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1.
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11 p, 3.5 MB |
Speech Illusions in People at Clinical High Risk for Psychosis Linked to Clinical Outcome
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Hird, Emily J ;
Ohmuro, Noriyuki ;
Allen, Paul ;
Moseley, Peter ;
Kempton, Matthew J ;
Modinos, Gemma ;
Sachs, Gabriele ;
van der Gaag, Mark ;
de Haan, Lieuwe ;
Gadelha, Ary ;
Bressan, Rodrigo Affonseca ;
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut) ;
Ruhrmann, Stephan ;
Catalan, Ana ;
McGuire, Philip
Around 20% of people at clinical high risk (CHR) for psychosis later develop a psychotic disorder, but it is difficult to predict who this will be. We assessed the incidence of hearing speech (termed speech illusions [SIs]) in noise in CHR participants and examined whether this was associated with adverse clinical outcomes. [...]
2022 -  10.1093/schbul/sbac163
Schizophrenia bulletin, Vol. 49 (december 2022) , p. 339-349
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2.
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9 p, 242.5 KB |
Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis
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Catalan, Ana (Hospital de Basurto (Bilbao, Biscaia)) ;
Tognin, Stefania (South London and Maudsley NHS Foundation Trust) ;
Kempton, Matthew J. (National Institute for Health Research (NIHR)) ;
Stahl, Daniel (King's College London) ;
Salazar de Pablo, Gonzalo (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Nelson, Barnaby (University of Melbourne) ;
Pantelis, Christos (The University of Melbourne & Melbourne Health) ;
Riecher-Rössler, Anita (University of Basel) ;
Bressan, Rodrigo Affonseca (Universidade Federal de São Paulo - UNIFESP) ;
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut) ;
Krebs, Marie-Odile (Pôle Hospitalo Universitaire PEPIT C'JAAD) ;
Nordentoft, Merete (University of Copenhagen) ;
Ruhrmann, Stephan (University of Cologne) ;
Sachs, Gabriele (Medical University of Vienna) ;
Rutten, Bart P. F. (Maastricht University) ;
van Os, Jim (Universiteit Utrecht) ;
de Haan, Lieuwe (Amsterdam UMC) ;
van der Gaag, Mark (Parnassia Psychiatric Institute) ;
Valmaggia, Lucia R. (King's College London) ;
McGuire, Philip (Biomedical Research Centre (BRC))
Psychosis is associated with a reasoning bias, which manifests as a tendency to 'jump to conclusions'. We examined this bias in people at clinical high-risk for psychosis (CHR) and investigated its relationship with their clinical outcomes. [...]
2022 - 10.1017/S0033291720003396
Psychological Medicine, Vol. 52 (june 2022) , p. 1569-1577
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3.
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8 p, 352.0 KB |
Impact of adverse childhood experiences on educational achievements in young people at clinical high risk of developing psychosis
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Tognin, Stefania (South London and Maudsley NHS Foundation Trust) ;
Catalan, Ana (Hospital de Basurto (Bilbao, Biscaia)) ;
Kempton, Matthew J. (National Institute for Health Research) ;
Nelson, Barnaby (The University of Melbourne) ;
McGorry, Patrick (University of Copenhagen) ;
Riecher-Rössler, Anita (University of Basel) ;
Bressan, Rodrigo Affonseca (Universidade Federal de São Paulo - UNIFESP) ;
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut) ;
Krebs, Marie-Odile (Service Hospitalo-Universitaire) ;
Nordentoft, Merete (University of Copenhagen) ;
Ruhrmann, Stephan (University of Cologne) ;
Sachs, Gabriele (Medical University of Vienna) ;
Rutten, Bart P. F. (Maastricht University) ;
van Os, Jim (Universiteit Utrecht) ;
de Haan, Lieuwe (Amsterdam UMC) ;
van der Gaag, Mark (Parnassia Psychiatric Institute) ;
McGuire, Philip (National Institute for Health Research) ;
Valmaggia, Lucia R. (King's College London)
Adverse childhood experiences (ACE) can affect educational attainments, but little is known about their impact on educational achievements in people at clinical high risk of psychosis (CHR). In total, 344 CHR individuals and 67 healthy controls (HC) were recruited as part of the European Community's Seventh Framework Programme-funded multicenter study the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI). [...]
2023 - 10.1192/j.eurpsy.2022.2351
European psychiatry, Vol. 66 (january 2023)
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4.
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8 p, 518.5 KB |
Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis
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Hedges, Emily P. (King's College London. Department of Psychosis Studies) ;
Dickson, Hannah (King's College London. Department of Forensic and Neurodevelopmental Sciences) ;
Tognin, Stefania (King's College London. Department of Psychosis Studies) ;
Modinos, Gemma (King's College London. Department of Psychosis Studies) ;
Antoniades, Mathilde (Icahn School of Medicine. Department of Psychiatry) ;
van der Gaag, Mark (Parnassia Psychiatric Institute (Nova Zelanda). Department of Psychosis Research) ;
de Haan, Lieuwe (Arkin Amsterdam) ;
McGorry, Patrick (University of Melbourne. Centre for Youth Mental Health) ;
Pantelis, Christos (Melbourne Neuropsychiatry Centre) ;
Riecher-Rössler, Anita (University of Basel (Suïssa). Faculty of Medicine) ;
Bressan, Rodrigo Affonseca (Universidade Federal de São Paulo (Brasil). Depto Psiquiatria) ;
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut) ;
Krebs, Marie-Odile (University of Paris. GHU Psychiatrie et Neurosciences of Paris) ;
Nordentoft, Merete (Mental Health Center Copenhagen and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (Dinamarca)) ;
Ruhrmann, Stephan (University of Cologne (Alemanya). Department of Psychiatry and Psychotherapy) ;
Sachs, Gabriele (Medical University of Vienna. Department of Psychiatry and Psychotherapy) ;
Rutten, Bart P. (Maastricht University Medical Centre. Department of Psychiatry and Neuropsychology) ;
van Os, Jim (Maastricht University Medical Centre. Department of Psychiatry and Neuropsychology) ;
Valmaggia, Lucia (King's College London) ;
McGuire, Philip (King's College London. Department of Psychosis Studies) ;
Kempton, Matthew J. (King's College London. Department of Psychosis Studies)
Robust deficits in cognitive functioning are present in people with psychosis and are evident in the early stages of the disorder. Impairments in verbal memory and verbal fluency are reliably seen in individuals at clinical high-risk for psychosis (CHR) compared to healthy populations. [...]
2021 - 10.1016/j.scog.2021.100222
Schizophrenia Research: Cognition, Vol. 28 (october 2021)
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5.
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9 p, 227.2 KB |
Sex differences in cognitive functioning of patients at-risk for psychosis and healthy controls : Results from the European Gene-Environment Interactions study
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Menghini-Müller, Stephanie (University of Basel, Department of Psychiatry) ;
Studerus, Erich (University of Basel. Department of Psychology) ;
Ittig, Sarah (University of Basel. Department of Psychiatry) ;
Valmaggia, Lucia (King's College London) ;
Kempton, Matthew J. (King's College London) ;
van der Gaag, Mark (Parnassia Psychiatric Institute. Department of Psychosis Research) ;
de Haan, Lieuwe (Mental Health Institute (Amsterdam)) ;
Nelson, Barnaby (University of Melbourne. Centre for Youth Mental Health) ;
Bressan, Rodrigo Affonseca (Universidade Federal de São Paulo (UNIFESP). Departamento de Psiquiatria) ;
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut) ;
Jantac, Célia (University Paris Descartes) ;
Nordentoft, Merete (University of Copenhagen. Institute for Clinical Medicine) ;
Ruhrmann, Stephan (University of Cologne. Department of Psychiatry and Psychotherapy) ;
Sachs, Garbiele (Medical University of Vienna. Department of Psychiatry and Psychotherapy) ;
Rutten, Bart P. (School for Mental Health and Neuroscience. Department of Psychiatry and Neuropsychology) ;
van Os, Jim (King's College London. Department of Psychosis Studies) ;
Riecher-Rössler, Anita (University of Basel, Department of Psychiatry) ;
LiNC-Lab Interdisciplinar Neurociências Clínicas
Sex differences in cognitive functioning have long been recognized in schizophrenia patients and healthy controls (HC). However, few studies have focused on patients with an at-risk mental state (ARMS) for psychosis. [...]
2020 - 10.1192/j.eurpsy.2019.10
European psychiatry, Vol. 63 (march 2020)
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6.
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11 p, 6.6 MB |
Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis : A Network Perspective
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Ong, Hui Lin (Universiteit van Amsterdam) ;
Isvoranu, Adela-Maria (Universiteit van Amsterdam) ;
Schirmbeck, Frederike (Arkin Institute for Mental Health (Amsterdam)) ;
McGuire, Philip (King's College London. Department of Psychosis Studies) ;
Valmaggia, Lucia (King's College London) ;
Kempton, Matthew J. (King's College London) ;
van der Gaag, Mark (Vrije Universiteit Amsterdam) ;
Riecher-Rössler, Anita (Universität Basel) ;
Bressan, Rodrigo Affonseca (Universidade Federal de São Paulo) ;
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut) ;
Nelson, Barnaby (The University of Melbourne) ;
Amminger, G. Paul (Orygen) ;
McGorry, Patrick (The University of Melbourne) ;
Pantelis, Christos (University of Melbourne & Melbourne Health) ;
Krebs, Marie-Odile (University of Paris) ;
Nordentoft, Merete (University of Copenhagen) ;
Glenthøj, Birte (University of Copenhagen) ;
Ruhrmann, Stephan (University of Cologne) ;
Sachs, Gabriele (Department of Psychiatry and Psychotherapy, Medical University of Vienna) ;
Rutten, Bart P. F. (Maastricht University Medical Centre) ;
van Os, Jim (Universiteit Utrecht) ;
de Haan, Lieuwe (Arkin Institute for Mental Health (Amsterdam)) ;
Borsboom, Denny (Department of Psychology, Psychological Methods, University of Amsterdam)
The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. [...]
2021 - 10.1093/schbul/sbaa187
Schizophrenia bulletin, Vol. 47 (february 2021) , p. 1018-1028
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7.
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15 p, 1.4 MB |
Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis
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Pollak, Thomas A. (King's College London. Department of Psychosis Studies) ;
Kempton, Matthew J. (King's College London. Department of Psychosis Studies) ;
Iyegbe, Conrad (King's College London. Department of Psychosis Studies) ;
Vincent, Angela (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Irani, Sarosh R. (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Coutinho, Ester (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Menassa, David A. (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Jacobson, Leslie (John Radcliffe Hospital (Oxford, Regne Unit)) ;
de Haan, Lieuwe (University of Amsterdam. Department Early Psychosis) ;
Ruhrmann, Stephan (University of Cologne. Department of Psychiatry and Psychotherapy) ;
Sachs, Gabriele (Medical University of Vienna. Department of Psychiatry and Psychotherapy) ;
Riecher-Rössler, Anita (University of Basel. Medical Faculty) ;
Krebs, Marie-Odile (University of Paris. Institut de Psychiatrie) ;
Amminger, Paul (University of Melbourne. Centre for Youth Mental Health) ;
Glenthøj, Birte (University of Copenhagen. Centre for Neuropsychiatric Schizophrenia Research & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research) ;
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut) ;
van Os, Jim (Maastricht University Medical Centre. Department of Psychiatry and Neuropsychology) ;
Rutten, Bart P. F. (Maastricht University Medical Centre. Department of Psychiatry and Neuropsychology) ;
Bressan, Rodrigo Affonseca (Universidade Federal de São Paulo. Institute for Prevention of Mental Disorders) ;
van der Gaag, Mark (VU University. Department of Clinical Psychology) ;
Yolken, Robert (Johns Hopkins School of Medicine. Department of Pediatrics) ;
Hotopf, Matthew (King's College London. Department of Psychological Medicine) ;
Valmaggia, Lucia (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Stone, James (King's College London. Department of Psychosis Studies) ;
David, Anthony S. (King's College London. Department of Psychosis Studies) ;
McGuire, Philip (King's College London. Department of Psychosis Studies)
Serum neuronal autoantibodies, such as those to the NMDA receptor (NMDAR), are detectable in a subgroup of patients with psychotic disorders. It is not known if they are present before the onset of psychosis or whether they are associated with particular clinical features or outcomes. [...]
2020 - 10.1038/s41380-020-00899-w
Molecular psychiatry, Vol. 26 (october 2020) , p. 2590-2604
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11 p, 481.9 KB |
Impact of comorbid affective disorders on longitudinal clinical outcomes in individuals at ultra-high risk for psychosis
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Schirmbeck, Frederike ;
Van der Burg, Nadine C. ;
Blankers, Matthijs ;
Vermeulen, Jentien M. ;
McGuire, Philip ;
Valmaggia, Lucia ;
Kempton, Matthew J. ;
Van der Gaag, Mark ;
Riecher-Rössler, Anita ;
Bressan, Rodrigo Affonseca ;
Barrantes-Vidal, Neus ;
Nelson, Barnaby ;
Amminger, G. Paul ;
McGorry, Patrick ;
Pantelis, Christos ;
Krebs, Marie-Odile ;
Ruhrmann, Stephan ;
Sachs, Gabriele ;
Rutten, Bart P. F. ;
Van Os, Jim ;
Nordentoft, Merete ;
Glenthøj, Birte ;
Fusar-Poli, Paolo ;
Haan, Lieuwe de ;
EU-GEI High Risk Study Group
Diagnoses of anxiety and/or depression are common in subjects at Ultra-High Risk for Psychosis (UHR) and associated with extensive functional impairment. Less is known about the impact of affective comorbidities on the prospective course of attenuated psychotic symptoms (APS). [...]
2021 - 10.1093/schbul/sbab088
Schizophrenia Bulletin, Núm. sbab088 (2021)
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9.
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6 p, 458.4 KB |
Association between tobacco use and symptomatology in individuals at ultra-high risk to develop a psychosis: A longitudinal study
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Van der Heijden, Heleen S. (Amsterdam UMC. Department of Psychiatry) ;
Schirmbeck, Frederike (Arkin Institute for Mental Health (Amsterdam)) ;
McGuire, Philip (King's College London. Department of Psychosis Studies) ;
Valmaggia, Lucia (King's College London. Department of Psychosis Studies) ;
Kempton, Matthew J. (King's College London. Department of Psychosis Studies) ;
Van der Gaag, Mark (Psychosis Research Institute) ;
Nelson, Barnaby (University of Melbourne. Centre for Youth Mental Health) ;
Riecher-Rössler, Anita (University of Basel (Suïssa). Faculty of Medicine) ;
Bressan, Rodrigo Affonseca (Universidade Federal de São Paulo (Brasil). LiNC-Lab Interdisciplinar Neurociências Clínicas) ;
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut) ;
Ruhrmann, Stephan (University of Cologne. Department of Psychiatry and Psychotherapy) ;
Sachs, Gabriele (Medical University of Vienna. Department of Psychiatry and Psychotherapy) ;
Haan, Lieuwe de (Arkin Institute for Mental Health (Amsterdam)) ;
Vermeulen, Jentien M. (Amsterdam UMC. Department of Psychiatry) ;
EU-GEI High Risk Study
Background: The high prevalence rates and impact of tobacco smoking in individuals with a psychotic disorder have become an increasing interest. Little is known about tobacco smoking in individuals at ultra-high risk of psychosis (UHR). [...]
2021 - 10.1016/j.schres.2021.08.006
Schizophrenia Research, 2021
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10.
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11 p, 713.9 KB |
Association of Adverse Outcomes With Emotion Processing and Its Neural Substrate in Individuals at Clinical High Risk for Psychosis
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Modinos, Gemma (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Kempton, Matthew J. (National Institute for Health Research, Biomedical Research Centre, London, United Kingdom) ;
Tognin, Stefania (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Calem, Maria (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Porffy, Lilla (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Antoniades, Mathilde (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Mason, Ava (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Azis, Matilda (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Allen, Paul (Department of Psychology, University of Roehampton, London, United Kingdom) ;
Nelson, Barnaby (Centre for Youth Mental Health, University of Melbourne, Melbourne, Victoria, Australia) ;
McGorry, Patrick (Centre for Youth Mental Health, University of Melbourne, Melbourne, Victoria, Australia) ;
Pantelis, Christos (Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) ;
Riecher-Rössler, Anita (University Hospital Basel (Basilea, Suïssa)) ;
Borgwardt, Stefan (University Hospital Basel (Basilea, Suïssa)) ;
Bressan, Rodrigo Affonseca (LiNC-Lab Interdisciplinar Neurociências Clínicas, Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo-UNIFESP, São Paulo, Brazil) ;
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut) ;
Krebs, Marie-Odile (University of Paris, GHU-Paris, Sainte-Anne, C'JAAD, Hospitalo-Universitaire Department SHU, Inserm U1266, Institut de Psychiatrie (CNRS 3557), Paris, France) ;
Nordentoft, Merete (Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Mental Health Services in the Capital Region of Copenhagen, University of Copenhagen, Copenhagen, Denmark) ;
Glenthøj, Birte (University of Copenhagen. Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research) ;
Ruhrmann, Stephan (Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany) ;
Sachs, Gabriele (Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria) ;
Rutten, Bart (School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands) ;
van Os, Jim (Universiteit Utrecht) ;
de Haan, Lieuwe (Early Psychosis Department, Amsterdam UMC, Amsterdam, the Netherlands) ;
Velthorst, Eva (Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York) ;
van der Gaag, Mark (Parnassia Psychiatric Institute, Department of Psychosis Research, The Hague, the Netherlands) ;
Valmaggia, Lucia (Institute of Psychiatry, Psychology & Neuroscience, Department of Psychology, King's College London, London, United Kingdom) ;
McGuire, Philip (South London and Maudsley National Health Service Foundation Trust, London, United Kingdom)
This case-control study analyzes emotion recognition and neuroimaging data as well as clinical and functional outcomes for individuals at risk for transition to psychosis and those without psychiatric or neurological disorders. [...]
2019 - 10.1001/jamapsychiatry.2019.3501
JAMA Psychiatry, Vol. 77 (november 2019) , p. 190-200
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