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10 p, 1.4 MB |
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
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Manry, Jérémy ;
Bastard, Paul ;
Gervais, Adrian ;
Le Voyer, Tom ;
Rosain, Jérémie ;
Philippot, Quentin ;
Michailidis, Eleftherios ;
Hoffmann, Hans-Heinrich ;
Eto, Shohei ;
Garcia-Prat, Marina (Hospital Universitari Vall d'Hebron) ;
Bizien, Lucy ;
Parra-Martínez, Alba (Hospital Universitari Vall d'Hebron) ;
Yang, Rui ;
Haljasmägi, Liis ;
Migaud, Mélanie ;
Särekannu, Karita ;
Maslovskaja, Julia ;
de Prost, Nicolas ;
Tandjaoui-Lambiotte, Yacine ;
Luyt, Charles-Edouard ;
Amador-Borrero, Blanca ;
Gaudet, Alexandre ;
Poissy, Julien ;
Morel, Pascal ;
Richard, Pascale ;
Cognasse, Fabrice ;
Troya, Jesús ;
Trouillet-Assant, Sophie ;
Belot, Alexandre ;
Saker, Kahina ;
Garçon, Pierre ;
Rivière, Jacques G.. (Hospital Universitari Vall d'Hebron) ;
Lagier, Jean-Christophe ;
Gentile, Stéphanie ;
Rosen, Lindsey B. ;
Shaw, Elana ;
Morio, Tomohiro ;
Tanaka, Junko ;
Dalmau, David ;
Tharaux, Pierre-Louis ;
Sene, Damien ;
Stepanian, Alain ;
Mégarbane, Bruno ;
Triantafyllia, Vasiliki ;
Fekkar, Arnaud ;
Heath, James R. ;
Franco, Jose Luis ;
Anaya, Juan-Manuel ;
Solé-Violán, Jordi ;
Imberti, Luisa ;
Biondi, Andrea ;
Bonfanti, Paolo ;
Castagnoli, Riccardo ;
Delmonte, Ottavia M. ;
Zhang, Yu ;
Snow, Andrew ;
Holland, Steven M. ;
Biggs, Catherine M. ;
Moncada-Vélez, Marcela ;
Arias, Andrés Augusto ;
Lorenzo, Lazaro ;
Boucherit, Soraya ;
Anglicheau, Dany ;
Planas, Anna Maria ;
Haerynck, Filomeen ;
Duvlis, Sotirija ;
Ozcelik, Tayfun ;
Keles, Sevgi ;
Bousfiha, Ahmed A. ;
El Bakkouri, Jalila ;
Ramirez-Santana, Carolina ;
Paul, Stephane ;
Pan-Hammarström, Qiang ;
Hammarström, Lennart ;
Dupont, Annabelle ;
Kurolap, Alina ;
Metz, Christine N. ;
Aiuti, Alessandro ;
Casari, Giorgio ;
Lampasona, Vito ;
Ciceri, Fabio ;
Barreiros, Lucila A. ;
Domínguez-Garrido, Elena ;
Vidigal, Mateus ;
Zatz, Mayana ;
van de Beek, Diederik ;
Sahanic, Sabina ;
Tancevski, Ivan ;
Stepanovskyy, Yurii ;
Boyarchuk, Oksana ;
Nukui, Yoko ;
Tsumura, Miyuki ;
Vidaur, Loreto ;
Tangye, Stuart G. ;
Burrel, Sonia ;
Duffy, Darragh ;
Quintana-Murci, Lluis ;
Klocperk, Adam ;
Kann, Nelli Y. ;
Shcherbina, Anna ;
Lau, Yu-Lung ;
Leung, Daniel ;
Coulongeat, Matthieu ;
Marlet, Julien ;
Koning, Rutger ;
Reyes, Luis Felipe ;
Chauvineau-Grenier, Angélique ;
Venet, Fabienne ;
Monneret, Guillaume ;
Nussenzweig, Michel C. ;
Arrestier, Romain ;
Boudhabhay, Idris ;
Baris-Feldman, Hagit ;
Hagin, David ;
Wauters, Joost ;
Meyts, Isabelle ;
Dyer, Adam H. ;
Kennelly, Sean P. ;
Bourke, Nollaig M. ;
Halwani, Rabih ;
Sharif-Askari, Fatemeh Saheb ;
Dorgham, Karim ;
Sallette, Jérôme ;
Sedkaoui, Souad Mehlal ;
AlKhater, Suzan ;
Rigo Bonnin, Raül (Institut d'Investigació Biomèdica de Bellvitge) ;
Morandeira, Francisco ;
Roussel, Lucie ;
Vinh, Donald C. ;
Erikstrup, Christian ;
Condino-Neto, Antonio ;
Prando, Carolina ;
Bondarenko, Anastasiia ;
Spaan, András N. ;
Gilardin, Laurent ;
Fellay, Jacques ;
Lyonnet, Stanislas ;
Bilguvar, Kaya ;
Lifton, Richard P. ;
Mane, Shrikant ;
Anderson, Mark S. ;
Boisson, Bertrand ;
Béziat, Vivien ;
Zhang, Shen-Ying ;
Andreakos, Evangelos ;
Hermine, Olivier ;
Pujol, Aurora 1968- (Institut d'Investigació Biomèdica de Bellvitge) ;
Peterson, Pärt ;
Mogensen, Trine H. ;
Rowen, Lee ;
Mond, James ;
Debette, Stéphanie ;
De Lamballerie, Xavier ;
Burdet, Charles ;
Bouadma, Lila ;
Zins, Marie ;
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron) ;
Colobrán Oriol, Roger (Hospital Universitari Vall d'Hebron) ;
Gorochov, Guy ;
Solanich, Xavier (Institut d'Investigació Biomèdica de Bellvitge) ;
Susen, Sophie ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Raoult, Didier ;
Vasse, Marc ;
Gregersen, Peter K. ;
Piemonti, Lorenzo ;
Rodríguez-Gallego, Carlos ;
Notarangelo, Luigi ;
Su, Helen C. ;
Kisand, Kai ;
Okada, Satoshi ;
Puel, Anne ;
Jouanguy, Emmanuelle ;
Rice, Charles M. ;
Tiberghien, Pierre ;
Zhang, Qian ;
Casanova, Jean-Laurent ;
Abel, Laurent ;
Cobat, Aurélie ;
Universitat Autònoma de Barcelona
There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. [...]
2022 -  10.1073/pnas.2200413119
Proceedings of the National Academy of Sciences of the United States of America, Vol. 119 (may 2022)
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22 p, 2.2 MB |
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
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Degenhardt, Frauke (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Ellinghaus, David (Novo Nordisk Foundation Center for Protein Research. University of Copenhagen (Copenhagen, Dinamarca)) ;
Juzenas, Simonas (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Lerga Jaso, Jon (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Wendorff, Mareike (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Maya-Miles, Douglas (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Uellendahl-Werth, Florian (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
ElAbd, Hesham (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Rühlemann, Malte C. (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Arora, Jatin (Program in Medical and Population Genetics. Broad Institute of MIT and Harvard (Cambridge, Estats Units)) ;
Özer, Onur (Research Group for Evolutionary Immunogenomics. Max Planck Institute for Evolutionary Biology (Plön, Alemanya)) ;
Lenning, Ole Bernt (Stavanger University Hospital (Stavanger, Noruega)) ;
Myhre, Ronny (Division of Health Data and Digitalization, Department of Genetics and Bioinformatics (HDGB). Norwegian Institute of Public Health (Oslo, Noruega)) ;
Vadla, May Sissel (Randaberg Municipality (Stavanger, Noruega)) ;
Wacker, Eike M. (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Wienbrandt, Lars (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Blandino Ortiz, Aaron (Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria. University of Alcalá (Madrid)) ;
de Salazar, Adolfo (Instituto de Investigación Biosanitaria. Hospital Universitario Clínico San Cecilio (Granada, Andalusia)) ;
Garrido Chercoles, Adolfo (Servicio Vasco de Salud de Osakidetza. Organización Sanitaria Integrada Donostialdea (Sant Sebastià, País Basc)) ;
Palom, Adriana (Hospital Universitari Vall d'Hebron) ;
Ruiz, Agustín (Universitat Internacional de Catalunya) ;
Garcia-Fernandez, Alba-Estela (Hospital Universitari Vall d'Hebron) ;
Blanco-Grau, Albert (Hospital Universitari Vall d'Hebron) ;
Mantovani, Alberto (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia)) ;
Zanella, Alberto (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Holten, Aleksander Rygh (Oslo University Hospital. Institute of Clinical Medicine. University of Oslo (Olso, Noruega)) ;
Mayer, Alena (Charite Universitätsmedizin (Berlín, Alemanya)) ;
Bandera, Alessandra (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Cherubini, Alessandro (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Protti, Alessandro (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia)) ;
Aghemo, Alessio (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia)) ;
Gerussi, Alessio (European Reference Network on Hepatological Diseases. San Gerardo Hospital (Monza, Itàlia)) ;
Ramirez, Alfredo (Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases. Faculty of Medicine and University Hospital Cologne. University of Cologne (Colònia, Alemanya)) ;
Braun, Alice (Charite Universitätsmedizin (Berlín, Alemanya)) ;
Nebel, Almut ;
Barreira-Diaz, Ana (Hospital Universitari Vall d'Hebron) ;
Lleo, Ana (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia)) ;
Teles, Ana (Research Group for Evolutionary Immunogenomics. Max Planck Institute for Evolutionary Biology (Plön, Alemanya)) ;
Kildal, Anders Benjamin (University Hospital of North Norway (Tromsø, Noruega)) ;
Biondi, Andrea (Centro Tettamanti-European Reference Network. PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale (San Gerardo, Itàlia)) ;
Caballero, Andrea (Laboratorio de Análisis Dr. Echevarne (Barcelona)) ;
Ganna, Andrea (Institute for Molecular Medicine Finland. University of Helsinki (Helsinki, Finlàndia)) ;
Gori, Andrea (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Glück, Andreas (Klinik für Innere Medizin I. Universitätsklinikum Schleswig-Holstein (Kiel, Alemanya)) ;
Lind, Andreas (Oslo University Hospital (Olso, Noruega)) ;
Tanck, Anja (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Hinney, Anke (University Hospital Essen. University of Duisburg-Essen (Essen, Alemanya)) ;
Carreras Nolla, Anna (Institut Germans Trias i Pujol) ;
Fracanzani, Anna Ludovica (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Peschuck, Anna (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Cavallero, Annalisa (Laboratory of Microbiology. San Gerardo Hospital (Monza, Itàlia)) ;
Dyrhol-Riise, Anne Ma (Institute of Clinical Medicine. University of Oslo (Olso, Noruega)) ;
Ruello, Antonella (Humanitas Gavazzeni-Castelli (Bergamo, Itàlia)) ;
Julià Cano, Antonio ;
Muscatello, Antonio (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Pesenti, Antonio (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Voza, Antonio (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia)) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Solier, Aurora (Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria. Universidad de Alcalá (Madrid)) ;
Schmidt, Axel (Institute of Human Genetics. University Hospital Bonn (Bonn, Alemanya)) ;
Cortés, Beatriz (Institut Germans Trias i Pujol) ;
Mateos, Beatriz (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Nafria-Jimenez, Beatriz (Servicio Vasco de Salud de Osakidetza. Organización Sanitaria Integrada Donostialdea (Sant Sebastià, País Basc)) ;
Schaefer, Benedikt (Medical University of Innsbruck (Innsbruck, Àustria)) ;
Jensen, Björn (University Hospital Duesseldorf. Medical Faculty Heinrich Heine University (Duesseldorf, Alemanya)) ;
Bellinghausen, Carla (University Hospital. Goethe University (Frankfurt am Main, Alemanya)) ;
Maj, Carlo (Institute of Genomic Statistics and Bioinformatics. University Hospital Bonn (Bonn, Alemanya)) ;
Ferrando, Carlos (Hospital Clínic i Provincial de Barcelona) ;
de la Horra, Carmen (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Quereda, Carmen (Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Skurk, Carsten (Charite Universitätsmedizin (Berlín, Alemanya)) ;
Thibeault, Charlotte (Charite Universitätsmedizin (Berlín, Alemanya)) ;
Scollo, Chiara (San Gerardo Hospital (Monzo, Itàlia)) ;
Herr, Christian (University Hospital Saarland (Homburg, Alemanya)) ;
Spinner, Christoph D. (University Hospital rechts der Isar. Technical University of Munich (Munich, Alemanya)) ;
Gassner, Christoph (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Lange, Christoph (University of Lübeck (Lübeck, Alemanya)) ;
Hu, Cinzia (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Paccapelo, Cinzia (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Lehmann, Clara (Faculty of Medicine and University Hospital Cologne. University of Cologne (Colònia, Alemanya)) ;
Angelini, Claudio (Humanitas Clinical and Research Center. Istituto di ricovero e cura a carattere scientifico(IRCCS)(Milà, Itàlia)) ;
Cappadona, Claudio (Humanitas University (Milà, Itàlia)) ;
Azuure, Clinton (Research Group for Evolutionary Immunogenomics. Max Planck Institute for Evolutionary Biology (Plön, Alemanya)) ;
Bianco, Cristiana (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Cea, Cristina (Hospital Universitari Vall d'Hebron) ;
Sancho, Cristina (Hospital de Basurto (Bilbao, Biscaia)) ;
Hoff, Dag Arne Lihaug (Norwegian University of Science and Technology (Trondheim, Noruega)) ;
Galimberti, Daniela (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Prati, Daniele (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Haschka, David (Medical University of Innsbruck (Innsbruck, Àustria)) ;
Jiménez Jiménez, David (Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria. Universidad de Alcalá (Madrid)) ;
Pestaña, David (Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Toapanta, David (Hospital Clínic i Provincial de Barcelona) ;
Muñíz Díaz, Eduardo (Universitat Autònoma de Barcelona) ;
Azzolini, Elena (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia)) ;
Sandoval, Elena (Hospital Clínic i Provincial de Barcelona) ;
Binatti, Eleonora (European Reference Network on Hepatological Diseases. San Gerardo Hospital (Monza, Itàlia)) ;
Scarpini, Elio (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Helbig, Elisa T. (Charite Universitätsmedizin (Berlín, Alemanya)) ;
Casalone, Elisabetta (Università degli Studi di Torino (Turin, Itàlia)) ;
Urrechaga, Eloisa (Instituto de Investigación Sanitaria Biobizkaia (Barakaldo, País Basc)) ;
Paraboschi, Elvezia Maria (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia)) ;
Pontali, Emanuele (Ente Ospedaliero Ospedali Galliera (Gènova, Itàlia)) ;
Reverter, Enric (Hospital Clínic i Provincial de Barcelona) ;
Calderón, Enrique J (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Navas, Enrique (Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Solligård, Erik (Geminicenter for Sepsis Research. Institute of Circulation and Medical Imaging. Norwegian Univesity of Science and Technology (Trondheim, Noruega)) ;
Contro, Ernesto (San Gerardo Hospital (Monza, Itàlia)) ;
Arana-Arri, Eunate (Instituto de Investigación Sanitaria Biobizkaia (Barakaldo, País Basc)) ;
Aziz, Fátima (Hospital Clínic i Provincial de Barcelona) ;
Garcia, Federico (Instituto de Investigación Biosanitaria. Hospital Universitario Clínico San Cecilio (Granada, Andalusia)) ;
García Sánchez, Félix (Centro de Transfusión (Madrid)) ;
Ceriotti, Ferruccio (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Martinelli-Boneschi, Filippo (Dino Ferrari Center. University of Milan (Milà, Itàlia)) ;
Peyvandi, Flora (University of Milan (Milà, Itàlia)) ;
Kurth, Florian (Charite Universitätsmedizin (Berlín, Alemanya)) ;
Blasi, Francesco (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Malvestiti, Francesco (University of Milan (Milà, Itàlia)) ;
Medrano, Francisco J. (Instituto de Biomedicina de Sevilla. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (Madrid)) ;
Mesonero, Francisco (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Hanses, Frank (University Hospital Regensburg (Regensburg, Alemanya)) ;
Müller, Fredrik (Oslo University Hospital. Institute of Clinical Medicine. University of Oslo (Olso, Noruega)) ;
Hemmrich-Stanisak, Georg (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Bellani, Giacomo (San Gerardo Hospital (Monza, Itàlia)) ;
Grasselli, Giacomo (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Pezzoli, Gianni (Fondazione Grigioni per il Morbo di Parkinson and Parkinson Institute. ASST Gaetano Pini-CTO (Milà, Itàlia)) ;
Costantino, Giorgio (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Albano, Giovanni (Humanitas Gavazzeni-Castelli (Bergamo, Itàlia)) ;
Cardamone, Giulia (Humanitas University (Milà, Itàlia)) ;
Bellelli, Giuseppe (University of Milano-Bicocca (Milà, Itàlia)) ;
Citerio, Giuseppe (University of Milano-Bicocca (Milà, Itàlia)) ;
Foti, Giuseppe (San Gerardo Hospital (Monza, Itàlia)) ;
Lamorte, Giuseppe (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Matullo, Giuseppe (Università degli Studi di Torino (Turin, Itàlia)) ;
Baselli, Guido (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Kurihara, Hayato (Humanitas Clinical and Research Center. Istituto di ricovero e cura a carattere scientifico(IRCCS)(Milà, Itàlia)) ;
Neb, Holger (University Hospital Frankfurt (Frankfurt am Main, Alemanya)) ;
My, Ilaria ;
Kurth, Ingo (Institute of Human Genetics. RWTH Aachen University (Aachen, Alemanya)) ;
Hernández, Isabel (Universitat Internacional de Catalunya) ;
Pink, Isabell (Hannover Medical School (Hannover, Alemanya)) ;
De Rojas, Itziar (Universitat Internacional de Catalunya) ;
Galván-Femenía, Iván (Institut Germans Trias i Pujol) ;
Holter, Jan Cato (Oslo University Hospital. Institute of Clinical Medicine. University of Oslo (Olso, Noruega)) ;
Afset, Jan Egil (Hospital de Basurto (Bilbao, Biscaia)) ;
Heyckendorf, Jan (University of Lübeck (Lübeck, Alemanya)) ;
Kässens, Jan (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Damås, Jan Kristian (St. Olavs Hospital. Trondheim University Hospital (Trondheim, Noruega)) ;
Rybniker, Jan (Faculty of Medicine and University Hospital Cologne. University of Cologne (Colònia, Alemanya)) ;
Altmüller, Janine (Cologne Center for Genomics. University of Cologne (Colònia, Alemanya)) ;
Ampuero, Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Martín, Javier (Instituto de Parasitología y Biomedicina López-Neyra (Granada, Andalusia)) ;
Erdmann, Jeanette (Institute for Cardiogenetics. University of Lübeck (Lübeck, Alemanya)) ;
Banales, Jesus (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Badia, Joan Ramon (Hospital Clínic i Provincial de Barcelona) ;
Dopazo, Joaquín (Instituto de Biomedicina de Sevilla (Sevilla, Andalusia)) ;
Schneider, Jochen (University Hospital Saarland (Homburg, Alemanya)) ;
Bergan, Jonas (Ostfold Hospital Trust (Gralum, Noruega)) ;
Barretina, Jordi (Institut Germans Trias i Pujol) ;
Walter, Jörn (Saarland University (Saarbrücken, Alemanya)) ;
Hernández Quero, Jose (Instituto de Investigación Biosanitaria (Granada, Andalusia)) ;
Goikoetxea, Josune (Instituto de Investigación Sanitaria Biocruces Bizkaia (Biscaia, País Basc)) ;
Delgado, Juan (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Guerrero, Juan M. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Fazaal, Julia (Institute of Human Genetics. University Hospital Bonn (Bonn, Alemanya)) ;
Kraft, Julia (Charite Universitätsmedizin (Berlín, Alemanya)) ;
Schröder, Julia (Institute of Human Genetics. University Hospital Bonn (Bonn, Alemanya)) ;
Risnes, Kari (Norwegian University of Science and Technology (Trondheim, Noruega)) ;
Banasik, Karina (Novo Nordisk Foundation Center for Protein Research. University of Copenhagen (Copenhagen, Dinamarca)) ;
Müller, Karl Erik (Drammen Hospital. Vestre Viken Hospital Trust (Drammen, Noruega)) ;
Gaede, Karoline I. (Research Center Borstel. BioMaterialBank Nord (Borstel, Alemanya)) ;
Garcia-Etxebarria, Koldo (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Tonby, Kristian (Institute of Clinical Medicine. University of Oslo (Olso, Noruega)) ;
Heggelund, Lars (Drammen Hospital. Vestre Viken Hospital Trust (Drammen, Noruega)) ;
Izquierdo-Sanchez, Laura (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Bettini, Laura Rachele (Centro Tettamanti-European Reference Network. PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale (San Gerardo, Itàlia)) ;
Sumoy, Lauro (Institut Germans Trias i Pujol) ;
Sander, Leif Erik (Charite Universitätsmedizin (Berlín, Alemanya)) ;
Lippert, Lena J. (Charite Universitätsmedizin (Berlín, Alemanya)) ;
Terranova, Leonardo (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Nkambule, Lindokuhle (Massachusetts General Hospital (Boston, Estats Units)) ;
Knopp, Lisa (University Hospital Duesseldorf. Medical Faculty Heinrich Heine University (Duesseldorf, Alemanya)) ;
Gustad, Lise Tuset (Geminicenter for Sepsis Research. Institute of Circulation and Medical Imaging. Norwegian Univesity of Science and Technology (Trondheim, Noruega)) ;
Garbarino, Lucia (Ente Ospedaliero Ospedali Galliera (Gènova, Itàlia)) ;
Santoro, Luigi (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Téllez, Luis (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Roade, Luisa (Hospital Universitari Vall d'Hebron) ;
Ostadreza, Mahnoosh (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Intxausti, Maider (Hospital de Basurto (Bilbao, Biscaia)) ;
Kogevinas, M. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Berger, Marc M. (University Hospital Essen. University Duisburg-Essen (Essen, Alemanya)) ;
Schaefer, Marco (Stefan-Morsch-Stiftung (Birkenfeld, Alemanya)) ;
Niemi, Mari E. K. (Institute for Molecular Medicine Finland. University of Helsinki (Helsinki, Finlàndia)) ;
Gutiérrez-Stampa, María Ángeles (OSI Donostialdea. Biodonostia Instituto de Investigación Sanitaria (Sant Sebastià, País Basc)) ;
Carrabba, Maria (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Figuera Basso, Maria E. (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Valsecchi, Maria Grazia (Center of Bioinformatics. Biostatistics and Bioimaging. University of Milano-Bicocca (Milà, Itàlia)) ;
Hernandez-Tejero, María (Hospital Clínic i Provincial de Barcelona) ;
Vehreschild, Maria J. G. T. (University Hospital Frankfurt & Goethe University Frankfurt (Frankfurt am Main, Alemanya)) ;
Manunta, Maria (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Acosta-Herrera, Marialbert (Institute of Parasitology and Biomedicine Lopez-Neyra (Granada, Andalusia)) ;
D'Angiò, Mariella (Centro Tettamanti-European Reference Network. PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale (San Gerardo, Itàlia)) ;
Baldini, Marina (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Cazzaniga, Marina Elena (University of Milano-Bicocca (Monza, Itàlia)) ;
Grimsrud, Marit M. (Institute of Clinical Medicine. University of Oslo (Olso, Noruega)) ;
Cornberg, Markus (Hannover Medical School (Hannover, Alemanya)) ;
Nöthen, Markus M. (Institute of Human Genetics. University Hospital Bonn (Bonn, Alemanya)) ;
Marquié, Marta (Universitat Internacional de Catalunya) ;
Castoldi, Massimo (Humanitas Gavazzeni-Castelli (Bergamo, Itàlia)) ;
Cordioli, Mattia (Institute for Molecular Medicine Finland. University of Helsinki (Helsinki, Finlàndia)) ;
Cecconi, Maurizio (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia)) ;
D'Amato, Mauro ;
Augustin, Max (Faculty of Medicine and University Hospital Cologne. University of Cologne (Colònia, Alemanya)) ;
Tomasi, Melissa (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Boada, Mercè (Universitat Internacional de Catalunya) ;
Dreher, Michael (University Hospital Aachen (Aachen, Alemanya)) ;
Seilmaier, Michael J. (Munich Clinic Schwabing. Academic Teaching Hospital. Ludwig-Maximilians-University (Munich, Alemanya)) ;
Joannidis, Michael (Medical University Innsbruck (Innsbruck, Alemanya)) ;
Wittig, Michael (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Mazzocco, Michela (Ente Ospedaliero Ospedali Galliera (Gènova, Itàlia)) ;
Ciccarelli, Michele (Humanitas Clinical and Research Center. Istituto di ricovero e cura a carattere scientifico(IRCCS)(Milà, Itàlia)) ;
Rodríguez-Gandía, Miguel (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Bocciolone, Monica (Humanitas Clinical and Research Center. Istituto di ricovero e cura a carattere scientifico(IRCCS)(Milà, Itàlia)) ;
Miozzo, Monica (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Imaz Ayo, Natale (Instituto de Investigación Sanitaria Biobizkaia (Barakaldo, País Basc)) ;
Blay, Natalia (Institut Germans Trias i Pujol) ;
Chueca, Natalia (Hospital Universitario Clínico San Cecilio (Granada, Andalusia)) ;
Montano, Nicola (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Braun, Nicole (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Ludwig, Nicole (Center of Human and Molecular Biology. University Hospital Saarland (Homburg/Saar, Alemanya)) ;
Marx, Nikolaus (RWTH Aachen University Hospital (Aachen, Alemanya)) ;
Martínez, Nilda (Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Cornely, Oliver A (Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases. Faculty of Medicine and University Hospital Cologne. University of Cologne (Colònia, Alemanya)) ;
Witzke, Oliver ;
Palmieri, Orazio ;
Faverio, Paola (University of Milano-Bicocca (Milà, Itàlia)) ;
Preatoni, Paoletta (Humanitas Clinical and Research Center. Istituto di ricovero e cura a carattere scientifico(IRCCS)(Milà, Itàlia)) ;
Bonfanti, Paolo (University of Milano-Bicocca (Milà, Itàlia)) ;
Omodei, Paolo (Humanitas Clinical and Research Center. Istituto di ricovero e cura a carattere scientifico(IRCCS)(Milà, Itàlia)) ;
Tentorio, Paolo ;
Castro, Pedro (Hospital Clínic i Provincial de Barcelona) ;
Rodrigues, Pedro M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
España, PP. (Hospital de Galdakao (Galdakao, Biscaia)) ;
Hoffmann, Per (Institute of Human Genetics. University Hospital Bonn (Bonn, Alemanya)) ;
Rosenstiel, Philip (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Schommers, Philipp (Faculty of Medicine and University Hospital Cologne. University of Cologne (Colònia, Alemanya)) ;
Suwalski, Phillip (Charite Universitätsmedizin (Berlín, Alemanya)) ;
de Pablo, Raúl (Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria. University of Alcalá (Madrid)) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron) ;
Bals, Robert (University Hospital Saarland (Homburg, Alemanya)) ;
Gualtierotti, Roberta (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Gallego-Durán, Rocío (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Nieto, Rosa (Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria. Universidad de Alcalá (Madrid)) ;
Carpani, Rossana (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Morilla, Rubén (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Badalamenti, Salvatore ;
Haider, Sammra ;
Ciesek, Sandra ;
May, Sandra (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Bombace, Sara (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia)) ;
Marsal, Sara (Hospital Universitari Vall d'Hebron) ;
Pigazzini, Sara (Institute for Molecular Medicine Finland. University of Helsinki (Helsinki, Finlàndia)) ;
Klein, Sebastian (Medical University Innsbruck (Innsbruck, Alemanya)) ;
Pelusi, Serena (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Wilfling, Sibylle (Zentrum für Humangenetik Regensburg (Regensburg, Alemanya)) ;
Bosari, Silvano (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Volland, Sonja ;
Brunak, Søren (Novo Nordisk Foundation Center for Protein Research. University of Copenhagen (Copenhagen, Dinamarca)) ;
Raychaudhuri, Soumya (Program in Medical and Population Genetics. Broad Institute of MIT and Harvard (Cambridge, Estats Units)) ;
Schreiber, Stefan (Institute of Clinical Molecular Biology. Christian-Albrechts-University. Klinik für Innere Medizin I. Universitätsklinikum Schleswig-Holstein (Kiel, Alemanya)) ;
Heilmann-Heimbach, Stefanie (Institute of Human Genetics. University Hospital Bonn (Bonn, Alemanya)) ;
Aliberti, Stefano (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia)) ;
Ripke, Stephan (Charite Universitätsmedizin (Berlín, Alemanya)) ;
Dudman, Susanne (Oslo University Hospital. Institute of Clinical Medicine. University of Oslo (Olso, Noruega)) ;
Wesse, Tanja (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Zheng, Tenghao ;
Bahmer, Thomas (Klinik für Innere Medizin I. Universitätsklinikum Schleswig-Holstein (Kiel, Alemanya)) ;
Eggermann, Thomas (Institute of Human Genetics. RWTH Aachen University (Aachen, Alemanya)) ;
Illig, Thomas ;
Brenner, Thorsten (University Hospital Essen. University Duisburg-Essen (Essen, Alemanya)) ;
Pumarola Suñé, Tomàs (Hospital Universitari Vall d'Hebron) ;
Feldt, Torsten (University Hospital Duesseldorf. Medical Faculty Heinrich Heine University (Duesseldorf, Alemanya)) ;
Folseraas, Trine (Institute of Clinical Medicine. University of Oslo (Olso, Noruega)) ;
Gonzalez Cejudo, Trinidad ;
Landmesser, Ulf ;
Protzer, Ulrike ;
Hehr, Ute ;
Rimoldi, Valeria (Humanitas University (Milà, Itàlia)) ;
Monzani, Valter (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Skogen, Vegard (University Hospital of North Norway (Tromsø, Noruega)) ;
Keitel, Verena (University Hospital Duesseldorf. Medical Faculty Heinrich Heine University (Duesseldorf, Alemanya)) ;
Kopfnagel, Verena ;
Friaza, Vicente (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Andrade, Victor (Faculty of Medicine and University Hospital Cologne. University of Cologne (Colònia, Alemanya)) ;
Moreno Aguado, Víctor (Institut d'Investigació Biomèdica de Bellvitge) ;
Morros, Rosa ;
Albrecht, Wolfgang (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Peter, Wolfgang (Stefan-Morsch-Stiftung (Birkenfeld, Alemanya)) ;
Poller, Wolfgang (Charite Universitätsmedizin (Berlín, Alemanya)) ;
Farré, Xavier (Institut Germans Trias i Pujol) ;
Yi, Xiaoli (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Wang, Xiaomin (Charite Universitätsmedizin (Berlín, Alemanya)) ;
Khodamoradi, Yascha (University Hospital Frankfurt & Goethe University Frankfurt (Frankfurt am Main, Alemanya)) ;
Karadeniz, Zehra (Charite Universitätsmedizin (Berlín, Alemanya)) ;
Latiano, Anna ;
Goerg, Siegfried (Institute of Transfusionsmedicine. University Hospital Schleswig-Holstein (Kiel, Alemanya)) ;
Bacher, Petra (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya)) ;
Koehler, Philipp (Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases. Faculty of Medicine and University Hospital Cologne. University of Cologne (Colònia, Alemanya)) ;
Tran, Florian (Institute of Clinical Molecular Biology. Christian-Albrechts-University. Klinik für Innere Medizin I. Universitätsklinikum Schleswig-Holstein (Kiel, Alemanya)) ;
Zoller, Heinz (Medical University of Innsbruck (Innsbruck, Àustria)) ;
Schulte, Eva C ;
Heidecker, Bettina (Charite Universitätsmedizin (Berlín, Alemanya)) ;
Ludwig, Kerstin U. (Institute of Human Genetics. University Hospital Bonn (Bonn, Alemanya)) ;
Fernández, Javier (Hospital Clínic i Provincial de Barcelona) ;
Romero-Gómez, Manuel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Albillos, Agustín (Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas. Instituto de Salud Carlos III (Madrid)) ;
Invernizzi, Pietro (European Reference Network on Hepatological Diseases. San Gerardo Hospital (Monza, Itàlia)) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Duga, Stefano (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia)) ;
Bujanda, Luis (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Madrid)) ;
Hov, Johannes R. (Institute of Clinical Medicine. University of Oslo (Olso, Noruega)) ;
Lenz, Tobias L. (Research Group for Evolutionary Immunogenomics. Max Planck Institute for Evolutionary Biology (Plön, Alemanya)) ;
Asselta, Rosanna (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia)) ;
de Cid, Rafael (Institut Germans Trias i Pujol) ;
Valenti, Luca (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Karlsen, Tom H. (Institute of Clinical Medicine. University of Oslo (Olso, Noruega)) ;
Cáceres Aguilar, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Franke, Andre (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. [...]
2022 - 10.1093/hmg/ddac158
Human Molecular Genetics, Vol. 31 (july 2022) , p. 3945-3966
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18 p, 1.3 MB |
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
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Zhang, Qian (St. Rockefeller University) ;
Liu, Zhiyong (Rockefeller University) ;
Moncada-Velez, Marcela (Rockefeller University) ;
Chen, Jie (Rockefeller University) ;
Ogishi, Masato (Rockefeller University) ;
Bigio, Benedetta (Rockefeller University) ;
Yang, Rui (Rockefeller University) ;
Arias, Andrés Augusto (Universidad de Antioquia) ;
Zhou, Qinhua (Rockefeller University) ;
Han, Ji Eun (Rockefeller University) ;
Ugurbil, Aileen Camille (Rockefeller University) ;
Zhang, Peng (Rockefeller University) ;
Rapaport, Franck (Rockefeller University) ;
Li, Juan (Rockefeller University) ;
Spaan, András N. (University Medical Center Utrecht) ;
Boisson, Bertrand (University of Paris) ;
Boisson-Dupuis, S. (University of Paris) ;
Bustamante, J. (Necker Hospital for Sick Children) ;
Puel, A. (University of Paris) ;
Ciancanelli, Michael J (Turnstone Biologics) ;
Zhang, Shen-Ying (University of Paris) ;
Béziat, V. (University of Paris) ;
Jouanguy, E. (University of Paris) ;
Abel, Laurent (INSERM U1163. University of Paris) ;
Cobat, A. (University of Paris) ;
Casanova, Jean-Laurent (Rockefeller University) ;
Bastard, Paul (University of Paris) ;
Korol, Cecilia (Necker Hospital for Sick Children, Paris) ;
Rosain, Jérémie (University of Paris) ;
Philippot, Q. (APHP Tenon Hospital) ;
Chbihi, Marwa (University of Paris. Imagine Institute) ;
Lorenzo, L. (University of Paris. Imagine Institute) ;
Bizien, L. (University of Paris. Imagine Institute) ;
Neehus, A. L. (University of Paris. Imagine Institute) ;
Kerner, G. (University of Paris. Imagine Institute) ;
Seeleuthner, Y. (University of Paris. Imagine Institute) ;
Manry, J. (University of Paris. Imagine Institute) ;
Le Voyer, T. (University of Paris. Imagine Institute) ;
Boisson, Bertrand (University of Paris. Imagine Institute) ;
Boisson-Dupuis, S. (University of Paris. Imagine Institute) ;
Bustamante, J. (Necker Hospital for Sick Children. AP-HP) ;
Puel, A. (University of Paris. Imagine Institute) ;
Zhang, S. Y. (University of Paris. Imagine Institute) ;
Béziat, V. (University of Paris. Imagine Institute) ;
Jouanguy, E. (University of Paris) ;
Abel, Laurent (University of Paris) ;
Cobat, A. (University of Paris) ;
Bastard, Paul (University of Paris) ;
Rosain, J. (University of Paris) ;
Philippot, Q. (APHP Tenon Hospital) ;
Chbihi, M. (University of Paris) ;
Lorenzo, L. (University of Paris) ;
Bizien, L. (University of Paris) ;
Neehus, A. L. (University of Paris) ;
Kerner, G. (University of Paris) ;
Seeleuthner, Y. (University of Paris) ;
Manry, J. (University of Paris) ;
Le Voyer, T. (University of Paris) ;
Boisson, Bertrand (University of Paris) ;
Boisson-Dupuis, S. (University of Paris) ;
Bustamante, J. (Necker Hospital for Sick Children) ;
Puel, A. (University of Paris) ;
Zhang, S. Y. (University of Paris) ;
Béziat, Vivien (University of Paris) ;
Jouanguy, Emmanuelle (University of Paris) ;
Abel, Laurent (INSERM U1163. University of Paris) ;
Cobat, Aurélie (University of Paris) ;
Le Pen, Jérémie (Rockefeller University) ;
Schneider, W. M. (Rockefeller University) ;
Razooky, B. S. (Rockefeller University) ;
Hoffmann, Hans-Heinrich (Rockefeller University) ;
Michailidis, E. (Rockefeller University) ;
Rice, Charles M. (Rockefeller University) ;
Sabli, Ira K. D. (Imperial College London) ;
Hodeib, Stephanie (Imperial College London) ;
Sancho Shimizu, Vanessa (Imperial College London) ;
Bilguvar, Kaya (Yale School of Medicine) ;
Ye, Junqiang (Columbia University) ;
Bolze, Alexandre (Helix) ;
Zhang, Y. (NIAID Clinical Genomics Program) ;
Notarangelo, Luigi (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ;
Su, H. C. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ;
Zhang, Y. (NIAID Clinical Genomics Program) ;
Notarangelo, L. D. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ;
Su, H. C. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ;
Onodi, Fanny (Université de Paris) ;
Korniotis, Sarantis (Université de Paris) ;
Karpf, Léa (Université de Paris. Institut de Recherche Saint-Louis. INSERM U976. Hôpital Saint-Louis) ;
Soumelis, V. (AP-HP. Hôpital Saint-Louis. Laboratoire d'Immunologie) ;
Bonnet-Madin, Lucie (Université de Paris. Institut de Recherche Saint-Louis) ;
Amara, A. (Université de Paris. Institut de Recherche Saint-Louis) ;
Dorgham, Karim (Sorbonne Université. Inserm. Centre d'Immunologie et des Maladies Infectieuses-Paris (CIMI PARIS). Assistance Publique-Hôpitaux de Paris (AP-HP). Hôpital Pitié-Salpêtrière) ;
Gorochov, Guy (Sorbonne Université) ;
Smith, N. (Institut Pasteur) ;
Duffy, Darragh (Institut Pasteur) ;
Moens, L. (University Hospitals Leuven (Bèlgica)) ;
Meyts, I. (KU Leuven. Department of Immunology. Microbiology and Transplantation) ;
Meade, P. (Department of Microbiology) ;
Garcia-Sastre, Adolfo (Tisch Cancer Institute) ;
Krammer, Florian (Department of Microbiology) ;
Corneau, A. (Sorbonne Université) ;
Masson, C. (Imagine Institute) ;
Schmitt, Y. (Imagine Institute) ;
Schluter, A. (Neurometabolic Diseases Laboratory) ;
Pujol, Aurora 1968- (Institut d'Investigació Biomèdica de Bellvitge) ;
Khan, T. (Sidra Medicine) ;
Marr, Nico (Hamad Bin Khalifa University) ;
Fellay, Jacques (Swiss Federal Institute of Technology Lausanne) ;
Roussel, L. (McGill University Health Centre) ;
Vinh, D. C. (McGill University Health Centre) ;
Shahrooei, M. (Saeed Pathobiology and Genetic Lab) ;
Alosaimi, M. F. (College of Medicine. King Saud University) ;
Alsohime, F. ;
Hasanato, R. (Department of Pathology and Laboratory Medicine. College of Medicine. King Saud University) ;
Mansouri, D. (Shahid Beheshti University of Medical Sciences) ;
Al-Saud, H. (National Center of Genomics Technology. King Abdulaziz City for Science and Technology) ;
Almourfi, F. (National Center of Genomics Technology. King Abdulaziz City for Science and Technology) ;
Al-Mulla, F. (Kuwait University) ;
Al-Muhsen, S. Z. (Immunology Research Laboratory. Department of Pediatrics. College of Medicine. King Saud University Medical City. King Saud University) ;
Al Turki, S. (Cancer & Blood Research. King Abdullah International Medical Research Center) ;
van de Beek, D. (Amsterdam UMC. University Medical Center) ;
Biondi, A. (Pediatric Departement. Centro Tettamanti-European Reference Network PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale) ;
Bettini, L. R. (Pediatric Departement. Centro Tettamanti-European Reference Network PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale) ;
D'Angio, M. (Pediatric Departement. Centro Tettamanti-European Reference Network PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale) ;
Bonfanti, Paolo (Department of Infectious Diseases. San Gerardo Hospital. University of Milano-Bicocca) ;
Imberti, L. (CREA Laboratory. Diagnostic Laboratory. ASST Spedali Civili di Brescia) ;
Sottini, A. (CREA Laboratory. Diagnostic Laboratory. ASST Spedali Civili di Brescia) ;
Paghera, S. (CREA Laboratory. Diagnostic Laboratory. ASST Spedali Civili di Brescia) ;
Quiros-Roldan, E. (Department of Infectious and Tropical Diseases. University of Brescia. ASST Spedali di Brescia) ;
Rossi, C. (Medical Officer. ASST Spedali Civili di Brescia) ;
Oler, A. J. (Bioinformatics and Computational Biosciences Branch. Office of Cyber Infrastructure and Computational Biology. NIAID. NIH) ;
Tompkins, M. F. (PRIMER. Uniformed Services University of the Health Sciences) ;
Alba, Camille (PRIMER. Uniformed Services University of the Health Sciences) ;
Dalgard, C. L. (American Genome Center. Uniformed Services University of the Health Sciences) ;
Vandernoot, Isabelle (Center of Human Genetics. Hôpital Erasme. Université Libre de Bruxelles) ;
Smits, Guillaume (Center of Human Genetics. Hôpital Erasme. Université Libre de Bruxelles) ;
Goffard, Jean-Christope (Department of Internal Medicine. Hôpital Erasme. Université Libre de Bruxelles) ;
Migeotte, Isabelle (Hôpital Erasme) ;
Haerynck, Filomeen (Department of Paediatric Immunology and Pulmonology. Centre for Primary Immunodeficiency Ghent (CPIG). PID Research Lab. Jeffrey Modell Diagnosis and Research Centre. Ghent University Hospital) ;
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron) ;
Martín-Nalda, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Colobrán Oriol, Roger (Hospital Universitari Vall d'Hebron) ;
Morange, Pierre-Emmanuel (Aix Marseille Univ) ;
Keles, Sevgi (Meram Medical Faculty. Necmettin Erbakan University. Meram Medical Faculty) ;
Çölkesen, Fatma (Department of Infectious Diseases and Clinical Microbiology. Konya Training and Research Hospital) ;
Ozcelik, Tayfun (Bilkent University) ;
Yasar, Tayfun Kart (Departments of Infectious Diseases and Clinical Microbiology. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. University of Health Sciences) ;
Senoglu, Sevtap (Departments of Infectious Diseases and Clinical Microbiology. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. University of Health Sciences) ;
Karabela, Şemsi Nur (Departments of Infectious Diseases and Clinical Microbiology. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. University of Health Sciences) ;
Rodríguez-Gallego, Carlos (Hospital Universitario de Gran Canaria Dr. Negrín) ;
Novelli, Giuseppe (University of Rome "Tor Vergata) ;
Hraiech, Sami (Intensive Care Unit) ;
Tandjaoui-Lambiotte, Yacine (Avicenne Hospital) ;
Duval, Xavier (Hôpital Bichat Claude Bernard) ;
Laouénan, Cédric (Hôpital Bichat) ;
Duval, X. (Hôpital Bichat Claude Bernard) ;
Snow, Andrew (Uniformed Services University of the Health Sciences, Bethesda) ;
Dalgard, Clifton L. (American Genome Center) ;
Milner, Joshua D. (Columbia University) ;
Mogensen, Trine Hyrup (Aarhus University) ;
Spaan, András N. (Univer-sity Medical Center Utrecht) ;
Bustamante, Jacinta (Necker Hospital for Sick Children) ;
Ciancanelli, Michael J. (Turnstone Biologics) ;
Maniatis, Tom (New York Genome Center) ;
Soumelis, Vassili (Hôpital Saint-Louis, Paris) ;
Nussenzweig, Michel (Howard Hughes Medical Institute) ;
Garcia-Sastre, Adolfo (Icahn School of Medicine) ;
Lifton, Richard P. (Yale School of Medicine) ;
Foti, Giuseppe (University of Milano-Bicocca) ;
Bellani, G. (University of Milano-Bicocca) ;
Citerio, Giuseppe (University of Milano-Bicocca) ;
Contro, E. (University of Milano-Bicocca) ;
Pesci, Alberto (University of Milano-Bicocca.) ;
Valsecchi, M. G. (University of Milano-Bicocca) ;
Cazzaniga, M. (University of Milano-Bicocca) ;
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Blanco Guillermo, Ignacio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodrigo, C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Aguilera-Albesa, Sergio (Complejo Hospitalario de Navarra) ;
Akcan, O. M. (Necmettin Erbakan University) ;
Darazam, I. A. (Shahid Beheshti University of Medical Sciences) ;
Aldave, J. C. (Hospital Nacional Edgardo Rebagliati Martins) ;
Ramos, M. A. (Parc Sanitari Sant Joan de Déu) ;
Nadji, S. A. (Shahid Beheshti University of Medical Sciences) ;
Alkan, G. (Selcuk University) ;
Allardet-Servent, J. (Hôpital Européen) ;
Allende-Martinez, Luis M (Hospital Universitario 12 de Octubre (Madrid)) ;
Alsina, L. (Hospital Sant Joan de Déu (Manresa)) ;
Alyanakian, M. A. (Necker Hospital for Sick Children) ;
Amador-Borrero, B. (Université de Paris) ;
Mouly, S. (Internal Medicine Department. Hôpital Lariboisière. APHP. Université de Paris) ;
Sene, D. (Internal Medicine Department. Hôpital Lariboisière. APHP. Université de Paris) ;
Amoura, Zahir (Internal Medicine Department. Pitié-Salpétrière Hospital) ;
Mathian, Alexis (Internal Medicine Department. Pitié-Salpétrière Hospital) ;
Antolí, Arnau (Hospital Universitari de Bellvitge) ;
Blanch, G. R. (Hospital Universitari de Bellvitge) ;
Riera, J. S. (Hospital Universitari de Bellvitge) ;
Moreno, X. S. (Hospital Universitari de Bellvitge) ;
Arslan, S. (Necmettin Erbakan University) ;
Assant, S. (Lyon Sud Hospital) ;
Auguet, Teresa (Hospital Universitari Joan XXIII de Tarragona) ;
Azot, A. (Private Practice) ;
Bajolle, F. (Necker Hospital for Sick Children) ;
Bustamante, J. (Necker Hospital for Sick Children) ;
Lévy, R. (Necker Hospital for Sick Children) ;
Oualha, M. (Necker Hospital for Sick Children) ;
Baldolli, A. (Department of Infectious Diseases) ;
Ballester Devis, Maria (Consorcio Hospital General Universitario) ;
Feldman, H. B. (Tel Aviv University) ;
Barrou, B. (Sorbonne Université.) ;
Beurton, Alexandra (Hôpital Pitié-Salpêtrière) ;
Bilbao, A. (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Blanchard-Rohner, G. (Geneva University Hospitals (Suïssa)) ;
Blandinières, A. (Georges Pompidou Hospital) ;
Rivet, N. (Georges Pompidou Hospital) ;
Blázquez-Gamero, Daniel (Hospital Universitario 12 de Octubre (Madrid)) ;
Bloomfield, M. (Motol University Hospital) ;
Bolivar-Prados, Mireia (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Clavé i Civit, Pere (rie, R.) ;
Bosteels, C. (Universitair Ziekenhuis Gent) ;
Lambrecht, B. N. (Universitair Ziekenhuis Gent) ;
van Braeckel, E. (Universitair Ziekenhuis Gent) ;
Bousfiha, Ahmed A (Averroes University Hospital D'Inflammation et d'Allergie. Hassann II University) ;
Bouvattier, C. (Endocrinology Unit. APHP Hôpitaux Universitaires Paris-Sud) ;
Vincent, A. (Endocrinology Unit. APHP Hôpitaux Universitaires Paris-Sud) ;
Boyarchuk, O. (I. Horbachevsky Ternopil National Medical University) ;
Bueno, M. R. P. (University of São Paulo) ;
Castro, M. V. (University of São Paulo) ;
Matos, L. R. B. (University of São Paulo) ;
Zatz, M. (Human Genome and Stem-Cell Research Center. University of São Paulo) ;
Agra, J. J. C. (Hospital Universitario Insular de Gran Canaria) ;
Calimli, S. (Konya State Hospital) ;
Capra, R. (Spedali Civili) ;
Carrabba, M. (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico) ;
Fabio, G. (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico) ;
Casasnovas, Carlos (Hospital Universitari de Bellvitge) ;
Vélez-Santamaria, V. (Hospital Universitari de Bellvitge) ;
Caseris, M. (Hopital Robert Debré) ;
Falck, A. (Hopital Robert Debré) ;
Poncelet, G. (Hopital Robert Debré) ;
Castelle, M. (Necker Enfants Malades Hospital) ;
Castelli, F. (University of Brescia) ;
de Vera, M. C. (Canarian Health System) ;
Catherinot, E. (Hôpital Foch) ;
Chalumeau, M. (Necker Hospital for Sick Children) ;
Toubiana, J. (Necker Hospital for Sick Children) ;
Charbit, B. (Pasteur Institute) ;
Li, Z. (Pasteur Institute) ;
Pellegrini, S. (Pasteur Institute) ;
Cheng, M. P. (McGill University Health Centre) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Codina, A. (Institut de Recerca Sant Joan de Déu) ;
Çölkesen, F. (Necmettin Erbakan University) ;
Çölkesen, F. (Konya Training and Research Hospital) ;
Colobrán Oriol, Roger (Hospital Universitari Vall d'Hebron) ;
Comarmond, C. (Pitié-Salpêtrière Hospital) ;
Dalmau, David (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Darley, D. R. (Vincent's Hospital Darlinghurst) ;
Dauby, N. (Université Libre de Bruxelles) ;
Dauger, S. (Robert-Debré University Hospital) ;
Le Bourgeois, F. (Robert-Debré University Hospital) ;
Levy, M. (Robert-Debré University Hospital) ;
de Pontual, L. (Hôpital Jean Verdier) ;
Dehban, A. (Sina Medical Complex) ;
Delplancq, G. (Centre de Génétique Humaine) ;
Demoule, A. (Sorbonne Université Médecine) ;
Diehl, J. L. (Georges Pompidou Hospital) ;
Dobbelaere, S. (AZ Delta) ;
Durand, Sophie (Institut Jérôme Lejeune) ;
Mircher, C. (Institut Jérôme Lejeune) ;
Rebillat, A. S. (Institut Jérôme Lejeune) ;
Vilaire, M. E. (Institut Jérôme Lejeune) ;
Eldars, W. (DMansoura University) ;
Elgamal, M. (Mansoura University) ;
Elnagdy, M. H. (Mansoura University) ;
Emiroglu, M. (Selcuk University) ;
Erdeniz, E. H. (Ondokuz Mayıs University) ;
Aytekin, S. E. (Necmettin Erbakan University) ;
Euvrard, R. (Centre Hospitalier Fleyriat) ;
Evcen, R. (Necmettin Erbakan University) ;
Faivre, L. (CHU Dijon) ;
Fartoukh, M. (APHP Tenon Hospital) ;
Philippot, Q. (APHP Tenon Hospital) ;
Faure, M. (Sorbonne Universités) ;
Arquero, M. F. (Hospital Clínico San Carlos (Madrid)) ;
Flores, Carlos (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Francois, B. (CHU Limoges) ;
Fumadó, Victoria (Universitat de Barcelona) ;
Fusco, Francesca (Institute of Genetics and Biophysics "Adriano Buzzati-Traverso) ;
Ursini, M. V. (Institute of Genetics and Biophysics "Adriano Buzzati-Traverso) ;
Solis, B. G. (Hospital Universitario La Paz (Madrid)) ;
de Diego, R. P. (Hospital Universitario La Paz (Madrid)) ;
van Den Rym, A. M. (Hospital Universitario La Paz (Madrid)) ;
Gaussem, P. (Department of Hematology. APHP. Hopital Européen Georges Pompidou. Inserm UMR-S1140) ;
Gil-Herrera, J. (Hos-pital General Universitario. Instituto de Investigación Sanitaria "Gregorio Marañón) ;
Gilardin, L. (Bégin Military Hospital) ;
Girona-Alarcón, Mònica (Hospital Sant Joan de Déu (Manresa)) ;
Goffard, J. C. (Université Libre de Bruxelles) ;
Gok, F. (Necmettin Erbakan University) ;
Yosunkaya, A. (Necmettin Erbakan University) ;
Thy, M. (Center for Clinical Investigation. Assistance Publique-Hôpitaux de Paris. Bichat-Claude Bernard University Hospital) ;
van Agtmael, Michiel (Department of Infectious Diseases. Amsterdam UMC) ;
Bomers, Marije (Department of Infectious Diseases. Amsterdam UMC) ;
Chouchane, Osoul (Department of Infectious Diseases. Amsterdam UMC) ;
Geerlings, Suzanne (Department of Infectious Diseases. Amsterdam UMC) ;
Goorhuis, Bram (Department of Infectious Diseases. Amsterdam UMC) ;
Grobusch, Martin P. (Department of Infectious Diseases. Amsterdam UMC) ;
Harris, Vanessa (Department of Infectious Diseases. Amsterdam UMC) ;
Hermans, Sabine M. (Department of Infectious Diseases. Amsterdam UMC) ;
Hovius, Joppe W. (Department of Infectious Diseases. Amsterdam UMC) ;
Nellen, Jeaninne (Department of Infectious Diseases. Amsterdam UMC) ;
Peters, Edgar (Department of Infectious Diseases. Amsterdam UMC) ;
van der Poll, Tom (Department of Infectious Diseases. Amsterdam UMC) ;
Prins, Jan M. (Department of Infectious Diseases. Amsterdam UMC) ;
Reijnders, Tom (Department of Infectious Diseases. Amsterdam UMC) ;
Schinkel, Michiel (Department of Infectious Diseases. Amsterdam UMC) ;
Sigaloff, Kim (Department of Infectious Diseases. Amsterdam UMC) ;
Stijnis, Cornelis S. (Department of Infectious Diseases. Amsterdam UMC) ;
van der Valk, Marc (Department of Infectious Diseases. Amsterdam UMC) ;
van Vugt, Michèle (Department of Infectious Diseases. Amsterdam UMC) ;
Joost Wiersinga, W. (Department of Infectious Diseases. Amsterdam UMC) ;
Algera, Anna Geke (Department of Intensive Care. Amsterdam UMC) ;
van Baarle, Frank (Department of Intensive Care. Amsterdam UMC) ;
Bos, Lieuwe D.. (Department of Intensive Care. Amsterdam UMC) ;
Botta, Michela (Department of Intensive Care. Amsterdam UMC) ;
de Bruin, Sanne (Department of Intensive Care. Amsterdam UMC) ;
Bulle, Esther (Department of Intensive Care. Amsterdam UMC) ;
Elbers, Paul (Department of Intensive Care. Amsterdam UMC) ;
Fleuren, Lucas (Department of Intensive Care. Amsterdam UMC) ;
Girbes, Armand (Department of Intensive Care. Amsterdam UMC) ;
Hagens, Laura (Department of Intensive Care. Amsterdam UMC) ;
Heunks, Leo (Department of Intensive Care. Amsterdam UMC) ;
Horn, Janneke (Department of Intensive Care. Amsterdam UMC) ;
van Mourik, Niels (Department of Intensive Care. Amsterdam UMC) ;
Paulus, Frederique (Department of Intensive Care. Amsterdam UMC) ;
Raasveld, Jorinde (Department of Intensive Care. Amsterdam UMC) ;
Schultz, Marcus J. (Department of Intensive Care. Amsterdam UMC) ;
Smit, Marry (Department of Intensive Care. Amsterdam UMC) ;
Stilma, Willemke (Department of Intensive Care. Amsterdam UMC) ;
Thoral, Patrick (Department of Intensive Care. Amsterdam UMC) ;
Tsonas, Anissa M (Department of Intensive Care. Amsterdam UMC) ;
de Vries, Heder (Department of Intensive Care. Amsterdam UMC) ;
Bax, Diane (Experimental Immunology. Amsterdam UMC) ;
Cloherty, Alex (Experimental Immunology. Amsterdam UMC) ;
Beudel, Martijn (Department of Neurology. Amsterdam UMC. Amsterdam Neuroscience) ;
Brouwer, Matthijs C. (Department of Neurology. Amsterdam UMC. Amsterdam Neuroscience) ;
Koning, Rutger (Department of Neurology. Amsterdam UMC. Amsterdam Neuroscience) ;
van de Beek, Diederik (Amsterdam UMC. University Medical Center) ;
Bogaard, H. J. (Department of Pulmonology. Amsterdam UMC) ;
de Brabander, J. (Department of Infectious Diseases. Amsterdam UMC) ;
de Bree, G. (Department of Infectious Diseases. Amsterdam UMC) ;
Bugiani, Marianna (Department of Pathology. Amsterdam UMC) ;
Geerts, Bart (Department of Anesthesiology. Amsterdam UMC) ;
Hollmann, Markus W. (Department of Anesthesiology. Amsterdam UMC) ;
Preckel, Benedikt (Department of Anesthesiology. Amsterdam UMC) ;
Veelo, Denise (Department of Anesthesiology. Amsterdam UMC) ;
Geijtenbeek, Theo (Department of Experimental Immunology. Amsterdam UMC) ;
Hafkamp, Florianne (Department of Experimental Immunology. Amsterdam UMC) ;
Hamann, Jorg (Amsterdam UMC Biobank Core Facility. Amsterdam UMC) ;
Hemke, Robert (Department of Radiology. Amsterdam UMC) ;
de Jong, Menno D. (Department of Medical Microbiology. Amsterdam UMC) ;
Schuurman, Alex (Department of Internal Medicine. Amsterdam UMC) ;
Teunissen, Charlotte (Neurochemical Laboratory. Amsterdam UMC) ;
Vlaar, Alexander P. J. (Department of Intensive Care. Amsterdam UMC) ;
Wouters, Dorien (Department of Clinical Chemistry. Amsterdam UMC) ;
Zwinderman, A. H. (Department of Clinical Epidemiology. Biostatistics and Bioinformatics. Amsterdam UMC) ;
Abel, Laurent (INSERM U1163. University of Paris. Imagine Institute) ;
Aiuti, Alessandro (San Raffaele Telethon Institute for Gene Therapy. IRCCS Ospedale San Raffaele) ;
Muhsen, Saleh Al (King Saud University) ;
Al-Mulla, Fahd (Kuwait University) ;
Anderson, Mark S. (University of California. San Francisco) ;
Feldman, Hagit Baris (Genetics Institute. Tel Aviv Sourasky Medical Center. Sackler Faculty of Medicine. Tel Aviv University) ;
Bogunovic, Dusan (Icahn School of Medicine) ;
Itan, Yuval (Icahn School of Medicine) ;
Bolze, Alexandre (Helix) ;
Cirulli, Elizabeth (Helix) ;
Barrett, Kelly Schiabor . (Helix) ;
Washington, Nicole (Helix) ;
Bondarenko, Anastasiia (Shupyk National Medical Academy for Postgraduate Education) ;
Bousfiha, Ahmed A. (Clinical Immunology Unit. Pediatric Infectious Disease Departement. Faculty of Medicine and Pharmacy. Averroes University Hospital. LICIA Laboratoire d'Immunologie Clinique. D'Inflammation et d'Allergie. Hassann II University) ;
Brodin, Petter (Karolinska Institutet (Estocolm, Suècia)) ;
Bryceson, Yenan (Karolinska Institutet (Estocolm, Suècia)) ;
Bustamante, Carlos D. (Stanford University) ;
Butte, Manish J (University of California) ;
Casari, Giorgio (Medical Genetics. IRCCS Ospedale San Raffaele) ;
Chakravorty, Samya (Emory University. Department of Pediatrics. Children's Healthcare of Atlanta) ;
Christodoulou, John (Murdoch Children's Research Institute) ;
Le Mestre, S. (University of São Paulo) ;
Condino-Neto, Antonio (University of São Paulo) ;
Cooper, Megan A. (Washington University School of Medicine) ;
Dalgard, Clifton L. (American Genome Center. Uniformed Services University of the Health Sciences) ;
David, Alessia (Centre for Bioinformatics and System Biology. Department of Life Sciences. Imperial College London. South Kensington Campus) ;
DeRisi, Joseph L. (Chan Zuckerberg Biohub) ;
Desai, Murkesh (Bai Jerbai Wadia Hospital for Children) ;
Drolet, Beth A. (School of Medicine and Public Health. University of Wisconsin) ;
Espinosa, Sara (Instituto Nacional de Pediatria. (National Institute of Pediatrics)) ;
Fellay, Jacques (Swiss Federal Institute of Technology Lausanne) ;
Flores, Carlos (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Franco, Jose Luis (University of Antioquia) ;
Gregersen, Peter K. (Feinstein Institute for Medical Research. Northwell Health USA) ;
Haerynck, Filomeen (Department of Paediatric Immunology and Pulmonology. Centre for Primary Immunodeficiency Ghent (CPIG). PID Research Lab. Jeffrey Modell Diagnosis and Research Centre. Ghent University Hospital) ;
Hagin, David (Genetics Institute. Tel Aviv Sourasky Medical Center) ;
Halwani, Rabih (Sharjah Institute of Medical Research. College of Medicine. University of Sharjah) ;
Heath, Jim (Institute for Systems Biology) ;
Henrickson, Sarah E. (Children's Hospital of Philadelphia (Pennsilvània)) ;
Hsieh, Elena (Anschutz Medical Campus) ;
Imai, Kohsuke (Riken) ;
Karamitros, Timokratis (Hellenic Pasteur Institute) ;
Kisand, Kai (University of Tartu) ;
Ku, Cheng-Lung. (Chang Gung University) ;
Lau, Yu-Lung (University of Hong Kong) ;
Ling, Yun (Shanghai Public Health Clinical Center. Fudan University) ;
Lucas, Carrie L. (Yale School of Medicine) ;
Mansouri, Davoud (Shahid Beheshti University of Medical Sciences) ;
Marodi, Laszlo (Semmelweis University Budapest) ;
Milner, Joshua (Columbia University Medical Center) ;
Mironska, Kristina (University Clinic for Children's Diseases) ;
Morio, Tomohiro (Tokyo Medical & Dental University Hospital) ;
Notarangelo, Luigi (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ;
Su, Helen C. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ;
Novelli, Antonio (Bambino Gesù Children's Hospital) ;
Novelli, Giuseppe (Department of Biomedicine and Prevention. University of Rome "Tor Vergata) ;
O'Farrelly, Cliona (Trinity College) ;
Okada, Satoshi (Hiroshima University) ;
Ozcelik, Tayfun (Bilkent University) ;
Perez de Diego, Rebeca (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Planas, Anna M. (IIBB-CSIC. IDIBAPS) ;
Prando, Carolina (Faculdades Pequeno Príncipe. Instituto de Pesquisa Pelé Pequeno Príncipe) ;
Pujol, Aurora 1968- (Institut d'Investigació Biomèdica de Bellvitge) ;
Quintana-Murci, Luis (Institut Pasteur. CNRS. UMR 2000. Collège de France) ;
Renia, Laurent (Infectious Diseases Horizontal Technology Center. Singapore Immunology Network. Agency for Science Technology (A*STAR)) ;
Renieri, Alessandra (Medical Genetics. University of Siena) ;
Rodríguez-Gallego, Carlos (Hospital Universitario de Gran Canaria Dr. Negrín) ;
Sancho Shimizu, Vanessa (Imperial College London) ;
Sankaran, Vijay (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ;
Shahrooei, Mohammed (Saeed Pathobiology and Genetic Lab) ;
Snow, Andrew (Uniformed Services University of the Health Sciences) ;
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron) ;
Tangye, Stuart (Garvan Institute of Medical Research (Darlinghurst, Austràlia)) ;
Turvey, Stuart (University of British Columbia) ;
Uddin, Furkan (Holy Family Red Crescent Medical College. Centre for Precision Therapeutics. NeuroGen Children's Healthcare. Genetics and Genomic Medicine Centre. NeuroGen Children's Healthcare) ;
Uddin, Mohammed J. (Centre for Applied Genomics. Department of Genetics and Genome Biology. Hospital for Sick Children) ;
van de Beek, Diederik (Amsterdam UMC. University Medical Center) ;
Vazquez, Sara E. (University of California) ;
Vinh, Donald C. (McGill University Health Centre) ;
von Bernuth, Horst (Charité-Berlin University Hospital Center) ;
Zawadzki, Pawel (Molecular Biophysics Division. Faculty of Physics. A. Mickiewicz University) ;
Jing, H. (NIAID Clinical Genomics Program. National Institutes of Health) ;
Tung, W. (NIAID Clinical Genomics Program. National Institutes of Health) ;
Meguro, K. (NIAID Clinical Genomics Program. National Institutes of Health) ;
Shaw, E. (NIAID Clinical Genomics Program. National Institutes of Health) ;
Jing, Huie (NIAID Clinical Genomics Program. National Institutes of Health) ;
Tung, Wesley (NIAID Clinical Genomics Program. National Institutes of Health) ;
Shafer, S. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ;
Zheng, L. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ;
Zhang, Z. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ;
Kubo, S. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ;
Chauvin, S. D. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ;
Meguro, K. (NIAID Clinical Genomics Program. National Institutes of Health) ;
Shaw, Elana (NIAID Clinical Genomics Program. National Institutes of Health) ;
Lenardo, M. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ;
Luthers, Christopher R. (Department of Pharmacology & Molecular Therapeutics. Uniformed Services University of the Health Sciences) ;
Bauman, Bradly M. (Department of Pharmacology & Molecular Therapeutics. Uniformed Services University of the Health Sciences) ;
Shafer, Samantha (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ;
Zheng, Lixin (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ;
Zhang, Zinan (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ;
Kubo, Satoshi (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ;
Chauvin, Samuel D. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ;
Lenardo, Michael (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ;
Lack, Justin (NIAID Collaborative Bioinformatics Resource. Frederick National Laboratory for Cancer Research. Leidos Biomedical Research. Inc.) ;
Karlins, Eric (Bioinformatics and Computational Biosciences Branch. Office of Cyber Infrastructure and Computational Biology. NIAID. NIH) ;
Hupalo, Daniel M. (American Genome Center. Uniformed Services University of the Health Sciences) ;
Rosenberger, John (American Genome Center. Uniformed Services University of the Health Sciences) ;
Sukumar, Gauthaman (American Genome Center. Uniformed Services University of the Health Sciences) ;
Wilkerson, Matthew D. (American Genome Center. Uniformed Services University of the Health Sciences) ;
Zhang, Xijun (American Genome Center. Uniformed Services University of the Health Sciences) ;
Universitat Autònoma de Barcelona
Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection. [...]
2020 - 10.1126/science.abd4570
Science, Vol. 370 Núm. 6515 (23 2020) , p. eabd4570
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Autoantibodies against type I IFNs in patients with life-threatening COVID-19
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Bastard, Paul (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ;
Rosen, Lindsey B. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Zhang, Qian (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ;
Michailidis, Eleftherios (The Rockefeller University. Laboratory of Virology and Infectious Disease) ;
Hoffmann, Hans-Heinrich (The Rockefeller University. Laboratory of Virology and Infectious Disease) ;
Zhang, Yu (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Dorgham, Karim (Sorbonne Université. Centre d'Immunologie et des Maladies Infectieuses) ;
Philippot, Quentin (University of Paris. Imagine Institute) ;
Rosain, Jérémie (University of Paris. Imagine Institute) ;
Béziat, Vivien (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ;
Manry, Jeremy (University of Paris. Imagine Institute) ;
Shaw, Elana (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Haljasmägi, Liis (University of Tartu. Institute of Biomedicine and Translational Medicine) ;
Peterson, Pärt (University of Tartu. Institute of Biomedicine and Translational Medicine) ;
Lorenzo, Lazaro (University of Paris. Imagine Institute) ;
Bizien, Lucy (University of Paris. Imagine Institute) ;
Trouillet-Assant, Sophie (Lyon University. International Center of Research in Infectiology) ;
Dobbs, Kerry (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Almeida de Jesus, Adriana (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Belot, Alexandre (Lyon Immunopathology Federation. Hospices Civils de Lyon) ;
Kallaste, Anne (Internal Medicine Clinic. Tartu University Hospital) ;
Catherinot, Emilie (Hôpital Foch) ;
Tandjaoui-Lambiotte, Yacine (Avicenne Hospital. Assistance Publique Hôpitaux de Paris) ;
Le Pen, Jérémie (The Rockefeller University. Laboratory of Virology and Infectious Disease) ;
Kerner, Gaspard (University of Paris. Imagine Institute) ;
Bigio, Benedetta (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ;
Seeleuthner, Yoann (University of Paris. Imagine Institute) ;
Yang, Rui (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ;
Bolze, Alexandre (Helix) ;
Spaan, András N. (University Medical Center Utrecht) ;
Delmonte, Ottavia M. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Abers, Michael S. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Aiuti, Alessandro (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS)) ;
Casari, Giorgio (Medical Genetics. IRCCS Ospedale San Raffaele) ;
Lampasona, Vito (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS)) ;
Piemonti, Lorenzo (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS)) ;
Ciceri, Fabio (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS)) ;
Bilguvar, Kaya (Yale University School of Medicine. Department of Genetics) ;
Lifton, Richard P. (Rockefeller University. Laboratory of Human Genetics and Genomics) ;
Vasse, Marc (Consorcio Hospital. General Universitario) ;
Smadja, David M. (Paris University. European Georges Pompidou Hospital) ;
Migaud, Mélanie (University of Paris. Imagine Institute) ;
Hadjadj, Jérome (Hôpital Cochin. Department of Internal Medicine) ;
Terrier, Benjamin (Université de Paris. Department of Internal Medicine) ;
Duffy, Darragh (Pasteur Institute) ;
Quintana-Murci, Lluis (Institut Pasteur. Collège de France) ;
van de Beek, Diederik (Amsterdam UMC. University Medical Center) ;
Roussel, Lucie (McGill University Health Centre) ;
Vinh, Donald C. (McGill University Health Centre) ;
Tangye, Stuart (Garvan Institute of Medical Research (Darlinghurst, Austràlia)) ;
Haerynck, Filomeen (Ghent University Hospital. (Bèlgica)) ;
Dalmau, David (Fundació Docència i Recerca Mútua Terrassa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brodin, Petter (Karolinska Institutet (Estocolm, Suècia)) ;
Nussenzweig, Michel (Howard Hughes Medical Institute) ;
Boisson-Dupuis, Stephanie (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ;
Rodríguez-Gallego, Carlos (Hospital Universitario de Gran Canaria Dr. Negrín) ;
Vogt, Guillaume (University of Paris. Neglected Human Genetics Laboratory) ;
Mogensen, Trine Hyrup (Aarhus University) ;
Oler, Andrew J. (Bioinformatics and Computational Biosciences Branch. Office of Cyber Infrastructure and Computational Biology. NIAID. NIH) ;
Gu, Jingwen (Bioinformatics and Computational Biosciences Branch. Office of Cyber Infrastructure and Computational Biology. NIAID. NIH) ;
Burbelo, Peter D. (Division of Intramural Research. National Institute of Dental Craniofacial Research (NIDCR). NIH) ;
Cohen, Jeffrey I. (Laboratory of Infectious Diseases. Division of Intramural Research. NIAID. NIH) ;
Biondi, Andrea (Pediatric Department. Centro Tettamanti-European Reference Network PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBMOspedale) ;
Bettini, Laura Rachele (Pediatric Department. Centro Tettamanti-European Reference Network PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBMOspedale) ;
D'Angio, Mariella (University of Milano-Bicocca. Pediatric Department) ;
Bonfanti, Paolo (University of Milano-Bicocca. Department of Infectious Diseases) ;
Rossignol, Patrick (University of Lorraine. Plurithematic Clinical Investigation Centre) ;
Mayaux, Julien (APHP Pitié-Salpêtrière Hospital) ;
Rieux-Laucat, Frédéric (Laboratory of Immunogenetics of Pediatric Autoimmune Diseases. INSERM. UMR 1163. University of Paris. Imagine Institute) ;
Husebye, Eystein (Karolinska Institutet (Estocolm, Suècia). Department of Medicine) ;
Fusco, Francesca (Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'. IGB-CNR) ;
Ursini, Matilde Valeria (Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'. IGB-CNR) ;
Imberti, Luisa (Centro di Ricerca Emato-oncologica AIL (CREA) Laboratory. Diagnostic Department. ASST Spedali Civili di Brescia) ;
Sottini, Alessandra (Centro di Ricerca Emato-oncologica AIL (CREA) Laboratory. Diagnostic Department. ASST Spedali Civili di Brescia) ;
Paghera, Simone (Centro di Ricerca Emato-oncologica AIL (CREA) Laboratory. Diagnostic Department. ASST Spedali Civili di Brescia) ;
Quiros-Roldan, Eugenia (Department of Infectious and Tropical Diseases. University of Brescia. ASST Spedali di Brescia) ;
Rossi, Camillo (Direzione Sanitaria. ASST Spedali Civili di Brescia) ;
Castagnoli, Riccardo (Department of Pediatrics. Fondazione IRCCS Policlinico San Matteo. University of Pavia) ;
Montagna, Daniela (Department of Clinical. Surgical. Diagnostic and Pediatric Sciences. University of Pavia) ;
Licari, Amelia (Department of Pediatrics. Fondazione IRCCS Policlinico San Matteo. University of Pavia) ;
Marseglia, Gian Luigi (Department of Pediatrics. Fondazione IRCCS Policlinico San Matteo. University of Pavia) ;
Duval, Xavier (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ;
Ghosn, Jade (Hôpital Bichat) ;
Tsang, John S. (Multiscale Systems Biology Section. Laboratory of Immune System Biology. NIAID. NIH) ;
Goldbach-Mansky, Raphaela (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Kisand, Kai (Institute of Biomedicine and Translational Medicine. University of Tartu) ;
Lionakis, Michail S. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Puel, Anne (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University) ;
Zhang, Shein-Ying (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University) ;
Holland, Steven M. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Gorochov, Guy (Département d'Immunologie. AP-HP. Hôpital Pitié-Salpétrière) ;
Jouanguy, Emmanuelle (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University) ;
Rice, Charles M. (Laboratory of Virology and Infectious Disease. The Rockefeller University) ;
Cobat, Aurélie (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University) ;
Notarangelo, Luigi (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Abel, Laurent (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University) ;
Su, Helen C. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Casanova, Jean-Laurent (Pediatric Hematology and Immunology Unit. Necker Hospital for Sick Children. AP-HP) ;
The University of Hong Kong
HGID Lab ;
The University of Hong Kong
NIAID-USUHS Immune Response to COVID Group ;
COVID Clinicians ;
COVID-STORM Clinicians ;
Imagine COVID Group ;
French COVID Cohort Study Group ;
The Milieu Intérieur Consortium ;
CoV-Contact Cohort ;
Amsterdam UMC Covid-19 Biobank ;
COVID Human Genetic Effort ;
Universitat Autònoma de Barcelona
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. [...]
2020 - 10.1126/science.abd4585
Science, Vol. 370 Núm. 6515 (september 2020) , p. eabd4585
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