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16 p, 4.3 MB Common variants in Alzheimer's disease and risk stratification by polygenic risk scores / de Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Moreno-Grau, Sonia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Tesi, Niccolo (Delft Univeristy of Technology) ; Grenier-Boley, Benjamin (Institut Pasteur de Lille) ; Andrade, Victor (University Clinic Bonn) ; Jansen, Iris E. (Vrije Universiteit Amsterdam) ; Pedersen, Nancy L. (Karolinska Institutet.) ; Stringa, Najada (Amsterdam UMC-Vrije Universiteit Amsterdam) ; Zettergren, Anna (University of Gothenburg) ; Hernández, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Montrreal, Laura (Universitat Internacional de Catalunya) ; Antúnez, Carmen (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Antonell, Anna (Universitat de Barcelona) ; Tankard, Rick M. (Murdoch University) ; Bis, Joshua C. (University of Washington) ; Sims, Rebecca (Cardiff University) ; Bellenguez, Céline (Institut Pasteur de Lille) ; Quintela, Inés (Universidade de Santiago de Compostela) ; González-Perez, Antonio (Centro Andaluz de Estudios Bioinformáticos, Sevilla) ; Calero, Miguel (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Franco-Macías, Emilio (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Macías, Juan (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Cervera-Carles, Laura (Institut d'Investigació Biomèdica Sant Pau) ; Menéndez-González, Manuel (Universidad de Oviedo) ; Frank-García, Ana (Universidad Autónoma de Madrid) ; Royo, Jose Luís (Universidad de Málaga) ; Moreno, Fermin (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Huerto Vilas, Raquel (Institut de Recerca Biomedica de Lleida) ; Baquero, Miquel (Hospital Universitari i Politècnic La Fe de València) ; Diez-Fairen, Monica (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Lage, Carmen (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; García-Madrona, Sebastián (Hospital Universitario Ramón y Cajal (Madrid)) ; García-González, Pablo (Universitat Internacional de Catalunya) ; Alarcón-Martín, Emilio (Universidad de Málaga) ; Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Sotolongo-Grau, Oscar (Universitat Internacional de Catalunya) ; Ullgren, Abbe (Karolinska University Hospital-Solna) ; Naj, Adam C. (University of Pennsylvania) ; Lemstra, Afina W. (Vrije Universiteit Amsterdam) ; Benaque, Alba (Universitat Internacional de Catalunya) ; Pérez-Cordón, Alba (Universitat Internacional de Catalunya) ; Benussi, Alberto (University of Brescia) ; Rábano, Alberto (BT-CIEN, Madrid, Spain) ; Padovani, Alessandro (University of Brescia) ; Squassina, Alessio (University of Cagliari) ; de Mendonça, Alexandre (University of Lisbon) ; Arias Pastor, Alfonso (Institut de Recerca Biomedica de Lleida) ; Kok, Almar A. L. (Vrije Universiteit Amsterdam) ; Meggy, Alun (Cardiff University) ; Pastor, Ana Belén (BT-CIEN, Madrid, Spain) ; Espinosa, Ana (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Corma-Gómez, Anaïs (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Martín Montes, Angel (Hospital Universitario La Paz (Madrid)) ; Sanabria, Ángela (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; DeStefano, Anita L. (Boston University) ; Schneider, Anja (German Center for Neurodegenerative Diseases (DZNE)) ; Haapasalo, Annakaisa (University of Eastern Finland) ; Kinhult Ståhlbom, Anne (Karolinska University Hospital-Solna) ; Tybjærg-Hansen, Anne (University of Copenhagen) ; Hartmann, Annette M. (Martin-Luther-University Halle-Wittenberg) ; Spottke, Annika (University of Bonn) ; Corbatón-Anchuelo, Arturo (CIBERDEM) ; Rongve, Arvid (University of Bergen) ; Borroni, Barbara (University of Brescia) ; Arosio, Beatrice (IRCCS Ospedale Maggiore Policlinico) ; Nacmias, Benedetta (IRCCS Fondazione Don Carlo Gnocchi) ; Nordestgaard, Børge G. (Herlev Gentofte Hospital) ; Kunkle, Brian W. (University of Miami) ; Charbonnier, Camille (Normandie Univ, UNIROUEN) ; Abdelnour, Carla (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Masullo, Carlo (Catholic University of the Sacred Heart) ; Martínez Rodríguez, Carmen (Hospital de Cabueñes) ; Muñoz-Fernandez, Carmen (Hospital Universitario de Gran Canaria Dr. Negrín) ; Dufouil, Carole (CHU de Bordeaux) ; Graff, Caroline (Karolinska University Hospital-Solna) ; Ferreira, Catarina B. (Universidade de Lisboa) ; Chillotti, Caterina (University Hospital of Cagliari) ; Reynolds, Chandra A. (University of California-Riverside) ; Fenoglio, Chiara (Dino Ferrari Center. University of Milan) ; Van Broeckhoven, Christine (University of Antwerp) ; Clark, Christopher (University of Zürich) ; Pisanu, Claudia (University of Cagliari) ; Satizabal, Claudia L. (UT Health San Antonio) ; Holmes, Clive (University of Southampton) ; Buiza-Rueda, Dolores (Universidad de Sevilla) ; Aarsland, Dag (Stavanger University Hospital) ; Rujescu, Dan (Martin-Luther-University Halle-Wittenberg) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Galimberti, Daniela (Fondazione IRCCS Ca' Granda, Ospedale Policlinico) ; Wallon, David (Normandie Univ, UNIROUEN) ; Seripa, Davide (Fondazione IRCCS Casa Sollievo della Sofferenza) ; Grünblatt, Edna (University of Zurich) ; Dardiotis, Efthimios (University of Thessaly. School of Medicine) ; Düzel, Emrah (Otto-von-Guericke University) ; Scarpini, Elio (Fondazione IRCCS Ca' Granda, Ospedale Policlinico) ; Conti, Elisa (University of Milano-Bicocca) ; Rubino, Elisa (AOU Città della Salute e della Scienza di Torino) ; Gelpi, Ellen (Medical University of Vienna) ; Rodriguez-Rodriguez, Eloy (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Duron, Emmanuelle (APHP, Hôpital Broca) ; Boerwinkle, Eric (Baylor College of Medicine) ; Ferri, Evelyn (IRCCS Ospedale Maggiore Policlinico) ; Tagliavini, Fabrizio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Küçükali, Fahri (University of Antwerp) ; Pasquier, Florence (CHU CNR-MAJ, Lille) ; Sanchez-Garcia, Florentino (Hospital Universitario de Gran Canaria Dr. Negrín) ; Mangialasche, Francesca (Karolinska Institutet) ; Jessen, Frank (University of Cologne) ; Nicolas, Gaël (Hospital de Cabueñes) ; Selbæk, Geir (University of Oslo) ; Ortega, Gemma (National Institute of Health Carlos III) ; Chêne, Geneviève (CHU de Bordeaux, Pole de Santé Publique) ; Hadjigeorgiou, Georgios (University of Cyprus) ; Rossi, Giacomina (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Spalletta, Gianfranco (Baylor College of Medicine) ; Giaccone, Giorgio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Grande, Giulia (Karolinska Institutet and Stockholm University) ; Binetti, Giuliano (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Papenberg, Goran (Karolinska Institutet and Stockholm University) ; Hampel, Harald (Pitié-Salpêtrière Hospital) ; Bailly, Henri (Université Paris Descartes) ; Zetterberg, Henrik (UK Dementia Research Institute at UCL) ; Soininen, Hilkka (Kuopio University Hospital) ; Karlsson, Ida K. (Jönköping University) ; Alvarez, Ignacio (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Appollonio, Ildebrando (San Gerardo hospital) ; Giegling, Ina (Martin-Luther-University Halle-Wittenberg) ; Skoog, Ingmar (University of Gothenburg) ; Saltvedt, Ingvild (Norwegian University of Science and Technhology) ; Rainero, Innocenzo (University of Torino) ; Rosas Allende, Irene (Hospital Universitario Central de Asturias) ; Hort, Jakub (St. Anne's University Hospital Brno) ; Diehl-Schmid, Janine (Technical University of Munich) ; Van Dongen, Jasper (Institute Born-Bunge) ; Vidal, Jean-Sebastien (Université Paris Descartes) ; Lehtisalo, Jenni (Finnish Institute for Health and Welfare) ; Wiltfang, Jens (University of Aveiro) ; Thomassen, Jesper Qvist (Rigshospitalet. Department of Clinical Biochemistry) ; Kornhuber, Johannes (Friedrich-Alexander Universität Erlangen-Nürnberg) ; Haines, Jonathan L. (Case Western Reserve University) ; Vogelgsang, Jonathan (Harvard Medical School) ; Pineda, Juan A. (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Popp, Julius (Lausanne University Hospital) ; Deckert, Jürgen (University Hospital, Wuerzburg) ; Buerger, Katharina (German Center for Neurodegenerative Diseases) ; Morgan, Kevin (University of Nottingham) ; Fließbach, Klaus (University Clinic Bonn) ; Sleegers, Kristel (University of Antwerp) ; Molina-Porcel, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Kilander, Lena (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Weinhold, Leonie (University Hospital of Bonn) ; Farrer, Lindsay A. (Boston University) ; Wang, Li-San (University of Pennsylvania) ; Kleineidam, Luca (University Clinic Bonn) ; Farotti, Lucia (University of Perugia) ; Parnetti, Lucilla (University of Perugia) ; Tremolizzo, Lucio (Neurology Unit, 'San Gerardo' hospital) ; Hausner, Lucrezia (University of Heidelberg) ; Benussi, Luisa (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Froelich, Lutz (University of Heidelberg) ; Ikram, M. Arfan (Erasmus Medical Center) ; Deniz-Naranjo, M. Candida (Hospital Universitario de Gran Canaria Dr. Negrín) ; Tsolaki, Magda (University of Thessaloniki) ; Rosende-Roca, Maitée (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Löwenmark, Malin (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Hulsman, Marc (Vrije Universiteit Amsterdam) ; Spallazzi, Marco (Azienda Ospedaliero-Universitaria) ; Pericak-Vance, Margaret A. (University of Miami) ; Esiri, Margaret (Nuffield Department of Clinical Neurosciences) ; Bernal Sánchez-Arjona, María (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Dalmasso, Maria Carolina (University of Cologne) ; Martínez-Larrad, María Teresa (CIBERDEM) ; Arcaro, Marina (Fondazione IRCCS Ca' Granda, Ospedale Policlinico) ; Nöthen, Markus M. (University of Bonn) ; Fernández-Fuertes, Marta (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Dichgans, Martin (Munich Cluster for Systems Neurology) ; Ingelsson, Martin (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Herrmann, Martin J. (University Hospital, Wuerzburg) ; Scherer, Martin (University Medical Centre Hamburg-Eppendorf) ; Vyhnalek, Martin (St. Anne's University Hospital Brno) ; Kosmidis, Mary H. (Aristotle University of Thessaloniki) ; Yannakoulia, Mary (Harokopio University) ; Schmid, Matthias (University Hospital of Bonn) ; Ewers, Michael (German Center for Neurodegenerative Diseases) ; Heneka, Michael T. (German Center for Neurodegenerative Diseases) ; Wagner, Michael (German Center for Neurodegenerative Diseases) ; Scamosci, Michela (University of Perugia) ; Kivipelto, Miia (Stockholms Sjukhem, Research & Development Unit, Stockholm, Sweden) ; Hiltunen, Mikko (University of Eastern Finland. Institute of Biomedicine) ; Zulaica, Miren (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Fornage, Myriam (University of Texas) ; Roberto, Natalia (Universitat Internacional de Catalunya) ; van Schoor, Natasja M. (Vrije Universiteit Amsterdam) ; Seidu, Nazib M. (University of Gothenburg) ; Banaj, Nerisa (IRCCS Santa Lucia Foundation) ; Armstrong, Nicola J. (Murdoch University) ; Scarmeas, Nikolaos (Columbia University) ; Scherbaum, Norbert (University of Duisburg-Essen) ; Goldhardt, Oliver (Technical University of Munich) ; Hanon, Oliver (Université Paris Descartes) ; Peters, Oliver (German Center for Neurodegenerative Diseases) ; Skrobot, Olivia Anna (University of Bristol) ; Quenez, Olivier (FHU G4 Génomique. Normandie Univ) ; Lerch, Ondrej (St. Anne's University Hospital Brno) ; Bossù, Paola (IRCCS Santa Lucia Foundation) ; Caffarra, Paolo (University of Parma) ; Dionigi Rossi, Paolo (IRCCS Ospedale Maggiore Policlinico) ; Sakka, Paraskevi (Athens Association of Alzheimer's disease and Related Disorders) ; Hoffmann, Per (University Hospital Basel (Basilea, Suïssa)) ; Holmans, Peter A. (Cardiff University) ; Fischer, Peter (Social Medicine Center East- Donauspital) ; Riederer, Peter (University Hospital of Würzburg) ; Yang, Qiong (Boston University) ; Marshall, Rachel (Cardiff University) ; Kalaria, Rajesh N. (Campus for Ageing anf Vitality, Newcastle upon Tyne) ; Mayeux, Richard (Columbia University) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; Cecchetti, Roberta (University of Perugia) ; Ghidoni, Roberta (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Frikke-Schmidt, Ruth (University of Copenhagen) ; Sorbi, Sandro (IRCCS Fondazione Don Carlo Gnocchi) ; Hägg, Sara (Karolinska Institutet) ; Engelborghs, Sebastiaan (VUB University Hospital Brussels) ; Helisalmi, Seppo (University of Eastern Finland) ; Botne Sando, Sigrid (Norwegian University of Science and Technology) ; Kern, Silke (University of Gothenburg) ; Archetti, Silvana (Brescia Hospital) ; Boschi, Silvia (University of Torino) ; Fostinelli, Silvia (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Gil, Silvia (Universitat Internacional de Catalunya) ; Mendoza, Silvia (Instituto Andaluz de Neurociencia) ; Mead, Simon (Institute of Prion Diseases. MRC Prion Unit at UCL) ; Ciccone, Simona (IRCCS Ospedale Maggiore Policlinico) ; Djurovic, Srdjan (University of Bergen) ; Heilmann-Heimbach, Stefanie (University of Bonn) ; Riedel-Heller, Steffi (University of Leipzig) ; Kuulasmaa, Teemu (University of Eastern Finland) ; del Ser, Teodoro (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Lebouvier, Thibaud (CHU CNR-MAJ, Lille, France) ; Polak, Thomas (University Hospital, Wuerzburg) ; Ngandu, Tiia (Finnish Institute for Health and Welfare. Population Health Unit) ; Grimmer, Timo (Technical University of Munich) ; Bessi, Valentina (Azienda Ospedaliero-Universitaria Careggi Largo Brambilla) ; Escott-Price, Valentina (Cardiff University) ; Giedraitis, Vilmantas (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Deramecourt, Vincent (CHU CNR-MAJ, Lille, France) ; Maier, Wolfgang (German Center for Neurodegenerative Diseases) ; Jian, Xueqiu (Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Pijnenburg, Yolande A. L. (Vrije Universiteit Amsterdam) ; Kehoe, Patrick Gavin (German Center for Neurodegenerative Diseases) ; García-Ribas, Guillermo (Hospital Universitario Ramón y Cajal (Madrid)) ; Sánchez-Juan, Pascual (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Pérez-Tur, Jordi (Instituto de Investigación Sanitaria La Fe) ; Piñol-Ripoll, Gerard (Institut de Recerca Biomedica de Lleida) ; Lopez de Munain, Adolfo (Universidad del País Vasco) ; García-Alberca, Jose María (Instituto Andaluz de Neurociencia) ; Bullido, María J. (Hospital Universitario La Paz (Madrid)) ; Álvarez, Victoria (Hospital Universitario Central de Asturias) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Real, Luis M. (Universidad de Málaga) ; Mir, Pablo (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Medina, Miguel (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Scheltens, Philip (Vrije Universiteit Amsterdam) ; Holstege, Henne (Vrije Universiteit Amsterdam) ; Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Sáez, María Eugenia (Centro Andaluz de Estudios Bioinformáticos, Sevilla) ; Carracedo, Ángel (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Amouyel, Philippe (Institut Pasteur de Lille) ; Schellenberg, Gerard D. (University of Pennsylvania) ; Williams, Julie (Cardiff University) ; Seshadri, Sudha (Framingham Heart Study) ; van Duijn, Cornelia M. (University of Oxford) ; Mather, Karen A. (Neuroscience Research Australia) ; Sánchez-Valle, Raquel (Universitat de Barcelona) ; Serrano-Ríos, Manuel (CIBERDEM) ; Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Blennow, Kaj (University of Gothenburg) ; Huisman, Martijn (Vrije Universiteit Amsterdam) ; Andreassen, Ole A. (Oslo University Hospital (Oslo, Noruega)) ; Posthuma, Danielle (Vrije Universiteit Amsterdam) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; van der Flier, Wiesje M. (Vrije Universiteit Amsterdam) ; Ramirez, Alfredo (Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Lambert, Jean-Charles (Institut Pasteur de Lille) ; van der Lee, Sven J. (Vrije Universiteit Amsterdam) ; Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Universitat Autònoma de Barcelona
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. [...]
2021 - 10.1038/s41467-021-22491-8
Nature communications, Vol. 12 (june 2021)  
2.
13 p, 1.3 MB Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease / Escott-Price, Valentina (Clinical Cardiff University) ; Bellenguez, Céline (Institut Pasteur de Lille, Lille, France) ; Wang, Li-San (Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Choi, Seung-Hoan (Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America) ; Harold, Denise (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Jones, Lesley (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Holmans, Peter (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Gerrish, Amy (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Vedernikov, Alexey (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Richards, Alexander (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; DeStefano, Anita L. (Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America) ; Lambert, Jean-Charles (Institut Pasteur de Lille, Lille, France) ; Ibrahim-Verbaas, Carla A. (Department of Epidemiology and Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands) ; Naj, Adam C. (Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America) ; Sims, Rebecca (Cardiff University. Institute of Psychological Medicine and Clinical Neurosciences) ; Jun, Gyungah (Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America) ; Bis, Joshua C. (Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America) ; Beecham, Gary W. (Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America) ; Grenier-Boley, Benjamin (Institut Pasteur de Lille, Lille, France) ; Russo, Giancarlo (Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland) ; Thornton-Wells, Tricia A. (Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America) ; Denning, Nicola (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Smith, Albert V. (Icelandic Heart Association, Kopavogur, Iceland) ; Chouraki, Vincent (Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America) ; Thomas, Charlene (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Ikram, M. Arfan (Netherlands Consortium for Healthy Aging, Leiden, The Netherlands) ; Zelenika, Diana (Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France) ; Vardarajan, Badri N. (Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America) ; Kamatani, Yoichiro (Fondation Jean Dausset- CEPH, Paris, France) ; Lin, Chiao-Feng (Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Schmidt, Helena (Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria) ; Kunkle, Brian (The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America) ; Dunstan, Melanie L. (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Vronskaya, Maria (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Johnson, Andrew D. (NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, Massachusetts, United States of America) ; Ruiz, Agustin (Fundació ACE. Institut Català de Neurociències Aplicades) ; Bihoreau, Marie-Thérèse (Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France) ; Reitz, Christiane (Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America) ; Pasquier, Florence (CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France) ; Hollingworth, Paul (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Hanon, Olivier (University Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics department, Paris, France) ; Fitzpatrick, Annette L. (Departments of Epidemiology and Global Health, University of Washington, Seattle, Washington, United States of America) ; Buxbaum, Joseph D. (Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America) ; Campion, Dominique (CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France) ; Crane, Paul K. (Department of Medicine, University of Washington, Seattle, Washington, United States of America) ; Baldwin, Clinton (Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America) ; Becker, Tim (German Center for Neurodegenerative Diseases (DZNE), Bonn, and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany) ; Gudnason, Vilmundur (Icelandic Heart Association, Kopavogur, Iceland) ; Cruchaga, Carlos (Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America) ; Craig, David (Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom) ; Amin, Najaf (Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands) ; Berr, Claudine (INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France) ; Lopez, Oscar L. (Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America) ; De Jager, Philip L. (Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts, United States of America) ; Deramecourt, Vincent (CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France) ; Johnston, Janet A. (Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom) ; Evans, Denis (Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America) ; Lovestone, Simon (King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom) ; Letenneur, Luc (Inserm U897, Victor Segalen University, F-33076, Bordeaux, France) ; Hernández, Isabel (Fundació ACE. Institut Català de Neurociències Aplicades) ; Rubinsztein, David C. (Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom) ; Eiriksdottir, Gudny (Icelandic Heart Association, Kopavogur, Iceland) ; Sleegers, Kristel (Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Goate, Alison M. (Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America) ; Fiévet, Nathalie (Institut Pasteur de Lille, Lille, France) ; Huentelman, Matthew J. (Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America) ; Gill, Michael (Discipline of Psychiatry, Trinity College, Dublin, Ireland) ; Brown, Kristelle (Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom) ; Kamboh, M. Ilyas (Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America) ; Keller, Lina (Aging Reasearch Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden) ; Barberger-Gateau, Pascale (King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom) ; McGuinness, Bernadette (Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom) ; Larson, Eric B. (Group Health Research Institute, Group Health, Seattle, Washington, United States of America) ; Myers, Amanda J. (Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, United States of America) ; Dufouil, Carole (Inserm U897, Victor Segalen University, F-33076, Bordeaux, France) ; Todd, Stephen (Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom) ; Wallon, David (CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France) ; Love, Seth (University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, United Kingdom) ; Rogaeva, Ekaterina (Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada) ; Gallacher, John (Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom) ; George-Hyslop, Peter St (Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom) ; Clarimon, Jordi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Lleo, Alberto (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Bayer, Anthony (Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom) ; Tsuang, Debby W. (Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America) ; Yu, Lei (Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America) ; Tsolaki, Magda (3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece) ; Bossù, Paola (Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy) ; Spalletta, Gianfranco (Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy) ; Proitsi, Petra (King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom) ; Collinge, John (MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom) ; Sorbi, Sandro (Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy) ; Garcia, Florentino Sanchez (Hospital Universitario de Gran Canaria Dr. Negrín) ; Fox, Nick C. (Dementia Research Center, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom) ; Hardy, John (Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, United Kingdom) ; Naranjo, Maria Candida Deniz (Hospital Universitario de Gran Canaria Dr. Negrín) ; Bosco, Paolo (IRCCS Associazione Oasi Maria SS, Troina, Italy) ; Clarke, Robert (Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom) ; Brayne, Carol (Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge, United Kingdom) ; Galimberti, Daniela (University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy) ; Scarpini, Elio (University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy) ; Bonuccelli, Ubaldo (Neurological Clinic, University of Pisa, Pisa, Italy) ; Mancuso, Michelangelo (Neurological Clinic, University of Pisa, Pisa, Italy) ; Siciliano, Gabriele (Neurological Clinic, University of Pisa, Pisa, Italy) ; Moebus, Susanne (Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany) ; Mecocci, Patrizia (Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy) ; Zompo, Maria Del (Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy) ; Maier, Wolfgang (Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany) ; Hampel, Harald (Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany) ; Pilotto, Alberto (Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy) ; Frank-García, Ana (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ; Panza, Francesco (Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy) ; Solfrizzi, Vincenzo (Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy) ; Caffarra, Paolo (Center for Cognitive Disorders AUSL, Parma, Italy) ; Nacmias, Benedetta (Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy) ; Perry, William (Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America) ; Mayhaus, Manuel (Department Of Psychiatry, University Hospital, Saarland, Germany) ; Lannfelt, Lars (Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden) ; Hakonarson, Hakon (Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America) ; Pichler, Sabrina (Department Of Psychiatry, University Hospital, Saarland, Germany) ; Carrasquillo, Minerva M. (Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America) ; Ingelsson, Martin (Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden) ; Beekly, Duane (National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, United States of America) ; Alvarez, Victoria (Genetica molecular-Huca-Oviedo, Oviedo, Spain) ; Zou, Fanggeng (Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America) ; Valladares, Otto (Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Younkin, Steven G. (Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America) ; Coto, Eliecer (Genetica molecular-Huca-Oviedo, Oviedo, Spain) ; Hamilton-Nelson, Kara L. (The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America) ; Gu, Wei (Department of Psychiatry, University Hospital, Saarland, Germany) ; Razquin, Cristina (Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain) ; Pastor, Pau (CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain) ; Mateo, Ignacio (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Owen, Michael J. (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Faber, Kelley M. (Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America) ; Jonsson, Palmi V. (Landspitali University Hospital, Reykjavik, Iceland) ; Combarros, Onofre (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; O'Donovan, Michael C. (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Cantwell, Laura B. (Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Soininen, Hilkka (Department of Neurology, Kuopio University Hospital, Kuopio, Finland) ; Blacker, Deborah (Massachusetts General Hospital) ; Mead, Simon (MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom) ; Mosley, Thomas H. (Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, United States of America) ; Bennett, David A. (Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America) ; Harris, Tamara B. (Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America) ; Fratiglioni, Laura (Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden) ; Holmes, Clive (Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, United Kingdom) ; de Bruijn, Renee F. A. G. (Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands) ; Passmore, Peter (Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom) ; Montine, Thomas J. (Department of Pathology, University of Washington, Seattle, Washington, United States of America) ; Bettens, Karolien (Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Rotter, Jerome I. (Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America) ; Brice, Alexis (AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France) ; Morgan, Kevin (Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom) ; Foroud, Tatiana M. (Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America) ; Kukull, Walter A. (Department of Epidemiology, University of Washington, Seattle, Washington, United States of America) ; Hannequin, Didier (CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France) ; Powell, John F. (King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom) ; Nalls, Michael A. (Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America) ; Ritchie, Karen (Imperial College, London, United Kingdom) ; Lunetta, Kathryn L. (Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America) ; Kauwe, John S. K. (Department of Biology, Brigham Young University, Provo, Utah, United States of America) ; Boerwinkle, Eric (Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas, United States of America) ; Riemenschneider, Matthias (Department of Psychiatry, University Hospital, Saarland, Germany) ; Boada, Mercè (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hiltunen, Mikko (Department of Neurology, Kuopio University Hospital, Kuopio, Finland) ; Martin, Eden R. (Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America) ; Schmidt, Reinhold (Department of Neurology, Medical University Graz, Graz, Austria) ; Rujescu, Dan (Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany) ; Dartigues, Jean-François (Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France) ; Mayeux, Richard (Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America) ; Tzourio, Christophe (Inserm U708, Victor Segalen University, Bordeaux, France) ; Hofman, Albert (Netherlands Consortium for Healthy Aging, Leiden, The Netherlands) ; Nöthen, Markus M. (University of Bonn. Life and Brain Center) ; Graff, Caroline (Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KIADRC, Stockholm, Sweden) ; Psaty, Bruce M. (Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America) ; Haines, Jonathan L. (Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America) ; Lathrop, Mark (McGill University and Génome Québec Innovation Centre, Montreal, Canada) ; Pericak-Vance, Margaret A. (Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America) ; Launer, Lenore J. (Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America) ; Van Broeckhoven, Christine (Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Farrer, Lindsay A. (Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America) ; van Duijn, Cornelia M. (Center for Medical Systems Biology, Leiden, The Netherlands) ; Ramirez, Alfredo (Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn, Germany) ; Seshadri, Sudha (The Framingham Heart Study, Framingham, Massachusetts, United States of America) ; Schellenberg, Gerard D. (Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Amouyel, Philippe (Centre Hospitalier Régional Universitaire de Lille, Lille, France) ; Williams, Julie (Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom) ; Universitat Autònoma de Barcelona
Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. [...]
2014 - 10.1371/journal.pone.0094661
PloS one, Vol. 9 (june 2014)  
3.
10 p, 1.3 MB Usefulness of peripapillary nerve fiber layer thickness assessed by optical coherence tomography as a biomarker for Alzheimer's disease / Sánchez, Domingo (Fundació ACE) ; Castilla-Marti, Miguel (Hospital Universitari General de Catalunya - Grupo Quirónsalud) ; Rodríguez-Gómez, Octavio (Fundació ACE) ; Valero, Sergi (Hospital Universitari Vall d'Hebron) ; Piferrer, Albert (Topcon España Clinical Affairs, Sant Just Desvern) ; Martínez, Gabriel (Institut d'Investigació Biomèdica Sant Pau) ; Martínez, Joan (Fundació ACE) ; Serra, Judit (Fundació ACE) ; Moreno-Grau, Sonia (Fundació ACE) ; Hernández-Olasagarre, Begoña (Fundació ACE) ; De Rojas, Itziar (Fundació ACE) ; Hernández, Isabel (Fundació ACE) ; Abdelnour, Carla (Fundació ACE) ; Rosende-Roca, Maitée (Fundació ACE) ; Vargas, Liliana (Fundació ACE) ; Mauleón, Ana (Fundació ACE) ; Santos-Santos, Miguel A. (Fundació ACE) ; Alegret, Montserrat (Fundació ACE) ; Ortega, Gemma (Fundació ACE) ; Espinosa, Ana (Fundació ACE) ; Pérez-Cordón, Alba (Fundació ACE) ; Sanabria, Ángela (Fundació ACE) ; Ciudin, Andreea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Villoslada, Pablo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Ruiz, Agustín (Fundació ACE) ; Tàrraga, Lluís (Fundació ACE) ; Boada, Mercè (Fundació ACE) ; Universitat Autònoma de Barcelona
The use of optical coherence tomography (OCT) has been suggested as a potential biomarker for Alzheimer's Disease based on previously reported thinning of the retinal nerve fiber layer (RNFL) in Alzheimer's disease's (AD) and Mild Cognitive Impairment (MCI). [...]
2018 - 10.1038/s41598-018-34577-3
Scientific reports (Nature Publishing Group), Vol. 8 (november 2018)  
4.
1 p, 620.1 KB Author Correction : Usefulness of peripapillary nerve fiber layer thickness assessed by optical coherence tomography as a biomarker for Alzheimer's disease / Sánchez, Domingo (Fundació ACE) ; Castilla-Marti, Miguel (Hospital Universitari General de Catalunya - Grupo Quirónsalud) ; Rodríguez-Gómez, Octavio (Fundació ACE) ; Valero, Sergi (Hospital Universitari Vall d'Hebron) ; Piferrer, Albert (Topcon España Clinical Affairs, Sant Just Desvern, Spain) ; Martínez, Gabriel (Institut d'Investigació Biomèdica Sant Pau) ; Martínez, Joan (Fundació ACE) ; Serra, Judit (Fundació ACE) ; Moreno-Grau, Sonia (Fundació ACE) ; Hernández-Olasagarre, Begoña (Fundació ACE) ; De Rojas, Itziar (Fundació ACE) ; Hernández, Isabel (Fundació ACE) ; Abdelnour, Carla (Fundació ACE) ; Rosende-Roca, Maitée (Fundació ACE) ; Vargas, Liliana (Fundació ACE) ; Mauleón, Ana (Fundació ACE) ; Santos-Santos, Miguel A. (Fundació ACE) ; Alegret, Montserrat (Fundació ACE) ; Ortega, Gemma (Fundació ACE) ; Espinosa, Ana (Fundació ACE) ; Pérez-Cordón, Alba (Fundació ACE) ; Sanabria, Ángela (Fundació ACE) ; Ciudin, Andreea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Villoslada, Pablo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Ruiz, Agustín (Fundació ACE) ; Tàrraga, Lluís (Fundació ACE) ; Boada, Mercè (Fundació ACE) ; Universitat Autònoma de Barcelona
2019 - 10.1038/s41598-019-53339-3
Scientific reports (Nature Publishing Group), Vol. 9 (november 2019)  
5.
6 p, 427.4 KB Personality Factors and Subjective Cognitive Decline : The FACEHBI Cohort / Muñoz, Nathalia (Fundació ACE. Institut Català de Neurociències Aplicades) ; Gomà Freixanet, Montserrat (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut) ; Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Rodríguez-Gómez, Octavio (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Sanabria, Angela (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Pérez-Cordón, Alba (Fundació ACE. Institut Català de Neurociències Aplicades) ; Hernández, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Mir, Iolao (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut) ; Martín, Elvira (Fundació ACE. Institut Català de Neurociències Aplicades) ; Benaque, Alba (Fundació ACE. Institut Català de Neurociències Aplicades) ; Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Tarraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; on behalf of the FACEHBI study, None (Fundació ACE. Institut Català de Neurociències Aplicades)
Individuals with subjective cognitive decline (SCD) have the perception of memory problems without showing impairment on standardized cognitive tests. SCD has been associated with an increased risk of developing Alzheimer's disease (AD). [...]
2020 - 10.1155/2020/5232184
Behavioural Neurology, Vol. 2020 (february 2020)  
6.
13 p, 1.5 MB Parsing heterogeneity within dementia with Lewy bodies using clustering of biological, clinical, and demographic data / Abdelnour, Carla (Universitat Autònoma de Barcelona. Departament de Medicina) ; Ferreira, Daniel (Karolinska Institutet (Estocolm, Suècia)) ; van de Beek, Marleen (Vrije Universiteit Amsterdam) ; Cedres, Nira (Stockholm University) ; Oppedal, Ketil (University of Stavanger) ; Cavallin, Lena (Karolinska University Hospital) ; Blanc, Frédéric (Centre Mémoire, de Ressources et de Recherche d'Alsace (Strasbourg-Colmar)) ; Bousiges, Olivier (University Hospital of Strasbourg) ; Wahlund, Lars-Olof (Karolinska Institutet (Estocolm, Suècia)) ; Pilotto, Andrea (University of Brescia) ; Padovani, Alessandro (University of Brescia) ; Boada, Mercè (Universitat Internacional de Catalunya) ; Pagonabarraga, Javier (Institut d'Investigació Biomèdica Sant Pau) ; Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ; Aarsland, Dag (King's College London) ; Lemstra, Afina W. (Vrije Universiteit Amsterdam) ; Westman, Eric (King's College London)
Dementia with Lewy bodies (DLB) includes various core clinical features that result in different phenotypes. In addition, Alzheimer's disease (AD) and cerebrovascular pathologies are common in DLB. All this increases the heterogeneity within DLB and hampers clinical diagnosis. [...]
2022 - 10.1186/s13195-021-00946-w
Alzheimer's research & therapy, Vol. 14 (january 2022)  
7.
15 p, 570.6 KB C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts / Costa, Beatrice ; Manzoni, Claudia ; Bernal-Quiros, Manuel ; Kia, Demis A. ; Aguilar Barberà, Miquel ; Alvarez, Ignacio ; Alvarez, Victoria ; Andreassen, Ole A ; Anfossi, Maria ; Bagnoli, Silvia ; Benussi, Luisa ; Bernardi, Livia ; Binetti, Giuliano ; Blackburn, Daniel ; Boada, Mercè ; Borroni, Barbara ; Bowns, Lucy ; Bråthen, Geir ; Bruni, Amalia C. ; Chiang, Huei-Hsin ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Colville, Shuna ; Conidi, Maria E. ; Cope, Tom E. ; Cruchaga, Carlos ; Cupidi, Chiara ; Di Battista, Maria Elena ; Diehl-Schmid, Janine ; Diez-Fairen, Monica ; Dols Icardo, Oriol (Institut d'Investigació Biomèdica Sant Pau) ; Durante, Elisabetta ; Flisar, Dušan ; Frangipane, Francesca ; Galimberti, Daniela ; Gallo, Maura ; Gallucci, Maurizio ; Ghidoni, Roberta ; Graff, Caroline ; Grafman, Jordan H. ; Grossman, Murray ; Hardy, John ; Hernández, Isabel ; Holloway, Guy J.T. ; Huey, Edward D. ; Illán-Gala, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ; Karydas, Anna ; Khoshnood, Behzad ; Kramberger, Milica G. ; Kristiansen, Mark ; Lewis, Patrick A. ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Madhan, Gaganjit K. ; Maletta, Raffaele ; Maver, Aleš ; Menendez-Gonzalez, Manuel ; Milan, Graziella ; Miller, Bruce ; Mol, Merel O. ; Momeni, Parastoo ; Moreno-Grau, Sonia ; Morris, Chris M. ; Nacmias, Benedetta ; Nilsson, Christer ; Novelli, Valeria ; Öijerstedt, Linn ; Padovani, Alessandro ; Pal, Suvankar ; Panchbhaya, Yasmin ; Pastor, Pau ; Peterlin, Borut ; Piaceri, Irene ; Pickering-Brown, Stuart ; Pijnenburg, Yolande A.L. ; Puca, Annibale A. ; Rainero, Innocenzo ; Rendina, Antonella ; Richardson, Anna M.T. ; Rogaeva, Ekaterina ; Rogelj, Boris ; Rollinson, Sara ; Rossi, Giacomina ; Rossmeier, Carola ; Rowe, James B. ; Rubino, Elisa ; Ruiz, Agustín ; Sanchez-Valle, Raquel ; Sando, Sigrid B. ; Santillo, Alexander F. ; Saxon, Jennifer ; Scarpini, Elio ; Serpente, Maria ; Smirne, Nicoletta ; Sorbi, Sandro ; Suh, EunRan ; Tagliavini, Fabrizio ; Thompson, Jennifer C. ; Trojanowski, John Q. ; Van Deerlin, Vivianna M. ; Van der Zee, Julie ; Van Broeckhoven, Christine ; van Rooij, Jeroen ; Van Swieten, John C. ; Veronesi, Arianna ; Vitale, Emilia ; Waldö, Maria L. ; Woodward, Cathy ; Yokoyama, Jennifer ; Escott-Price, Valentina ; Polke, James M. ; Ferrari, Raffaele ; Universitat Autònoma de Barcelona
We sought to characterize C9orf72 expansions in relation to genetic ancestry and age at onset (AAO) and to use these measures to discriminate the behavioral from the language variant syndrome in a large pan-European cohort of frontotemporal lobar degeneration (FTLD) cases. [...]
2020 - 10.1212/WNL.0000000000010914
Neurology, Vol. 95 (december 2020) , p. e3288-e3302  
8.
12 p, 2.7 MB Long runs of homozygosity are associated with Alzheimer's disease / Moreno-Grau, Sonia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Fernández, Maria Victoria (Washington University School of Medicine. Hope Center for Neurological Disorders) ; de Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; García-González, Pablo (Institut Català de Neurociènces Aplicades) ; Hernández, Isabel (Institut Català de Neurociènces Aplicades) ; Farias, Fabiana (Washington University School of Medicine. Hope Center for Neurological Disorders) ; Budde, John P. (Washington University School of Medicine. Hope Center for Neurological Disorders) ; Quintela, Inés (Universidade de Santiago de Compostela. Grupo de Medicina Xenómica) ; Madrid, Laura (Centro Andaluz de Estudios Bioinformáticos-CAEBI) ; González-Pérez, Antonio (Centro Andaluz de Estudios Bioinformáticos-CAEBI) ; Montrreal, Laura (Institut Català de Neurociènces Aplicades) ; Alarcón-Martín, Emilio (Institut Català de Neurociènces Aplicades) ; Alegret, Montserrat (Institut Català de Neurociènces Aplicades) ; Maroñas, Olalla (Universidade de Santiago de Compostela. Grupo de Medicina Xenómica) ; Pineda, Juan Antonio (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Macías, Juan (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Benaque, Alba (Institut Català de Neurociènces Aplicades) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Bullido, María J (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ; García-Ribas, Guillermo (Hospital Universitario Ramón y Cajal (Madrid)) ; Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Sánchez-Juan, Pascual (Universidad de Cantabria) ; Álvarez, Victoria (Instituto de Investigación Biosanitaria del Principado de Asturias-ISPA (Oviedo)) ; Piñol-Ripoll, Gerard (Institut de Recerca Biomèdica de Lleida) ; García-Alberca, Jose María (Instituto Andaluz de Neurociencia) ; Royo, José Luis (Universidad de Málaga. Facultad de Medicina) ; Franco-Macías, Emilio (Instituto de Biomedicina de Sevilla) ; Mir, Pablo (Instituto de Biomedicina de Sevilla) ; Calero, Miguel (Instituto de Salud Carlos III) ; Medina, Miguel (Queen Sofia Foundation Alzheimer Center) ; Rábano, Alberto (BT-CIEN (Madrid)) ; Ávila, Jesús (Centro de Biología Molecular "Severo Ochoa" (CBMSO)) ; Antúnez, Carmen (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Real, Luis M (Universidad de Málaga. Facultad de Medicina) ; Orellana, Adelina (Institut Català de Neurociènces Aplicades) ; Carracedo, Ángel (Fundación Pública Galega de Medicina Xenómica) ; Sáez, María Eugenia (Centro Andaluz de Estudios Bioinformáticos-CAEBI) ; Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Cruchaga, Carlos (Washington University School of Medicine. Hope Center for Neurological Disorders) ; Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Universitat Autònoma de Barcelona
Long runs of homozygosity (ROH) are contiguous stretches of homozygous genotypes, which are a footprint of inbreeding and recessive inheritance. The presence of recessive loci is suggested for Alzheimer's disease (AD); however, their search has been poorly assessed to date. [...]
2021 - 10.1038/s41398-020-01145-1
Translational psychiatry, Vol. 11 (february 2021)  
9.
10 p, 661.4 KB Clinical Applicability of the Specific Risk Score of Dementia in Type 2 Diabetes in the Identification of Patients with Early Cognitive Impairment : results of the MOPEAD Study in Spain / Ortiz-Zuñiga, Angel Michael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodriguez-Gómez, Octavio (Institut Català de Neurociènces Aplicades) ; Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodrigo, Adrian (GMV Soluciones Globales Internet SAU. Valencia) ; Jamilis, Laura (GMV Soluciones Globales Internet SAU. Valencia) ; Campo, Laura (International Corporate Affairs, Alzheimer's Disease, Eli Lilly and Co. Italy) ; Alegret, Montserrat (Universitat Internacional de Catalunya. Institut Català de Neurociènces Aplicades) ; Boada, Mercè (Institut Català de Neurociènces Aplicades) ; Ciudin, Andreea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Introduction: Although the Diabetes Specific Dementia Risk Score (DSDRS) was proposed for predicting risk of dementia at 10 years, its usefulness as a screening tool is unknown. For this purpose, the European consortium MOPEAD included the DSDRS within the specific strategy for screening of cognitive impairment in type 2 diabetes (T2D) patients attended in a third-level hospital. [...]
2020 - 10.3390/jcm9092726
Journal of clinical medicine, Vol. 9 Núm. 9 (2020) , p. 2726  
10.
9 p, 763.7 KB The combined effect of amyloid-β and tau biomarkers on brain atrophy in dementia with Lewy bodies / Abdelnour, Carla (Universitat Autònoma de Barcelona. Departament de Medicina) ; Ferreira, Daniel (Karolinska Institutet (Estocolm, Suècia). Department of Neurobiology, Care Sciences and Society) ; Oppedal, Ketil (Department of Electrical Engineering and Computer Science, University of Stavanger, Stavanger, Norway) ; Cavallin, Lena (Department of Neuroscience, Karolinska Institutet and Department of Radiology Karolinska University Hospital, Stockholm, Sweden) ; Bousiges, Olivier (Hôpitaux Universitaire de Strasbourg, Laboratoire de Biochimie et Biologie Moléculaire, et CNRS, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), UMR7364, Strasbourg, France) ; Wahlund, Lars Olof (Karolinska Institutet (Estocolm, Suècia). Department of Neurobiology, Care Sciences and Society) ; Hort, Jakub (International Clinical Research Centre, Brno, Czech Republic) ; Nedelska, Zuzana (International Clinical Research Centre, Brno, Czech Republic) ; Padovani, Alessandro (Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy) ; Pilotto, Andrea (Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy) ; Bonanni, Laura (Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d'Annunzio of Chieti-Pescara, Chieti, Italy) ; Kramberger, Milica G. (Department of Neurology, University Medical Centre Ljubljana, Medical faculty, University of Ljubljana, Ljubljana, Slovenia) ; Boada, Mercè (Institut Català de Neurociènces Aplicades) ; Westman, Eric (Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK) ; Pagonabarraga, Javier (Institut d'Investigació Biomèdica Sant Pau) ; Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ; Blanc, Frédéric (Centre National de la Recherche Scientifique (França)) ; Aarsland, Dag (King's College London. Institute of Psychiatry, Psychology & Neuroscience)
Alzheimer's disease (AD)-related pathology is frequently found in patients with dementia with Lewy bodies (DLB). However, it is unknown how amyloid-β and tau-related pathologies influence neurodegeneration in DLB. [...]
2020 - 10.1016/j.nicl.2020.102333
NeuroImage, Vol. 27 (july 2020)  

Articles : 21 registres trobats   1 - 10següentfinal  anar al registre:
Documents de recerca 2 registres trobats  
1.
226 p, 4.2 MB Factores genéticos asociados a la degeneración lobar frontotemporal. Análisis de susceptibilidad genética y correlación fenotipo-genotipo / Hernández Ruiz, Mª Isabel ; Ruiz Laza, Agustín, dir. ; Boada, Mercè, dir. ; Blesa Gonzalez, Rafael, dir. ; Álvarez Sabin, José ; Universitat Autònoma de Barcelona. Departament de Medicina
La Degeneración Lobar Frontotemporal es un grupo heterogéneo de enfermedades, la segunda causa más frecuente de demencia en edad presenil y la que presenta el mayor número de casos hereditarios. Se caracteriza por una gran variabilidad clínica, genética e histopatológica. [...]
Frontotemporal Lobar Degeneration is a heterogeneous group of disorders, the second most frequent cause of early dementia and the one with the highest number of inherited cases. It is characterized by considerable variability in clinical, genetic and histopathologic features. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  
2.
42 p, 1.3 MB Degeneració Lobular Fronto-Temporal. Fenotips Clínics i Evolució / Hernández i Ruiz, Mª Isabel ; Blesa, Rafael ; Boada, Mercè ; Universitat Autònoma de Barcelona. Departament de Medicina ; Universitat Autònoma de Barcelona. Facultat de Medicina
Estudi retrospectiu de recollida de dades clíniques i de neuroimatge de pacients diagnosticats, em La clínica diària, de Degeneració Lobular Fronto-Temporal (DLFT) entre gener de 1996 i Marc de 2008. [...]
Estudio retrospectivo de recogida de datos clínicos y de neuroimagen de pacientes diagnosticados, en la clínica diaria, de Degeneración Lobular Fronto-temporal (DLFT) entre enero de 1996 y marzo de 2008. [...]

2012  

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