Boucher, Jeremie - Resultados de la búsqueda - Depósito Digital de Documentos de la UAB

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Artículos	Encontrados 2 registros

17 p, 2.0 MB

Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver / Khatib Shahidi, Roxana (University of Gothenburg. Department of Molecular and Clinical Medicine) ; M. Hoffmann, Jenny (University of Gothenburg. Department of Molecular and Clinical Medicine) ; Hedjazifar, Shahram (University of Gothenburg. Department of Molecular and Clinical Medicine) ; Bonnet, Laurianne (University of Gothenburg. Department of Molecular and Clinical Medicine) ; K. Baboota, Ritesh (University of Gothenburg. Department of Molecular and Clinical Medicine) ; Heasman, Stephanie (BioPharmaceuticals R&D. Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism) ; Church, Christopher (BioPharmaceuticals R&D. Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism) ; Elias Puigdomenech, Ivet (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Boucher, Jeremie (BioPharmaceuticals R&D. Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism) ; Hammarstedt, Ann (University of Gothenburg. Department of Molecular and Clinical Medicine) ; Smith, Ulf (University of Gothenburg. Department of Molecular and Clinical Medicine)
Gremlin 1 (GREM1) is a secreted BMP2/4 inhibitor which regulates commitment and differentiation of human adipose precursor cells and prevents the browning effect of BMP4. GREM1 is an insulin antagonist and serum levels are high in type 2 diabetes (T2D). [...]
2021 - DOI (Digital Object Identifier)

10.1371/journal.pone.0247300
PloS one, Vol. 16 (february 2021)

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12 p, 1.4 MB

BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice / Hoffmann, Jenny M. (University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Grünberg, John R. (University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Hammarstedt, Ann (University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Kroon, Tobias (BioPharmaceuticals. Bioscience Metabolism, Research and Early Development) ; Greiner, Thomas U. (University of Gothenburg. Department of Molecular and Clinical Medicine) ; Maurer, Stefanie (BioPharmaceuticals. Bioscience Metabolism, Research and Early Development) ; Elias Puigdomenech, Ivet (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Palsdottir, Vilborg (University of Gothenburg. Department of Physiology/Endocrinology) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG)) ; Boucher, Jeremie (University of Gothenburgç. Wallenberg Centre for Molecular and Translational Medicine) ; Hedjazifar, Shahram (University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Smith, Ulf (University of Gothenburg. The Lundberg Laboratory for Diabetes Research)
Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WAT) and enhancing energy expenditure. [...]
2019 - DOI (Digital Object Identifier)

10.1016/j.molmet.2019.11.016
Molecular metabolism, Vol. 32 (december 2019) , p. 15-26

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