Nacional de Investigaciones Oncológicas) ; Whittemore, Kurt (Centro Nacional de Investigaciones Oncológicas) ; Moisés-Silva, Ana Carolina (Centro Nacional de Investigaciones Oncológicas) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Blasco, María A. (Centro Nacional de Investigaciones Oncológicas)
Short and dysfunctional telomeres are sufficient to induce a persistent DNA damage response at chromosome ends, which leads to the induction of senescence and/or apoptosis and to various age-related conditions, including a group of diseases known as "telomere syndromes", which are provoked by extremely short telomeres owing to germline mutations in telomere genes. [...]
2018 - 10.1371/journal.pgen.1007562
PLoS Genetics, Vol. 14 (august 2018)  
4.
33 p, 9.6 MB Telomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in mice / Whittemore, Kurt (Centro Nacional de Investigaciones Oncológicas) ; Derevyanko, Aksinya (Centro Nacional de Investigaciones Oncológicas) ; Martínez, Paula (Centro Nacional de Investigaciones Oncológicas) ; Serrano, Rosa (Centro Nacional de Investigaciones Oncológicas) ; Pumarola, Martí 1825-1896 (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Blasco, María A. (Centro Nacional de Investigaciones Oncológicas)
Neurodegenerative diseases associated with old age such as Alzheimer's disease present major problems for society, and they currently have no cure. The telomere protective caps at the ends of chromosomes shorten with age, and when they become critically short, they can induce a persistent DNA damage response at chromosome ends, triggering secondary cellular responses such as cell death and cellular senescence. [...]
2019 - 10.18632/aging.101982
Aging (Albany NY), Vol. 11 (may 2019) , p. 2916-2948  
5.
14 p, 5.0 MB Single-cell telomere-length quantification couples telomere length to meristem activity and stem cell development in Arabidopsis / González-García, Mary Paz (Centre de Recerca en Agrigenòmica) ; Pavelescu, Irina (Centre de Recerca en Agrigenòmica) ; Canela, Andrés (Centro Nacional de Investigaciones Oncológicas) ; Sevillano, Xavier (Universitat Ramon Llull. Grup de Recerca en Tecnologies Mèdia) ; Leehy, Katherine A. (Texas A&M University. Department of Biochemistry and Biophysics) ; Nelson, Andrew D.L. (Texas A&M University. Department of Biochemistry and Biophysics) ; Ibañes, Marta (Universitat de Barcelona. Departament d'Estructura i Constituents de la Matèria) ; Shippen, Dorothy E. (Texas A&M University. Department of Biochemistry and Biophysics) ; Blasco, María A. (Centro Nacional de Investigaciones Oncológicas) ; Caño Delgado, Ana I. (Centre de Recerca en Agrigenòmica)
Telomeres are specialized nucleoprotein caps that protect chromosome ends assuring cell division. Single-cell telomere quantification in animals established a critical role for telomerase in stem cells, yet, in plants, telomere-length quantification has been reported only at the organ level. [...]
2015 - 10.1016/j.celrep.2015.04.013
Cell reports, Vol. 11, issue 6 (May 2015) , p. 977-989  
6.
24 p, 5.3 MB Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres / Povedano, Juan Manuel ; Martinez, Paula ; Serrano, Rosa ; Tejera, Águeda ; Gómez-López, Gonzalo ; Bobadilla, Maria ; Flores, Juana Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Bosch, Fátima ; Blasco, María A
Pulmonary fibrosis is a fatal lung disease characterized by fibrotic foci and inflammatory infiltrates. Short telomeres can impair tissue regeneration and are found both in hereditary and sporadic cases. [...]
2018 - 10.7554/eLife.31299
eLife, Vol. 7 (january 2018)  
7.
16 p, 2.7 MB Gene therapy with the 1 telomere gene rescues decreased 1 levels with aging and prolongs mouse health span / Derevyanko, Aksinya (Centro Nacional de Investigaciones Oncológicas) ; Whittemore, Kurt (Centro Nacional de Investigaciones Oncológicas) ; Schneider, Ralph P. (Centro Nacional de Investigaciones Oncológicas) ; Jiménez, Verónica (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Bosch, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Blasco, María A. (Centro Nacional de Investigaciones Oncológicas)
The shelterin complex protects telomeres by preventing them from being degraded and recognized as double-strand breaks. 1 is an essential component of shelterin, with important roles in telomere protection and telomere replication. [...]
2017 - 10.1111/acel.12677
Aging Cell, Vol. 16 (september 2017) , p. 1353-1368  

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