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Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates
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Bourdenx, M. (CNRS) ;
Nioche, A. (Institut Jean Nicod, Département d'études cognitives, CNRS) ;
Dovero, S. (CNRS, Institut des Maladies Neurodégénératives) ;
Arotcarena, M.-L. (CNRS, Institut des Maladies Neurodégénératives) ;
Camus, S. (CNRS, Institut des Maladies Neurodégénératives) ;
Porras, G. (CNRS, Institut des Maladies Neurodégénératives) ;
Thiolat, M.-L. (CNRS, Institut des Maladies Neurodégénératives) ;
Rougier, N. P. (INRIA Bordeaux Sud-Ouest) ;
Prigent, A. (CHU Nantes, Department of Neurology, Nantes) ;
Aubert, P. (CHU Nantes, Department of Neurology) ;
Bohic, S. (EA-7442 Rayonnement Synchrotron et Recherche Medicale, RSRM, University of Grenoble Alpes) ;
Sandt, C. (SMIS beamline, Synchrotron SOLEIL, l'orme des merisiers) ;
Laferrière, F. (CNRS, Institut des Maladies Neurodégénératives) ;
Doudnikoff, E. (CNRS, Institut des Maladies Neurodégénératives) ;
Kruse, Niels (University Medical Center Goettingen, Institute of Neuropathology) ;
Mollenhauer, B. (University Medical Center Goettingen, Institute of Neuropathology) ;
Novello, Salvatore (University of Ferrara. Neuroscience Center) ;
Morari, M. (University of Ferrara. Neuroscience Center) ;
Leste-Lasserre, T. (INSERM, Neurocentre Magendie, U1215, Physiopathologie de la Plasticité Neuronale) ;
Trigo-Damas, I. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Goillandeau, M. (CNRS, Institut des Maladies Neurodégénératives) ;
Perier, Celine (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Estrada, C. (Institute of Research on Aging (IUIE), Universidad de Murcia) ;
Garcia-Carrillo, N. (Centro Experimental en Investigaciones Biomédica (CEIB), Universidad de Murcia) ;
Recasens, A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vaikath, N. N. (Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Education City, Qatar) ;
El-Agnaf, O. M. A. (Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Education City, Qatar) ;
Herrero Ezquerdo, María Trinidad (Universidad de Murcia) ;
Derkinderen, Pascal (CHU Nantes, Department of Neurology) ;
Vila Bover, Miquel (Institució Catalana de Recerca i Estudis Avançats) ;
Obeso, J. A. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Dehay, B. (CNRS, Institut des Maladies Neurodégénératives) ;
Bezard, E. (CNRS, Institut des Maladies Neurodégénératives) ;
Universitat Autònoma de Barcelona
Machine learning-based approach unravels distinct pathological signatures induced by patient-derived α-synuclein seeds in monkeys. Dopaminergic neuronal cell death, associated with intracellular α-synuclein (α-syn)-rich protein aggregates [termed "Lewy bodies" (LBs)], is a well-established characteristic of Parkinson's disease (PD). [...]
2020 -  10.1126/sciadv.aaz9165
Science advances, Vol. 6 (may 2020)
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