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Articles, 2 records found
Articles 2 records found  
1.
Site-Specific mRNA Cleavage for Selective and Quantitative Profiling of Alternative Splicing with Label-Free Optical Biosensors / Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ; Bonnal, Sophie (Universitat Pompeu Fabra) ; Soler Aznar, Maria (Institut Català de Nanociència i Nanotecnologia) ; Escuela, Alfonso M. (Universidad de Las Palmas de Gran Canaria) ; Valcárcel, Juan (Universitat Pompeu Fabra) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Alternative splicing of mRNA precursors is a key process in gene regulation, contributing to the diversity of proteomes by the alternative selection of exonic sequences. Alterations in this mechanism are associated with most cancers, enhancing their proliferation and survival, and can be employed as cancer biomarkers. [...]
2019 - 10.1021/acs.analchem.9b03898
Analytical chemistry, Vol. 91, Issue 23 (December 2019) , p. 15138-15146  
2.
32 p, 1.1 MB Quantitative evaluation of alternatively spliced mRNA isoforms by label-free real-time plasmonic sensing / Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ; Carrascosa, Laura G. (Institut Català de Nanociència i Nanotecnologia) ; Bonnal, Sophie (Universitat Pompeu Fabra) ; Valcárcel, Juan (Universitat Pompeu Fabra) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Alternative splicing of mRNA precursors enables cells to generate different protein outputs from the same gene depending on their developmental or homeostatic status. Its deregulation is strongly linked to disease onset and progression. [...]
2016 - 10.1016/j.bios.2015.11.023
Biosensors and bioelectronics, Vol. 78 (April 2016) , p. 118-125  

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