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1.
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7 p, 1.2 MB |
C-Terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease
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García-Ayllón, María-Salud (Hospital General Universitario de Elche) ;
Lopez-Font, Inmaculada (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Boix, Claudia P. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Fortea, Juan (Fundació Catalana Síndrome de Down) ;
Sánchez-Valle, Raquel (Hospital Clínic i Provincial de Barcelona) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Zetterberg, Henrik (University College London) ;
Blennow, Kaj (University of Gothenburg) ;
Sáez-Valero, Javier (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Universitat Autònoma de Barcelona
This study assesses whether C-Terminal fragments (CTF) of the amyloid precursor protein (APP) are present in cerebrospinal fluid (CSF) and their potential as biomarkers for Alzheimer's disease (AD). Immunoprecipitation and simultaneous assay by Western blotting using multiplex fluorescence imaging with specific antibodies against particular domains served to characterize CTFs of APP in human CSF. [...]
2017 -  10.1038/s41598-017-02841-7
Scientific reports, Vol. 7 Núm. 1 (january 2017) , p. 2477
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2.
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135 p, 1.9 MB |
Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias : An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry
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Lewczuk, Piotr (University Hospital of Białystok) ;
Riederer, Peter (University Hospital Würzburg) ;
O'Bryant, Sid E. (University of North Texas Health Science Center) ;
Verbeek, Marcel M. (Radboud Alzheimer center) ;
Dubois, Bruno (Salpêtrièrie Hospital) ;
Visser, Pieter Jelle (Vrije Universiteit Amsterdam) ;
Jellinger, Kurt A. (Institute of Clinical Neurobiology) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Ramirez, Alfredo (University of Cologne) ;
Parnetti, Lucilla (University of Perugia) ;
Jack Jr, Clifford R. (Mayo Clinic) ;
Teunissen, Charlotte E. (VU University Medical Center Amsterdam) ;
Hampel, Harald (heimer (IM2A). Hôpital Pitié-Salpêtrière) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Jessen, Frank (German Center for Neurodegenerative Disorders (DZNE)) ;
Glodzik, Lidia (NYU Langone Medical Center) ;
de Leon, Mony J. (NYU Langone Medical Center) ;
Fagan, Anne M. (Washington University School of Medicine) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Jansen, Willemijn J. (Maastricht University) ;
Winblad, Bengt (Karolinska Institutet (Estocolm, Suècia)) ;
Shaw, Leslie M. (University of Pennsylvania) ;
Andreasson, Ulf (The Sahlgrenska Academy at the University of Gothenburg) ;
Otto, Markus (University of Ulm) ;
Mollenhauer, Brit (Kassel and University Medical Center Göttingen) ;
Wiltfang, Jens (University of Aveiro) ;
Turner, Martin R. (University of Oxford) ;
Zerr, Inga (German Center for Neurodegenerative Diseases) ;
Handels, Ron (Karolinska Institutet (Estocolm, Suècia)) ;
Thompson, Alexander G. (University of Oxford) ;
Johansson, Gunilla (Karolinska Institutet (Estocolm, Suècia)) ;
Ermann, Natalia (Universitätsklinikum Erlangen. and Friedrich-Alexander Universität Erlangen-Nürnberg) ;
Trojanowski, John Q. (University of Pennsylvania) ;
Karaca, Ilker (University of Bonn) ;
Wagner, Holger (University of Bonn) ;
Oeckl, Patrick (University of Ulm) ;
van Waalwijk van Doorn, Linda (Radboud Alzheimer center) ;
Bjerke, Maria (University of Antwerp) ;
Kapogiannis, Dimitrios (National Institute on Aging/National Institutes of Health (NIA/NIH)) ;
Kuiperij, H.Bea (Radboud Alzheimer center) ;
Farotti, Lucia (University of Perugia) ;
Li, Yi (NYU Langone Medical Center) ;
Gordon, Brian A. (Washington University School of Medicine) ;
Epelbaum, Stéphane (Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A)) ;
Vos, Stephanie J.B. (Maastricht University) ;
Klijn, Catharina J.M. (Radboud Alzheimer Center) ;
Van Nostrand, William E. (Stony Brook University) ;
Minguillon, Carolina (Fundació Pasqual Maragall) ;
Schmitz, Matthias (University Medical School) ;
Gallo, Carla (Universidad Peruana Cayetano Heredia) ;
Lopez Mato, Andrea (Maimonides University) ;
Thibaut, Florence (University Hospital Cochin-Site Tarnier 89 rue d'Assas) ;
Lista, Simone (heimer (IM2A). Hôpital Pitié-Salpêtrière) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Kornhuber, Johannes (Universitätsklinikum Erlangen) ;
Universitat Autònoma de Barcelona
In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. [...]
2018 - 10.1080/15622975.2017.1375556
World Journal of Biological Psychiatry, Vol. 19 Núm. 4 (19 2018) , p. 244-328
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3.
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8 p, 1.0 MB |
Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aβ species
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Oliveira, Francisco (University of Coimbra) ;
Leuzy, Antoine (Karolinska Institutet (Estocolm, Suècia)) ;
Castelhano, Joäo (University of Coimbra) ;
Chiotis, Konstantinos (Karolinska Institutet (Estocolm, Suècia)) ;
Hasselbalch, Steen Gregers (University of Copenhagen) ;
Rinne, Juha (University of Turku) ;
Mendonça, Alexandre (University of Lisbon) ;
Otto, Markus (University of Ulm) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Santana, Isabel (University of Coimbra) ;
Johansson, Jarkko (Turku University Hospital (Finlàndia)) ;
Anderl-Straub, Sarah (University of Ulm) ;
Arnim, Christine (University of Ulm) ;
Beer, Ambros (Ulleval University Hospital (Norway)) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Sanna-Kaisa, Herukka (University of Eastern Finland and Kuopio University Hospital) ;
Portelius, Erik (Sahlgrenska University Hospital (Suècia)) ;
Pannee, Josef (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik. (UK Dementia Research Institute) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Moreira, Ana P. (University of Coimbra) ;
Abrunhosa, Antero (University of Coimbra) ;
Nordberg, Agneta (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Castelo-Branco, Miguel (University of Coimbra) ;
Universitat Autònoma de Barcelona
Positron emission tomography (PET) neuroimaging with the Pittsburgh Compound_B (PiB) is widely used to assess amyloid plaque burden. Standard quantification approaches normalize PiB-PET by mean cerebellar gray matter uptake. [...]
2018 - 10.1016/j.nicl.2018.08.023
NeuroImage, Vol. 20 (january 2018) , p. 603-610
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4.
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6 p, 731.5 KB |
A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood : Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort
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Stamate, Daniel (University of London) ;
Kim, Min (Steno Diabetes Center Copenhagen) ;
Proitsi, Petroula (King's College London) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison (University of Oxford) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Hye, Abdul (King's College London) ;
Bos, Isabelle (Amsterdam UMC) ;
Vos, Stephanie J.B. (Maastricht University) ;
Vandenberghe, Rik (Amsterdam UMC) ;
Teunissen, Charlotte E. (Amsterdam UMC. University Medical Center) ;
Kate, Mara Ten (Amsterdam UMC. University Medical Center) ;
Scheltens, Philip (Vrije Universiteit Amsterdam) ;
Gabel, Silvy (Laboratory for Cognitive Neurology) ;
Meersmans, Karen (Laboratory for Cognitive Neurology) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, Jill (GlaxoSmithKline R&D) ;
De Roeck, Ellen (University of Antwerp) ;
Engelborghs, Sebastiaan (Vrije Universiteit Brussel (VUB)) ;
Sleegers, Kristel (Center for Molecular Neurology. VIB) ;
Bordet, Régis (University of Lille) ;
Ramit, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Kettunen, Petronella (Sahlgrenska Academy at University of Gothenburg) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (Fundacion CITA-alzheimer Fundazioa) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska Institutet (Estocolm, Suècia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Molinuevo, José Luis (Universitat Pompeu Fabra) ;
Wallin, Anders (Sahlgrenska Academy at the University of Gothenburg) ;
Popp, Julius (Geneva University Hospitals) ;
Martinez-Lage, Pablo (Fundación CITA-Alzhéimer Fundazioa) ;
Bertram, Lars (University of Oslo) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Streffer, Johannes (University of Antwerp) ;
Visser, Pieter J. (Amsterdam UMC) ;
Lovestone, Simon (Janssen-Cilag UK Ltd) ;
Legido-Quigley, Cristina (King's College London) ;
Universitat Autònoma de Barcelona
Machine learning (ML) may harbor the potential to capture the metabolic complexity in Alzheimer Disease (AD). Here we set out to test the performance of metabolites in blood to categorize AD when compared to CSF biomarkers. [...]
2019 - 10.1016/j.trci.2019.11.001
Alzheimer's & dementia, Vol. 5 (2019) , p. 933-938
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5.
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11 p, 783.1 KB |
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay
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Shi, Liu (University of Oxford) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison L. (University of Oxford) ;
Winchester, Laura (University of Oxford) ;
Dobricic, Valerija (University of Lübeck) ;
Kilpert, Fabian (University of Lübeck) ;
Hong, Shengjun (University of Lübeck) ;
Franke, Andre (Christian-Albrechts-University of Kiel) ;
Hye, Abdul (King's College London) ;
Ashton, Nicholas J. (South London and Maudsley NHS Foundation) ;
Morgan, Angharad R. (Cardiff University) ;
Bos, Isabelle (Maastricht University) ;
Vos, Stephanie J.B. (Amsterdam UMC. University Medical Center) ;
Buckley, Noel J (University of Oxford) ;
Kate, Mara ten (Amsterdam UMC. University Medical Center) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Gabel, Silvy (Laboratory for Cognitive Neurology) ;
Meersmans, Karen (Laboratory for Cognitive Neurology) ;
Engelborghs, Sebastiaan (VUB University Hospital Brussels (UZ Brussel)) ;
De Roeck, Ellen E. (Institute Born-Bunge. University of Antwerp) ;
Sleegers, Kristel (Center for Molecular Neurology. VIB) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, Jill C. (GlaxoSmithKline R&D) ;
Bordet, Régis (University of Lille) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Rami, Lorena (Universitat Pompeu Fabra) ;
Wallin, Anders (Sahlgrenska Academy at University of Gothenburg) ;
Kettunen, Petronella (University of Oxford) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (Geneva University Hospitals) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Martinez-Lage, Pablo (Fundación CITA-Alzhéimer Fundazioa) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter Copenhagen University Hospital ;
Teunissen, Charlotte E. (Vrije Universiteit Amsterdam) ;
Freund-Levi, Yvonne (King's College London) ;
Frölich, Lutz (University of Heidelberg) ;
Legido-Quigley, Cristina (Steno Diabetes Center) ;
Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Baker, Susan (Janssen R&D) ;
Morgan, B.Paul (Cardiff University) ;
Streffer, Johannes (Janssen R&D. LLC) ;
Visser, Pieter Jelle (Karolinska Institutet (Estocolm, Suècia)) ;
Bertram, Lars (University of Oslo) ;
Lovestone, Simon (University of Oxford) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Universitat Autònoma de Barcelona
Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. [...]
2019 - 10.1016/j.jalz.2019.06.4951
Alzheimer's & Dementia, Vol. 15 Núm. 11 (november 2019) , p. 1478-1488
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6.
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22 p, 986.7 KB |
Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
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Kim, Min (Steno Diabetes Center Copenhagen) ;
Snowden, Stuart (University of Cambridge) ;
Suvitaival, Tommi (Steno Diabetes Center Copenhagen) ;
Ali, Ashfaq (Steno Diabetes Center Copenhagen) ;
Merkler, David J. (University of South Florida) ;
Ahmad, Tahmina (King's College London) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison (University of Oxford) ;
Proitsi, Petroula (King's College London) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Hye, Abdul (Steno Diabetes Center Copenhagen) ;
Bos, Isabelle (Maastricht University) ;
Vos, Stephanie (Maastricht University) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Teunissen, Charlotte (Amsterdam Neuroscience) ;
ten Kate, Mara (Amsterdam Neuroscience) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Gabel, Silvy (KU Leuven) ;
Meersmans, Karen (KU Leuven) ;
Blin, Olivier ;
Richardson, Jill (GlaxoSmithKline R&D) ;
De Roeck, Ellen (University of Antwerp) ;
Sleegers, Kristel (VIB) ;
Bordet, Régis (University of Lille) ;
Rami Gonzalez, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Kettunen, Petronella (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Frisoni, Giovanni B. (University of Geneva) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Wallin, Anders (University of Gothenburg) ;
Popp, Julius (Geneva University Hospitals) ;
Martinez-Lage, Pablo (CITA-Alzheimer Foundation) ;
Bertram, Lars (University of Lübeck) ;
Barkhof, Frederik (Amsterdam Neuroscience) ;
Ashton, Nicholas J (University of Gothenburg) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UK Dementia Research Institute) ;
Streffer, Johannes (Janssen Pharmaceutical Companies) ;
Visser, Pieter J. (Amsterdam Neuroscience) ;
Lovestone, Simon (University of Oxford) ;
Legido-Quigley, Cristina (Steno Diabetes Center Copenhagen) ;
Universitat Autònoma de Barcelona
A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. [...]
2019 - 10.1016/j.jalz.2019.03.004
Alzheimer's & Dementia, Vol. 15 Núm. 6 (june 2019) , p. 817-827
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12 p, 1.3 MB |
Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset
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Hong, S. (University of Lübeck) ;
Prokopenko, D. (Massachusetts General Hospital) ;
Dobricic, V. (University of Lübeck) ;
Kilpert, F. (University of Lübeck) ;
Bos, I. (Vrije Universiteit Amsterdam) ;
Vos, S.J.B. (Maastricht University) ;
Tijms, Betty M (Vrije Universiteit Amsterdam) ;
Andreasson, Ulf (Sahlgrenska University Hospital (Suècia)) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Vandenberghe, R. (University Hospitals Leuven (Bèlgica)) ;
Cleynen, I. (KU Leuven) ;
Gabel, Silvy (KU Leuven) ;
Schaeverbeke, J. (KU Leuven) ;
Scheltens, Philip (Vrije Universiteit Amsterdam) ;
Teunissen, C.E. (Vrije Universiteit) ;
Niemantsverdriet, E. (University of Antwerp) ;
Engelborghs, Sebastiaan (UZ Brussel and Vrije Universiteit Brussel (VUB)) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, J.C. (GlaxoSmithKline R&D) ;
Bordet, Régis (University of Lille) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Rami Gonzalez, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Kettunen, P. (University of Oxford) ;
Wallin, Anders (University of Gothenburg) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, J. (Lausanne University Hospital) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Martinez-Lage, P. (CITA-Alzheimer Foundation) ;
Tainta, M. (CITA-Alzheimer Foundation) ;
Dobson, R.J.B. (University College London) ;
Legido-Quigley, Cristina (King's College London) ;
Sleegers, K. (University of Antwerp) ;
Van Broeckhoven, C. (University of Antwerp) ;
ten Kate, M. (Amsterdam Neuroscience) ;
Barkhof, Frederik (University College London) ;
Zetterberg, H. (UK Dementia Research Institute) ;
Lovestone, S. (University of Oxford) ;
Streffer, J. (UCB Biopharma SPRL) ;
Wittig, M. (Christian-Albrechts-University of Kiel) ;
Franke, Andre (Christian-Albrechts-University of Kiel) ;
Tanzi, R.E. (Massachusetts General Hospital) ;
Visser, Pieter Jelle (Vrije Universiteit Amsterdam) ;
Bertram, Lars (University of Oslo) ;
Universitat Autònoma de Barcelona
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the most common form of dementia in the elderly. Susceptibility to AD is considerably determined by genetic factors which hitherto were primarily identified using case-control designs. [...]
2020 - 10.1038/s41398-020-01074-z
Translational psychiatry, Vol. 10 Núm. 1 (december 2020) , p. 403
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8.
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11 p, 1.4 MB |
APOE ϵ4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease
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Konijnenberg, E. (Alzheimer Center Amsterdam) ;
Tijms, Betty M (Alzheimer Center Amsterdam) ;
Gobom, J. (University of Gothenburg) ;
Dobricic, V. (University of Lübeck) ;
Bos, Isabelle (Maastricht University) ;
Vos, S. (Maastricht University) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, F. (Maastricht University) ;
Popp, J. (Lausanne University Hospital) ;
Martinez-Lage, P. (CITA-Alzheimer Foundation) ;
Vandenberghe, R. (University Hospitals Leuven (Bèlgica)) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Frölich, L. (University of Heidelberg) ;
Lovestone, S. (Janssen RandD) ;
Streffer, J. (Janssen RandD) ;
Bertram, Lars (University of Oslo) ;
Blennow, Kaj (University of Gothenburg) ;
Teunissen, C.E. (Vrije Universiteit Amsterdam) ;
Veerhuis, R. (Vrije Universiteit Amsterdam) ;
Smit, A.B. (Vrije Universiteit Amsterdam) ;
Scheltens, P. (Vrije Universiteit Amsterdam) ;
Zetterberg, H. (UK Dementia Research Institute) ;
Visser, P.J. (Karolinska Instutet) ;
Universitat Autònoma de Barcelona
Aggregation of amyloid β into plaques in the brain is one of the earliest pathological events in Alzheimer's disease (AD). The exact pathophysiology leading to dementia is still uncertain, but the apolipoprotein E (APOE) ϵ4 genotype plays a major role. [...]
2020 - 10.1186/s13195-020-00628-z
Alzheimer's research & therapy, Vol. 12 Núm. 1 (27 2020) , p. 65
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9.
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11 p, 1.6 MB |
Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
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Rozalem Aranha, Mateus (Institut d'Investigació Biomèdica Sant Pau) ;
Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau) ;
Montal, Victor (Institut d'Investigació Biomèdica Sant Pau) ;
Pegueroles, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Bejanin, Alexandre (Institut d'Investigació Biomèdica Sant Pau) ;
Vaqué-Alcázar, Lídia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Grothe, Michel (Universitario Virgen del Rocío) ;
Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ;
Videla Toro, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Benejam, Bessy (Institut d'Investigació Biomèdica Sant Pau) ;
Arranz Martínez, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Padilla, Concepción (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Valldeneu, Sílvia (Institut d'Investigació Biomèdica Sant Pau) ;
Barroeta, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Altuna-Azkargorta, Miren (Institut d'Investigació Biomèdica Sant Pau) ;
Fernández, Susana (Fundació Catalana Síndrome de Down) ;
Ribas, Laia (Institut d'Investigació Biomèdica Sant Pau) ;
Valle-Tamayo, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
González-Ortiz, Sofía (Hospital Clínic i Provincial de Barcelona) ;
Bargalló, Núria (Magnetic Resonance Image Core Facility) ;
Zetterberg, Henrik (Hong Kong Center for Neurodegenerative Diseases) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Wisniewski, Thomas M. (New York University Grossman School of Medicine) ;
Busciglio, Jorge A. (University of California at Irvine) ;
Cuello, A. C. (Oxford University) ;
Lleó, Alberto (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background: Basal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS. [...]
2023 - 10.1002/alz.12999
Alzheimer's & Dementia, 2023
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10.
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19 p, 3.1 MB |
Apolipoprotein E imbalance in the cerebrospinal fluid of Alzheimer's disease patients
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Lennol, Matthew Paul (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Sánchez-Domínguez, Irene (Universitat de Barcelona. Institut de Neurociències) ;
Cuchillo-Ibañez, Inmaculada (Instituto de Investigación Sanitaria y Biomédica de Alicante) ;
Camporesi, Elena (Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry. the Sahlgrenska Academy at the University of Gothenburg) ;
Brinkmalm, Gunnar (Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry. the Sahlgrenska Academy at the University of Gothenburg) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Soria, Guadalupe (Universitat de Barcelona. Laboratori de Neuroanatomia Quirúrgica. Facultat de Medicina i Ciències de la Salut) ;
Aguado, Fernando (Universitat de Barcelona. Institut de Neurociències) ;
Zetterberg, Henrik (Hong Kong Center for Neurodegenerative Diseases) ;
Blennow, Kaj (Clinical Neurochemistry Laboratory. Sahlgrenska University Hospital) ;
Sáez-Valero, Javier (Instituto de Investigación Sanitaria y Biomédica de Alicante) ;
Universitat Autònoma de Barcelona
Objective: The purpose of this study was to examine the levels of cerebrospinal fluid (CSF) apolipoprotein E (apoE) species in Alzheimer's disease (AD) patients. Methods: We analyzed two CSF cohorts of AD and control individuals expressing different APOE genotypes. [...]
2022 - 10.1186/s13195-022-01108-2
Alzheimer's research & therapy, Vol. 14 Núm. 1 (december 2022) , p. 161
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