Results overview: Found 2 records in 0.02 seconds.
Articles, 1 records found
Research literature, 1 records found
Articles 1 records found  
14 p, 7.0 MB Structural insights into positive and negative allosteric regulation of a G protein-coupled receptor through protein-lipid interactions / Bruzzese, Agustín (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gil Giró, Carles (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Dalton, James A. R (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
Lipids are becoming known as essential allosteric modulators of G protein-coupled receptor (GPCRs). However, how they exert their efects on GPCR conformation at the atomic level is still unclear. In light of recent experimental data, we have performed several long-timescale molecular dynamics (MD) simulations, totalling 24 μs, to rigorously map allosteric modulation and conformational changes in the β2 adrenergic receptor (β2AR) that occur as a result of interactions with three diferent phospholipids. [...]
2018 - 10.1038/s41598-018-22735-6
Scientific reports (Nature Publishing Group), Vol. 8 (2018) , art. 4456  

Research literature 1 records found  
1 p, 472.3 KB Estratègies terapèutiques contra l'obesitat : teixit adipós / Bruzzese Novoa, Agustín Alberto ; Terradas, Mariona, dir. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
Grau en Bioquímica [814]  

Interested in being notified about new results for this query?
Set up a personal email alert or subscribe to the RSS feed.