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1.
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14 p, 12.2 MB |
Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction
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Monguió-Tortajada, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ;
Moron-Font, Miriam (Institut Germans Trias i Pujol) ;
Clos-Sansalvador, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Calle Arias, Alexandra (Departamento de Reproducción Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain) ;
Gastelurrutia, Paloma (Institut Germans Trias i Pujol) ;
Cserkoova, Adriana (Institut Germans Trias i Pujol) ;
Morancho, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramírez, Miguel Ángel (Departamento de Reproducción Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ;
Borràs, Francesc E. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Roura, Santiago (Institut Germans Trias i Pujol)
The administration of extracellular vesicles (EV) from mesenchymal stromal cells (MSC) is a promising cell-free nanotherapy for tissue repair after myocardial infarction (MI). However, the optimal EV delivery strategy remains undetermined. [...]
2021 -  10.1016/j.bioactmat.2021.02.026
Bioactive Materials, Vol. 6 (march 2021) , p. 3314-3327
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2.
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17 p, 2.5 MB |
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles
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Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Drobniewski, Francis (Imperial College) ;
Kontsevaya, Irina (N.V. Postnikov Samara Region Clinical Tuberculosis Dispensary) ;
Arias, Lilibeth (Institut Germans Trias i Pujol) ;
Monguió-Tortajada, Marta (Universitat Autònoma de Barcelona) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ong, Ruo-Yan (University of Dundee) ;
Luquín Fernández, M (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Dupont, Maeva (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Chojnacki, Jakub (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cardona, Paula (Institut Germans Trias i Pujol) ;
Neyrolles, Olivier (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Lugo-Villarino, Geanncarlo (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Vérollet, Christel (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Furrer, Hansjakob (University of Bern) ;
Günthard, Huldrych F. (University of Zurich) ;
Crocker, Paul R. (University of Dundee) ;
Tapia Melendo, Gustavo (Institut Germans Trias i Pujol) ;
Borràs, Francesc E (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fellay, Jacques (Lausanne University Hospital and University of Lausanne) ;
McLaren, Paul J. (University of Manitoba) ;
Telenti, Amalio (The Scripps Research Institute) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non-functional variant in SIGLEC1, which encodes the myeloid-cell receptor Siglec-1/CD169 implicated in HIV-1 cell-to-cell transmission. [...]
2021 - 10.1002/jev2.12046
Journal of extracellular vesicles, Vol. 10 (january 2021)
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3.
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11 p, 909.4 KB |
Molecular profile of urine extracellular vesicles from normo-functional kidneys reveal minimal differences between living and deceased donors
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Lozano-Ramos, S. Inés (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Bancu, Ioana (Institut Germans Trias i Pujol) ;
Carreras-Planella, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Monguió-Tortajada, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Cañas, Laura (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Juega, Javier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Bonet, Josep (Institut Germans Trias i Pujol) ;
Armengol, Maria del Pilar (Institut Germans Trias i Pujol) ;
Lauzurica, Ricardo (Institut Germans Trias i Pujol) ;
Borràs, Francesc E (Institut Germans Trias i Pujol)
Kidney transplantation (KTx) is the best therapeutic approach for chronic kidney diseases leading to irreversible kidney failure. Considering the origin of the graft, several studies have reported differences between living (LD) and deceased donors (DD) in graft and patient survival. [...]
2018 - 10.1186/s12882-018-0985-3
BMC Nephrology, Vol. 19 (july 2018)
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4.
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2.5 MB |
Graphene oxide enhances alginate encapsulated cells viability and functionality while not affecting the foreign body response
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Ciriza, Jesús (NanoBioCel Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, UPV/EHU) ;
Saenz del Burgo, Laura (NanoBioCel Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, UPV/EHU) ;
Gurruchaga, Haritz (NanoBioCel Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, UPV/EHU) ;
Borràs, Francesc E. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Franquesa, Marcella (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Orive, Gorka (NanoBioCel Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, UPV/EHU) ;
Hernández, Rosa Maria (NanoBioCel Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, UPV/EHU) ;
Pedraz, José Luis (NanoBioCel Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, UPV/EHU) ;
Universitat Autònoma de Barcelona
The combination of protein-coated graphene oxide (GO) and microencapsulation technology has moved a step forward in the challenge of improving long-term alginate encapsulated cell survival and sustainable therapeutic protein release, bringing closer its translation from bench to the clinic. [...]
2018 - 10.1080/10717544.2018.1474966
Drug Delivery, Vol. 25 (may 2018) , p. 1147-1160
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5.
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17 p, 1.4 MB |
Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer's disease and dementia with Lewy bodies
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Gámez-Valero, Ana (Institut Germans Trias i Pujol) ;
Campdelacreu, Jaume (Hospital Universitari de Bellvitge. Department of Neurology) ;
Vilas, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ispierto, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Reñé, Ramón (Hospital Universitari de Bellvitge. Department of Neurology) ;
Álvarez, Ramiro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Armengol, Maria del Pilar (Institut Germans Trias i Pujol) ;
Borràs, Francesc E (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Beyer, Katrin (Institut Germans Trias i Pujol)
Because of the increasing life expectancy in our society, aging-related neurodegenerative disorders are one of the main issues in global health. Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline. [...]
2019 - 10.1186/s40035-019-0169-5
Translational Neurodegeneration, Vol. 8 (october 2019)
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6.
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12 p, 5.3 MB |
Bovine endometrial MSC : mesenchymal to epithelial transition during luteolysis and tropism to implantation niche for immunomodulation
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Calle, Alexandra (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA). Departamento de Reproducción Animal) ;
López-Martín, Soraya (UAM. Departamento de Biología Molecular) ;
Monguió-Tortajada, Marta (Institut Germans Trias i Pujol) ;
Borràs, Francesc E (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Yáñez-Mó, María (CBM-SO, Instituto de Investigación Sanitaria Princesa (IIS-IP)) ;
Ramírez, Miguel Ángel (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA). Departamento de Reproducción Animal)
The uterus is a histologically dynamic organ, and the mechanisms coordinating its regeneration during the oestrous cycle and implantation are poorly understood. The aim of this study was to isolate, immortalize and characterize bovine endometrial mesenchymal stem cell (eMSC) lines from different oestrous cycle stages (embryo in the oviduct, embryo in the uterus or absence of embryo) and examine their migratory and immunomodulatory properties in an inflammatory or implantation-like environment, as well as possible changes in cell transdifferentiation. [...]
2019 - 10.1186/s13287-018-1129-1
Stem cell research & therapy, Vol. 10 (january 2019)
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7.
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13 p, 3.2 MB |
Comprehensive proteomic profiling of plasma-derived Extracellular Vesicles from dementia with Lewy Bodies patients
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Gámez-Valero, Ana (Institut Germans Trias i Pujol) ;
Campdelacreu, Jaume (Hospital Universitari de Bellvitge. Departament de Neurologia) ;
Reñé, Ramón (Hospital Universitari de Bellvitge. Departament de Neurologia) ;
Beyer, Katrin (Institut Germans Trias i Pujol) ;
Borràs, Francesc E. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Proteins and nucleic acids contained in extracellular vesicles (EVs) are considered a feasible source of putative biomarkers for physiological and pathological conditions. Within the nervous system, not only neurons but also other brain cells are able to produce EVs, which have been involved in their physiological processes and also in the development and course of several neurodegenerative diseases. [...]
2019 - 10.1038/s41598-019-49668-y
Scientific reports (Nature Publishing Group), Vol. 9 (September 2019) , art. 13282
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8.
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13 p, 6.0 MB |
Mesenchymal stem cells induce expression of cD73 in human monocytes in vitro and in a swine model of myocardial infarction in vivo
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Monguió-Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roura, Santiago (Institut Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ;
Franquesa, Marcella (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Borràs,Francesc E. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The ectoenzymes CD39 and CD73 regulate the purinergic signaling through the hydrolysis of adenosine triphosphate (ATP)/ADP to AMP and to adenosine (Ado), respectively. This shifts the pro-inflammatory milieu induced by extracellular ATP to the anti- inflammatory regulation by Ado. [...]
2017 - 10.3389/fimmu.2017.01577
Frontiers in immunology, Vol. 8 (november 2017) , p. 1-13
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9.
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20 p, 9.7 MB |
Characterization and proteomic profile of extracellular vesicles from peritoneal dialysis efflux
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Carreras Planella, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler Majoral,Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rubio Esteve, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lozano Ramos, Sara Inés (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Franquesa, Marcella (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bonet, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Troya Saborido, Maria Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Borràs,Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Peritoneal Dialysis (PD) is considered the best option for a cost-effective mid-term dialysis in patients with Chronic Renal Failure. However, functional failure of the peritoneal membrane (PM) force many patients to stop PD treatment and start haemodialysis. [...]
2017 - 10.1371/journal.pone.0176987
PloS one, Vol. 12 Núm. 5 (2017) , p. 1-20
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