Home > Search Results: Bolea, Irene
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Results overview: Found 6 records in 0.01 seconds.
Articles, 5 records found
Research literature, 1 records found
Articles 5 records found  
1.
28 p, 2.4 MB Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases / Di Giovanni, Giuseppe (University of Malta) ; Svob Strac, Dubravka (Rudjer Boskovic Institute) ; Sole, Montse (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Unzeta, Mercedes (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Tipton, Keith F. (Trinity College Dublin) ; Mück-Šeler, Dorotea (Rudjer Boskovic Institute Zagreb, Croatia) ; Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Della Corte, Laura (University of Florence) ; Nikolac Perkovic, Matea (Rudjer Boskovic Institute Zagreb, Croatia) ; Pivac, Nela (Rudjer Boskovic Institute Zagreb, Croatia) ; Smolders, Ilse J. (Vrije Universiteit Brussels, Belgium) ; Stasiak, Anna (Medical University of Lodz, Poland) ; Fogel, Wieslawa A. (Medical University of Lodz, Poland) ; De Deurwaerdère, Philippe (Institut of Neurodegenerative Diseases Bordeaux Cedex, France)
The monoaminergic systems are the target of several drugs for the treatment of mood, motor and cognitive disorders as well as neurological conditions. In most cases, advances have occurred through serendipity, except for Parkinson's disease where the pathophysiology led almost immediately to the introduction of dopamine restoring agents. [...]
2016 - 10.3389/fnins.2016.00541
Frontiers in Neuroscience, Vol. 10 (november 2016)  
Detailed record - Creative Commons
2.
615.4 KB ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy / Marco-Contelles, José (Laboratori de Química Mèdica, Institut de Química Orgànica General (CSIC), Madrid) ; Unzeta López, Mercedes (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Esteban, Gerard (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ramsay, Rona R. (Biomedical Sciences Research Complex, University of St Andrews) ; Romero, Alejandro (Universidad Complutense de Madrid) ; Martínez-Murillo, Ricard (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Carreiras, M. Carmo (University of Lisbon) ; Ismaili, Lhassane (Université Bourgogne Franche-Comté)
Highlights: The complex nature of Alzheimer's disease (AD) has prompted the design of Multi-Target-Directed Ligands (MTDL) able to bind to diverse biochemical targets involved in the progress and development of the disease. [...]
2016 - 10.3389/fnins.2016.00294
Frontiers in Neuroscience, Vol. 10 (june 2016)  
Detailed record - Creative Commons
3.
26 p, 4.7 MB Defined neuronal populations drive fatal phenotype in a mouse model of leigh syndrome / Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gella, Alejandro (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Sanz, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Prada Dacasa, Patricia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Menardy, Fabien (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bard, Angela M. (Seattle Children's Research Institute) ; Machuca Márquez, Pablo (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Eraso-Pichot, Abel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Mòdol Caballero, Guillem (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Kalume, Frank (Department of Pharmacology. University of Washington) ; Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències)
Mitochondrial deficits in energy production cause untreatable and fatal pathologies known as mitochondrial disease (MD). Central nervous system affectation is critical in Leigh Syndrome (LS), a common MD presentation, leading to motor and respiratory deficits, seizures and premature death. [...]
2019 - 10.7554/eLife.47163
eLife, Vol. 8 (august 2019) , p. e47163  
Detailed record - Creative Commons
4.
24 p, 5.9 MB Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease / Unzeta López, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Esteban, Gerard (Trinity College Dublin. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute) ; Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Fogel, Wieslawa A. (Medical University of Lodz. Department of Hormone Biochemistry) ; Ramsay, Rona R. (University of St Andrews. Biomedical Sciences Research Complex) ; Youdim, Moussa B. H. (Ruth and Bruce Rappaport Faculty of Medicine. Department of Pharmacology) ; Tipton, Keith F. (Trinity College Dublin. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute) ; Marco-Contelles, José (Spanish National Research Council. Institute of General Organic Chemistry) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
HIGHLIGHTS Alzheimer's disease (AD), the most common form of adult onset dementia, is an age-related neurodegenerative disorder characterized by progressive memory loss, decline in language skills, and other cognitive impairments. [...]
2016 - 10.3389/fnins.2016.00205
Frontiers in Neuroscience, Vol. 10 (May 2016) , art. 205  
Detailed record - Creative Commons
5.
8 p, 2.2 MB Loss of mitochondrial Ndufs4 in striatal medium spiny neurons mediates progressive motor impairment in a mouse model of leigh syndrome / Chen, Byron (University of Washington. Howard Hughes Medical Institute) ; Hui, Jessica (Seattle Children's Research Institute (Seattle, Estats Units d'Amèrica)) ; Montgomery, Kelsey S. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gella, Alejandro (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Sanz Iglesias, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Palmiter, Richard D. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica)) ; Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències)
Inability of mitochondria to generate energy leads to severe and often fatal myoencephalopathies. Among these, Leigh syndrome (LS) is one of the most common childhood mitochondrial diseases; it is characterized by hypotonia, failure to thrive, respiratory insufficiency and progressive mental and motor dysfunction, leading to early death. [...]
2017 - 10.3389/fnmol.2017.00265
Frontiers in molecular neuroscience, Vol. 10 (August 2017) , article 265  
Detailed record - Creative Commons

Research literature 1 records found  
1.
324 p, 5.6 MB Study of new propargylamine and donepezil-derived compounds as multitarget agents for the treatment of alzheimer's disease / Bolea Tomás, Irene ; Unzeta López, Mercedes, dir. ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
El compuesto PF9601N es un derivado de propargilamina y un potente inhibidor irreversible de la enzima monoamino oxidasa B (IMAO-B) el cual fue identificado por nuestro grupo tras una extensiva búsqueda de potenciales IMAOs. [...]
PF9601N is a propargylamine-containing irreversible monoamine oxidase B inhibitor (MAOBI) previously identified by our group in an extensive screen of potential MAOIs. Besides its potent inhibitory capacity, it possesses several neuroprotective properties demonstrated in different animal and cellular models of Parkinson's disease (PD). [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2012  
Detailed record -

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