Resultats globals: 7 registres trobats en 0.02 segons.
Articles, 5 registres trobats
Documents de recerca, 2 registres trobats
Articles 5 registres trobats  
1.
9 p, 1.5 MB Structural and biochemical characterization of the relaxosome auxiliary proteins encoded on the Bacillus subtilis plasmid pLS20 / Crespo, Isidro (ALBA Laboratori de Llum de Sincrotró) ; Bernardo, Nerea (ALBA Laboratori de Llum de Sincrotró) ; Cuppari, Anna (ALBA Laboratori de Llum de Sincrotró) ; Calisto, Bárbara Luísa Machado (ALBA Laboratori de Llum de Sincrotró) ; Val-Calvo, Jorge (Centro de Biología Molecular Severo Ochoa) ; Miguel-Arribas, Andrés (Centro de Biología Molecular Severo Ochoa) ; Meijer, Wilfried J. J. (Centro de Biología Molecular Severo Ochoa) ; Carpena, Xavi (ALBA Laboratori de Llum de Sincrotró) ; Gil-Ortiz, Fernando (ALBA Laboratori de Llum de Sincrotró) ; Malfois, Marc (ALBA Laboratori de Llum de Sincrotró) ; Boer, D. Roeland (ALBA Laboratori de Llum de Sincrotró)
Bacterial conjugation is an important route for horizontal gene transfer. The initial step in this process involves a macromolecular protein-DNA complex called the relaxosome, which in plasmids consists of the origin of transfer (oriT) and several proteins that prepare the transfer. [...]
2022 - 10.1016/j.csbj.2021.12.041
Computational and Structural Biotechnology Journal, Vol. 20 (January 2022) , p. 757-765  
2.
14 p, 1.5 MB Multiple Layered Control of the Conjugation Process of the Bacillus subtilis Plasmid pLS20 / Meijer, Wilfried J. J. (Centro de Biología Molecular Severo Ochoa) ; Boer, Roeland (ALBA Laboratori de Llum de Sincrotró) ; Ares, Saúl (Centro Nacional de Biotecnología. Departamento de Biología de Sistemas) ; Alfonso, Carlos (Centro de Investigaciones Biológicas (Madrid)) ; Rojo, Fernando (Centro Nacional de Biotecnología. Department of Microbial Biotechnology) ; Luque-Ortega, Juan R. (Centro de Investigaciones Biológicas (Madrid)) ; Wu, Ling Juan (Newcastle University. Centre for Bacterial Cell Biology, Biosciences Institute)
Bacterial conjugation is the main horizontal gene transfer route responsible for the spread of antibiotic resistance, virulence and toxin genes. During conjugation, DNA is transferred from a donor to a recipient cell via a sophisticated channel connecting the two cells. [...]
2021 - 10.3389/fmolb.2021.648468
Frontiers in Molecular Biosciences, Vol. 8 (March 2021) , art. 648468  
3.
15 p, 7.0 MB Inactivation of the dimeric Rap anti-repressor of the conjugation operon is mediated by peptide-induced tetramerization / Crespo, Isidro (ALBA Laboratori de Llum de Sincrotró) ; Bernardo, Nerea (ALBA Laboratori de Llum de Sincrotró) ; Miguel-Arribas, Andrés (Centro de Biología Molecular Severo Ochoa) ; Singh, Praveen K. (Centro de Biología Molecular Severo Ochoa) ; Luque-Ortega, Juan R. (Centro de Investigaciones Biológicas (Madrid)) ; Alfonso, Carlos (Centro de Investigaciones Biológicas (Madrid)) ; Malfois, Marc (ALBA Laboratori de Llum de Sincrotró) ; Meijer, Wilfried J. J. (Centro de Biología Molecular Severo Ochoa) ; Boer, Roeland (ALBA Laboratori de Llum de Sincrotró)
Quorum sensing allows bacterial cells to communicate through the release of soluble signaling molecules into the surrounding medium. It plays a pivotal role in controlling bacterial conjugation in Gram-positive cells, a process that has tremendous impact on health. [...]
2020 - 10.1093/nar/gkaa540
Nucleic acids research, Vol. 48, issue 14 (Aug. 2020) , p. 8113-8127  
4.
17 p, 5.8 MB Novel regulatory mechanism of establishment genes of conjugative plasmids / Val-Calvo, Jorge (Centro de Biología Molecular Severo Ochoa) ; Luque-Ortega, Juan Roman (Centro de Investigaciones Biológicas (Madrid)) ; Crespo, Isidro (ALBA Laboratori de Llum de Sincrotró) ; Miguel Arribas, Andrés (Centro de Biología Molecular Severo Ochoa) ; Abia, David (Centro de Biología Molecular Severo Ochoa) ; Sánchez-Hevia, Dione L. (Centro de Biología Molecular Severo Ochoa) ; Serrano, Ester (Centro de Biología Molecular Severo Ochoa) ; Gago-Córdoba, César (Centro de Biología Molecular Severo Ochoa) ; Ares, Saúl (Universidad Carlos III de Madrid) ; Alfonso, Carlos (Centro de Investigaciones Biológicas (Madrid)) ; Rojo, Fernando (Centro Nacional de Biotecnología (CSIC)) ; Wu, Ling J. (Newcastle University) ; Boer, Roeland (ALBA Laboratori de Llum de Sincrotró) ; Meijer, Wilfried J. J. (Centro de Biología Molecular Severo Ochoa)
The principal route for dissemination of antibiotic resistance genes is conjugation by which a conjugative DNA element is transferred from a donor to a recipient cell. Conjugative elements contain genes that are important for their establishment in the new host, for instance by counteracting the host defense mechanisms acting against incoming foreign DNA. [...]
2018 - 10.1093/nar/gky996
Nucleic acids research, Vol. 46, Issue 22 (December 2018) , p. 11910-11926  
5.
23 p, 2.2 MB Discovery of a new family of relaxases in Firmicutes bacteria / Gayetri Ramachandran, Andrés (Centro de Biología Molecular Severo Ochoa) ; Miguel Arribas, Andrés (Centro de Biología Molecular Severo Ochoa) ; Abia, David (Centro de Biología Molecular Severo Ochoa) ; Singh, Praveen K. (Centro de Biología Molecular Severo Ochoa) ; Crespo, Isidro (ALBA Laboratori de Llum de Sincrotró) ; Gago-Córdoba, César (Centro de Biología Molecular Severo Ochoa) ; Hao, Jian An (Centro de Biología Molecular Severo Ochoa) ; Luque-Ortega, Juan Roman (Centro de Investigaciones Biológicas (Madrid)) ; Alfonso, Carlos (Centro de Investigaciones Biológicas (Madrid)) ; Wu, Ling J. (Newcastle University. Institute for Cell and Molecular Biosciences. Centre for Bacterial Cell Biology) ; Boer, Roeland (ALBA Laboratori de Llum de Sincrotró) ; Meijer, Wilfried J. J. (Centro de Biología Molecular Severo Ochoa)
Antibiotic resistance is a serious global problem. Antibiotic resistance genes (ARG), which are widespread in environmental bacteria, can be transferred to pathogenic bacteria via horizontal gene transfer (HGT). [...]
2017 - 10.1371/journal.pgen.1006586
PLoS Genetics, Vol. 13, issue 2 (Feb. 2017) , e1006586  

Documents de recerca 2 registres trobats  
1.
157 p, 8.4 MB Auxin Response Factors : integrating auxin signalling with DNA recognition and epigenetics / Crespo, Isidro ; Boer, Roeland D., 1972-, dir. ; Weijers, Dolf, dir.
Les auxines són les principals fitohormones que governen el creixement i desenvolupament de les plantes, principalment a través de la via nuclear de l'auxina, NAP. Els efectors finals en NAP són els factors de resposta d'auxina (ARF). [...]
Las auxinas son las principales fitohormonas que gobiernan el crecimiento y desarrollo de las plantas, principalmente a través de la vía de las auxinas nucleares, NAP. Los efectores finales en NAP son los factores de respuesta de auxina (ARF). [...]
Auxins are the main phytohormones governing plant growth and development mainly through the Nuclear Auxin Pathway, NAP. The final effectors on NAP are the Auxin Response Factors (ARFs). ARFs has been linked to auxin and gene expression for decades, but the recent crystallographic structures of the DNA Binding Domain (ARF-DBD) of two divergent Arabidopsis thaliana ARFs revealed an exceptionally high conservation of the DNA contact points, so this point was unlikely to determine specificity of gene selection. [...]

2021  
2.
149 p, 8.1 MB Prevention of the spread of antibiotic resistance via the structural and molecular study of pLS20 conjugative plasmid proteins / Bernardo, Nerea ; Boer, Roeland D., 1972-, dir. ; Reverter Cendrós, David, dir.
La resistència a antibiòtics està considerada una de les principals amenaces a la salut pública del segle XXI per la OMS. A causa del seu consum excessiu i incorrecte, els bacteris han desenvolupat mecanismes per fer-les front y així, ser capaços de sobreviure a la seva presència. [...]
La resistencia a antibióticos está considerada una de las principales amenazas a la salud pública del siglo XXI por la OMS. Debido a su consumo excesivo e incorrecto, las bacterias desarrollan mecanismos para hacerles frente y así, ser capaces de sobrevivir en su presencia. [...]
Antibiotic Resistance is considered one of the most important public health threats of the 21st century by the WHO. Due to human overuse and misuse of antibiotics, bacteria develop new mechanisms to survive in the presence of antibiotics. [...]

2020  

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