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1.
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25 p, 3.6 MB |
Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control
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Oriol-Tordera, Bruna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Berdasco, Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Llano, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Duran-Castells, Clara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ganoza, C. (Alberto Hurtado School of Medicine. Universidad Peruana Cayetano Heredia) ;
Sanchez, J. (Centro de Investigaciones Tecnológicas. Biomédicas y Medioambientales. CITBM) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Calle, M.L. (University of Vic-Central University of Catalonia) ;
Sánchez-Pla, Àlex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
GWAS, immune analyses and biomarker screenings have identified host factors associated with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms that regulate the expression of such host factors. [...]
2020 -  10.1371/JOURNAL.PPAT.1008678
PLoS pathogens, Vol. 16 Núm. 8 (june 2020) , p. e1008678
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2.
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5 p, 190.8 KB |
In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction
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Silva-Arrieta, Sandra (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Goulder, Phillip J.R. (Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, United States of America) ;
Brander, Christian. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
2020 - 10.1371/journal.ppat.1008607
PLoS pathogens, Vol. 16 Núm. 6 (january 2020) , p. e1008607
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3.
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15 p, 676.0 KB |
Mechanisms of abrupt loss of virus control in a cohort of previous HIV controllers
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Rosás Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Bellido, Rocío (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz-Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rocafort, Muntsa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fernández, Marco A. (Institut Germans Trias i Pujol) ;
Cobarsi, Patricia (Institut Germans Trias i Pujol) ;
Crespo, Manel (Complexo Hospitalario Universitario de Vigo) ;
Dorrell, Lucy (Nuffield Department of Medicine, University of Oxford) ;
del Romero, Jorge (Centro Sanitario Sandoval, Madrid) ;
Alcami, José (Instituto de Salud Carlos III, Madrid) ;
Paredes, Roger (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
A few individuals can control HIV infection without the need for antiretroviral treatment and are referred to as HIV controllers. We have studied HIV controllers who suddenly lose this ability and present with high in vivo viral replication and decays in their CD4 + T-cell counts to identify potential immune and virological factors that were responsible for initial virus control. [...]
2019 - 10.1128/JVI.01436-18
Journal of Virology, Vol. 93 (february 2019)
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4.
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14 p, 2.0 MB |
Differential Immunodominance Hierarchy of CD8 + T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection
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Adland, Emily ;
Hill, Matilda ;
Lavandier, Nora ;
Csala, Anna ;
Edwards, Anne ;
Chen, Fabian ;
Radkowski, Marek ;
Kowalska, Justyna D. ;
Paraskevis, Dimitrios ;
Hatzakis, Angelos ;
Valenzuela-Ponce, Humberto ;
Pfafferott, Katja ;
Williams, Ian ;
Pellegrino, Pierre ;
Borrow, Persephone ;
Mori, Masahiko ;
Rockstroh, Jürgen ;
Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Tudor-Williams, Gareth ;
Frater, John ;
Stryhn, Anette ;
Buus, Soren ;
Teran, Gustavo Reyes ;
Mallal, Simon ;
John, Mina ;
Buchbinder, Susan ;
Kirk, Gregory ;
Martin, Jeffrey ;
Michael, Nelson ;
Fellay, Jacques ;
Deeks, Steve ;
Walker, Bruce ;
Avila-Rios, Santiago ;
Cole, David ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrington, Mary ;
Goulder, Philip ;
Universitat Autònoma de Barcelona
The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05-restricted CD8 + T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and polymerase (Pol) KY9 (residues 901 to 909) epitopes. [...]
2018 - 10.1128/JVI.01685-17
Journal of Virology, Vol. 92 (january 2018)
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5.
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13 p, 2.5 MB |
Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for In Vivo HIV Control
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Ruiz-Riol, M. (Institut Germans Trias i Pujol) ;
Berdnik, D. ;
Llano, A. (Institut Germans Trias i Pujol) ;
Mothe, Beatriz. (Institut Germans Trias i Pujol) ;
Gálvez, C. (Institut Germans Trias i Pujol) ;
Pérez-Álvarez, S. (Institut Germans Trias i Pujol) ;
Oriol-Tordera, B. (Institut Germans Trias i Pujol) ;
Olvera, A. (Institut Germans Trias i Pujol) ;
Silva-Arrieta, S. (Institut Germans Trias i Pujol) ;
Meulbroek, M. (Institut Germans Trias i Pujol) ;
Pujol, F. ;
Coll, J. (Institut Germans Trias i Pujol) ;
Martinez-Picado, J. (Institut Germans Trias i Pujol) ;
Ganoza, C. ;
Sanchez, J. ;
Gómez, G. ;
Wyss-Coray, T. ;
Brander, Christian. (Institut Germans Trias i Pujol)
Intact and broad immune cell effector functions and specific individual cytokines have been linked to HIV disease outcome, but their relative contribution to HIV control remains unclear. We asked whether the proteome of secreted cytokines and signaling factors in peripheral blood can be used to discover specific pathways critical for host viral control. [...]
2017 - 10.1128/JVI.00441-17
Journal of Virology, Vol. 91 (july 2017)
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6.
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12 p, 2.8 MB |
Gut microbiota linked to sexual preference and HIV infection
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Noguera-Julian, Marc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rocafort, Muntsa (Institut Germans Trias i Pujol. IrsiCaixa) ;
Guillén, Yolanda (Institut Germans Trias i Pujol. IrsiCaixa) ;
Rivera, Javier (Institut Germans Trias i Pujol. IrsiCaixa) ;
Casadellà, Maria (Institut Germans Trias i Pujol. IrsiCaixa) ;
Nowak, Piotr (Karolinska Universitetssjukhuset) ;
Hildebrand, Falk (European Molecular Biology Laboratory) ;
Zeller, Georg (European Molecular Biology Laboratory) ;
Parera, Mariona (Institut Germans Trias i Pujol. IrsiCaixa) ;
Bellido, Rocío (Institut Germans Trias i Pujol. IrsiCaixa) ;
Rodríguez, Cristina (Institut Germans Trias i Pujol. IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. IrsiCaixa) ;
Coll, Josep (Institut Germans Trias i Pujol. IrsiCaixa) ;
Bravo, Isabel (Hospital Universitari Germans Trias i Pujol) ;
Estany, Carla (Hospital Universitari Germans Trias i Pujol) ;
Herrero, Cristina (Hospital Universitari Germans Trias i Pujol) ;
Saz, Jorge (BCN Checkpoint) ;
Sirera, Guillem (Hospital Universitari Germans Trias i Pujol) ;
Torrela, Ariadna (Hospital Universitari Vall d'Hebron) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebron) ;
Crespo, Manel (Hospital Universitari Vall d'Hebron) ;
Brander, Christian (Institut Germans Trias i Pujol. IrsiCaixa) ;
Negredo Puigmal, Eugènia (Universitat de Vic) ;
Blanco, Julià (Institut Germans Trias i Pujol. IrsiCaixa) ;
Guarner, Francisco (Hospital Universitari Vall d'Hebron) ;
Calle, Maria Luz (Universitat de Vic) ;
Bork, Peer (European Molecular Biology Laboratory) ;
Sönnerborg, Anders (Karolinska Universitetssjukhuset) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. IrsiCaixa) ;
Paredes, Roger (Institut Germans Trias i Pujol. IrsiCaixa)
The precise effects of HIV-1 on the gut microbiome are unclear. Initial cross-sectional studies provided contradictory associations between microbial richness and HIV serostatus and suggested shifts from Bacteroides to Prevotella predominance following HIV-1 infection, which have not been found in animal models or in studies matched for HIV-1 transmission groups. [...]
2016 - 10.1016/j.ebiom.2016.01.032
EBioMedicine, Vol. 5 (March 2016) , p. 135-146
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7.
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10 p, 868.0 KB |
Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells
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Ternette, Nicola (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Yang, Hongbing (University of Oxford. Nuffield Department of Medicine) ;
Partridge, Thomas (University of Oxford. Nuffield Department of Medicine) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fischer, Roman (University of Oxford. Nuffield Department of Medicine) ;
Charles, Philip D. (University of Oxford. Nuffield Department of Medicine) ;
Dudek, Nadine L. (Monash University. Department of Biochemistry and Molecular Biology) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Crespo, Manuel (Hospital Universitari Vall d'Hebron) ;
Fischer, William M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ;
Korber, Bette T. M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ;
Nielsen, Morten (Technical University of Denmark. Center for Biological Sequence Analysis) ;
Borrow, Persephone (University of Oxford. Nuffield Department of Medicine) ;
Purcell, Anthony W. (Monash University. Department of Biochemistry and Molecular Biology) ;
Brander, Christian (Institució Catalana de Recerca i Estudis Avançats) ;
Dorrell, Lucy (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Kessler, Benedikt M. (University of Oxford. Nuffield Department of Medicine) ;
Hanke, Tomáš (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Universitat Autònoma de Barcelona
Recognition and eradication of infected cells by cytotoxic T lymphocytes is a key defense mechanism against intracellular pathogens. High-throughput definition of HLA class I-associated immunopeptidomes by mass spectrometry is an increasingly important analytical tool to advance our understanding of the induction of T-cell responses against pathogens such as HIV-1. [...]
2015 - 10.1002/eji.201545890
European Journal of Immunology, Vol. 46 (november 2015) , p. 60-69
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16 p, 131.7 KB |
Virological, Immune and Host genetics Markers in the Control of HIV Infection
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Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ibarrondo, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institució Catalana de Recerca i Estudis Avançats)
HIV infection, if left untreated, leads in most cases to the development of wide immune deterioration, opportunistic infections and eventually AIDS and death. The identification of individuals who despite persisting infection show no or few signs of HIV disease progression has spurred hopes that an effective HIV vaccine could be attainable. [...]
2009 - 10.3233/DMA-2009-0655
Disease markers, Vol. 27 (11 2009) , p. 105-120
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12 p, 1.2 MB |
Lymphocyte Activation Dynamics Is Shaped by Hereditary Components at Chromosome Region 17q12-q21
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Carreras Sureda, Amado, 1986- (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Rubio Moscardo, Fanny (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Argilaguet, Jordi (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Kiefer, Kerstin (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Meyerhans, Andreas (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vicente, Rubén (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Single nucleotide polymorphisms (SNPs) located in the chromosome region 17q12-q21 are risk factors for asthma. Particularly, there are cis-regulatory haplotypes within this region that regulate differentially the expression levels of ORMDL3, GSDMB and ZPBP2 genes. [...]
2016 - 10.1371/journal.pone.0166414
PloS one, Vol. 11 Núm. 11 (November 2016)
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10.
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19 p, 1.2 MB |
Identification of Immunogenic Cytotoxic T Lymphocyte Epitopes Containing Drug Resistance Mutations in Antiretroviral Treatment-Naïve HIV-Infected Individuals
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Blanco Heredia, Juan (Instituto Nacional de Enfermedades Respiratorias (México)) ;
Lecanda, Aarón (Instituto Nacional de Enfermedades Respiratorias (México)) ;
Valenzuela Ponce, Humberto (Instituto Nacional de Enfermedades Respiratorias (México)) ;
Brander Silva, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ávila Ríos, Santiago (Instituto Nacional de Enfermedades Respiratorias (México)) ;
Reyes Terán, Gustavo (Instituto Nacional de Enfermedades Respiratorias (México))
Background: therapeutic HIV vaccines may prove helpful to intensify antiretroviral treatment (ART) efficacy and may be an integral part of future cure strategies. Methods: we examined IFN-gamma ELISpot responses to a panel of 218 HIV clade B consensus-based HIV protease-reverse transcriptase peptides, designed to mimic previously described and predicted cytotoxic T lymphocyte epitopes overlapping drug resistance (DR) positions, that either included the consensus sequence or the DR variant sequence, in 49 ART-naïve HIV-infected individuals. [...]
2016 - 10.1371/journal.pone.0147571
PloS one, Vol. 11 Núm. 1 (January 2016)
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