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15 p, 676.0 KB |
Mechanisms of abrupt loss of virus control in a cohort of previous HIV controllers
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Rosás Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Bellido, Rocío (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz-Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rocafort, Muntsa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fernández, Marco A. (Institut Germans Trias i Pujol) ;
Cobarsi, Patricia (Institut Germans Trias i Pujol) ;
Crespo, Manel (Complexo Hospitalario Universitario de Vigo) ;
Dorrell, Lucy (Nuffield Department of Medicine, University of Oxford,) ;
del Romero, Jorge (Centro Sanitario Sandoval, Madrid) ;
Alcami, José (Instituto de Salud Carlos III, Madrid) ;
Paredes, Roger (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
A few individuals can control HIV infection without the need for antiretroviral treatment and are referred to as HIV controllers. We have studied HIV controllers who suddenly lose this ability and present with high in vivo viral replication and decays in their CD4 + T-cell counts to identify potential immune and virological factors that were responsible for initial virus control. [...]
2019 -  10.1128/JVI.01436-18
Journal of Virology, Vol. 93 (february 2019)
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2.
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12 p, 2.8 MB |
Gut microbiota linked to sexual preference and HIV infection
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Noguera-Julian, Marc (Institut Germans Trias i Pujol. IrsiCaixa) ;
Rocafort, Muntsa (Institut Germans Trias i Pujol. IrsiCaixa) ;
Guillén, Yolanda (Institut Germans Trias i Pujol. IrsiCaixa) ;
Rivera, Javier (Institut Germans Trias i Pujol. IrsiCaixa) ;
Casadellà, Maria (Institut Germans Trias i Pujol. IrsiCaixa) ;
Nowak, Piotr (Karolinska Universitetssjukhuset) ;
Hildebrand, Falk (European Molecular Biology Laboratory) ;
Zeller, Georg (European Molecular Biology Laboratory) ;
Parera, Mariona (Institut Germans Trias i Pujol. IrsiCaixa) ;
Bellido, Rocío (Institut Germans Trias i Pujol. IrsiCaixa) ;
Rodríguez, Cristina (Institut Germans Trias i Pujol. IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. IrsiCaixa) ;
Coll, Josep (Institut Germans Trias i Pujol. IrsiCaixa) ;
Bravo, Isabel (Hospital Universitari Germans Trias i Pujol) ;
Estany, Carla (Hospital Universitari Germans Trias i Pujol) ;
Herrero, Cristina (Hospital Universitari Germans Trias i Pujol) ;
Saz, Jorge (BCN Checkpoint,) ;
Sirera, Guillem (Hospital Universitari Germans Trias i Pujol) ;
Torrela, Ariadna (Hospital Universitari Vall d'Hebrón) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebrón) ;
Crespo, Manel (Hospital Universitari Vall d'Hebrón) ;
Brander, Christian (Institut Germans Trias i Pujol. IrsiCaixa) ;
Negredo, Eugènia (Universitat de Vic) ;
Blanco, Julià (Institut Germans Trias i Pujol. IrsiCaixa) ;
Guarner, Francisco (Hospital Universitari Vall d'Hebrón) ;
Calle, Maria Luz (Universitat de Vic) ;
Bork, Peer (European Molecular Biology Laboratory) ;
Sönnerborg, Anders (Karolinska Universitetssjukhuset) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. IrsiCaixa) ;
Paredes, Roger (Institut Germans Trias i Pujol. IrsiCaixa)
The precise effects of HIV-1 on the gut microbiome are unclear. Initial cross-sectional studies provided contradictory associations between microbial richness and HIV serostatus and suggested shifts from Bacteroides to Prevotella predominance following HIV-1 infection, which have not been found in animal models or in studies matched for HIV-1 transmission groups. [...]
2016 - 10.1016/j.ebiom.2016.01.032
EBioMedicine, Vol. 5 (March 2016) , p. 135-146
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3.
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10 p, 868.0 KB |
Defining the HLA class I‐associated viral antigen repertoire from HIV‐1‐infected human cells
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Ternette, Nicola (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Yang, Hongbing (University of Oxford. Nuffield Department of Medicine) ;
Partridge, Thomas (University of Oxford. Nuffield Department of Medicine) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fischer, Roman (University of Oxford. Nuffield Department of Medicine) ;
Charles, Philip D. (University of Oxford. Nuffield Department of Medicine) ;
Dudek, Nadine L. (Monash University. Department of Biochemistry and Molecular Biology) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Crespo, Manuel (Hospital de la Vall d'Hebron. HIV Unit) ;
Fischer, William M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ;
Korber, Bette T. M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ;
Nielsen, Morten (Technical University of Denmark. Center for Biological Sequence Analysis) ;
Borrow, Persephone (University of Oxford. Nuffield Department of Medicine) ;
Purcell, Anthony W. (Monash University. Department of Biochemistry and Molecular Biology) ;
Brander, Christian (Institució Catalana de Recerca i Estudis Avançats) ;
Dorrell, Lucy (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Kessler, Benedikt M. (University of Oxford. Nuffield Department of Medicine) ;
Hanke, Tomáš (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Universitat Autònoma de Barcelona
Recognition and eradication of infected cells by cytotoxic T lymphocytes is a key defense mechanism against intracellular pathogens. High‐throughput definition of HLA class I‐associated immunopeptidomes by mass spectrometry is an increasingly important analytical tool to advance our understanding of the induction of T‐cell responses against pathogens such as HIV‐1. [...]
2015 - 10.1002/eji.201545890
European Journal of Immunology, Vol. 46 (november 2015) , p. 60-69
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4.
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12 p, 1.2 MB |
Lymphocyte Activation Dynamics Is Shaped by Hereditary Components at Chromosome Region 17q12-q21
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Carreras Sureda, Amado, 1986- (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Rubio Moscardo, Fanny (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Argilaguet, Jordi (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Kiefer, Kerstin (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Meyerhans, Andreas (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vicente, Rubén (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Single nucleotide polymorphisms (SNPs) located in the chromosome region 17q12-q21 are risk factors for asthma. Particularly, there are cis-regulatory haplotypes within this region that regulate differentially the expression levels of ORMDL3, GSDMB and ZPBP2 genes. [...]
2016 - 10.1371/journal.pone.0166414
PloS one, Vol. 11 Núm. 11 (November 2016)
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5.
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19 p, 1.2 MB |
Identification of Immunogenic Cytotoxic T Lymphocyte Epitopes Containing Drug Resistance Mutations in Antiretroviral Treatment-Naïve HIV-Infected Individuals
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Blanco Heredia, Juan (Instituto Nacional de Enfermedades Respiratorias (México)) ;
Lecanda, Aarón (Instituto Nacional de Enfermedades Respiratorias (México)) ;
Valenzuela Ponce, Humberto (Instituto Nacional de Enfermedades Respiratorias (México)) ;
Brander Silva, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ávila Ríos, Santiago (Instituto Nacional de Enfermedades Respiratorias (México)) ;
Reyes Terán, Gustavo (Instituto Nacional de Enfermedades Respiratorias (México))
Background: therapeutic HIV vaccines may prove helpful to intensify antiretroviral treatment (ART) efficacy and may be an integral part of future cure strategies. Methods: we examined IFN-gamma ELISpot responses to a panel of 218 HIV clade B consensus-based HIV protease-reverse transcriptase peptides, designed to mimic previously described and predicted cytotoxic T lymphocyte epitopes overlapping drug resistance (DR) positions, that either included the consensus sequence or the DR variant sequence, in 49 ART-naïve HIV-infected individuals. [...]
2016 - 10.1371/journal.pone.0147571
PloS one, Vol. 11 Núm. 1 (January 2016)
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5 p, 846.7 KB |
Variants in the CYP7B1 gene region do not affect natural resistance to HIV-1 infection
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Sironi, Manuela (San Raffaele Scientific Institute (Milà, Itàlia)) ;
Biasin, Mara (University of Milan (Itàlia)) ;
Pontremoli, Chiara (San Raffaele Scientific Institute (Milà, Itàlia)) ;
Cagliani, Rachele (San Raffaele Scientific Institute (Milà, Itàlia)) ;
Saulle, Irma (University of Milan (Itàlia)) ;
Trabattoni, Daria (University of Milan (Itàlia)) ;
Vichi, Francesca (Santa Maria Annunziata Hospital (Florència, Itàlia)) ;
Lo Caputo, Sergio (Santa Maria Annunziata Hospital (Florència, Itàlia)) ;
Mazzotta, Francesco (Santa Maria Annunziata Hospital (Florència, Itàlia)) ;
Aguilar-Jimenez, Wbeimar (Universidad de Antioquia (Medellín, Colòmbia)) ;
Rugeles, María Teresa (Universidad de Antioquia (Medellín, Colòmbia)) ;
Cedeno, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Sanchez, Jorge (Asociación Civil Impacta Salud y Educación (Lima, Perú)) ;
Brander, Christian (Universitat de Vic) ;
Clerici, Mario (Foundation ONLUS (Milà, Itàlia)) ;
Universitat Autònoma de Barcelona
Abstract. BACKGROUND: The genetic bases of natural resistance to HIV-1 infection remain largely unknown. Recently, two genome-wide association studies suggested a role for variants within or in the vicinity of the CYP7B1 gene in modulating HIV susceptibility. [...]
2015 - 10.1186/s12977-015-0206-0
Retrovirology, Vol. 12 Núm. 80 (september 2015)
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22 p, 877.6 KB |
Identification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses
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Hancock, Gemma (University of Oxford) ;
Yang, Hongbing (University of Oxford) ;
Yorke, Elisabeth (University of Toronto) ;
Wainwright, Emma (Royal Berkshire NHS Foundation Trust (Reading, Gran Bretanya)) ;
Bourne, Victoria (University of Oxford) ;
Frisbee, Alyse (Duke University (Durham, Estats Units d'Amèrica)) ;
Payne, Tamika L. (Duke University (Durham, Estats Units d'Amèrica)) ;
Berrong, Mark (Duke University (Durham, Estats Units d'Amèrica)) ;
Ferrari, Guido (Duke University (Durham, Estats Units d'Amèrica)) ;
Chopera, Denis (University of Cape Town) ;
Hanke, Tomas (University of Oxford) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Brander, Christian (Hospital Germans Trias i Pujol) ;
McElrath, M. Juliana (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ;
McMichael, Andrew (University of Oxford) ;
Goonetilleke, Nilu (University of North Carolina School of Medicine) ;
Tomaras, Georgia D. (Duke University (North Carolina, Estats Units d'Amèrica)) ;
Frahm, Nicole (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ;
Dorrell, Lucy (University of Oxford)
Abstract. Defining the components of an HIV immunogen that could induce effective CD8+ T cell responses is critical to vaccine development. We addressed this question by investigating the viral targets of CD8+ T cells that potently inhibit HIV replication in vitro, as this is highly predictive of virus control in vivo. [...]
2015 - 10.1371/journal.ppat.1004658
PLoS Pathogens, Vol. 11 Núm. 2 (february 2015)
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20 p, 1.4 MB |
A Phase I Randomized Therapeutic MVA-B Vaccination Improves the Magnitude and Quality of the T Cell Immune Responses in HIV-1-Infected Subjects on HAART
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Gómez, Carmen Elena (Centro Nacional de Biotecnología (Madrid, Espanya)) ;
Perdiguero, Beatriz (Centro Nacional de Biotecnología (Madrid, Espanya)) ;
García-Arriaza, Juan (Centro Nacional de Biotecnología (Madrid, Espanya)) ;
Cepeda, Victoria (Centro Nacional de Biotecnología (Madrid, Espanya)) ;
Sánchez-Sorzano, Carlos Óscar (Centro Nacional de Biotecnología (Madrid, Espanya)) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Jiménez, José Luis (Hospital Gregorio Marañón (Madrid)) ;
Muñoz-Fernández, María Ángeles (Hospital Gregorio Marañón (Madrid)) ;
Gatell, José María (Hospital Clínic i Provincial de Barcelona) ;
López Bernaldo de Quirós, Juan Carlos (Hospital Gregorio Marañón (Madrid)) ;
Brander, Christian (Institució Catalana de Recerca i Estudis Avancats (ICREA)) ;
García, Felipe (Hospital Clínic i Provincial de Barcelona) ;
Esteban, Mariano (Centro Nacional de Biotecnología (Madrid, Espanya)) ;
Universitat Autònoma de Barcelona
TRIAL DESIGN: Previous studies suggested that poxvirus-based vaccines might be instrumental in the therapeutic HIV field. A phase I clinical trial was conducted in HIV-1-infected patients on highly active antiretroviral therapy (HAART), with CD4 T cell counts above 450 cells/mm3 and undetectable viremia. [...]
2015 - 10.1371/journal.pone.0141456
PloS one, Vol. 10 Núm. 11 (november 2015)
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9.
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23 p, 3.3 MB |
A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques
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Mothe Pujadas, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hu, Xintao (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rosati, Margherita (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Kulkarni, Viraj (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Valentin, Antonio (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Alicea, Cándido (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Pilkington, Guy R. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Sardesai, Niranjan Y. (Inovio Pharmaceuticals) ;
Rocafort, Muntsa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Crespo, Manel (Hospital Universitari Vall d'Hebron) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Marco, Andrés (Centre Penitenciari d'Homes (Barcelona, Catalunya)) ;
Mullins, James I. (University of Washington (Estats Units d'Amèrica)) ;
Dorrell, Lucy (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Hanke, Tomáš (University of Oxford (Regne Unit)) ;
Clotet i Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pavlakis, George N. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Felber, Barbara K. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
BACKGROUND: None of the HIV T-cell vaccine candidates that have reached advanced clinical testing have been able to induce protective T cell immunity. A major reason for these failures may have been suboptimal T cell immunogen designs. [...]
2015 - 10.1186/s12967-015-0392-5
Journal of translational medicine, Vol. 13 Núm. 60 (february 2015)
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